{"id":10062,"date":"2013-12-22T17:00:00","date_gmt":"2013-12-22T10:00:00","guid":{"rendered":"https:\/\/yhoccongdong.org\/du-an-khac\/methotrexat-thuoc-chong-thap-khop-tac-dung-cham\/"},"modified":"2024-03-17T02:16:38","modified_gmt":"2024-03-16T19:16:38","slug":"methotrexat-thuoc-chong-thap-khop-tac-dung-cham","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/du-an-khac\/methotrexat-thuoc-chong-thap-khop-tac-dung-cham\/","title":{"rendered":"Methotrexat – Thu\u1ed1c ch\u1ed1ng th\u1ea5p kh\u1edbp t\u00e1c d\u1ee5ng ch\u1eadm"},"content":{"rendered":"

Thu\u1ed1c do th\u00e0y thu\u1ed1c chuy\u00ean khoa ch\u1ec9 \u0111\u1ecbnh <\/p>\n

T\u00ean chung qu\u1ed1c t\u1ebf Methotrexat <\/h2>\n

Methotrexate <\/p>\n

D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng Methotrexat <\/h2>\n

Vi\u00ean n\u00e9n 2,5 mg. <\/p>\n

\"methotrexat-thuoc-chong-thap-khop-tac-dung-cham\" <\/a> <\/p>\n

H\u00ecnh <\/p>\n

Ch\u1ec9 \u0111\u1ecbnh Methotrexat <\/h2>\n

Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p n\u1eb7ng kh\u00f4ng \u0111\u00e1p \u1ee9ng v\u1edbi penicilamin ho\u1eb7c cloroquin; b\u1ec7nh ung th\u01b0 (M\u1ee5c 8.2). <\/p>\n

Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh Methotrexat <\/h2>\n

Mang thai v\u00e0 cho con b\u00fa (Ph\u1ee5 l\u1ee5c 2 v\u00e0 3); h\u1ed9i ch\u1ee9ng suy gi\u1ea3m mi\u1ec5n d\u1ecbch; tr\u00e0n d\u1ecbch m\u00e0ng ph\u1ed5i nhi\u1ec1u ho\u1eb7c c\u1ed5 tr\u01b0\u1edbng. <\/p>\n

Th\u1eadn tr\u1ecdng Methotrexat <\/h2>\n

C\u1ea7n theo d\u00f5i su\u1ed1t th\u1eddi gian \u0111i\u1ec1u tr\u1ecb s\u1ed1 l\u01b0\u1ee3ng huy\u1ebft c\u1ea7u v\u00e0 c\u00e1c x\u00e9t nghi\u1ec7m gan v\u00e0 th\u1eadn; t\u1ed5n th\u01b0\u01a1ng gan v\u00e0 th\u1eadn (tr\u00e1nh d\u00f9ng n\u1ebfu n\u1eb7ng, xem Ph\u1ee5 l\u1ee5c 4 v\u00e0 5); gi\u1ea3m li\u1ec1u ho\u1eb7c ng\u1eebng n\u1ebfu nhi\u1ec5m khu\u1ea9n c\u1ea5p; \u0111\u1ed1i v\u1edbi nam ho\u1eb7c n\u1eef c\u1ea7n tr\u00e1nh c\u00f3 con trong v\u00e0 \u00edt nh\u1ea5t 6 th\u00e1ng sau khi \u0111i\u1ec1u tr\u1ecb; lo\u00e9t d\u1ea1 d\u00e0y t\u00e1 tr\u00e0ng; vi\u00eam \u0111\u1ea1i tr\u00e0ng lo\u00e9t, \u1ec9a ch\u1ea3y, vi\u00eam mi\u1ec7ng lo\u00e9t; khuy\u00ean ng\u01b0\u1eddi b\u1ec7nh tr\u00e1nh t\u1ef1 \u0111i\u1ec1u tr\u1ecb b\u1eb1ng salicylat ho\u1eb7c c\u00e1c thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid kh\u00e1c; c\u1ea3nh b\u00e1o ng\u01b0\u1eddi b\u1ec7nh c\u1ea7n b\u00e1o ngay t\u1ea5t c\u1ea3 c\u00e1c tri\u1ec7u ch\u1ee9ng kh\u00f4ng gi\u1ea3i th\u00edch \u0111\u01b0\u1ee3c nh\u01b0 ch\u1ea3y m\u00e1u, b\u1ea7m t\u00edm, ch\u1ea5m xu\u1ea5t huy\u1ebft, nhi\u1ec5m khu\u1ea9n, \u0111au h\u1ecdng ho\u1eb7c s\u1ed1t, ho hay kh\u00f3 th\u1edf. <\/p>\n

T\u01b0\u01a1ng t\u00e1c thu\u1ed1c Methotrexat <\/h2>\n

(Ph\u1ee5 l\u1ee5c 1). <\/p>\n

Li\u1ec1u l\u01b0\u1ee3ng v\u00e0 c\u00e1ch d\u00f9ng Methotrexat <\/h2>\n

C\u00e1ch d\u00f9ng: <\/em> <\/em> Thu\u1ed1c u\u1ed1ng theo ch\u1ec9 \u0111\u1ecbnh c\u1ee7a th\u1ea7y thu\u1ed1c chuy\u00ean khoa. Th\u1ee9c \u0103n l\u00e0m gi\u1ea3m h\u1ea5p thu thu\u1ed1c. <\/p>\n

Li\u1ec1u d\u00f9ng: <\/em> Vi\u00eam kh\u1edbp d\u1ea1ng th\u1ea5p: u\u1ed1ng, ng\u01b0\u1eddi l\u1edbn, 7,5 mg, m\u1ed7i tu\u1ea7n u\u1ed1ng 1 l\u1ea7n (u\u1ed1ng 1 li\u1ec1u ho\u1eb7c chia l\u00e0m 3 li\u1ec1u nh\u1ecf, m\u1ed7i li\u1ec1u 2,5 mg, c\u00e1ch nhau 12 gi\u1edd), \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u tu\u1ef3 theo \u0111\u00e1p \u1ee9ng; t\u1ed5ng li\u1ec1u t\u1ed1i \u0111a m\u1ed7i tu\u1ea7n 20 mg. Ng\u01b0\u1eddi cao tu\u1ed5i, gi\u1ed1ng li\u1ec1u ng\u01b0\u1eddi l\u1edbn. Gi\u1ea3m li\u1ec1u khi c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn gi\u1ea3m. Tr\u1ebb em: u\u1ed1ng 10 mg\/m2 ho\u1eb7c 0,2 – 0,3 mg\/kg\/li\u1ec1u, c\u00f3 th\u1ec3 t\u0103ng l\u00ean t\u1edbi 0,8 mg\/kg\/li\u1ec1u khi c\u1ea7n \u0111\u1ec3 kh\u1ed1ng ch\u1ebf s\u1ed1t v\u00e0 vi\u00eam kh\u1edbp. U\u1ed1ng c\u00e1ch nhau 1 tu\u1ea7n. <\/p>\n

T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n Methotrexat <\/h2>\n

Hay g\u1eb7p nh\u1ea5t l\u00e0 bu\u1ed3n n\u00f4n, t\u0103ng enzym gan trong huy\u1ebft t\u01b0\u01a1ng. R\u1ed1i lo\u1ea1n m\u00e1u (\u1ee9c ch\u1ebf tu\u1ef7 x\u01b0\u01a1ng), t\u1ed5n th\u01b0\u01a1ng gan, nhi\u1ec5m \u0111\u1ed9c ph\u1ed5i; r\u1ed1i lo\u1ea1n ti\u00eau ho\u00e1. N\u1ebfu vi\u00eam mi\u1ec7ng v\u00e0 \u1ec9a ch\u1ea3y x\u1ea3y ra, ph\u1ea3i ng\u1eebng \u0111i\u1ec1u tr\u1ecb; suy th\u1eadn, ph\u1ea3n \u1ee9ng da, r\u1ee5ng t\u00f3c, lo\u00e3ng x\u01b0\u01a1ng, \u0111au kh\u1edbp, \u0111au c\u01a1, k\u00edch \u1ee9ng m\u1eaft, \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng. S\u00fac mi\u1ec7ng lu\u00f4n b\u1eb1ng dung d\u1ecbch acid folinic l\u00e0m gi\u1ea3m vi\u00eam mi\u1ec7ng. C\u00e1c ph\u1ea3n \u1ee9ng c\u00f3 h\u1ea1i tr\u00ean h\u1ec7 th\u1ea7n kinh th\u01b0\u1eddng h\u1ed3i ph\u1ee5c sau khi gi\u1ea3m li\u1ec1u ho\u1eb7c ng\u1eebng thu\u1ed1c. Ki\u1ec1m ho\u00e1 n\u01b0\u1edbc ti\u1ec3u v\u00e0 ti\u1ebfp n\u01b0\u1edbc \u0111\u1ea7y \u0111\u1ee7 \u00edt nh\u1ea5t 3 l\u00edt\/ng\u00e0y (ng\u01b0\u1eddi l\u1edbn) \u0111\u1ec3 tr\u00e1nh l\u1eafng \u0111\u1ecdng \u1edf th\u1eadn. <\/p>\n

Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed Methotrexat <\/h2>\n

Thu\u1ed1c gi\u1ea3i \u0111\u1ed9c l\u00e0 calci leucovorin ti\u00eam t\u0129nh m\u1ea1ch ho\u1eb7c ti\u00eam b\u1eafp v\u1edbi li\u1ec1u t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi methotrexat, t\u1edbi 75 mg c\u00e1ch nhau 6 gi\u1edd (4 li\u1ec1u). \u0110i\u1ec1u tr\u1ecb ch\u1eadm sau 36 gi\u1edd l\u00e0m gi\u1ea3m c\u01a1 may c\u1ee9u tho\u00e1t. <\/p>\n

\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n Methotrexat <\/h2>\n

B\u1ea3o qu\u1ea3n thu\u1ed1c vi\u00ean trong l\u1ecd k\u00edn, tr\u00e1nh \u00e1nh s\u00e1ng, \u1edf nhi\u1ec7t \u0111\u1ed9 15 – 25 o <\/sup> C. <\/p>\n<\/p>\n

http:\/\/nidqc.org.vn\/duocthu\/175\/ <\/p>\n","protected":false},"excerpt":{"rendered":"

Methotrexatl\u00e0 Methotrexate.Thu\u1ed1c ch\u1ed1ng th\u1ea5p kh\u1edbp t\u00e1c d\u1ee5ng ch\u1eadm.Thu\u1ed1c gi\u1ea3m \u0111au, h\u1ea1 s\u1ed1t, ch\u1ed1ng vi\u00eam.<\/p>\n","protected":false},"author":143,"featured_media":10063,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5377,5379,5316,5380,5378,5317],"tags":[],"series":[],"coauthors":[2170],"acf":[],"yoast_head":"\nMethotrexat - Thu\u1ed1c ch\u1ed1ng th\u1ea5p kh\u1edbp t\u00e1c d\u1ee5ng ch\u1eadm - D\u1ef1 \u00e1n kh\u00e1c<\/title>\n<meta name=\"description\" content=\"Methotrexat - Thu\u1ed1c ch\u1ed1ng th\u1ea5p kh\u1edbp t\u00e1c d\u1ee5ng ch\u1eadm - D\u1ef1 \u00e1n kh\u00e1c\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/yhoccongdong.com\/du-an-khac\/methotrexat-thuoc-chong-thap-khop-tac-dung-cham\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Methotrexat - 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