H\u00ecnh Pyrimethamin <\/em> <\/p>\n Ch\u1ec9 \u0111\u1ecbnh Pyrimethamin <\/h2>\n
B\u1ec7nh do Toxoplasma (+ sulfadiazin); s\u1ed1t r\u00e9t (+ sulfadoxin) (M\u1ee5c 6.6.4). <\/p>\n
Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh Pyrimethamin <\/h2>\n
Suy gan v\u00e0 suy th\u1eadn. <\/p>\n
Th\u1eadn tr\u1ecdng Pyrimethamin <\/h2>\n
Th\u1eddi k\u1ef3 mang thai: Tr\u00e1nh d\u00f9ng \u1edf 3 th\u00e1ng \u0111\u1ea7u c\u1ee7a thai k\u1ef3, nh\u01b0ng d\u00f9ng \u1edf nh\u1eefng th\u00e1ng cu\u1ed1i thai k\u1ef3 n\u1ebfu c\u00f3 nguy c\u01a1 l\u00e2y truy\u1ec1n b\u1ea9m sinh (Ph\u1ee5 l\u1ee5c 2), th\u1eddi k\u1ef3 cho con b\u00fa (Ph\u1ee5 l\u1ee5c 3), \u0111i\u1ec1u tr\u1ecb k\u00e9o d\u00e0i c\u1ea7n theo d\u00f5i c\u00f4ng th\u1ee9c m\u00e1u; b\u1ed5 sung folat trong su\u1ed1t \u0111\u1ee3t \u0111i\u1ec1u tr\u1ecb. <\/p>\n
T\u01b0\u01a1ng t\u00e1c thu\u1ed1c Pyrimethamin <\/h2>\n
(Ph\u1ee5 l\u1ee5c 1). <\/p>\n
Li\u1ec1u l\u01b0\u1ee3ng v\u00e0 c\u00e1ch d\u00f9ng Pyrimethamin <\/h2>\n
Nhi\u1ec5m Toxoplasma 3 th\u00e1ng gi\u1eefa v\u00e0 3 th\u00e1ng cu\u1ed1i c\u1ee7a thai k\u1ef3 <\/em> , ng\u01b0\u1eddi l\u1edbn u\u1ed1ng 25 mg\/ng\u00e0y trong 3 – 4 tu\u1ea7n. <\/p>\n Nhi\u1ec5m Toxoplasma s\u01a1 sinh <\/em> , s\u01a1 sinh u\u1ed1ng 1 mg\/kg\/ng\u00e0y, th\u1eddi gian \u0111i\u1ec1u tr\u1ecb ph\u1ee5 thu\u1ed9c v\u00e0o s\u01a1 sinh c\u00f3 bi\u1ec3u hi\u1ec7n l\u00e2m s\u00e0ng – ti\u1ebfp t\u1ee5c \u0111i\u1ec1u tr\u1ecb trong 6 th\u00e1ng ho\u1eb7c kh\u00f4ng c\u00f3 bi\u1ec3u hi\u1ec7n, nh\u01b0ng sinh ra t\u1eeb m\u1eb9 b\u1ecb nhi\u1ec5m trong th\u1eddi k\u1ef3 mang thai – \u0111i\u1ec1u tr\u1ecb trong 4 tu\u1ea7n, \u0111i\u1ec1u tr\u1ecb ti\u1ebfp n\u1ebfu nhi\u1ec5m Toxoplasma \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh. <\/p>\n Nhi\u1ec5m Toxoplasma tr\u00ean ng\u01b0\u1eddi suy gi\u1ea3m mi\u1ec5n d\u1ecbch <\/em> , ng\u01b0\u1eddi l\u1edbn ng\u00e0y th\u1ee9 nh\u1ea5t u\u1ed1ng 200 mg chia l\u00e0m nhi\u1ec1u l\u1ea7n, sau \u0111\u00f3 75 – 100 mg\/ng\u00e0y trong 6 tu\u1ea7n sau, ti\u1ebfp theo d\u00f9ng li\u1ec1u di\u1ec7t k\u00fd sinh tr\u00f9ng 25 – 50 mg\/ng\u00e0y. <\/p>\n Vi\u00eam v\u00f5ng m\u1ea1c m\u00e0ng m\u1ea1ch <\/em> , ng\u01b0\u1eddi l\u1edbn u\u1ed1ng 75 mg\/ng\u00e0y, trong 3 ng\u00e0y, sau \u0111\u00f3 u\u1ed1ng 25 mg, trong 4 tu\u1ea7n; b\u1ec7nh nh\u00e2n kh\u00f4ng \u0111\u00e1p \u1ee9ng u\u1ed1ng 50 mg\/ng\u00e0y, trong 4 tu\u1ea7n ti\u1ebfp theo. <\/p>\n Ch\u00fa \u00fd: Trong \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m Toxoplasma, pyrimethamin ph\u1ea3i lu\u00f4n \u0111\u01b0\u1ee3c k\u1ebft h\u1ee3p v\u1edbi sulfadiazin (xem \u1edf d\u01b0\u1edbi) <\/p>\n
T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n Pyrimethamin <\/h2>\n
Suy gi\u1ea3m kh\u1ea3 n\u0103ng t\u1ea1o huy\u1ebft khi d\u00f9ng li\u1ec1u cao; thi\u1ebfu m\u00e1u nguy\u00ean h\u1ed3ng c\u1ea7u kh\u1ed5ng l\u1ed3, ph\u00e1t ban; m\u1ea5t ng\u1ee7; r\u1ed1i lo\u1ea1n ti\u00eau ho\u00e1. <\/p>\n
Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed Pyrimethamin <\/h2>\n
N\u1ebfu d\u00f9ng qu\u00e1 li\u1ec1u, x\u1eed tr\u00ed c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t, r\u1eeda d\u1ea1 d\u00e0y. D\u00f9ng barbiturat \u0111\u1ec3 ch\u1ed1ng co gi\u1eadt. C\u00f3 th\u1ec3 d\u00f9ng acid folinic \u0111\u1ec3 gi\u1ea3m c\u00e1c t\u00e1c d\u1ee5ng c\u00f3 h\u1ea1i tr\u00ean h\u1ec7 t\u1ea1o m\u00e1u. <\/p>\n
\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n Pyrimethamin <\/h2>\n
Thu\u1ed1c \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n trong \u0111\u1ed3 \u0111\u1ef1ng k\u00edn \u1edf 15 – 25 o <\/sup> C, tr\u00e1nh \u00e1nh s\u00e1ng v\u00e0 \u1ea9m. <\/p>\n<\/p>\n http:\/\/nidqc.org.vn\/duocthu\/331\/ <\/p>\n","protected":false},"excerpt":{"rendered":"
Pyrimethamin – Ch\u1ed1ng Pneumocystis carinii v\u00e0 Toxoplasma gondii c\u00f3 th\u1ec3 tr\u1ecb s\u1ed1t r\u00e9t<\/p>\n","protected":false},"author":143,"featured_media":10087,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5392,5360,5316,5391,5363,5317],"tags":[],"series":[],"coauthors":[],"acf":[],"yoast_head":"\n
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