{"id":10160,"date":"2016-03-11T08:25:09","date_gmt":"2016-03-11T01:25:09","guid":{"rendered":"https:\/\/yhoccongdong.org\/du-an-khac\/flucytosin-thuoc-chong-nam\/"},"modified":"2024-03-17T02:31:32","modified_gmt":"2024-03-16T19:31:32","slug":"flucytosin-thuoc-chong-nam","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/du-an-khac\/flucytosin-thuoc-chong-nam\/","title":{"rendered":"Flucytosin – Thu\u1ed1c ch\u1ed1ng n\u1ea5m"},"content":{"rendered":"

T\u00ean chung qu\u1ed1c t\u1ebf Flucytosin<\/h2>\n

Flucytosine<\/p>\n

D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng Flucytosin<\/h2>\n

Nang 250 mg v\u00e0 500 mg. Dung d\u1ecbch truy\u1ec1n t\u0129nh m\u1ea1ch 10 mg\/ml, l\u1ecd 250 ml.<\/p>\n

\"flucytosin-thuoc-chong-nam\" <\/a><\/p>\n

H\u00ecnh<\/p>\n

Ch\u1ec9 \u0111\u1ecbnh Flucytosin<\/h2>\n

Flucytosin th\u01b0\u1eddng \u0111\u01b0\u1ee3c d\u00f9ng k\u1ebft h\u1ee3p v\u1edbi amphotericin B, flu- conazol hay itraconazol \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb vi\u00eam m\u00e0ng n\u00e3o do Cryptococcus v\u00e0 nhi\u1ec5m Candida to\u00e0n th\u00e2n.<\/p>\n

Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh Flucytosin<\/h2>\n

D\u1ecb \u1ee9ng v\u1edbi flucytosin.<\/p>\n

Th\u1eadn tr\u1ecdng Flucytosin<\/h2>\n

Ng\u01b0\u1eddi cao tu\u1ed5i; ng\u01b0\u1eddi suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn (Ph\u1ee5 l\u1ee5c 4). Th\u1eadn tr\u1ecdng khi ph\u1ed1i h\u1ee3p v\u1edbi amphotericin B (c\u1ea3 hai \u0111\u1ec1u \u0111\u1ed9c cho th\u1eadn). Kh\u00f4ng n\u00ean cho ng\u01b0\u1eddi suy th\u1eadn d\u00f9ng flucytosin n\u1ebfu kh\u00f4ng c\u00f3 ph\u01b0\u01a1ng ti\u1ec7n theo d\u00f5i n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong m\u00e1u. L\u00e0m test ch\u1ee9c n\u0103ng gan, th\u1eadn v\u00e0 \u0111\u1ebfm s\u1ed1 l\u01b0\u1ee3ng huy\u1ebft c\u1ea7u (h\u00e0ng tu\u1ea7n \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi suy th\u1eadn ho\u1eb7c r\u1ed1i lo\u1ea1n huy\u1ebft h\u1ecdc). Th\u1eddi k\u1ef3 mang thai (Ph\u1ee5 l\u1ee5c 2) v\u00e0 cho con b\u00fa (Ph\u1ee5 l\u1ee5c 3).<\/p>\n

T\u01b0\u01a1ng t\u00e1c thu\u1ed1c Flucytosin<\/h2>\n

(Ph\u1ee5 l\u1ee5c 1). Th\u1eadn tr\u1ecdng \u0111\u1ed1i v\u1edbi ng\u01b0\u1eddi suy tu\u1ef7, ng\u01b0\u1eddi \u0111ang chi\u1ebfu tia x\u1ea1 ho\u1eb7c \u0111ang d\u00f9ng c\u00e1c thu\u1ed1c \u1ee9c ch\u1ebf tu\u1ef7 x\u01b0\u01a1ng.<\/p>\n

Li\u1ec1u l\u01b0\u1ee3ng v\u00e0 c\u00e1ch d\u00f9ng Flucytosin<\/h2>\n

Nhi\u1ec5m Candida <\/em> v\u00e0 Cryptococcus <\/em> to\u00e0n th\u00e2n.<\/p>\n

U\u1ed1ng: Tr\u1ebb em v\u00e0 ng\u01b0\u1eddi l\u1edbn c\u00f3 ch\u1ee9c n\u0103ng th\u1eadn b\u00ecnh th\u01b0\u1eddng, u\u1ed1ng, 50 – 150 mg\/kg, chia th\u00e0nh li\u1ec1u nh\u1ecf, c\u00e1ch nhau 6 gi\u1edd. Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng kh\u00f4ng qu\u00e1 7 ng\u00e0y (\u00edt nh\u1ea5t 4 th\u00e1ng \u0111\u1ed1i v\u1edbi vi\u00eam m\u00e0ng n\u00e3o do Cryptococcus <\/em> ).<\/p>\n

Ti\u00eam truy\u1ec1n: Ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em, 200 mg\/kg\/ng\u00e0y (th\u1eddi gian ti\u00eam truy\u1ec1n 20 – 40 ph\u00fat) chia l\u00e0m 4 l\u1ea7n. Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng kh\u00f4ng qu\u00e1 7 ng\u00e0y (\u00edt nh\u1ea5t 4 th\u00e1ng \u0111\u1ed1i v\u1edbi vi\u00eam m\u00e0ng n\u00e3o do Cryptococcus). \u0110\u1ed1i v\u1edbi n\u1ea5m r\u1ea5t nh\u1ea1y c\u1ea3m, 100 – 150 mg\/kg\/ng\u00e0y, chia l\u00e0m 4 l\u1ea7n trong ng\u00e0y.<\/p>\n

T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n Flucytosin<\/h2>\n

Bu\u1ed3n n\u00f4n, n\u00f4n m\u1eeda, ti\u00eau ch\u1ea3y; h\u1ea1 glucose – huy\u1ebft, h\u1ea1 kali – huy\u1ebft; \u0111au \u0111\u1ea7u, ch\u00f3ng m\u1eb7t, l\u00fa l\u1eabn, \u1ea3o gi\u00e1c, co gi\u1eadt; d\u1ecb \u1ee9ng thu\u1ed1c: ng\u1ee9a, ph\u00e1t ban, h\u1ed9i ch\u1ee9ng Lyell; gi\u1ea3m b\u1ea1ch c\u1ea7u, gi\u1ea3m ti\u1ec3u c\u1ea7u v\u00e0 thi\u1ebfu m\u00e1u gi\u1ea3m s\u1ea3n; t\u0103ng nit\u01a1 huy\u1ebft, t\u0103ng creatinin, suy th\u1eadn.<\/p>\n

X\u1eed tr\u00ed ADR: <\/em> N\u1ebfu c\u00e1c tri\u1ec7u ch\u1ee9ng ti\u00eau ch\u1ea3y, h\u1ea1 glucose huy\u1ebft, n\u00f4n m\u1eeda k\u00e9o d\u00e0i ph\u1ea3i ng\u1eebng thu\u1ed1c. Ph\u1ea3i cho v\u00e0o b\u1ec7nh vi\u1ec7n \u0111i\u1ec1u tr\u1ecb n\u1ed9i tr\u00fa khi c\u00f3 d\u1ea5u hi\u1ec7u d\u1ecb \u1ee9ng thu\u1ed1c.<\/p>\n

Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed Flucytosin<\/h2>\n

N\u1ebfu qu\u00e1 li\u1ec1u c\u1ea5p, r\u1eeda d\u1ea1 d\u00e0y ho\u1eb7c g\u00e2y n\u00f4n. Duy tr\u00ec b\u00f9 d\u1ecbch th\u00edch h\u1ee3p. Th\u1ea9m ph\u00e2n m\u00e1u gi\u00fap l\u00e0m gi\u1ea3m n\u1ed3ng \u0111\u1ed9 flucytosin trong m\u00e1u \u1edf ng\u01b0\u1eddi v\u00f4 ni\u1ec7u. Th\u01b0\u1eddng xuy\u00ean theo d\u00f5i c\u00e1c ch\u1ec9 s\u1ed1 huy\u1ebft h\u1ecdc, ch\u1ee9c n\u0103ng gan v\u00e0 th\u1eadn.<\/p>\n

\u0110\u1ed9 \u1ed5n \u0111\u1ecbnh v\u00e0 b\u1ea3o qu\u1ea3n Flucytosin<\/h2>\n

D\u1ecbch truy\u1ec1n b\u1ea3o qu\u1ea3n \u1edf nhi\u1ec7t \u0111\u1ed9 18 – 25 o <\/sup> C. N\u1ebfu \u0111\u1ec3 d\u01b0\u1edbi 18 o <\/sup> C, c\u00f3 th\u1ec3 c\u00f3 k\u1ebft t\u1ee7a; \u0111un n\u00f3ng \u1edf 80 o <\/sup> C trong th\u1eddi gian kh\u00f4ng qu\u00e1 30 ph\u00fat, t\u1ee7a s\u1ebd tan tr\u1edf l\u1ea1i. B\u1ea3o qu\u1ea3n d\u00e0i ng\u00e0y \u1edf nhi\u1ec7t \u0111\u1ed9 tr\u00ean 25 o <\/sup> C c\u00f3 th\u1ec3 ph\u00e2n hu\u1ef7 thu\u1ed1c, t\u1ea1o th\u00e0nh 5-fluorouracil.<\/p>\n

 <\/p>\n

http:\/\/nidqc.org.vn\/duocthu\/323\/<\/p>\n","protected":false},"excerpt":{"rendered":"

Flucytosin l\u00e0 Flucytosine. Thu\u1ed1c ch\u1ed1ng n\u1ea5m. Thu\u1ed1c tr\u1ecb k\u00fd sinh tr\u00f9ng, ch\u1ed1ng nhi\u1ec5m khu\u1ea9n.<\/p>\n","protected":false},"author":143,"featured_media":10161,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5360,5316,5397,5363,5317],"tags":[3881,3362],"series":[],"coauthors":[2170],"acf":[],"yoast_head":"\nFlucytosin - Thu\u1ed1c ch\u1ed1ng n\u1ea5m - D\u1ef1 \u00e1n kh\u00e1c<\/title>\n<meta name=\"description\" content=\"Flucytosin - Thu\u1ed1c ch\u1ed1ng n\u1ea5m - D\u1ef1 \u00e1n kh\u00e1c\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/yhoccongdong.com\/du-an-khac\/flucytosin-thuoc-chong-nam\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Flucytosin - Thu\u1ed1c ch\u1ed1ng n\u1ea5m - 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