{"id":10632,"date":"2013-12-22T17:00:00","date_gmt":"2013-12-22T10:00:00","guid":{"rendered":"https:\/\/yhoccongdong.org\/du-an-khac\/molgramostim-giam-tac-dung-phu-do-hoa-tri-lieu-chong-ung-thu\/"},"modified":"2024-03-17T02:41:52","modified_gmt":"2024-03-16T19:41:52","slug":"molgramostim-giam-tac-dung-phu-do-hoa-tri-lieu-chong-ung-thu","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/du-an-khac\/molgramostim-giam-tac-dung-phu-do-hoa-tri-lieu-chong-ung-thu\/","title":{"rendered":"Molgramostim – Gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 do ho\u00e1 tr\u1ecb li\u1ec7u ch\u1ed1ng ung th\u01b0"},"content":{"rendered":"

(Molgramastim, leucomax) <\/p>\n

T\u00ean chung qu\u1ed1c t\u1ebf Molgramostim <\/h2>\n

Molgramostim (GM-CSF) <\/p>\n

D\u1ea1ng thu\u1ed1c v\u00e0 h\u00e0m l\u01b0\u1ee3ng Molgramostim <\/h2>\n

L\u1ecd thu\u1ed1c b\u1ed9t 150 microgam, 300 microgam v\u00e0 400 microgam \u0111\u1ec3 pha ti\u00eam. 1 mg t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 11 tri\u1ec7u \u0111vqt. Trong thu\u1ed1c c\u00f2n c\u00f3 mannitol, acid citric khan, natri dihydrophosphat, macrogol 4000 v\u00e0 albumin ng\u01b0\u1eddi. <\/p>\n

Ch\u1ec9 \u0111\u1ecbnh Molgramostim <\/h2>\n

\u0110i\u1ec1u tr\u1ecb b\u1ed5 tr\u1ee3 v\u1edbi ho\u00e1 tr\u1ecb li\u1ec7u ch\u1ed1ng ung th\u01b0 n\u00e0o d\u1ec5 g\u00e2y suy t\u1ee7y \u0111\u1ec3 \u0111\u1ec1 ph\u00f2ng gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh, ng\u0103n ch\u1eb7n nhi\u1ec5m khu\u1ea9n, k\u1ec3 c\u1ea3 v\u1edbi thu\u1ed1c ch\u1ed1ng virus d\u1ec5 g\u00e2y gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh (nh\u01b0 \u0111i\u1ec1u tr\u1ecb b\u1ed5 tr\u1ee3 v\u1edbi ganciclovir \u0111\u1ec3 l\u00e0m gi\u1ea3m ch\u1ee9ng gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh do ganciclovir); ng\u01b0\u1eddi b\u1ecb \u1ee9c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng (suy t\u1ee7y, lo\u1ea1n s\u1ea3n t\u1ee7y); ng\u01b0\u1eddi c\u1ea5y gh\u00e9p t\u1ee7y x\u01b0\u01a1ng; ch\u1ee9ng gi\u1ea3m b\u1ea1ch c\u1ea7u trung t\u00ednh c\u00f3 s\u1ed1t ho\u1eb7c ch\u1ee9ng m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t do \u0111\u00e3 d\u00f9ng ho\u00e1 tr\u1ecb li\u1ec7u ch\u1ed1ng ung th\u01b0 g\u00e2y \u1ee9c ch\u1ebf t\u1ee7y x\u01b0\u01a1ng; ng\u01b0\u1eddi b\u1ecb vi\u00eam v\u00f5ng m\u1ea1c do cytomegalovirus c\u00f3 li\u00ean quan \u0111\u1ebfn AIDS. <\/p>\n

Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh Molgramostim <\/h2>\n

Ung th\u01b0 t\u1ee7y x\u01b0\u01a1ng. Ng\u01b0\u1eddi m\u1eabn c\u1ea3m v\u1edbi thu\u1ed1c. <\/p>\n

Th\u1eadn tr\u1ecdng Molgramostim <\/h2>\n

Th\u1eddi k\u1ef3 c\u00f3 thai (Ph\u1ee5 l\u1ee5c 2) mu\u1ed1n d\u00f9ng ph\u1ea3i c\u00e2n nh\u1eafc; \u0111\u00e3 th\u1ea5y ch\u1ebft thai v\u00e0 s\u1ea3y thai t\u1ef1 nhi\u00ean \u1edf kh\u1ec9 d\u00f9ng li\u1ec1u 6 – 10 microgam\/ng\u00e0y. Th\u1eddi k\u1ef3 cho con b\u00fa (Ph\u1ee5 l\u1ee5c 3) mu\u1ed1n d\u00f9ng thu\u1ed1c, ph\u1ea3i ng\u1eebng cho con b\u00fa. Ng\u01b0\u1eddi c\u00f3 b\u1ec7nh ph\u1ed5i, c\u00f3 th\u1ec3 d\u1ec5 x\u1ea3y ra suy ch\u1ee9c n\u0103ng ph\u1ed5i v\u00e0 kh\u00f3 th\u1edf. Ng\u01b0\u1eddi c\u00f3 b\u1ec7nh t\u1ef1 mi\u1ec5n, b\u1ec7nh d\u1ec5 n\u1eb7ng th\u00eam n\u1ebfu d\u00f9ng molgramostim. Ph\u1ea3i theo d\u00f5i \u0111\u1ecbnh k\u1ef3 s\u1ed1 l\u01b0\u1ee3ng huy\u1ebft c\u1ea7u, \u0111\u1eb7c bi\u1ec7t l\u00e0 b\u1ea1ch c\u1ea7u, ti\u1ec3u c\u1ea7u, hematocrit v\u00e0 h\u00e0m l\u01b0\u1ee3ng albumin trong m\u00e1u. <\/p>\n

T\u01b0\u01a1ng t\u00e1c thu\u1ed1c Molgramostim <\/h2>\n

Do mol- gramostim l\u00e0m gi\u1ea3m h\u00e0m l\u01b0\u1ee3ng albumin trong huy\u1ebft t\u01b0\u01a1ng, do \u0111\u00f3, ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u khi d\u00f9ng nh\u1eefng thu\u1ed1c li\u00ean k\u1ebft nhi\u1ec1u v\u1edbi albumin trong huy\u1ebft thanh. <\/p>\n

Li\u1ec1u l\u01b0\u1ee3ng v\u00e0 c\u00e1ch d\u00f9ng Molgramostim <\/h2>\n

Li\u1ec1u l\u01b0\u1ee3ng d\u00f9ng ph\u1ea3i t\u00f9y theo b\u1ec7nh, nh\u01b0ng li\u1ec1u t\u1ed1i \u0111a kh\u00f4ng \u0111\u01b0\u1ee3c qu\u00e1 10 microgam\/kg\/ng\u00e0y. <\/p>\n

B\u1ed5 tr\u1ee3 v\u1edbi ho\u00e1 tr\u1ecb li\u1ec7u ch\u1ed1ng ung th\u01b0: <\/em> Ti\u00eam d\u01b0\u1edbi da 5 – 10 microgam\/kg\/ng\u00e0y. Vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ph\u1ea3i b\u1eaft \u0111\u1ea7u 24 gi\u1edd sau li\u1ec1u d\u00f9ng thu\u1ed1c ch\u1ed1ng ung th\u01b0, v\u00e0 ti\u1ebfp t\u1ee5c trong 7 – 10 ng\u00e0y. Li\u1ec1u d\u00f9ng l\u1ea7n \u0111\u1ea7u ch\u1ec9 l\u00e0 5 microgam\/kg\/ng\u00e0y. <\/p>\n

H\u1ed9i ch\u1ee9ng suy t\u1ee7y, lo\u1ea1n s\u1ea3n t\u1ee7y <\/em> : Ti\u00eam d\u01b0\u1edbi da 3 microgam\/kg\/ng\u00e0y. Th\u00f4ng th\u01b0\u1eddng ph\u1ea3i d\u00f9ng 2 – 4 ng\u00e0y m\u1edbi th\u1ea5y s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u t\u0103ng r\u00f5. Sau \u0111\u00f3, \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u0111\u1ec3 s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh \u0111\u1ea1t y\u00eau c\u1ea7u (th\u01b0\u1eddng kho\u1ea3ng 1000\/mm3). <\/p>\n

Gh\u00e9p t\u1ee7y x\u01b0\u01a1ng: <\/em> Truy\u1ec1n t\u0129nh m\u1ea1ch li\u1ec1u 10 microgam\/kg\/ng\u00e0y trong th\u1eddi gian 4 – 6 gi\u1edd, b\u1eaft \u0111\u1ea7u v\u00e0o ng\u00e0y sau khi gh\u00e9p t\u1ee7y x\u01b0\u01a1ng v\u00e0 ti\u1ebfp t\u1ee5c cho \u0111\u1ebfn khi s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh tuy\u1ec7t \u0111\u1ed1i b\u1eb1ng ho\u1eb7c l\u1edbn h\u01a1n 1000\/mm3. Th\u1eddi gian \u0111i\u1ec1u tr\u1ecb t\u1ed1i \u0111a l\u00e0 30 ng\u00e0y. <\/p>\n

Ch\u1ee9ng gi\u1ea3m b\u1ea1ch c\u1ea7u khi d\u00f9ng thu\u1ed1c ch\u1ed1ng ung th\u01b0 ho\u1eb7c thu\u1ed1c ch\u1ed1ng HIV: <\/em> Ti\u00eam d\u01b0\u1edbi da 1 – 5 microgam\/kg\/ng\u00e0y. \u0110\u1ed1i v\u1edbi ng\u01b0\u1eddi b\u1ec7nh b\u1ecb AIDS \u0111ang \u0111i\u1ec1u tr\u1ecb b\u1eb1ng zidovudin ho\u1eb7c ph\u1ed1i h\u1ee3p zidovudin v\u1edbi \u03b1-interferon, ti\u00eam d\u01b0\u1edbi da 1 – 3 microgam\/kg\/ng\u00e0y. Th\u01b0\u1eddng ph\u1ea3i 2 – 4 ng\u00e0y m\u1edbi th\u1ea5y s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u c\u00f3 \u0111\u00e1p \u1ee9ng. Sau \u0111\u00f3, c\u1ee9 3 – 5 ng\u00e0y l\u1ea1i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u0111\u1ec3 duy tr\u00ec \u0111\u01b0\u1ee3c s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh kho\u1ea3ng 1000\/mm3. <\/p>\n

\u0110i\u1ec1u tr\u1ecb b\u1ed5 tr\u1ee3 trong vi\u00eam v\u00f5ng m\u1ea1c do cytomegalovirus c\u00f3 li\u00ean quan \u0111\u1ebfn AIDS: <\/em> Ti\u00eam d\u01b0\u1edbi da 5 microgam\/kg\/ng\u00e0y. Sau li\u1ec1u th\u1ee9 n\u0103m, ph\u1ea3i \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u \u0111\u1ec3 gi\u1eef s\u1ed1 l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u trung t\u00ednh tuy\u1ec7t \u0111\u1ed1i \u1edf m\u1ee9c kh\u00f4ng d\u01b0\u1edbi 1000\/mm3 v\u00e0 t\u1ed5ng l\u01b0\u1ee3ng b\u1ea1ch c\u1ea7u ph\u1ea3i d\u01b0\u1edbi 20 000\/mm3. <\/p>\n

T\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n Molgramostim <\/h2>\n<\/p>\n

Th\u01b0\u1eddng g\u1eb7p: <\/em> S\u1ed1t, bu\u1ed3n n\u00f4n, kh\u00f3 th\u1edf, \u1ec9a ch\u1ea3y, ph\u00e1t ban, r\u00e9t run, ph\u1ea3n \u1ee9ng \u1edf ch\u1ed7 ti\u00eam d\u01b0\u1edbi da, n\u00f4n, m\u1ec7t m\u1ecfi, ch\u00e1n \u0103n, \u0111au c\u01a1 x\u01b0\u01a1ng v\u00e0 suy nh\u01b0\u1ee3c. <\/p>\n

\u00cdt g\u1eb7p <\/em> : \u0110au ng\u1ef1c, vi\u00eam mi\u1ec7ng, nh\u1ee9c \u0111\u1ea7u, ra nhi\u1ec1u m\u1ed3 h\u00f4i, \u0111au b\u1ee5ng, ng\u1ee9a, hoa m\u1eaft, ph\u00f9 ngo\u1ea1i vi, d\u1ecb c\u1ea3m. <\/p>\n

Nh\u1eefng tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng, nh\u01b0ng hi\u1ebfm g\u1eb7p: <\/em> Ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7, co th\u1eaft ph\u1ebf qu\u1ea3n, suy tim, r\u1ed1i lo\u1ea1n m\u1ea1ch n\u00e3o, l\u00fa l\u1eabn, co gi\u1eadt, h\u1ea1 huy\u1ebft \u00e1p, lo\u1ea1n nh\u1ecbp tim, t\u0103ng \u00e1p s\u1ecd n\u00e3o, vi\u00eam m\u00e0ng tim, ph\u00f9 ph\u1ed5i c\u1ea5p, ng\u1ea5t, n\u1ebfu x\u1ea3y ra, ph\u1ea3i ng\u1eebng thu\u1ed1c ngay. <\/p>\n

Khi x\u00e9t nghi\u1ec7m <\/em> s\u1ebd th\u1ea5y gi\u1ea3m ti\u1ec3u c\u1ea7u, gi\u1ea3m hemoglobin, gi\u1ea3m albumin, nh\u01b0ng t\u0103ng b\u1ea1ch c\u1ea7u \u01b0a eosin. <\/p>\n

Qu\u00e1 li\u1ec1u v\u00e0 x\u1eed tr\u00ed Molgramostim <\/h2>\n

Nh\u1eefng ng\u01b0\u1eddi d\u00f9ng li\u1ec1u cao 20 microgam\/kg\/ng\u00e0y tr\u1edf l\u00ean, c\u00f3 th\u1ec3 b\u1ecb nh\u1ecbp tim nhanh, h\u1ea1 huy\u1ebft \u00e1p v\u00e0 h\u1ed9i ch\u1ee9ng nh\u01b0 b\u1ecb c\u00fam. Ng\u1eebng thu\u1ed1c, c\u00e1c tri\u1ec7u ch\u1ee9ng tr\u00ean s\u1ebd gi\u1ea3m nhanh. <\/p>\n

B\u1ea3o qu\u1ea3n Molgramostim <\/h2>\n

Trong bao b\u00ec k\u00edn \u1edf 2 – 8 o <\/sup> C v\u00e0 tr\u00e1nh \u00e1nh s\u00e1ng, \u1ed5n \u0111\u1ecbnh \u0111\u01b0\u1ee3c 24 th\u00e1ng k\u1ec3 t\u1eeb ng\u00e0y s\u1ea3n xu\u1ea5t. Dung d\u1ecbch molgramostim \u0111\u00e3 pha v\u1edbi n\u01b0\u1edbc c\u1ea5t ti\u00eam v\u00f4 khu\u1ea9n c\u00f3 th\u1ec3 d\u00f9ng \u0111\u01b0\u1ee3c trong v\u00f2ng 24 gi\u1edd n\u1ebfu \u0111\u1ec3 \u1edf 2 – 8 o <\/sup> C. <\/p>\n<\/p>\n

http:\/\/nidqc.org.vn\/duocthu\/411\/ <\/p>\n","protected":false},"excerpt":{"rendered":"

Molgramostim.Thu\u1ed1c l\u00e0m gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 do ho\u00e1 tr\u1ecb li\u1ec7u ch\u1ed1ng ung th\u01b0.Thu\u1ed1c \u0111i\u1ec1u tr\u1ecb ung th\u01b0.Thu\u1ed1c ch\u1ed1ng ung th\u01b0 v\u00e0 gi\u1ea3m mi\u1ec5n d\u1ecbch.<\/p>\n","protected":false},"author":143,"featured_media":10633,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5316,5371,5469,5372,5317],"tags":[],"series":[],"coauthors":[],"acf":[],"yoast_head":"\nMolgramostim - Gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 do ho\u00e1 tr\u1ecb li\u1ec7u ch\u1ed1ng ung th\u01b0 - D\u1ef1 \u00e1n kh\u00e1c<\/title>\n<meta name=\"description\" content=\"Molgramostim - Gi\u1ea3m t\u00e1c d\u1ee5ng ph\u1ee5 do ho\u00e1 tr\u1ecb li\u1ec7u ch\u1ed1ng ung th\u01b0 - D\u1ef1 \u00e1n kh\u00e1c\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/yhoccongdong.com\/du-an-khac\/molgramostim-giam-tac-dung-phu-do-hoa-tri-lieu-chong-ung-thu\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Molgramostim - 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