{"id":10770,"date":"2018-07-31T06:03:23","date_gmt":"2018-07-30T23:03:23","guid":{"rendered":"https:\/\/yhoccongdong.org\/du-an-khac\/diem-moi-trong-nghien-cuu-va-dieu-tri-ung-thu-mau-dong-lympho-man-tinh-cll\/"},"modified":"2024-03-17T02:44:55","modified_gmt":"2024-03-16T19:44:55","slug":"diem-moi-trong-nghien-cuu-va-dieu-tri-ung-thu-mau-dong-lympho-man-tinh-cll","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/du-an-khac\/diem-moi-trong-nghien-cuu-va-dieu-tri-ung-thu-mau-dong-lympho-man-tinh-cll\/","title":{"rendered":"\u0110i\u1ec3m m\u1edbi trong nghi\u00ean c\u1ee9u v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 m\u00e1u d\u00f2ng lympho m\u00e3n t\u00ednh (CLL)"},"content":{"rendered":"

\"Ung<\/p>\n

R\u1ea5t nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111ang \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n trong c\u00e1c ph\u00f2ng th\u00ed nghi\u1ec7m c\u0169ng nh\u01b0 d\u01b0\u1edbi d\u1ea1ng th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u1edf kh\u1eafp n\u01a1i tr\u00ean th\u1ebf gi\u1edbi.<\/p>\n

Di truy\u1ec1n h\u1ecdc c\u1ee7a ung th\u01b0 m\u00e1u d\u00f2ng lympho m\u00e3n t\u00ednh (CLL)<\/h2>\n

C\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c b\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 trong nghi\u00ean c\u1ee9u t\u00ecm ra nguy\u00ean nh\u00e2n t\u1ea1i sao nh\u1eefng thay \u0111\u1ed5i gene c\u00f3 th\u1ec3 bi\u1ebfn c\u00e1c t\u1ebf b\u00e0o t\u1ee7y x\u01b0\u01a1ng b\u00ecnh th\u01b0\u1eddng th\u00e0nh c\u00e1c t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u \u00e1c t\u00ednh. Nghi\u00ean c\u1ee9u v\u1ec1 nh\u1eefng thay \u0111\u1ed5i gene (m\u1ed9t v\u00f9ng DNA) th\u01b0\u1eddng x\u1ea3y ra \u1edf c\u00e1c b\u1ec7nh nh\u00e2n m\u1eafc CLL gi\u00fap c\u00e1c nh\u00e0 khoa h\u1ecdc hi\u1ec3u r\u00f5 t\u1ea1i sao c\u00e1c t\u1ebf b\u00e0o n\u00e0y l\u1ea1i ph\u00e1t tri\u1ec3n nhanh ch\u00f3ng, t\u1ed3n t\u1ea1i l\u00e2u d\u00e0i v\u00e0 kh\u00f4ng th\u1ec3 bi\u1ec7t h\u00f3a th\u00e0nh c\u00e1c t\u1ebf b\u00e0o m\u00e1u th\u00f4ng th\u01b0\u1eddng. C\u00e1c b\u00e1c s\u0129 c\u0169ng \u0111ang t\u00ecm ki\u1ebfm c\u00e1ch \u1ee9ng d\u1ee5ng nh\u1eefng ki\u1ebfn th\u1ee9c m\u1edbi n\u00e0y \u0111\u1ec3 c\u1ea3i ti\u1ebfn quy tr\u00ecnh ch\u1ea9n \u0111o\u00e1n, ti\u00ean l\u01b0\u1ee3ng b\u1ec7nh v\u00e0 quy\u1ebft \u0111\u1ecbnh c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb c\u1ea7n thi\u1ebft.<\/p>\n

C\u00e1c lo\u1ea1i thu\u1ed1c m\u1edbi d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb CLL<\/h2>\n

R\u1ea5t nhi\u1ec1u thu\u1ed1c m\u1edbi \u0111ang \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m \u0111\u1ec3 d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb CLL. \u0110a s\u1ed1 c\u00e1c thu\u1ed1c n\u00e0y nh\u1eafm v\u00e0o m\u1ed9t v\u1ecb tr\u00ed\/ch\u1ee9c n\u0103ng c\u1ee5 th\u1ec3 ch\u1ec9 c\u00f3 \u1edf t\u1ebf b\u00e0o ung th\u01b0, trong khi m\u1ed9t s\u1ed1 thu\u1ed1c kh\u00e1c t\u00e1c d\u1ee5ng g\u1ea7n gi\u1ed1ng nh\u01b0 c\u00e1c lo\u1ea1i thu\u1ed1c h\u00f3a tr\u1ecb ti\u00eau chu\u1ea9n.<\/p>\n

Oblimersen (Genasense\u00ae) l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u trong qu\u00e1 tr\u00ecnh \u0111i\u1ec1u tr\u1ecb CLL. Trong nh\u1eefng nghi\u00ean c\u1ee9u n\u00e0y, vi\u1ec7c k\u1ebft h\u1ee3p Oblimersen v\u1edbi h\u00f3a tr\u1ecb \u0111\u00e3 l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng \u1ed5n \u0111\u1ecbnh b\u1ec7nh.<\/p>\n

M\u1ed9t s\u1ed1 kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng c\u0169ng \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb CLL. Ch\u00fang l\u00e0 c\u00e1c kh\u00e1ng th\u1ec3 \u0111\u01b0\u1ee3c t\u1ed5ng h\u1ee3p nh\u00e2n t\u1ea1o, c\u00f3 kh\u1ea3 n\u0103ng g\u1eafn v\u1edbi c\u00e1c ph\u00e2n t\u1eed \u0111\u00edch nh\u01b0 protein \u0111\u1eb7c hi\u1ec7u ch\u1ec9 bi\u1ec3u hi\u1ec7n tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ung th\u01b0. Lumiliximab l\u00e0 m\u1ed9t kh\u00e1ng th\u1ec3 gi\u00fap k\u00edch th\u00edch h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u \u00e1c t\u00ednh.<\/p>\n

C\u00e1c kh\u00e1ng th\u1ec3 kh\u00e1c \u0111\u01b0\u1ee3c g\u1eafn v\u1edbi c\u00e1c h\u1ee3p ch\u1ea5t c\u00f3 th\u1ec3 g\u00e2y \u0111\u1ed9c t\u00ednh cho c\u00e1c t\u1ebf b\u00e0o ung th\u01b0, c\u00f2n \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn nh\u01b0 l\u00e0 c\u00e1c ch\u1ea5t \u0111\u1ed9c mi\u1ec5n d\u1ecbch (immunotoxins). Ch\u00fang ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t thi\u1ebft b\u1ecb d\u1eabn \u0111\u01b0\u1eddng gi\u00fap v\u1eadn chuy\u1ec3n \u0111\u1ed9c t\u1ed1 tr\u1ef1c ti\u1ebfp v\u00e0 ch\u1ecdn l\u1ecdc t\u1edbi c\u00e1c t\u1ebf b\u00e0o ung th\u01b0. M\u1ed9t immunotoxin \u0111i\u1ec3n h\u00ecnh l\u00e0 BL22 \u0111\u00e3 cho th\u1ea5y nhi\u1ec1u k\u1ebft qu\u1ea3 kh\u00edch l\u1ec7 trong vi\u1ec7c ch\u1eefa tr\u1ecb HCL (hairy cell leukemia). M\u1ed9t th\u1ebf h\u1ec7 m\u1edbi c\u1ee7a lo\u1ea1i thu\u1ed1c n\u00e0y HA22 (CAT-8015) c\u0169ng \u0111ang trong giai \u0111o\u1ea1n th\u1eed nghi\u1ec7m.<\/p>\n

Lenalidomide (Revlimid) l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb \u0111a u t\u1ee7y x\u01b0\u01a1ng (multiple myeloma) v\u00e0 m\u1ed9t v\u00e0i d\u1ea1ng ung th\u01b0 h\u1ea1ch b\u1ea1ch huy\u1ebft (lymphoma). Nghi\u00ean c\u1ee9u c\u0169ng ch\u1ec9 ra r\u1eb1ng Lenalidomide c\u0169ng c\u00f3 t\u00e1c d\u1ee5ng hi\u1ec7u qu\u1ea3 v\u00e0 h\u1ee9a h\u1eb9n trong \u0111i\u1ec1u tr\u1ecb CLL.<\/p>\n

Bi\u00ean so\u1ea1n: 06\/01\/2015<\/p>\n

C\u1eadp nh\u1eadt v\u00e0 hi\u1ec7u \u0111\u00ednh: 26\/02\/2015<\/p>\n

T\u00e0i li\u1ec7u tham kh\u1ea3o <\/span> <\/strong> <\/span><\/h2>\n

http:\/\/www.cancer.org\/cancer\/leukemia-chroniclymphocyticcll\/detailedguide\/leukemia-chronic-lymphocytic-new-research <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u0110i\u1ec3m m\u1edbi trong nghi\u00ean c\u1ee9u v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 m\u00e1u d\u00f2ng lympho m\u00e3n t\u00ednh (CLL). Thu\u1ed1c m\u1edbi \u0111ang \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m \u0111\u1ec3 d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb CLL<\/p>\n","protected":false},"author":165,"featured_media":10772,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5664,5164,5148,5663],"tags":[5665,5667,5666],"series":[5668],"coauthors":[],"acf":[],"yoast_head":"\n\u0110i\u1ec3m m\u1edbi trong nghi\u00ean c\u1ee9u v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 m\u00e1u d\u00f2ng lympho m\u00e3n t\u00ednh (CLL) - Y H\u1ecdc C\u1ed9ng \u0110\u1ed3ng<\/title>\n<meta name=\"description\" content=\"\u0110i\u1ec3m m\u1edbi trong nghi\u00ean c\u1ee9u v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 m\u00e1u d\u00f2ng lympho m\u00e3n t\u00ednh (CLL). 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