{"id":18566,"date":"2019-05-30T09:28:12","date_gmt":"2019-05-30T02:28:12","guid":{"rendered":"https:\/\/yhoccongdong.org\/du-an-khac\/nghien-cuu-moi-ve-benh-bach-cau-man-tinh-dong-lympho\/"},"modified":"2019-05-30T09:28:12","modified_gmt":"2019-05-30T02:28:12","slug":"nghien-cuu-moi-ve-benh-bach-cau-man-tinh-dong-lympho","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/du-an-khac\/nghien-cuu-moi-ve-benh-bach-cau-man-tinh-dong-lympho\/","title":{"rendered":"Nghi\u00ean c\u1ee9u m\u1edbi v\u1ec1 b\u1ec7nh b\u1ea1ch c\u1ea7u m\u00e3n t\u00ednh d\u00f2ng Lympho"},"content":{"rendered":"

Bi\u00ean d\u1ecbch:<\/strong> Nguy\u1ec5n T\u1ea5n S\u01a1n, \u0110\u00e0o Duy S\u01a1n, Nguy\u1ec5n L\u00ea H\u1ed3ng Ph\u00fac<\/p>\n

M\u1eddi qu\u00fd \u0111\u1ed9c gi\u1ea3 xem b\u00e0i\u00a0C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1ec1 b\u1ec7nh b\u1ea1ch c\u1ea7u m\u00e3n t\u00ednh d\u00f2ng Lympho<\/a>\u00a0<\/strong>tr\u01b0\u1edbc khi \u0111\u1ecdc b\u00e0i vi\u1ebft n\u00e0y.<\/p>\n

C\u00e1c b\u00e1c s\u0129 \u0111ang nghi\u00ean c\u1ee9u \u0111\u1ec3 t\u00ecm hi\u1ec3u th\u00eam v\u1ec1 b\u1ec7nh b\u1ea1ch c\u1ea7u m\u00e3n t\u00ednh d\u00f2ng Lympho<\/a> (BBCMTDL), c\u00e1ch ph\u00f2ng ng\u1eeba, ph\u01b0\u01a1ng h\u01b0\u1edbng \u0111i\u1ec1u tr\u1ecb<\/a> t\u1ed1t nh\u1ea5t, v\u00e0 c\u00e1ch ch\u0103m s\u00f3c t\u1ed1t nh\u1ea5t cho b\u1ec7nh nh\u00e2n<\/a>. C\u00e1c l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u sau \u0111\u00e2y c\u00f3 th\u1ec3 bao g\u1ed3m c\u00e1c l\u1ef1a ch\u1ecdn m\u1edbi cho b\u1ec7nh nh\u00e2n th\u00f4ng qua c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng. H\u1ea7u h\u1ebft c\u00e1c trung t\u00e2m ung th\u01b0 \u0111\u1ec1u t\u1eadp trung v\u00e0o c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng nh\u1eb1m t\u0103ng s\u1ed1 b\u1ec7nh nh\u00e2n b\u1ecb thuy\u00ean gi\u1ea3m ho\u00e0n to\u00e0n. Lu\u00f4n lu\u00f4n n\u00f3i chuy\u1ec7n v\u1edbi b\u00e1c s\u0129 c\u1ee7a b\u1ea1n v\u1ec1 c\u00e1c t\u00f9y ch\u1ecdn ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb t\u1ed1t nh\u1ea5t cho b\u1ea1n.<\/p>\n

Thu\u1ed1c m\u1edbi v\u00e0 k\u1ebft h\u1ee3p thu\u1ed1c<\/strong><\/h2>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang l\u00e0m vi\u1ec7c \u0111\u1ec3 t\u00ecm thu\u1ed1c m\u1edbi cho BBCMTDL. C\u00e1c k\u1ebft h\u1ee3p kh\u00e1c nhau c\u1ee7a h\u00f3a tr\u1ecb li\u1ec7u v\u00e0 li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch c\u0169ng \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u nh\u01b0 m\u1ed9t c\u00e1ch \u0111\u1ec3 t\u0103ng kh\u1ea3 n\u0103ng b\u1ec7nh nh\u00e2n s\u1ebd thuy\u00ean gi\u1ea3m ho\u00e0n to\u00e0n v\u00e0 s\u1ed1ng l\u00e2u h\u01a1n. C\u00f3 nhi\u1ec1u lo\u1ea1i thu\u1ed1c m\u1edbi cho BBCMTDL, bao g\u1ed3m nhi\u1ec1u ch\u1ea5t \u1ee9c ch\u1ebf kinase m\u1edbi, \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng cho nh\u1eefng ng\u01b0\u1eddi b\u1ecb BBCMTDL t\u00e1i ph\u00e1t v\u1edbi hy v\u1ecdng th\u1eed nghi\u1ec7m m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c n\u00e0y nh\u01b0 l\u00e0 li\u1ec7u ph\u00e1p ban \u0111\u1ea7u trong t\u01b0\u01a1ng lai g\u1ea7n.<\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u0169ng \u0111ang xem x\u00e9t k\u1ebft h\u1ee3p ibrutinib<\/em> v\u1edbi bendamustine<\/em>, ofatumumab<\/em>, v\u00e0 rituximab<\/em> v\u00e0 ibrutinib<\/em> v\u1edbi fludarabine<\/em>, cychlophosphamide<\/em> v\u00e0 rituximab<\/em>. Ibrutinib<\/em> c\u0169ng \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u c\u00f9ng v\u1edbi venetoclax<\/em>.<\/p>\n

Idelalisib<\/em> \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u k\u1ebft h\u1ee3p v\u1edbi bendamustine, rituximab<\/em> v\u00e0 ofatumumab<\/em>.<\/p>\n

Xm5574 l\u00e0 m\u1ed9t kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng c\u0169ng \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb BBCMTDL.<\/p>\n

Lenalidomide<\/em> (Revlimid<\/em>) l\u00e0 lo\u1ea1i thu\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nhi\u1ec1u u t\u1ee7y c\u0169ng \u0111\u01b0\u1ee3c xem nh\u01b0 l\u00e0 m\u1ed9t \u0111i\u1ec1u tr\u1ecb cho BBCMTDL, ho\u1eb7c t\u1ef1 k\u1ebft h\u1ee3p v\u1edbi m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c kh\u00e1c nhau cho nh\u1eefng ng\u01b0\u1eddi c\u00f3 BBCMTDL t\u00e1i ph\u00e1t ho\u1eb7c dai d\u1eb3ng, c\u0169ng nh\u01b0 cho nh\u1eefng ng\u01b0\u1eddi ch\u01b0a \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb.<\/p>\n

Dinaciclib<\/em> l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c kh\u00e1c \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u cho BBCMTDL.<\/p>\n

Duvelisib<\/em>, m\u1ed9t lo\u1ea1i ch\u1ea5t \u1ee9c ch\u1ebf kinase, c\u0169ng \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u.<\/p>\n

Di truy\u1ec1n h\u1ecdc<\/strong><\/h2>\n

Nh\u1eefng thay \u0111\u1ed5i di truy\u1ec1n c\u1ee5 th\u1ec3 \u0111\u1ed1i v\u1edbi t\u1ebf b\u00e0o BBCMTDL c\u0169ng \u0111ang \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 \u0111\u1ec3 gi\u00fap d\u1ef1 \u0111o\u00e1n c\u00e1ch \u0111i\u1ec1u tr\u1ecb t\u1ed1t s\u1ebd hi\u1ec7u qu\u1ea3, x\u00e1c \u0111\u1ecbnh c\u00e1ch \u0111i\u1ec1u tr\u1ecb t\u1ed1t nh\u1ea5t v\u00e0 cung c\u1ea5p th\u00f4ng tin v\u1ec1 nguy\u00ean nh\u00e2n c\u1ee7a b\u1ec7nh. Nh\u1eefng v\u00ed d\u1ee5 bao g\u1ed3m:<\/p>\n

\u0110o \u0111\u1ed9t bi\u1ebfn globulin mi\u1ec5n d\u1ecbch c\u1ee7a t\u1ebf b\u00e0o BBCMTDL<\/p>\n

T\u00ecm c\u00e1c b\u1ea5t th\u01b0\u1eddng nhi\u1ec5m s\u1eafc th\u1ec3 kh\u00e1c nhau trong c\u00e1c t\u1ebf b\u00e0o BBCMTDL<\/p>\n

Nghi\u00ean c\u1ee9u \u1ea3nh h\u01b0\u1edfng c\u1ee7a m\u1ed9t lo\u1ea1i protein g\u1ecdi l\u00e0 ZAP-70, \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a c\u00e1c t\u1ebf b\u00e0o BBCMTDL<\/p>\n

M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u cho th\u1ea5y r\u1eb1ng nh\u1eefng d\u1ea5u hi\u1ec7u n\u00e0y c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n kh\u1ea3 n\u0103ng b\u1ec7nh c\u00f3 th\u1ec3 x\u1ea5u \u0111i nhanh h\u01a1n. Tuy nhi\u00ean, th\u01b0\u1eddng c\u00f3 s\u1ef1 kh\u00e1c bi\u1ec7t l\u1edbn trong c\u00e1ch \u0111i\u1ec1u tr\u1ecb t\u1ed1t cho nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 d\u1ea5u hi\u1ec7u di truy\u1ec1n gi\u1ed1ng nhau. C\u00f2n qu\u00e1 s\u1edbm \u0111\u1ec3 s\u1eed d\u1ee5ng c\u00e1c x\u00e9t nghi\u1ec7m n\u00e0y \u0111\u1ec3 \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh v\u1ec1 th\u1eddi \u0111i\u1ec3m b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u00e0 lo\u1ea1i \u0111i\u1ec1u tr\u1ecb s\u1eed d\u1ee5ng.<\/p>\n

Ch\u0103m s\u00f3c gi\u1ea3m nh\u1eb9<\/a><\/h2>\n

C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh \u0111\u1ec3 t\u00ecm ra c\u00e1ch t\u1ed1t h\u01a1n \u0111\u1ec3 gi\u1ea3m tri\u1ec7u ch\u1ee9ng v\u00e0 t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb BBCMTDL hi\u1ec7n t\u1ea1i \u0111\u1ec3 c\u1ea3i thi\u1ec7n s\u1ef1 tho\u1ea3i m\u00e1i v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n

T\u00ecm ki\u1ebfm th\u00eam v\u1ec1 nghi\u00ean c\u1ee9u m\u1edbi nh\u1ea5t?<\/h2>\n

N\u1ebfu b\u1ea1n mu\u1ed1n bi\u1ebft th\u00eam th\u00f4ng tin v\u1ec1 c\u00e1c l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u m\u1edbi nh\u1ea5t li\u00ean quan \u0111\u1ebfn BBCMTDL, h\u00e3y t\u00ecm \u0111\u1ebfn c\u00e1c m\u1ee5c li\u00ean quan n\u00e0y \u0111\u01b0a b\u1ea1n ra ngo\u00e0i h\u01b0\u1edbng d\u1eabn n\u00e0y:<\/p>\n

\u0110\u1ec3 t\u00ecm c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u1ee5 th\u1ec3 cho ch\u1ea9n \u0111o\u00e1n c\u1ee7a b\u1ea1n, h\u00e3y trao \u0111\u1ed5i v\u1edbi b\u00e1c s\u0129 c\u1ee7a b\u1ea1n ho\u1eb7c t\u00ecm ki\u1ebfm c\u01a1 s\u1edf d\u1eef li\u1ec7u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng tr\u1ef1c tuy\u1ebfn ngay b\u00e2y gi\u1edd.<\/p>\n

Nghe podcast<\/a> t\u1eeb chuy\u00ean gia ASCO th\u1ea3o lu\u1eadn v\u1ec1 nh\u1eefng \u0111i\u1ec3m n\u1ed5i b\u1eadt t\u1eeb c\u00e1c cu\u1ed9c h\u1ecdp khoa h\u1ecdc g\u1ea7n \u0111\u00e2y.<\/p>\n

Truy c\u1eadp trang web c\u1ee7a Qu\u1ef9 ung th\u01b0 chinh ph\u1ee5c ASCO<\/a> \u0111\u1ec3 t\u00ecm hi\u1ec3u c\u00e1ch h\u1ed7 tr\u1ee3 nghi\u00ean c\u1ee9u ung th\u01b0. Xin l\u01b0u \u00fd r\u1eb1ng li\u00ean k\u1ebft n\u00e0y s\u1ebd \u0111\u01b0a b\u1ea1n \u0111\u1ebfn m\u1ed9t trang web ri\u00eang c\u1ee7a ASCO.<\/p>\n

Ph\u1ea7n ti\u1ebfp theo trong h\u01b0\u1edbng d\u1eabn n\u00e0y l\u00e0 th\u00edch nghi v\u1edbi \u0111i\u1ec1u tr\u1ecb<\/a>.<\/strong> N\u00f3 cung c\u1ea5p m\u1ed9t s\u1ed1 h\u01b0\u1edbng d\u1eabn v\u1ec1 c\u00e1ch \u0111\u1ed1i ph\u00f3 v\u1edbi nh\u1eefng thay \u0111\u1ed5i th\u1ec3 ch\u1ea5t, t\u00ecnh c\u1ea3m v\u00e0 x\u00e3 h\u1ed9i m\u00e0 ung th\u01b0 v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u1ee7a n\u00f3 c\u00f3 th\u1ec3 mang l\u1ea1i. S\u1eed d\u1ee5ng menu \u0111\u1ec3 ch\u1ecdn m\u1ed9t ph\u1ea7n kh\u00e1c \u0111\u1ec3 \u0111\u1ecdc trong h\u01b0\u1edbng d\u1eabn n\u00e0y.<\/em><\/p>\n

T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n

https:\/\/www.cancer.net\/cancer-types\/leukemia-chronic-lymphocytic-cll<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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