{"id":19451,"date":"2021-03-31T14:57:36","date_gmt":"2021-03-31T07:57:36","guid":{"rendered":"https:\/\/yhoccongdong.org\/du-an-khac\/tamoxifen\/"},"modified":"2021-03-31T14:57:36","modified_gmt":"2021-03-31T07:57:36","slug":"tamoxifen","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/du-an-khac\/tamoxifen\/","title":{"rendered":"Tamoxifen"},"content":{"rendered":"<p>T\u00e0i li\u1ec7u n\u00e0y gi\u1ea3i th\u00edch v\u1ec1 c\u00f4ng d\u1ee5ng v\u00e0 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 x\u1ea3y ra c\u1ee7a thu\u1ed1c tamoxifen, m\u1ed9t lo\u1ea1i thu\u1ed1c quan tr\u1ecdng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa.<\/p>\n<h2>Tamoxifen l\u00e0 g\u00ec?<\/h2>\n<p>Tamoxifen l\u00e0 thu\u1ed1c thu\u1ed9c nh\u00f3m \u0111i\u1ec1u tr\u1ecb n\u1ed9i ti\u1ebft, \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa cho c\u1ea3 ph\u1ee5 n\u1eef ti\u1ec1n m\u00e3n kinh v\u00e0 sau m\u00e3n kinh. Thu\u1ed1c c\u0169ng c\u00f3 th\u1ec3 d\u00f9ng cho nam gi\u1edbi b\u1ecb ung th\u01b0 v\u00fa.<\/p>\n<h2>Tamoxifen ho\u1ea1t \u0111\u1ed9ng nh\u01b0 th\u1ebf n\u00e0o?<\/h2>\n<p>N\u1ed9i ti\u1ebft t\u1ed1 hay hormone (c\u00f2n g\u1ecdi l\u00e0 ch\u1ea5t n\u1ed9i ti\u1ebft) estrogen c\u00f3 th\u1ec3 th\u00fac \u0111\u1ea9y s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0 v\u00fa.<\/p>\n<p>T\u1ea5t c\u1ea3 c\u00e1c d\u1ea1ng ung th\u01b0 v\u00fa \u0111\u1ec1u \u0111\u01b0\u1ee3c x\u00e9t nghi\u1ec7m xem ch\u00fang c\u00f3 \u201cnh\u1ea1y\u201d v\u1edbi estrogen hay kh\u00f4ng, c\u1ee5 th\u1ec3 l\u00e0 xem trong kh\u1ed1i u (m\u1eabu m\u00f4 l\u1ea5y qua sinh thi\u1ebft ho\u1eb7c ph\u1eabu thu\u1eadt) c\u00f3 bi\u1ec3u hi\u1ec7n th\u1ee5 th\u1ec3 n\u1ed9i ti\u1ebft hay kh\u00f4ng.<\/p>\n<p>N\u1ebfu d\u1ea1ng ung th\u01b0 v\u00fa l\u00e0 \u201cnh\u1ea1y\u201d v\u1edbi estrogen, c\u00f2n g\u1ecdi l\u00e0 <strong>d\u01b0\u01a1ng t\u00ednh<\/strong> v\u1edbi th\u1ee5 th\u1ec3 n\u1ed9i ti\u1ebft ho\u1eb7c ER+, tamoxifen s\u1ebd l\u00e0 m\u1ed9t l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ung th\u01b0.<\/p>\n<p>N\u1ebfu d\u1ea1ng ung th\u01b0 v\u00fa l\u00e0 \u201ckh\u00f4ng nh\u1ea1y\u201d v\u1edbi estrogen, t\u1ee9c <strong>\u00e2m t\u00ednh<\/strong> v\u1edbi th\u1ee5 th\u1ec3 estrogen, hay ER-, tamoxifen th\u01b0\u1eddng kh\u00f4ng ph\u1ea3i l\u00e0 l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Tuy nhi\u00ean, c\u00f3 m\u1ed9t s\u1ed1 r\u1ea5t \u00edt tr\u01b0\u1eddng h\u1ee3p th\u1ee5 th\u1ec3 estrogen \u00e2m t\u00ednh (ER-), nh\u01b0ng th\u1ee5 th\u1ec3 progesteron (m\u1ed9t ch\u1ea5t n\u1ed9i ti\u1ebft kh\u00e1c) l\u1ea1i d\u01b0\u01a1ng t\u00ednh.<\/p>\n<p>L\u1ee3i \u00edch c\u1ee7a li\u1ec7u ph\u00e1p n\u1ed9i ti\u1ebft \u1edf d\u1ea1ng b\u1ec7nh n\u00e0y l\u00e0 k\u00e9m r\u00f5 r\u00e0ng v\u00e0 b\u00e1c s\u0129 s\u1ebd th\u1ea3o lu\u1eadn v\u1edbi b\u1ea1n xem c\u00f3 n\u00ean d\u00f9ng tamoxifen hay kh\u00f4ng.<\/p>\n<p>H\u1ea7u h\u1ebft ung th\u01b0 v\u00fa \u1edf nam gi\u1edbi l\u00e0 d\u01b0\u01a1ng t\u00ednh v\u1edbi th\u1ee5 th\u1ec3 estrogen. \u0110\u1ec3 c\u00f3 th\u00eam th\u00f4ng tin h\u00e3y \u0111\u1ecdc ph\u1ea7n \u201cUng th\u01b0 v\u00fa \u1edf nam gi\u1edbi \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb th\u1ebf n\u00e0o\u201d tr\u00ean website <a href=\"http:\/\/www.breastcancercare.org.uk\" target=\"_blank\" rel=\"noopener\">www.breastcancercare.org.uk<\/a><\/p>\n<h2><strong>Khi n\u00e0o tamoxifen \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh?<\/strong><\/h2>\n<h3><strong>\u0110i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa nguy\u00ean ph\u00e1t<\/strong><\/h3>\n<p>Tamoxifen c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh n\u1ebfu b\u1ea1n m\u1eafc ung th\u01b0 v\u00fa nguy\u00ean ph\u00e1t (ung th\u01b0 v\u00fa c\u00f2n khu tr\u00fa \u1edf v\u00fa v\u00e0 c\u00e1c h\u1ea1ch b\u1ea1ch huy\u1ebft trong h\u1ed1c n\u00e1ch.<\/p>\n<p>Thu\u1ed1c th\u01b0\u1eddng d\u00f9ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ed5 tr\u1ee3 sau ph\u1eabu thu\u1eadt \u0111\u1ec3 l\u00e0m gi\u1ea3m nguy c\u01a1 t\u00e1i ph\u00e1t ung th\u01b0 v\u00fa. N\u1ebfu b\u1ea1n s\u1eafp \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh u\u1ed1ng tamoxifen \u1edf t\u00ecnh hu\u1ed1ng n\u00e0y, b\u00e1c s\u0129 s\u1ebd n\u00f3i v\u1edbi b\u1ea1n khi n\u00e0o b\u1eaft \u0111\u1ea7u u\u1ed1ng thu\u1ed1c l\u00e0 t\u1ed1t nh\u1ea5t.<\/p>\n<p>Thi tho\u1ea3ng, tamoxifen c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng nh\u01b0 l\u00e0 \u0111i\u1ec1u tr\u1ecb \u0111\u1ea7u ti\u00ean cho ung th\u01b0 v\u00fa, khi ph\u1eabu thu\u1eadt l\u00e0 kh\u00f4ng th\u00edch h\u1ee3p, kh\u00f4ng kh\u1ea3 thi ho\u1eb7c c\u1ea7n ph\u1ea3i tr\u00ec ho\u00e3n. \u0110\u00f4i khi, thu\u1ed1c \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh tr\u01b0\u1edbc ph\u1eabu thu\u1eadt (\u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 li\u1ec7u ph\u00e1p t\u00e2n b\u1ed5 tr\u1ee3) \u0111\u1ec3 l\u00e0m thu nh\u1ecf kh\u1ed1i u nh\u1eb1m th\u1ef1c hi\u1ec7n ph\u1eabu thu\u1eadt b\u1ea3o t\u1ed3n v\u00fa. Ph\u1eabu thu\u1eadt b\u1ea3o t\u1ed3n v\u00fa l\u00e0 lo\u1ea1i b\u1ecf kh\u1ed1i u v\u1edbi bi\u00ean l\u00e0 m\u00f4 v\u00fa b\u00ecnh th\u01b0\u1eddng xung quanh, trong khi ph\u1eabu thu\u1eadt \u0111o\u1ea1n nh\u0169 l\u00e0 lo\u1ea1i b\u1ecf ho\u00e0n to\u00e0n m\u00f4 v\u00fa k\u1ec3 c\u1ea3 khu v\u1ef1c n\u00fam v\u00fa.<\/p>\n<p>\u0110\u1ed1i v\u1edbi ung th\u01b0 v\u00fa giai \u0111o\u1ea1n s\u1edbm d\u1ea1ng carcinoma tuy\u1ebfn \u1ed1ng v\u00fa t\u1ea1i ch\u1ed7 (DCIS) th\u00ec l\u1ee3i \u00edch c\u1ee7a tamoxifen l\u00e0 k\u00e9m r\u00f5 r\u00e0ng h\u01a1n m\u1eb7c d\u00f9 m\u1ed9t s\u1ed1 b\u1eb1ng ch\u1ee9ng g\u1ee3i \u00fd r\u1eb1ng u\u1ed1ng tamoxifen sau ph\u1eabu thu\u1eadt DCIS l\u00e0m g\u1ea3m nguy c\u01a1 t\u00e1i ph\u00e1t. B\u00e1c s\u0129 s\u1ebd th\u1ea3o lu\u1eadn v\u1edbi b\u1ea1n li\u1ec7u thu\u1ed1c c\u00f3 l\u1ee3i cho b\u1ea1n hay kh\u00f4ng.<\/p>\n<h3><strong>\u0110i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa t\u00e1i ph\u00e1t hay th\u1ee9 ph\u00e1t<\/strong><\/h3>\n<p>Tamoxifen c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng cho ung th\u01b0 v\u00fa \u0111\u00e3 t\u00e1i ph\u00e1t \u1edf khu v\u1ef1c th\u00e0nh ng\u1ef1c\/v\u00fa (t\u00e1i ph\u00e1t t\u1ea1i ch\u1ed7) ho\u1eb7c v\u00f9ng l\u00e2n c\u1eadn (t\u00e1i ph\u00e1t ti\u1ebfn tri\u1ec3n t\u1ea1i ch\u1ed7 ho\u1eb7c t\u00e1i ph\u00e1t khu v\u1ef1c). Thu\u1ed1c c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng trong m\u1ed9t s\u1ed1 t\u00ecnh hu\u1ed1ng ung th\u01b0 v\u00fa th\u1ee9 ph\u00e1t, khi t\u1ebf b\u00e0o ung th\u01b0 t\u1eeb v\u00fa \u0111\u00e3 lan t\u1edbi c\u00e1c b\u1ed9 ph\u1eadn kh\u00e1c c\u1ee7a c\u01a1 th\u1ec3.<\/p>\n<h3><strong>Ph\u00f2ng ng\u1eeba v\u00e0 l\u00e0m gi\u1ea3m nguy c\u01a1 m\u1eafc ung th\u01b0 v\u00fa <\/strong><\/h3>\n<p>Tamoxifen c\u0169ng c\u00f3 th\u1ec3 l\u00e0 l\u1ef1a ch\u1ecdn cho m\u1ed9t s\u1ed1 ng\u01b0\u1eddi ch\u01b0a b\u1ecb ung th\u01b0 v\u00fa nh\u01b0ng c\u00f3 nguy c\u01a1 cao m\u1eafc b\u1ec7nh n\u00e0y do b\u1ec7nh s\u1eed gia \u0111\u00ecnh. Thu\u1ed1c \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh \u0111\u1ec3 c\u1ed1 g\u1eafng l\u00e0m gi\u1ea3m nguy c\u01a1 h\u00ecnh th\u00e0nh ung th\u01b0 v\u00fa. B\u00e1c s\u0129 c\u1ee7a b\u1ea1n s\u1ebd th\u1ea3o lu\u1eadn v\u1ec1 l\u1ef1a ch\u1ecdn th\u00edch h\u1ee3p cho b\u1ea1n. B\u1ea1n c\u00f3 th\u1ec3 \u0111\u1ecdc th\u00eam th\u00f4ng tin \u0111\u1ec3 qu\u1ea3n l\u00fd nguy c\u01a1 m\u1eafc b\u1ec7nh trong quy\u1ec3n <strong>B\u1ec7nh s\u1eed gia \u0111\u00ecnh, di truy\u1ec1n v\u00e0 ung th\u01b0 v\u00fa. <\/strong><\/p>\n<h2><strong>Tamoxifen \u0111\u01b0\u1ee3c d\u00f9ng nh\u01b0 th\u1ebf n\u00e0o?<\/strong><\/h2>\n<p>Tamoxifen \u0111\u01b0\u1ee3c k\u00ea qua \u0111\u01b0\u1eddng u\u1ed1ng, \u1edf d\u1ea1ng vi\u00ean n\u00e9n. Th\u1ec9nh tho\u1ea3ng thu\u1ed1c c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c d\u00f9ng \u1edf d\u1ea1ng l\u1ecfng cho nh\u1eefng ng\u01b0\u1eddi kh\u00f3 nu\u1ed1t. Li\u1ec1u khuy\u1ebfn ngh\u1ecb cho h\u1ea7u h\u1ebft m\u1ecdi ng\u01b0\u1eddi l\u00e0 20 mg\/ng\u00e0y. T\u1ed1t nh\u1ea5t l\u00e0 u\u1ed1ng thu\u1ed1c v\u00e0o c\u00f9ng th\u1eddi \u0111i\u1ec3m m\u1ed7i ng\u00e0y. N\u1ebfu qu\u00ean li\u1ec1u, b\u1ea1n kh\u00f4ng c\u1ea7n u\u1ed1ng th\u00eam m\u1ed9t vi\u00ean v\u00e0o ng\u00e0y k\u1ebf ti\u1ebfp. N\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong c\u01a1 th\u1ec3 s\u1ebd gi\u1eef \u0111\u1ee7 cao t\u1eeb ng\u00e0y tr\u01b0\u1edbc. N\u1ebfu v\u00ec l\u00fd do n\u00e0o \u0111\u00f3, b\u1ea1n mu\u1ed1n d\u1eebng thu\u1ed1c th\u00ec h\u00e3y n\u00f3i chuy\u1ec7n v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc. Vi\u1ec7c kh\u00f4ng u\u1ed1ng thu\u1ed1c trong th\u1eddi gian \u0111\u00e3 khuy\u1ebfn ngh\u1ecb c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 ung th\u01b0 v\u00fa t\u00e1i ph\u00e1t.<\/p>\n<h2><strong>T\u00f4i s\u1ebd u\u1ed1ng tamoxifen trong bao l\u00e2u?<\/strong><\/h2>\n<p>Kho\u1ea3ng th\u1eddi gian khuy\u1ebfn ngh\u1ecb cho tamoxifen s\u1ebd thay \u0111\u1ed5i t\u00f9y theo t\u1eebng tr\u01b0\u1eddng h\u1ee3p. Nh\u1eefng ng\u01b0\u1eddi \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa nguy\u00ean ph\u00e1t th\u01b0\u1eddng u\u1ed1ng tamoxifen trong kho\u1ea3ng t\u1eeb 5 t\u1edbi 10 n\u0103m.<\/p>\n<p>N\u1ebfu b\u1ea1n m\u00e3n kinh trong khi u\u1ed1ng tamoxifen th\u00ec b\u00e1c s\u0129 c\u00f3 th\u1ec3 khuy\u00ean b\u1ea1n \u0111\u1ed5i t\u1eeb tamoxifen sang m\u1ed9t li\u1ec7u ph\u00e1p n\u1ed9t ti\u1ebft kh\u00e1c \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 thu\u1ed1c \u1ee9c ch\u1ebf aromatase (n\u1ed9i ti\u1ebft b\u1eadc 2) nh\u01b0 l\u00e0 anastrozole, exemestane ho\u1eb7c letrozole. Vi\u1ec7c \u0111\u1ed5i thu\u1ed1c c\u00f3 th\u1ec3 l\u00e0 2-3 n\u0103m sau khi u\u1ed1ng tamoxifen, ho\u1eb7c sau khi u\u1ed1ng tamoxifen 5 n\u0103m. B\u00e1c s\u0129 c\u00f3 th\u1ec3 cho l\u00e0m x\u00e9t nghi\u1ec7m m\u00e1u \u0111\u1ec3 ki\u1ec3m tra t\u00ecnh tr\u1ea1ng m\u00e3n kinh c\u1ee7a b\u1ea1n tr\u01b0\u1edbc khi \u0111\u1ed5i li\u1ec7u ph\u00e1p n\u1ed9i ti\u1ebft.<\/p>\n<p>\u0110\u00f4i khi tamoxifen \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb sau khi u\u1ed1ng m\u1ed9t thu\u1ed1c \u1ee9c ch\u1ebf aromatase.<\/p>\n<p>\u0110\u1ec3 c\u00f3 th\u00eam th\u00f4ng tin, \u0111\u1ec1 ngh\u1ecb xem quy\u1ec3n <strong>Anastrozole (Arimidex), Exemestane (Aromasin)<\/strong> v\u00e0 <strong>Letrozole (Femara).<\/strong><\/p>\n<p>\u0110\u1ed1i v\u1edbi ph\u1ee5 n\u1eefa tr\u1ebb ch\u01b0a m\u00e3n kinh, tamoxifen c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c u\u1ed1ng m\u1ed9t m\u00ecnh ho\u1eb7c \u0111\u00f4i khi c\u00f9ng v\u1edbi li\u1ec7u ph\u00e1p \u1ee9c ch\u1ebf bu\u1ed3ng tr\u1ee9ng (\u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 ng\u01b0ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a bu\u1ed3ng tr\u1ee9ng). \u0110\u1ec3 c\u00f3 th\u1ec3 th\u00f4ng tin v\u1ec1 \u0111i\u1ec1u tr\u1ecb n\u00e0y, h\u00e3y xem t\u00e0i li\u1ec7u <strong>\u1ee8c ch\u1ebf bu\u1ed3ng tr\u1ee9ng v\u00e0 ung th\u01b0 v\u00fa.<\/strong><\/p>\n<p>N\u1ebfu b\u1ea1n \u0111ang u\u1ed1ng tamoxifen \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa t\u00e1i ph\u00e1t t\u1ea1i ch\u1ed7 ho\u1eb7c th\u1ee9 ph\u00e1t, b\u1ea1n s\u1ebd ti\u1ebfp t\u1ee5c u\u1ed1ng cho t\u1edbi khi thu\u1ed1c kh\u00f4ng c\u00f2n kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c c\u0103n b\u1ec7nh.<\/p>\n<p>N\u1ebfu b\u1ea1n thu\u1ed9c nh\u00f3m c\u00f3 nguy c\u01a1 cao m\u1eafc ung th\u01b0 v\u00fa v\u00e0 \u0111ang u\u1ed1ng tamoxifen \u0111\u1ec3 ph\u00f2ng ng\u1eeba, b\u1ea1n s\u1ebd u\u1ed1ng thu\u1ed1c trong 5 n\u0103m. H\u00e3y xem t\u00e0i li\u1ec7u <strong>B\u1ec7nh s\u1eed\u00a0 gia \u0111\u00ecnh, di truy\u1ec1n v\u00e0 ung th\u01b0 v\u00fa<\/strong> \u0111\u1ec3 c\u00f3 th\u00eam th\u00f4ng tin.<\/p>\n<p><strong>L\u01b0u \u00fd khi d\u1eebng thu\u1ed1c tamoxifen<\/strong><\/p>\n<p>B\u00e1c s\u0129 s\u1ebd cho b\u1ea1n bi\u1ebft khi n\u00e0o n\u00ean d\u1eebng u\u1ed1ng tamoxifen. B\u1ea1n s\u1ebd kh\u00f4ng c\u1ea7n d\u1eebng thu\u1ed1c t\u1eeb t\u1eeb.<\/p>\n<h2><strong>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a tamoxifen l\u00e0 g\u00ec?<\/strong><\/h2>\n<p>Gi\u1ed1ng nh\u01b0 b\u1ea5t k\u1ef3 thu\u1ed1c n\u00e0o kh\u00e1c, tamoxifen c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5. M\u1ed7i ng\u01b0\u1eddi s\u1ebd ph\u1ea3n \u1ee9ng kh\u00e1c nhau v\u1edbi thu\u1ed1c. M\u1ed9t s\u1ed1 ng\u01b0\u1eddi g\u1eb7p nhi\u1ec1u t\u00e1c d\u1ee5ng ph\u1ee5 h\u01a1n nh\u1eefng ng\u01b0\u1eddi kh\u00e1c, trong khi m\u1ed9t s\u1ed1 l\u1ea1i kh\u00f4ng h\u1ec1 b\u1ecb t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0o. C\u00f3 \u00edt ho\u1eb7c kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 thu\u1ed1c kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng.<\/p>\n<p>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a tamoxifen th\u01b0\u1eddng l\u00e0 kh\u00f4ng nghi\u00eam tr\u1ecdng. Tuy nhi\u00ean, \u0111\u1ed1i v\u1edbi m\u1ed9t s\u1ed1 ng\u01b0\u1eddi, thu\u1ed1c c\u00f3 th\u1ec3 g\u00e2y m\u1ec7t m\u1ecfi v\u00e0 \u1ea3nh h\u01b0\u1edfng l\u00ean cu\u1ed9c s\u1ed1ng h\u00e0ng ng\u00e0y. H\u00e3y n\u00f3i v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb ho\u1eb7c b\u00e1c s\u0129 \u0111a khoa v\u00ec c\u00f3 nhi\u1ec1u c\u00e1ch c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3m b\u1edbt t\u00e1c d\u1ee5ng ph\u1ee5.<\/p>\n<p>T\u00e0i li\u1ec7u n\u00e0y kh\u00f4ng li\u1ec7t k\u00ea t\u1ea5t c\u1ea3 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 c\u00f3 c\u1ee7a thu\u1ed1c. N\u1ebfu b\u1ea1n c\u00f3 th\u1eafc m\u1eafc ho\u1eb7c lo ng\u1ea1i n\u00e0o v\u1ec1 t\u00e1c d\u1ee5ng ph\u1ee5, h\u00e3y n\u00f3i v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>Thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c nhi\u1ec1u c\u00f4ng ty\/h\u00e3ng d\u01b0\u1ee3c s\u1ea3n xu\u1ea5t. M\u1ed9t s\u1ed1 vi\u00ean n\u00e9n c\u00f3 th\u1ec3 kh\u00e1c nhau v\u1ec1 c\u00e1c th\u00e0nh ph\u1ea7n b\u1ed5 sung (v\u00ed d\u1ee5: ch\u1ea5t b\u1ea3o qu\u1ea3n); \u0111i\u1ec1u c\u00f3 c\u00f3 ngh\u0129a r\u1eb1ng m\u00e0u, h\u00ecnh d\u1ea1ng, k\u00edch c\u1ee1 v\u00e0 \u0111\u00f4i khi v\u1ecb c\u1ee7a vi\u00ean thu\u1ed1c c\u00f3 th\u1ec3 kh\u00e1c nhau gi\u1eefa c\u00e1c nh\u00e3n h\u00e0ng. Tuy nhi\u00ean, \u0111i\u1ec1u n\u00e0y kh\u00f4ng thay \u0111\u1ed5i hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>M\u1ed9t s\u1ed1 ng\u01b0\u1eddi b\u00e1o c\u00e1o g\u1eb7p \u00a0t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c nhau khi u\u1ed1ng tamoxifen c\u1ee7a c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t kh\u00e1c nhau. \u0110i\u1ec1u \u0111\u00f3 g\u1ee3i \u00fd r\u1eb1ng m\u1ed9t s\u1ed1 ng\u01b0\u1eddi th\u1ea5y tamoxifen c\u1ee7a h\u00e3ng n\u00e0y ph\u00f9 h\u1ee3p v\u1edbi h\u1ecd h\u01a1n l\u00e0 c\u1ee7a h\u00e3ng kh\u00e1c.<\/p>\n<p>B\u1ea1n c\u00f3 th\u1ec3 th\u1ea3o lu\u1eadn v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb ho\u1eb7c d\u01b0\u1ee3c s\u0129 v\u1ec1 lo\u1ea1i tamoxifen c\u1ee7a nh\u00e0 s\u1ea3n xu\u1ea5t m\u00e0 b\u1ea1n th\u1ea5y ph\u00f9 h\u1ee3p h\u01a1n v\u1edbi b\u1ea1n.<\/p>\n<h3><strong>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 hay g\u1eb7p<\/strong><\/h3>\n<p><strong><em>C\u00e1c tri\u1ec7u ch\u1ee9ng m\u00e3n kinh<\/em><\/strong><\/p>\n<p>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 ph\u1ed5 bi\u1ebfn nh\u1ea5t khi u\u1ed1ng tamoxifen l\u00e0 c\u00e1c tri\u1ec7u ch\u1ee9ng m\u00e3n kinh, g\u1ed3m b\u1ed1c h\u1ecfa, ra m\u1ed3 h\u00f4i ban \u0111\u00eam, ng\u1ee7 kh\u00f4ng ngon, k\u00edch \u1ee9ng \u00e2m \u0111\u1ea1o (kh\u00f4 v\u00e0 ng\u1ee9a \u00e2m \u0111\u1ea1o), gi\u1ea3m ham mu\u1ed1n\u00a0 t\u00ecnh d\u1ee5c v\u00e0 thay \u0111\u1ed5i t\u00e2m tr\u1ea1ng. \u0110\u1ec3 c\u00f3 th\u00eam th\u00f4ng tin v\u1ec1 \u1ee9ng ph\u00f3 v\u1edbi c\u00e1c tri\u1ec7u ch\u1ee9ng m\u00e3n kinh, h\u00e3y \u0111\u1ecdc t\u00e0i li\u1ec7u <strong>C\u00e1c tri\u1ec7u ch\u1ee9ng m\u00e3n kinh v\u00e0 ung th\u01b0 v\u00fa.\u00a0 <\/strong><\/p>\n<p><strong><em>\u1ea2nh h\u01b0\u1edfng l\u00ean kinh nguy\u1ec7t<\/em><\/strong><\/p>\n<p>M\u1ed9t s\u1ed1 ph\u1ee5 n\u1eef c\u00f3 th\u1ec3 th\u1ea5y kinh nguy\u1ec7t thay \u0111\u1ed5i. V\u00ed d\u1ee5, kinh nguy\u1ec7t c\u00f3 th\u1ec3 \u00edt \u0111i v\u00e0\/ho\u1eb7c kh\u00f4ng \u0111\u1ec1u ho\u1eb7c m\u1ea5t kinh. \u0110\u00f3 c\u00f3 th\u1ec3 l\u00e0 do m\u00e3n kinh \u0111\u00e3 x\u1ea3y ra t\u1ef1 nhi\u00ean trong th\u1eddi gian n\u00e0y ho\u1eb7c do c\u00e1c \u0111i\u1ec1u tr\u1ecb kh\u00e1c nh\u01b0 h\u00f3a tr\u1ecb \u0111\u00e3 g\u00e2y m\u00e3n kinh s\u1edbm. \u0110\u00f4i khi kinh nguy\u1ec7t s\u1ebd tr\u1edf l\u1ea1i sau khi d\u1eebng tamoxifen (Xem m\u1ee5c \u201c<strong>Tamoxifen c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn kh\u1ea3 n\u0103ng sinh s\u1ea3n kh\u00f4ng<\/strong>?\u201d).<\/p>\n<p><strong><em>Gi\u1eef n\u01b0\u1edbc trong c\u01a1 th\u1ec3<\/em><\/strong><\/p>\n<p>M\u1ed9t s\u1ed1 ph\u1ee5 n\u1eef th\u1ea5y h\u1ecd l\u00ean c\u00e2n trong khi \u0111i\u1ec1u tr\u1ecb, m\u1eb7c d\u00f9 kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng r\u00f5 r\u00e0ng v\u1ec1 s\u1ef1 li\u00ean quan gi\u1eefa t\u0103ng c\u00e2n v\u00e0 tamoxifen. \u0110\u00f4i khi tamoxifen c\u00f3 th\u1ec3 g\u00e2y ra ph\u00f9 n\u1ec1, gi\u1eef n\u01b0\u1edbc trong c\u01a1 th\u1ec3 v\u00e0 c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng t\u1edbi c\u00e2n n\u1eb7ng.<\/p>\n<p><strong><em>Ti\u1ebft d\u1ecbch \u00e2m \u0111\u1ea1o<\/em><\/strong><\/p>\n<p>Ti\u1ebft d\u1ecbch \u00e2m \u0111\u1ea1o l\u00e0 t\u00e1c d\u1ee5ng ngo\u1ea1i \u00fd hay g\u1eb7p khi u\u1ed1ng tamoxifen. H\u00e3y n\u00f3i v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 c\u00f3 th\u1ec3 lo\u1ea1i tr\u1eeb c\u00e1c nguy\u00ean nh\u00e2n vi\u00eam nhi\u1ec5m \u00e2m \u0111\u1ea1o.<strong><em>\u00a0<\/em><\/strong><\/p>\n<p><strong><em>Kh\u00f3 ti\u00eau ho\u1eb7c bu\u1ed3n n\u00f4n<\/em><\/strong><\/p>\n<p>M\u1ed9t s\u1ed1 ng\u01b0\u1eddi th\u1ea5y kh\u00f3 ti\u00eau ho\u1eb7c bu\u1ed3n n\u00f4n nh\u1eb9. C\u00e1c tri\u1ec7u ch\u1ee9ng n\u00e0y th\u01b0\u1eddng x\u1ea3y ra khi b\u1eaft \u0111\u1ea7u u\u1ed1ng tamoxifen, v\u00e0 n\u00f3i chung s\u1ebd c\u1ea3i thi\u1ec7n ho\u1eb7c d\u1ec5 qu\u1ea3n l\u00fd h\u01a1n theo th\u1eddi gian. B\u1ea1n c\u00f3 th\u1ec3 \u0111\u1ed1i ph\u00f3 b\u1eb1ng c\u00e1ch u\u1ed1ng tamoxifen c\u00f9ng v\u1edbi th\u1ee9c \u0103n.<\/p>\n<p><strong><em>\u1ea2nh h\u01b0\u1edfng l\u00ean x\u01b0\u01a1ng<\/em><\/strong><\/p>\n<p>N\u1ebfu b\u1ea1n \u0111\u00e3 m\u00e3n kinh, tamoxifen c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh m\u1ea5t x\u01b0\u01a1ng v\u00e0 l\u00e0m gi\u1ea3m nguy c\u01a1 lo\u00e3ng x\u01b0\u01a1ng. Tuy nhi\u00ean, tamoxifen c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nh\u1eb9 nguy c\u01a1 lo\u00e3ng x\u01b0\u01a1ng \u1edf ph\u1ee5 n\u1eef ti\u1ec1n m\u00e3n kinh. \u0110i\u1ec1u n\u00e0y hi\u1ebfm khi d\u1eabn t\u1edbi lo\u00e3ng x\u01b0\u01a1ng, tr\u1eeb khi b\u1ea1n d\u00f9ng k\u00e8m \u0111i\u1ec1u tr\u1ecb \u1ee9c ch\u1ebf bu\u1ed3ng tr\u1ee9ng.<\/p>\n<p>\u0110\u1ec3 c\u00f3 th\u00eam th\u00f4ng tin h\u00e3y \u0111\u1ecdc b\u00e0i <strong>Lo\u00e3ng x\u01b0\u01a1ng v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa<\/strong>.<\/p>\n<h3><strong>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 hi\u1ebfm g\u1eb7p h\u01a1n <\/strong><\/h3>\n<p><strong><em>\u1ea2nh h\u01b0\u1edfng l\u00ean t\u1eed cung<\/em><\/strong><\/p>\n<p>Tamoxifen c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng l\u00ean l\u1edbp l\u00f3t trong c\u1ee7a t\u1eed cung, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 n\u1ed9i m\u1ea1c t\u1eed cung, v\u00e0 l\u00e0m n\u1ed9i m\u1ea1c t\u1eed cung d\u00e0y l\u00ean. N\u1ebfu b\u1ea1n b\u1ecb ch\u1ea3y m\u00e1u \u00e2m \u0111\u1ea1o b\u1ea5t ng\u1edd ho\u1eb7c \u0111au \u00e2m \u0111\u1ea1o, h\u00e3y n\u00f3i v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb. Trong m\u1ed9t v\u00e0i tr\u01b0\u1eddng h\u1ee3p, s\u1eed d\u1ee5ng tamoxifen \u1edf ph\u1ee5 n\u1eef ti\u1ec1n m\u00e3n kinh c\u00f3 th\u1ec3 g\u00e2y polyp ho\u1eb7c nang bu\u1ed3ng tr\u1ee9ng.<\/p>\n<p>B\u1eb1ng ch\u1ee9ng hi\u1ec7n nay cho r\u1eb1ng tamoxifen kh\u00f4ng l\u00e0m t\u0103ng nguy c\u01a1 ung th\u01b0 t\u1eed cung \u1edf ph\u1ee5 n\u1eef ti\u1ec1n m\u00e3n kinh.<\/p>\n<p><strong><em>Thay \u0111\u1ed5i \u1edf t\u00f3c ho\u1eb7c l\u00f4ng t\u01a1 \u1edf m\u1eb7t<\/em><\/strong><\/p>\n<p>M\u1ed9t s\u1ed1 ph\u1ee5 n\u1eef th\u1ea5y t\u00f3c r\u1ee5ng ho\u1eb7c m\u1ecfng \u0111i trong khi u\u1ed1ng tamoxifen. M\u1ed9t s\u1ed1 \u00edt kh\u00e1c th\u1ea5y t\u0103ng l\u00f4ng t\u01a1 \u1edf m\u1eb7t.<\/p>\n<p><strong><em>Thay \u0111\u1ed5i th\u1ecb l\u1ef1c<\/em><\/strong><\/p>\n<p>C\u00f3 nguy c\u01a1 r\u1ea5t nh\u1ecf v\u1ec1 thay \u0111\u1ed5i th\u1ecb l\u1ef1c, g\u1ed3m nguy c\u01a1 \u0111\u1ee5c th\u1ec3 tinh th\u1ec3 cao h\u01a1n b\u00ecnh th\u01b0\u1eddng. N\u1ebfu b\u1ea1n nh\u1eadn th\u1ea5y b\u1ea5t k\u1ef3 thay \u0111\u1ed5i n\u00e0o v\u1ec1 th\u1ecb l\u1ef1c, h\u00e3y n\u00f3i v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p><strong><em>Thay \u0111\u1ed5i \u1edf gan<\/em><\/strong><\/p>\n<p>Tamoxifen thi tho\u1ea3ng c\u00f3 th\u1ec3 l\u00e0m t\u0103ng men gan. Nh\u1eefng thay \u0111\u1ed5i n\u00e0y th\u01b0\u1eddng r\u1ea5t nh\u1eb9 v\u00e0 kh\u00f4ng g\u00e2y ra b\u1ea5t k\u1ef3 tri\u1ec7u ch\u1ee9ng n\u00e0o. Gan c\u1ee7a b\u1ea1n s\u1ebd th\u01b0\u1eddng tr\u1edf l\u1ea1i b\u00ecnh th\u01b0\u1eddng khi k\u1ebft th\u00fac \u0111i\u1ec1u tr\u1ecb.<\/p>\n<h3><strong>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c<\/strong><\/h3>\n<p>M\u1ed9t s\u1ed1 ph\u1ee5 n\u1eef c\u00f3 th\u1ec3 nh\u1eadn th\u1ea5y thay \u0111\u1ed5i gi\u1ecdng n\u00f3i.<\/p>\n<p>Nh\u1eefng ng\u01b0\u1eddi kh\u00e1c c\u00f3 th\u1ec3 g\u1eb7p c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 \u0111au kh\u1edbp, m\u1ec7t m\u1ecfi, kh\u00f3 t\u1eadp trung, \u0111au \u0111\u1ea7u v\u00e0 chu\u1ed9t r\u00fat v\u00e0o \u0111\u00eam.<\/p>\n<h3><strong>C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 \u1edf nam gi\u1edbi l\u00e0 g\u00ec?<\/strong><\/h3>\n<p>Nam gi\u1edbi c\u0169ng c\u00f3 th\u1ec3 g\u1eb7p c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 t\u01b0\u01a1ng t\u1ef1 nh\u01b0 \u1edf n\u1eef gi\u1edbi, v\u00ed d\u1ee5 b\u1ed1c h\u1ecfa v\u00e0 \u0111au \u0111\u1ea7u. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u c\u0169ng l\u01b0u \u00fd c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00e1c nh\u01b0 gi\u1ea3m ham mu\u1ed1n t\u00ecnh d\u1ee5c, m\u1eb7c d\u00f9 ham mu\u1ed1n s\u1ebd h\u1ed3i ph\u1ee5c sau khi k\u1ebft th\u00fac \u0111i\u1ec1u tr\u1ecb tamoxifen. \u0110\u1ec3 c\u00f3 th\u00eam th\u00f4ng tin c\u1ee5 th\u1ec3, h\u00e3y xem th\u00f4ng tin v\u1ec1 Ung th\u01b0 v\u00fa \u1edf nam gi\u1edbi t\u1ea1i <a href=\"http:\/\/www.breastcancer.org.uk\" target=\"_blank\" rel=\"noopener\">www.breastcancer.org.uk<\/a>.<\/p>\n<h2><strong>C\u00e1c v\u1ea5n \u0111\u1ec1 kh\u00e1c<\/strong><\/h2>\n<h3><strong>Huy\u1ebft kh\u1ed1i<\/strong><\/h3>\n<p>Nh\u1eefng ng\u01b0\u1eddi b\u1ecb ung th\u01b0 v\u00fa c\u00f3 nguy c\u01a1 b\u1ecb huy\u1ebft kh\u1ed1i (h\u00ecnh th\u00e0nh c\u1ee5c m\u00e1u \u0111\u00f4ng) cao h\u01a1n. Nguy c\u01a1 n\u00e0y do b\u1ea3n th\u00e2n b\u1ec7nh ung th\u01b0 v\u00e0 do m\u1ed9t s\u1ed1 c\u00e1ch \u0111i\u1ec1u tr\u1ecb ung th\u01b0. Tamoxifen l\u00e0m t\u0103ng nguy c\u01a1 huy\u1ebft kh\u1ed1i nh\u01b0 b\u1ec7nh huy\u1ebft kh\u1ed1i t\u0129nh m\u1ea1ch s\u00e2u (DVT). Nh\u1eefng ng\u01b0\u1eddi b\u1ecb DVT c\u00f3 nguy c\u01a1 b\u1ecb thuy\u00ean t\u1eafc (\u0111\u1ed9ng m\u1ea1ch) ph\u1ed5i (PTE), x\u1ea3y ra khi m\u1ed9t ph\u1ea7n c\u1ee5c m\u00e1u \u0111\u00f4ng b\u1ecb v\u1ee1 ra v\u00e0 \u0111i t\u1edbi ph\u1ed5i.<\/p>\n<p>Huy\u1ebft kh\u1ed1i c\u00f3 th\u1ec3 g\u00e2y nguy hi\u1ec3m nh\u01b0ng c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c. \u0110i\u1ec1u quan tr\u1ecdng l\u00e0 b\u00e1o cho b\u00e1c s\u0129 khi c\u00f3 c\u00e1c tri\u1ec7u ch\u1ee9ng c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t.<\/p>\n<p style=\"padding-left: 30px;\"><em>N\u1ebfu b\u1ea1n c\u00f3 b\u1ea5t k\u1ef3 tri\u1ec7u ch\u1ee9ng n\u00e0o trong c\u00e1c tri\u1ec7u ch\u1ee9ng sau, h\u00e3y li\u00ean l\u1ea1c ngay v\u1edbi b\u00e1c s\u0129 :<\/em><\/p>\n<ul>\n<li><em>\u0110au, \u0111\u1ecf\/thay \u0111\u1ed5i m\u00e0u da, n\u00f3ng v\u00e0 s\u01b0ng \u1edf b\u1eafp ch\u00e2n, c\u1eb3ng ch\u00e2n ho\u1eb7c \u0111\u00f9i.<\/em><\/li>\n<li><em>S\u01b0ng, \u0111\u1ecf ho\u1eb7c m\u1ec1m \u1edf n\u01a1i \u0111\u01b0\u1eddng truy\u1ec1n t\u0129nh m\u1ea1ch trung t\u00e2m \u0111\u01b0\u1ee3c lu\u1ed3n v\u00e0o \u0111\u1ec3 truy\u1ec1n h\u00f3a ch\u1ea5t, v\u00ed d\u1ee5 \u1edf c\u00e1nh tay, khu v\u1ef1c ng\u1ef1c ho\u1eb7c l\u00ean t\u1edbi t\u1eadn c\u1ed5.<\/em><\/li>\n<li><em>Kh\u00f3 th\u1edf, ngh\u1eb9t th\u1edf.<\/em><\/li>\n<li><em>\u0110au th\u1eaft ng\u1ef1c.<\/em><\/li>\n<li><em>Ho kh\u00f4ng r\u00f5 nguy\u00ean nh\u00e2n (c\u00f3 th\u1ec3 ho ra m\u00e1u).<\/em><\/li>\n<\/ul>\n<p>N\u1ebfu b\u1ea1n t\u1eebng b\u1ecb huy\u1ebft kh\u1ed1i ho\u1eb7c c\u00f3 nguy c\u01a1 b\u1ecb huy\u1ebft kh\u1ed1i th\u00ec b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb s\u1ebd c\u00e2n nh\u1eafc \u0111i\u1ec1u n\u00e0y v\u00e0 c\u00f3 th\u1ec3 d\u00f9ng m\u1ed9t \u0111i\u1ec1u tr\u1ecb thay th\u1ebf kh\u00e1c. N\u1ebfu b\u1ea1n \u0111ang u\u1ed1ng thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng m\u00e1u nh\u01b0 wafarin th\u00ec b\u00e1c s\u0129 c\u00f3 th\u1ec3 theo d\u00f5i b\u1ea1n \u0111\u1ec1u \u0111\u1eb7n h\u01a1n ho\u1eb7c xem x\u00e9t \u0111\u1ed5i thu\u1ed1c ch\u1ed1ng \u0111\u00f4ng trong khi d\u00f9ng tamoxifen.<\/p>\n<p>Nh\u1eefng ng\u01b0\u1eddi u\u1ed1ng tamoxifen c\u1ea7n hi\u1ec3u v\u1ec1 nguy c\u01a1 b\u1ecb huy\u1ebft kh\u1ed1i v\u00e0 c\u00e1ch th\u1ee9c gi\u00fap gi\u1ea3m nguy c\u01a1. N\u1eb1m\/ng\u1ed3i b\u1ea5t \u0111\u1ed9ng trong th\u1eddi gian d\u00e0i c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 b\u1ecb huy\u1ebft kh\u1ed1i. N\u1ebfu b\u1ea1n \u0111ang l\u00ean k\u1ebf ho\u1ea1ch cho chuy\u1ebfn bay d\u00e0i, \u0111i tr\u00ean \u00f4 t\u00f4 ho\u1eb7c t\u00e0u h\u1ecfa nhi\u1ec1u gi\u1edd th\u00ec b\u1ea1n c\u00f3 th\u1ec3 c\u1ea7n \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n t\u1eeb b\u00e1c s\u0129. T\u01b0 v\u1ea5n n\u00e0y c\u00f3 th\u1ec3 g\u1ed3m \u0111i t\u1ea5t thun (t\u1ea5t d\u00e0i d\u01b0\u1edbi \u0111\u1ea7u g\u1ed1i t\u1ea1o s\u1ee9c \u00e9p nh\u1eb9 gi\u00fap m\u00e1u \u1edf ch\u00e2n l\u01b0u th\u00f4ng). B\u00edt t\u1ea5t n\u00e0y ph\u1ea3i th\u1eadt v\u1eeba v\u1eb7n n\u00ean c\u1ea7n c\u00f3 t\u01b0 v\u1ea5n c\u1ee7a \u0111i\u1ec1u d\u01b0\u1ee1ng, d\u01b0\u1ee3c s\u0129 ho\u1eb7c chuy\u00ean gia ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe kh\u00e1c.<\/p>\n<p>N\u1ebfu b\u1ea1n c\u1ea7n \u0111i\u1ec1u tr\u1ecb ho\u1eb7c ph\u1eabu thu\u1eadt c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng v\u1eadn \u0111\u1ed9ng, b\u1ea1n n\u00ean th\u1ea3o lu\u1eadn v\u1edbi b\u00e1c s\u0129 v\u1ec1 vi\u1ec7c c\u00f3 c\u1ea7n d\u1eebng u\u1ed1ng tamoxifen tr\u01b0\u1edbc v\u00e0 sau ph\u1eabu thu\u1eadt kh\u00f4ng. Nguy c\u01a1 huy\u1ebft kh\u1ed1i s\u1ebd \u0111\u01b0\u1ee3c xem x\u00e9t v\u00e0 b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb s\u1ebd cho b\u1ea1n bi\u1ebft li\u1ec7u c\u00f3 c\u1ea7n d\u1eebng kh\u00f4ng v\u00e0 d\u1eebng trong bao l\u00e2u.<\/p>\n<h3><strong>T\u00f4i c\u00f3 th\u1ec3 u\u1ed1ng tamoxifen v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1c \u0111\u01b0\u1ee3c kh\u00f4ng?<\/strong><\/h3>\n<p>N\u1ebfu b\u1ea1n \u0111ang thu\u1ed1c b\u1ea5t k\u1ef3 thu\u1ed1c n\u00e0o kh\u00e1c, h\u00e3y h\u1ecfi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb xem b\u1ea1n c\u00f3 th\u1ec3 u\u1ed1ng c\u00e1c thu\u1ed1c n\u00e0y v\u1edbi tamoxifen \u0111\u01b0\u1ee3c kh\u00f4ng.<\/p>\n<p>M\u1ed9t v\u00e0i nghi\u00ean c\u1ee9u \u0111\u00e3 g\u1ee3i \u00fd r\u1eb1ng m\u1ed9t s\u1ed1 thu\u1ed1c nh\u01b0 l\u00e0 fluoxetine (Prozac), paroxetine (Seroxat), bupropion (Welbutrin, Zyban, Voxra, Budeprion ho\u1eb7c Alenzin), quinidine (Quinedine Gluconate ho\u1eb7c Quinedien Sulfate), cinacalcet (Sensipar) c\u00f3 th\u1ec3 \u1ea3nh h\u01b0\u1edfng l\u00ean t\u00e1c d\u1ee5ng c\u1ee7a tamoxifen, l\u00e0m thu\u1ed1c n\u00e0y gi\u1ea3m hi\u1ec7u qu\u1ea3. Nhi\u1ec1u nghi\u00ean c\u1ee9u g\u1ea7n \u0111\u00e2y cho r\u1eb1ng kh\u1ea3 n\u0103ng n\u00e0y \u00edt x\u1ea3y ra, nh\u01b0ng m\u1ed9t s\u1ed1 chuy\u00ean gia v\u1eabn khuy\u1ebfn ngh\u1ecb r\u1eb1ng c\u00e1c thu\u1ed1c n\u00e0y kh\u00f4ng n\u00ean d\u00f9ng c\u00f9ng tamoxifen, n\u1ebfu c\u00f3 th\u1ec3 \u0111\u1ed5i thu\u1ed1c kh\u00e1c. H\u00e3y lu\u00f4n h\u1ecfi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc khi d\u1eebng c\u00e1c thu\u1ed1c n\u00e0y do vi\u1ec7c d\u1eebng \u0111\u1ed9t ng\u1ed9t c\u00f3 th\u1ec3 g\u00e2y nguy hi\u1ec3m.<\/p>\n<p style=\"padding-left: 30px;\"><em><strong>Th\u1ea3o d\u01b0\u1ee3c v\u00e0 th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng<\/strong><\/em><\/p>\n<p style=\"padding-left: 30px;\">Nhi\u1ec1u<em> ph\u1ee5 n\u1eef xem x\u00e9t u\u1ed1ng c\u00e1c thu\u1ed1c th\u1ea3o d\u01b0\u1ee3c ho\u1eb7c th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng trong khi \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa. Tuy nhi\u00ean, c\u1ea7n c\u1ea9n th\u1eadn khi d\u00f9ng c\u00e1c s\u1ea3n ph\u1ea9m n\u00e0y do t\u00e1c d\u1ee5ng v\u00e0 \u0111\u1ed9 an to\u00e0n c\u1ee7a ch\u00fang ch\u01b0a \u0111\u01b0\u1ee3c hi\u1ec3u r\u00f5. B\u1ea1n n\u00ean h\u1ecfi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc khi d\u00f9ng th\u1ea3o d\u01b0\u1ee3c ho\u1eb7c th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng.<\/em><\/p>\n<p style=\"padding-left: 30px;\"><em>\u0110\u1ec3 c\u00f3 th\u00eam th\u00f4ng tin v\u1ec1 th\u1ef1c ph\u1ea9m ch\u1ee9c n\u0103ng, h\u00e3y \u0111\u1ecdc t\u00e0i li\u1ec7u <strong>Ch\u1ebf \u0111\u1ed9 \u0103n v\u00e0 ung th\u01b0 v\u00fa<\/strong>. T\u00e0i li\u1ec7u <strong>C\u00e1c li\u1ec7u ph\u00e1p h\u1ed7 tr\u1ee3, th\u01b0 gi\u00e3n v\u00e0 s\u1ed1ng kh\u1ecfe<\/strong> c\u0169ng c\u00f3 th\u00f4ng tin v\u1ec1 th\u1ea3o d\u01b0\u1ee3c v\u00e0 li\u1ec7u ph\u00e1p vi l\u01b0\u1ee3ng \u0111\u1ed3ng c\u0103n.<\/em><\/p>\n<p><strong>Tr\u00e1nh thai trong khi u\u1ed1ng tamoxifen <\/strong><\/p>\n<p>B\u1ea1n c\u00f3 th\u1ec3 th\u1ee5 thai trong khi \u0111ang u\u1ed1ng tamoxifen, th\u1eadm ch\u00ed ngay c\u1ea3 khi kinh nguy\u1ec7t kh\u00f4ng \u0111\u1ec1u ho\u1eb7c \u0111\u00e3 d\u1eebng h\u1eb3n. V\u00ec tamoxifen c\u00f3 th\u1ec3 g\u00e2y nguy hi\u1ec3m cho thai nhi,n\u1ebfu b\u1ea1n c\u00f3 quan h\u1ec7 t\u00ecnh d\u1ee5c v\u1edbi nam gi\u1edbi th\u00ec b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb th\u01b0\u1eddng khuy\u00ean d\u00f9ng ph\u01b0\u01a1ng ph\u00e1p tr\u00e1nh thai nh\u01b0 bao cao su ho\u1eb7c m\u00e0ng ch\u1eafn \u00e2m \u0111\u1ea1o trong khi u\u1ed1ng tamoxifen v\u00e0 trong hai th\u00e1ng sau khi d\u1eebng thu\u1ed1c. \u0110\u1eb7t v\u00f2ng tr\u00e1nh thai l\u00e0 m\u1ed9t l\u1ef1a ch\u1ecdn, m\u1eb7c d\u00f9 b\u1ea1n s\u1ebd c\u1ea7n th\u1ea3o lu\u1eadn v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 ch\u1ecdn lo\u1ea1i v\u00f2ng tr\u00e1nh thai ph\u00f9 h\u1ee3p.<\/p>\n<p>N\u1ebfu b\u1ea1n ngh\u0129 b\u1ea1n c\u00f3 th\u1ec3 \u0111ang mang thai, h\u00e3y n\u00f3i v\u1edbi b\u00e1c s\u0129 c\u00e0ng s\u1edbm c\u00e0ng t\u1ed1t.<\/p>\n<h3><strong>Tamoxifen c\u00f3 \u1ea3nh h\u01b0\u1edfng t\u1edbi kh\u1ea3 n\u0103ng sinh s\u1ea3n kh\u00f4ng?<\/strong><\/h3>\n<p>\u1ede h\u1ea7u h\u1ebft ph\u1ee5 n\u1eef \u1edf tu\u1ed5i ti\u1ec1n m\u00e3n kinh u\u1ed1ng tamoxifen th\u00ec bu\u1ed3ng tr\u1ee9ng v\u1eabn ti\u1ebfp t\u1ee5c ho\u1ea1t \u0111\u1ed9ng. Khi b\u1ea1n b\u1eaft \u0111\u1ea7u u\u1ed1ng tamoxifen n\u00f3 c\u00f3 th\u1ec3 k\u00edch th\u00edch r\u1ee5ng tr\u1ee9ng (gi\u1ea3i ph\u00f3ng tr\u1ee9ng t\u1eeb bu\u1ed3ng tr\u1ee9ng) v\u00e0 c\u00f3 th\u1ec3 d\u1ec5 l\u00e0m b\u1ea1n mang thai h\u01a1n. Tuy nhi\u00ean, vi\u1ec7c mang thai l\u00e0 kh\u00f4ng n\u00ean (Xem ph\u1ea7n \u201cTr\u00e1nh thai trong khi u\u1ed1ng tamoxifen\u201d \u1edf tr\u00ean).<\/p>\n<p>\u0110\u1ed1i v\u1edbi m\u1ed9t s\u1ed1 ph\u1ee5 n\u1eef, s\u1eed d\u1ee5ng li\u00ean t\u1ee5c tamoxifen l\u00e0m chu k\u1ef3 kinh nguy\u1ec7t tr\u1edf n\u00ean th\u1ea5t th\u01b0\u1eddng, ra \u00edt kinh ho\u1eb7c m\u1ea5t kinh. Khi b\u1ea1n ch\u01b0a m\u00e3n kinh t\u1ef1 nhi\u00ean trong th\u1eddi gian \u0111i\u1ec1u tr\u1ecb, chu k\u1ef3 kinh nguy\u1ec7t th\u01b0\u1eddng s\u1ebd b\u1eaft \u0111\u1ea7u l\u1ea1i khi d\u1eebng u\u1ed1ng tamoxifen. Tuy nhi\u00ean, c\u00f3 th\u1ec3 m\u1ea5t t\u1eeb 4-5 th\u00e1ng th\u00ec chu k\u1ef3 kinh nguy\u1ec7t m\u1edbi tr\u1edf n\u00ean \u0111\u1ec1u.<\/p>\n<p>Do th\u1eddi gian u\u1ed1ng tamoxifen th\u01b0\u1eddng d\u00e0i, c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 che \u0111i c\u00e1c d\u1ea5u hi\u1ec7u c\u1ee7a m\u00e3n kinh t\u1ef1 nhi\u00ean v\u00e0 m\u00e3n kinh ch\u1ec9 \u0111\u01b0\u1ee3c nh\u1eadn th\u1ea5y khi k\u1ebft th\u00fac u\u1ed1ng thu\u1ed1c.<\/p>\n<p>N\u1ebfu b\u1ea1n \u0111ang \u1edf trong l\u1ee9a tu\u1ed5i 30 ho\u1eb7c 40, \u0111ang \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb n\u1ed9i ti\u1ebft trong h\u01a1n 5 n\u0103m v\u00e0 mu\u1ed1n c\u00f3 con, h\u00e3y th\u1ea3o lu\u1eadn \u0111i\u1ec1u n\u00e0y v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p>\u0110\u1ec3 c\u00f3 th\u00eam th\u00f4ng tin, h\u00e3y \u0111\u1ecdc t\u00e0i li\u1ec7u <strong>Kh\u1ea3 n\u0103ng sinh s\u1ea3n v\u00e0 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa.<\/strong><\/p>\n<p>N\u1ebfu b\u1ea1n \u0111ang l\u00ean k\u1ebf ho\u1ea1ch c\u00f3 thai sau khi k\u1ebft th\u00fac u\u1ed1ng tamoxifen, b\u1ea1n c\u1ea7n ch\u1edd \u00edt nh\u1ea5t hai th\u00e1ng \u0111\u1ec3 thu\u1ed1c \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i kh\u1ecfi c\u01a1 th\u1ec3. B\u1ea1n n\u00ean n\u00f3i chuy\u1ec7n v\u1edbi b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb v\u1ec1 th\u1eddi gian mang thai th\u00edch h\u1ee3p .<\/p>\n<p>Ph\u1ee5 n\u1eef u\u1ed1ng tamoxifen \u0111\u01b0\u1ee3c khuy\u00ean kh\u00f4ng nu\u00f4i con b\u1eb1ng s\u1eefa m\u1eb9 do thu\u1ed1c c\u00f3 th\u1ec3 \u0111i v\u00e0o s\u1eefa m\u1eb9.<\/p>\n<h2>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n<p><a href=\"https:\/\/breastcancernow.org\/information-support\/facing-breast-cancer\/going-through-treatment-breast-cancer\/hormone-therapy\/tamoxifen\" target=\"_blank\" rel=\"noopener\">https:\/\/breastcancernow.org\/information-support\/facing-breast-cancer\/going-through-treatment-breast-cancer\/hormone-therapy\/tamoxifen<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>C\u00f9ng t\u00ecm hi\u1ec3u v\u1ec1 c\u00f4ng d\u1ee5ng v\u00e0 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 x\u1ea3y ra c\u1ee7a thu\u1ed1c tamoxifen, m\u1ed9t lo\u1ea1i thu\u1ed1c quan tr\u1ecdng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa.<\/p>\n","protected":false},"author":548,"featured_media":19452,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5316],"tags":[9311,9312,3596],"series":[7032],"coauthors":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - 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