{"id":6460,"date":"2019-01-28T09:22:29","date_gmt":"2019-01-28T02:22:29","guid":{"rendered":"https:\/\/yhoccongdong.org\/du-an-khac\/2018\/12\/04\/vi-khuan-helicobacter-pylori-h-pylori-va-nguy-co-ung-thu-da-day\/"},"modified":"2024-03-17T05:17:47","modified_gmt":"2024-03-16T22:17:47","slug":"vi-khuan-helicobacter-pylori-va-nguy-co-ung-thu-da-day","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/du-an-khac\/vi-khuan-helicobacter-pylori-va-nguy-co-ung-thu-da-day\/","title":{"rendered":"Vi khu\u1ea9n Helicobacter pylori (H. pylori) v\u00e0 nguy c\u01a1 ung th\u01b0 d\u1ea1 d\u00e0y."},"content":{"rendered":"

Bi\u00ean d\u1ecbch: Ch\u00e2u Ti\u1ec3u Lan<\/strong><\/em><\/p>\n

C\u00f3 r\u1ea5t nhi\u1ec1u y\u1ebfu t\u1ed1 nguy c\u01a1 cho ung th\u01b0 d\u1ea1 d\u00e0y<\/a> \u0111\u01b0\u1ee3c k\u1ec3 \u0111\u1ebfn: di truy\u1ec1n, tu\u1ed5i t\u00e1c, b\u00e9o ph\u00ec, ti\u00eau th\u1ee5 bia r\u01b0\u1ee3u, th\u1ee9c \u0103n \u0111\u00f3ng h\u1ed9p b\u1ea3o qu\u1ea3n b\u1eb1ng mu\u1ed1i, th\u1ecbt x\u1eed l\u00fd c\u00f4ng nghi\u1ec7p (x\u00fac x\u00edch, th\u1ecbt ngu\u1ed9i\u2026), ho\u1eb7c th\u1ee9c \u0103n n\u01b0\u1edbng, nh\u01b0ng 2 y\u1ebfu t\u1ed1 ch\u1eafc ch\u1eafn l\u00e0m gi\u1ea3m nguy c\u01a1 b\u1ecb b\u1ec7nh n\u00e0y l\u00e0 ng\u01b0ng h\u00fat thu\u1ed1c l\u00e1 v\u00e0 \u0111i\u1ec1u tr\u1ecb kh\u1ecfi vi\u00eam lo\u00e9t d\u1ea1 d\u00e0y do H. pylori g\u00e2y ra.<\/p>\n

Helicobacter pylori l\u00e0 g\u00ec?<\/strong><\/h2>\n

Helicobacter pylori<\/a>, hay H. pylori, l\u00e0 m\u1ed9t lo\u1ea1i vi khu\u1ea9n h\u00ecnh xo\u1eafn (helico-) s\u1ed1ng trong l\u1edbp ni\u00eam m\u1ea1c d\u1ea1 d\u00e0y c\u1ee7a con ng\u01b0\u1eddi. \u0110\u1ec3 t\u1ed3n t\u1ea1i \u0111\u01b0\u1ee3c trong m\u00f4i tr\u01b0\u1eddng acid c\u1ee7a d\u1ea1 d\u00e0y, vi khu\u1ea9n n\u00e0y ti\u1ebft ra enzyme urease \u0111\u1ec3 chuy\u1ec3n h\u00f3a urea th\u00e0nh ammonia NH3 v\u1ed1n mang t\u00ednh ki\u1ec1m, nh\u1eb1m trung h\u00f2a m\u00f4i tr\u01b0\u1eddng cho ch\u00fang ph\u00e1t tri\u1ec3n. M\u1eb7t kh\u00e1c, h\u00ecnh d\u1ea1ng xo\u1eafn c\u1ee7a vi khu\u1ea9n c\u00f2n n\u00e0y gi\u00fap ch\u00fang chui s\u00e2u v\u00e0o b\u00ean trong l\u1edbp ni\u00eam m\u1ea1c, n\u01a1i c\u00f3 \u00edt t\u00ednh acid h\u01a1n, ho\u1eb7c chui v\u00e0o th\u00e0nh bao t\u1eed. Ch\u00ednh c\u01a1 ch\u1ebf n\u00e0y c\u00e0ng l\u00e0m cho c\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch kh\u00f3 t\u1ea5n c\u00f4ng ti\u00eau di\u1ec7t ch\u00fang h\u01a1n.<\/p>\n

Vi khu\u1ea9n H. pylori \u0111\u00e3 s\u1ed1ng k\u00fd sinh v\u1edbi lo\u00e0i ng\u01b0\u1eddi h\u00e0ng ng\u00e0n n\u0103m qua. C\u00f3 nghi\u00ean c\u1ee9u \u0111\u00e3 cho th\u1ea5y kho\u1ea3ng 2\/3 d\u00e2n s\u1ed1 th\u1ebf gi\u1edbi b\u1ecb nhi\u1ec5m vi khu\u1ea9n n\u00e0y v\u00e0 c\u00e1c n\u01b0\u1edbc \u0111ang ph\u00e1t tri\u1ec3n c\u00f3 t\u1ec9 l\u1ec7 nhi\u1ec5m cao h\u01a1n c\u00e1c n\u01b0\u1edbc ph\u00e1t tri\u1ec3n v\u00e0 gi\u00e0u c\u00f3. D\u00f9 v\u1eady ch\u1ec9 c\u00f3 1-3% ng\u01b0\u1eddi mang vi khu\u1ea9n s\u1ebd ti\u1ebfn tri\u1ec3n \u0111\u1ebfn ung th\u01b0 d\u1ea1 d\u00e0y. Tuy nhi\u00ean n\u1ebfu gia \u0111\u00ecnh c\u00f3 ti\u1ec1n s\u1eed ung th\u01b0 d\u1ea1 d\u00e0y, ng\u01b0\u1eddi nhi\u1ec5m \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb n\u00ean \u0111i\u1ec1u tr\u1ecb \u0111\u1ec3 ti\u00eau di\u1ec7t H. pylori tri\u1ec7t \u0111\u1ec3. pylori \u0111\u01b0\u1ee3c cho l\u00e0 \u0111\u01b0\u1ee3c l\u00e2y truy\u1ec1n qua th\u1ef1c ph\u1ea9m v\u00e0 n\u01b0\u1edbc u\u1ed1ng b\u1ecb nhi\u1ec5m b\u1ea9n, qua ti\u1ebfp x\u00fac mi\u1ec7ng. V\u1edbi \u0111a s\u1ed1 qu\u1ea7n th\u1ec3 c\u01b0 d\u00e2n th\u00ec vi khu\u1ea9n x\u00e2m nh\u1eadp t\u1eeb th\u1eddi th\u01a1 \u1ea5u c\u1ee7a m\u1ed9t ng\u01b0\u1eddi v\u00e0 s\u1ed1ng c\u00f9ng t\u1eeb \u0111\u00f3, th\u01b0\u1eddng l\u00e0 \u1edf nh\u1eefng n\u01a1i c\u00f3 tr\u1ebb em ngh\u00e8o, c\u01b0 d\u00e2n \u0111\u00f4ng \u0111\u00fac, kh\u00f4ng \u0111\u1ee7 \u0111i\u1ec1u ki\u1ec7n v\u1ec7 sinh.<\/p>\n

Pylori, nguy c\u01a1 g\u00e2y ung th\u01b0 d\u1ea1 d\u00e0y?<\/strong><\/h2>\n

B\u1ec7nh ung th\u01b0 d\u1ea1 d\u00e0y tho\u1ea1t \u0111\u1ea7u \u0111\u01b0\u1ee3c hi\u1ec3u l\u00e0 1 b\u1ec7nh duy nh\u1ea5t nh\u01b0ng c\u00e1c nh\u00e0 chuy\u00ean m\u00f4n sau \u0111\u00f3 l\u00e0 ph\u00e2n ra 2 lo\u1ea1i: ung th\u01b0 cu\u1ed1ng d\u1ea1 d\u00e0y (cardia gastric cancer) v\u00e0 ung th\u01b0 t\u00fai d\u1ea1 d\u00e0y (non- cardia gastric cancer). Nguy c\u01a1 c\u1ee7a vi khu\u1ea9n H.pylori d\u01b0\u1eddng nh\u01b0 ch\u1ec9 g\u1eafn li\u1ec1n v\u1edbi ung th\u01b0 t\u00fai d\u1ea1 d\u00e0y, trong khi s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a vi khu\u1ea9n l\u1ea1i c\u00f3 m\u1ed1i t\u01b0\u01a1ng quan t\u1edbi s\u1ef1 gi\u1ea3m nguy c\u01a1 ung th\u01b0 cu\u1ed1ng d\u1ea1 d\u00e0y, m\u1eb7c d\u00f9 c\u01a1 ch\u1ebf c\u1ee7a s\u1ef1 kh\u00e1c bi\u1ec7t n\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c hi\u1ec3u r\u00f5 r\u00e0ng.<\/p>\n

Nh\u01b0 \u0111\u00e3 n\u00f3i, vi khu\u1ea9n H. pylori \u0111\u00e3 s\u1ed1ng k\u00fd sinh trong con ng\u01b0\u1eddi t\u1eeb xa x\u01b0a, v\u00ec v\u1eady kh\u00f4ng ph\u1ea3i ng\u01b0\u1eddi n\u00e0o mang vi khu\u1ea9n H. pylori \u0111\u1ec1u s\u1ebd ph\u00e1t b\u1ec7nh. Tuy nhi\u00ean \u0111\u00e2y l\u00e0 y\u1ebfu t\u1ed1 nguy c\u01a1 tr\u1ef1c ti\u1ebfp g\u00e2y n\u00ean c\u00e1c b\u1ec7nh lo\u00e9t \u1ed1ng ti\u00eau h\u00f3a (th\u1ef1c qu\u1ea3n- d\u1ea1 d\u00e0y- ru\u1ed9t non; peptic ulcer diseases). Vai tr\u00f2 c\u1ee7a vi khu\u1ea9n n\u00e0y trong vi\u1ec7c g\u00e2y n\u00ean b\u1ec7nh ung th\u01b0 d\u1ea1 d\u00e0y c\u0169ng ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c c\u1ee7ng c\u1ed1. C\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y ng\u01b0\u1eddi b\u1ecb nhi\u1ec5m vi khu\u1ea9n n\u00e0y s\u1ebd c\u00f3 nguy c\u01a1 cao h\u01a1n ng\u01b0\u1eddi kh\u00f4ng b\u1ecb nhi\u1ec5m 6 l\u1ea7n. B\u00ean c\u1ea1nh \u0111\u00f3, g\u1ea7n 90% b\u1ec7nh ung th\u01b0 d\u1ea1 d\u00e0y c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c nhi\u1ec5m tr\u00f9ng con vi khu\u1ea9n n\u00e0y. S\u1ef1 ph\u00e1t hi\u1ec7n v\u1ec1 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa vi\u00eam nhi\u1ec5m H. pylori v\u00e0 ung th\u01b0 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n \u0111\u1ed3ng th\u1eddi v\u1edbi m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa virus v\u00e0 ung th\u01b0.<\/p>\n

Theo nghi\u00ean c\u1ee9u ti\u1ebfn h\u00e0nh t\u1ea1i Shangdong, Trung Qu\u1ed1c, n\u01a1i c\u00f3 t\u1ec9 l\u1ec7 ung th\u01b0 d\u1ea1 d\u00e0y r\u1ea5t cao: sau 15 n\u0103m ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb vi khu\u1ea9n H.pylori b\u1eb1ng kh\u00e1ng sinh \u0111\u00e3 l\u00e0m gi\u1ea3m t\u1ec9 l\u1ec7 ung th\u01b0 d\u1ea1 d\u00e0y \u0111\u01b0\u1ee3c g\u1ea7n 40%.<\/p>\n

C\u0169ng c\u1ea7n l\u01b0u \u00fd th\u00eam vi khu\u1ea9n H pylori c\u0169ng c\u00f3 nhi\u1ec1u ch\u1ee7ng (strains) kh\u00e1c nhau, ch\u1ec9 c\u00f3 CagA positive th\u00ec m\u1edbi g\u00e2y n\u00ean c\u00e1c b\u1ec7nh n\u00e0y.<\/p>\n

Khi n\u00e0o c\u1ea7n ch\u1eefa tr\u1ecb lo\u1ea1i b\u1ecf H pylori?<\/strong><\/h2>\n

Ng\u01b0\u1eddi c\u00f3 s\u1ee9c kh\u1ecfe b\u00ecnh th\u01b0\u1eddng th\u00ec kh\u00f4ng c\u1ea7n ph\u1ea3i x\u00e9t nghi\u1ec7m v\u00e0 ti\u00eau di\u1ec7t H.pylori, nh\u01b0ng n\u1ebfu b\u1ea1n c\u00f3 vi\u00eam lo\u00e9t d\u1ea1 d\u00e0y t\u00e1 tr\u00e0ng th\u00ec n\u00ean \u0111\u1ebfn b\u1ec7nh vi\u1ec7n ki\u1ec3m tra xem m\u00ecnh c\u00f3 b\u1ecb nhi\u1ec5m H. pylori hay kh\u00f4ng. N\u1ebfu c\u00f3 th\u00ec ho\u00e0n to\u00e0n n\u00ean d\u00f9ng thu\u1ed1c kh\u00e1ng sinh \u0111\u1ec3 ti\u00eau di\u1ec7t ch\u00fang tri\u1ec7t \u0111\u1ec3. C\u00f3 \u0111i\u1ec1u c\u1ea7n l\u01b0u \u00fd, vi\u1ec7c s\u1eed d\u1ee5ng kh\u00e1ng sinh ph\u1ea3i \u0111\u01b0\u1ee3c tu\u00e2n th\u1ee7 ch\u1eb7t ch\u1ebd \u0111\u00fang nh\u01b0 b\u00e1c s\u0129 d\u1eb7n v\u00ec n\u1ebfu kh\u00f4ng b\u1ea1n s\u1ebd kh\u00f4ng th\u1ec3 n\u00e0o kh\u1ecfi b\u1ec7nh m\u00e0 c\u00f2n g\u00f3p ph\u1ea7n l\u00e0m vi khu\u1ea9n l\u1eddn thu\u1ed1c. Khi \u0111\u00f3 ch\u00fang s\u1ebd x\u00e2m nh\u1eadp g\u00e2y h\u1ea1i th\u00eam nhi\u1ec1u ng\u01b0\u1eddi kh\u00e1c m\u00e0 lo\u00e0i ng\u01b0\u1eddi kh\u00f4ng c\u00f2n ph\u01b0\u01a1ng thu\u1ed1c n\u00e0o \u0111\u1ec3 ch\u1eefa cho ai c\u1ea3.<\/p>\n

B\u1ea1n c\u00f3 bi\u1ebft<\/strong><\/h2>\n

S\u1ef1 kh\u00e1m ph\u00e1 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa vi khu\u1ea9n v\u00e0 vi\u00eam lo\u00e9t d\u1ea1 d\u00e0y \u0111\u01b0\u1ee3c th\u01b0\u1edfng gi\u1ea3i Nobel Y h\u1ecdc n\u0103m 2005 cho hai b\u00e1c s\u0129, nh\u00e0 khoa h\u1ecdc: Robin Warren and Barry Marshall. Trong \u0111\u00f3 \u00f4ng Barry Marshall, do kh\u00f4ng th\u1ec3 ch\u1ee9ng minh vi khu\u1ea9n g\u00e2y n\u00ean b\u1ec7nh n\u00e0y b\u1eb1ng m\u00f4 h\u00ecnh \u0111\u1ed9ng v\u1eadt, \u0111\u00e3 t\u1ef1 nguy\u1ec7n u\u1ed1ng h\u1ed7n d\u1ecbch vi khu\u1ea9n. Ba ng\u00e0y sau \u00f4ng l\u1eadp t\u1ee9c b\u1ecb b\u1ec7nh d\u00f9 tr\u01b0\u1edbc \u0111\u00f3 \u00f4ng \u0111\u00e3 th\u1ef1c hi\u1ec7n cu\u1ed9c n\u1ed9i soi x\u00e1c minh t\u00ecnh tr\u1ea1ng kh\u1ecfe m\u1ea1nh tr\u01b0\u1edbc th\u1eed nghi\u1ec7m. Sau 14 ng\u00e0y th\u1ef1c hi\u1ec7n v\u00e0 l\u01b0u d\u1eef li\u1ec7u c\u1ee7a cu\u1ed9c th\u00ed nghi\u1ec7m, \u00f4ng ti\u1ebfn h\u00e0nh \u0111i\u1ec1u tr\u1ecb b\u1eb1ng kh\u00e1ng sinh v\u00e0 \u0111\u01b0\u1ee3c kh\u1ecfi h\u1eb3n t\u1ee9c th\u00ec. Cu\u1ed9c hy sinh t\u1ef1 th\u1eed nghi\u1ec7m c\u1ee7a \u00f4ng \u0111\u00e3 c\u1ee7ng c\u1ed1 s\u1ef1 suy \u0111o\u00e1n c\u1ee7a nh\u00e0 khoa h\u1ecdc Koch r\u1eb1ng c\u00f3 m\u1ed1i li\u00ean h\u1ec7 n\u00e0o \u0111\u00f3 gi\u1eefa vi khu\u1ea9n v\u00e0 vi\u00eam lo\u00e9t d\u1ea1 d\u00e0y, m\u1ed9t b\u1ec7nh m\u00e0 cho \u0111\u1ebfn th\u1eddi c\u1ee7a \u00f4ng Marshall, m\u1ecdi ng\u01b0\u1eddi trong ng\u00e0nh ch\u1ec9 cho r\u1eb1ng nguy\u00ean nh\u00e2n l\u00e0 do stress v\u00e0 th\u1ef1c ph\u1ea9m.<\/p>\n

T\u00e0i li\u1ec7u tham kh\u1ea3o<\/strong><\/h2>\n

1.https:\/\/www.wcrf.org\/\u2026\/cancer-tre\u2026\/stomach-cancer-statistics<\/a>
\n2.https:\/\/www.cancer.org\/\u2026\/causes-risks-pre\u2026\/risk-factors.html<\/a>
\n3.https:\/\/www.cancer.gov\/\u2026\/infectious-age\u2026\/h-pylori-fact-sheet<\/a>
\n4.https:\/\/www.webmd.com\/cancer\/hpylori-stomach-cancer#1<\/a>
\n5.https:\/\/www.cancerresearchuk.org\/\u2026\/infe\u2026\/h-pylori-and-cancer<\/a><\/p>\n

B\u1ea1n c\u00f3 th\u1ec3 \u0111\u1ecdc th\u00eam v\u1ec1 ti\u1ec3u s\u1eed kh\u00e1m ph\u00e1 \u1edf nh\u1eefng links sau:<\/em><\/strong><\/p>\n

6.https:\/\/www.thelancet.com\/\u2026\/PIIS0140-6736(05)67587\u2026\/fulltext<\/a>
\n7.https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1246068\/<\/a>
\nV\u00e0 \u0111\u00e2y l\u00e0 cu\u1ed1n s\u00e1ch vi\u1ebft v\u1ec1 to\u00e0n b\u1ed9 qu\u00e1 tr\u00ecnh ph\u00e1t hi\u1ec7n vi khu\u1ea9n H. pylori \u0111\u01b0\u1ee3c xu\u1ea5t b\u1ea3n n\u0103m 2016 nh\u00e2n d\u1ecbp k\u1ef7 ni\u1ec7m 10 n\u0103m gi\u1ea3i Nobel 2005:<\/em><\/strong><\/p>\n

8.https:\/\/link.springer.com\/chapt\u2026\/10.1007\/978-4-431-55705-0_1<\/a><\/p>\n

*** L\u01b0u \u00fd ***: b\u00e0i vi\u1ebft kh\u00f4ng nh\u1eb1m m\u1ee5c \u0111\u00edch \u0111em l\u1ea1i l\u1eddi khuy\u00ean ch\u1eefa tr\u1ecb n\u00e0o cho c\u00e1c b\u1ec7nh nh\u00e2n. V\u1edbi c\u00e1c t\u00ecnh hu\u1ed1ng b\u1ec7nh c\u1ee5 th\u1ec3, b\u1ec7nh nh\u00e2n ph\u1ea3i li\u00ean h\u1ec7 v\u1edbi b\u00e1c s\u0129 c\u1ee7a m\u00ecnh.<\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Theo th\u1ed1ng k\u00ea c\u1ee7a t\u1ed5 ch\u1ee9c y t\u1ebf th\u1ebf gi\u1edbi WHO, ung th\u01b0 d\u1ea1 d\u00e0y (stomach cancer hay gastric cancer) l\u00e0 b\u1ec7nh ung th\u01b0 ph\u1ed5 bi\u1ebfn th\u01b0\u1eddng x\u1ea3y ra \u1edf h\u00e0ng th\u1ee9 4 \u1edf \u0111\u00e0n \u00f4ng, v\u00e0 h\u00e0ng th\u1ee9 7 \u1edf ph\u1ee5 n\u1eef. Trong top 20 qu\u1ed1c gia c\u00f3 t\u1ec9 l\u1ec7 m\u1eafc cao nh\u1ea5t t\u00ednh \u0111\u1ebfn n\u0103m 2018, n\u01b0\u1edbc Vi\u1ec7t Nam x\u1ebfp th\u1ee9 10.<\/p>\n","protected":false},"author":142,"featured_media":6629,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4837,3288,5146,5302,1],"tags":[4879,4823,4880],"series":[2676],"coauthors":[2479],"acf":[],"yoast_head":"\nVi khu\u1ea9n Helicobacter pylori (H. pylori) v\u00e0 nguy c\u01a1 ung th\u01b0 d\u1ea1 d\u00e0y.- Y H\u1ecdc C\u1ed9ng \u0110\u1ed3ng<\/title>\n<meta name=\"description\" content=\"2 y\u1ebfu t\u1ed1 ch\u1eafc ch\u1eafn l\u00e0m gi\u1ea3m nguy c\u01a1 b\u1ecb b\u1ec7nh n\u00e0y l\u00e0 ng\u01b0ng h\u00fat thu\u1ed1c l\u00e1 v\u00e0 \u0111i\u1ec1u tr\u1ecb kh\u1ecfi vi\u00eam lo\u00e9t d\u1ea1 d\u00e0y do H. pylori g\u00e2y ra.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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