{"id":9481,"date":"2023-06-21T14:43:10","date_gmt":"2023-06-21T07:43:10","guid":{"rendered":"https:\/\/yhoccongdong.org\/du-an-khac\/anh-huong-cua-calcium-hydroxyde-doi-voi-vi-sinh-vat-trong-benh-ly-tuy\/"},"modified":"2024-03-17T06:49:20","modified_gmt":"2024-03-16T23:49:20","slug":"anh-huong-cua-calcium-hydroxyde-doi-voi-vi-sinh-vat-trong-benh-ly-tuy","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/du-an-khac\/anh-huong-cua-calcium-hydroxyde-doi-voi-vi-sinh-vat-trong-benh-ly-tuy\/","title":{"rendered":"\u1ea2nh h\u01b0\u1edfng c\u1ee7a Calcium Hydroxyde \u0111\u1ed1i v\u1edbi vi sinh v\u1eadt trong b\u1ec7nh l\u00fd tu\u1ef7"},"content":{"rendered":"<p>B\u1ec7nh l\u00fd \u1edf t\u1ee7y v\u00e0 c\u00e1c m\u00f4 quanh ch\u00f3p r\u0103ng l\u00e0 m\u1ed9t b\u1ec7nh l\u00fd r\u1ea5t ph\u1ed5 bi\u1ebfn [8]. C\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 ch\u1ee9ng minh s\u1ef1 phong ph\u00fa v\u00e0 \u0111a d\u1ea1ng c\u1ee7a h\u1ec7 vi khu\u1ea9n v\u00f9ng mi\u1ec7ng v\u1edbi s\u1ed1 l\u01b0\u1ee3ng l\u00ean \u0111\u1ebfn h\u01a1n 700 ch\u1ee7ng v\u00e0 ch\u00fang l\u00e0 y\u1ebfu t\u1ed1 quan tr\u1ecdng trong c\u00e1c b\u1ec7nh l\u00fd nhi\u1ec5m tr\u00f9ng tu\u1ef7. Calcium hydroxide \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t v\u1eadt li\u1ec7u che tu\u1ef7 t\u1eeb nh\u1eefng n\u0103m 1920 v\u00e0 sau \u0111\u00f3 d\u1ea7n tr\u1edf n\u00ean ph\u1ed5 bi\u1ebfn trong nha khoa nh\u01b0 m\u1ed9t c\u00f4ng th\u1ee9c kh\u00e1ng vi sinh v\u1eadt \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb trong n\u1ed9i nha, ch\u1eb3ng h\u1ea1n nh\u01b0 thu\u1ed1c \u0111\u1eb7t trong \u1ed1ng t\u1ee7y gi\u1eefa c\u00e1c cu\u1ed9c h\u1eb9n.<\/p>\n<h2><a name=\"_Toc130257389\"><\/a> Calcium hydroxide l\u00e0 g\u00ec?<\/h2>\n<p>Calcium hydroxide \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e2u d\u00e0i trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng trong h\u01a1n m\u1ed9t th\u1ebf k\u1ef7. N\u0103m 1920, Herman \u0111\u01b0a calcium hydroxide v\u00e0o nha khoa v\u1edbi t\u00ean g\u1ecdi \u201cCalcyl\u201d (Otto &amp; CO; Frankfurt, Germany) nh\u01b0 m\u1ed9t t\u00e1c nh\u00e2n che t\u1ee7y v\u00e0 hi\u1ec7n nay n\u00f3 ng\u00e0y c\u00e0ng \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i trong l\u0129nh v\u1ef1c n\u1ed9i nha.<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"size-medium wp-image-43246\" src=\"https:\/\/yhoccongdong.com\/du-an-khac\/wp-content\/uploads\/sites\/6\/2023\/06\/San-pham-Calxyl-300x246-1.jpg\" alt=\"San-pham-Calxyl\" width=\"300\" height=\"246\" \/><\/p>\n<p style=\"text-align: center\"><strong><em>H\u00ecnh<\/em><em>.<\/em> <em>S\u1ea3n ph\u1ea9m Calxyl<\/em><\/strong><\/p>\n<h2><a name=\"_Toc130257390\"><\/a>\u00a0\u0110\u1eb7c \u0111i\u1ec3m chung c\u1ee7a Calcium hydroxide<\/h2>\n<p>Calcium hydroxide l\u00e0 m\u1ed9t lo\u1ea1i b\u1ed9t kh\u00f4ng m\u00f9i m\u00e0u tr\u1eafng c\u00f3 tr\u1ecdng l\u01b0\u1ee3ng ph\u00e2n t\u1eed l\u00e0 7,08, \u0111\u1ed9 h\u00f2a tan th\u1ea5p trong n\u01b0\u1edbc. V\u1ec1 m\u1eb7t h\u00f3a h\u1ecdc, n\u00f3 \u0111\u01b0\u1ee3c ph\u00e2n lo\u1ea1i l\u00e0 m\u1ed9t baz\u01a1 m\u1ea1nh khi ti\u1ebfp x\u00fac v\u1edbi n\u01b0\u1edbc (\u0111\u1ed9 pH c\u1ee7a n\u00f3 kho\u1ea3ng 12,5 -12,8), v\u00e0 ph\u00e2n ly th\u00e0nh nh\u1eefng ion calci v\u00e0 hydroxyl.<\/p>\n<p>\u0110\u1ed9 pH v\u00e0 m\u00f4i tr\u01b0\u1eddng ch\u1ee9a \u0111\u1ef1ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u00ednh ch\u1ea5t c\u1ee7a calcium hydroxide. Polyethylene glycol l\u00e0 m\u1ed9t trong nh\u1eefng ph\u01b0\u01a1ng ti\u1ec7n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ph\u1ed5 bi\u1ebfn nh\u1ea5t do kh\u1ea3 n\u0103ng h\u00f2a tan th\u1ea5p v\u00e0 \u0111\u1eb7c t\u00ednh kh\u00e1ng khu\u1ea9n c\u1ee7a n\u00f3.<\/p>\n<p>C\u00e1c \u1ee9ng d\u1ee5ng kh\u00e1c nhau c\u1ee7a canxihydroxide l\u00e0 do c\u00e1c \u0111\u1eb7c t\u00ednh quan tr\u1ecdng c\u1ee7a n\u00f3 nh\u01b0 kho\u00e1ng h\u00f3a, \u0111\u1eb7c t\u00ednh kh\u00e1ng khu\u1ea9n v\u00e0 h\u00f2a tan v\u1eadt li\u1ec7u ho\u1ea1i t\u1eed.<\/p>\n<p><strong><em>B\u1ea3ng<\/em><em>.<\/em><em> C\u00e1c lo\u1ea1i m\u00f4i tr\u01b0\u1eddng c\u1ee7a calcium hydroxite v\u00e0 \u1ee9ng d\u1ee5ng c\u1ee7a n\u00f3<\/em><\/strong><\/p>\n<table width=\"586\">\n<tbody>\n<tr>\n<td width=\"151\"><strong>M\u00f4i tr\u01b0\u1eddng<\/strong><\/td>\n<td width=\"132\"><strong>T\u1ed1c \u0111\u1ed9 gi\u1ea3i ph\u00f3ng ion<\/strong><\/td>\n<td width=\"91\"><strong>T\u00ednh ho\u00e0 tan<\/strong><\/td>\n<td width=\"212\"><strong>C\u00e1c \u1ee9ng d\u1ee5ng<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"151\">L\u1ecfng (n\u01b0\u1edbc c\u1ea5t, Ringer\u2019s solution)<\/td>\n<td width=\"132\">Nhanh<\/td>\n<td width=\"91\">Cao<\/td>\n<td width=\"212\">Che tu\u1ef7 tr\u1ef1c ti\u1ebfp ho\u1eb7c gi\u00e1n ti\u1ebfp<\/td>\n<\/tr>\n<tr>\n<td width=\"151\">Nh\u1edbt\u00a0 (Glycerine, Polyethylene glycol)<\/td>\n<td width=\"132\">Ch\u1eadm h\u01a1n, trong th\u1eddi gian d\u00e0i<\/td>\n<td width=\"91\">Trung b\u00ecnh<\/td>\n<td width=\"212\">\u0110\u00f3ng ch\u00f3p<\/p>\n<p>Gi\u1eefa 2 l\u1ea7n h\u1eb9n n\u1ed9i nha<\/td>\n<\/tr>\n<tr>\n<td width=\"151\">Nh\u1eddn (Olive oil, Silicone oil)<\/td>\n<td width=\"132\">Ch\u1eadm h\u01a1n, trong th\u1eddi gian d\u00e0i<\/td>\n<td width=\"91\">Th\u1ea5p<\/td>\n<td width=\"212\">S\u1eeda ch\u1eefa nh\u1eefng l\u1ed7 th\u1ee7ng<\/p>\n<p>T\u00ecnh tr\u1ea1ng ngo\u1ea1i ti\u00eau<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><a name=\"_Toc130257391\"><\/a> \u01afu \u0111i\u1ec3m Calcium hydroxyde<\/h2>\n<p>Calcium hydroxyde c\u00f3 nhi\u1ec1u \u01b0u \u0111i\u1ec3m kh\u00e1c nhau nh\u01b0:<\/p>\n<ul>\n<li>T\u00ednh di\u1ec7t khu\u1ea9n ban \u0111\u1ea7u v\u00e0 sau \u0111\u00f3 l\u00e0 ho\u1ea1t t\u00ednh k\u00ecm khu\u1ea9n<\/li>\n<li>\u0110\u1ed9 pH cao gi\u00fap k\u00edch th\u00edch nguy\u00ean b\u00e0o s\u1ee3i<\/li>\n<li>Trung h\u00f2a \u0111\u1ed9 pH th\u1ea5p<\/li>\n<li>Th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh ch\u1eefa l\u00e0nh v\u00e0 s\u1eeda ch\u1eefa<\/li>\n<li>D\u1ec5 s\u1eed d\u1ee5ng<\/li>\n<\/ul>\n<h2><a name=\"_Toc130257392\"><\/a> Nh\u01b0\u1ee3c \u0111i\u1ec3m Calcium hydroxyde<\/h2>\n<ul>\n<li>B\u1ecb ph\u00e2n h\u1ee7y trong qu\u00e1 tr\u00ecnh \u0103n m\u00f2n axit<\/li>\n<li>Kh\u00f4ng b\u00e1m d\u00ednh<\/li>\n<\/ul>\n<h2>C\u01a1 ch\u1ebf c\u1ee7a s\u1ef1 kh\u00e1ng khu\u1ea9n<\/h2>\n<p>C\u00e1c g\u1ed1c t\u1ef1 do c\u00f3 t\u00ednh oxy h\u00f3a cao \u0111\u01b0\u1ee3c gi\u1ea3i ph\u00f3ng t\u1eebCalcium hydroxyde l\u00e0 l\u00fd do ch\u00ednh t\u1ea1o n\u00ean \u0111\u1eb7c t\u00ednh kh\u00e1ng khu\u1ea9n c\u1ee7a n\u00f3. Ho\u1ea1t \u0111\u1ed9ng c\u1ee7a c\u00e1c ion hydroxyl tr\u00ean t\u1ebf b\u00e0o vi khu\u1ea9n g\u00e2y ra s\u1ef1 peroxy h\u00f3a lipid c\u1ee7a phospholipid, do \u0111\u00f3 l\u00e0m h\u1ecfng m\u00e0ng t\u1ebf b\u00e0o ch\u1ea5t c\u1ee7a vi khu\u1ea9n. Hydroxylion c\u0169ng g\u00e2y ra thi\u1ec7t h\u1ea1i cho DNA \u1ee9c ch\u1ebf s\u1ef1 sao ch\u00e9p c\u1ee7a n\u00f3. \u0110\u1ed9 pH cao c\u1ee7a n\u00f3 g\u00e2y ra s\u1ef1 ph\u00e1 v\u1ee1 c\u00e1c li\u00ean k\u1ebft protein d\u1eabn \u0111\u1ebfn s\u1ef1 bi\u1ebfn t\u00ednh protein v\u00e0 \u1ee9c ch\u1ebf chuy\u1ec3n h\u00f3a t\u1ebf b\u00e0o. M\u1eb7c d\u00f9 ba c\u01a1 ch\u1ebf n\u00e0y c\u00f3 th\u1ec3 x\u1ea3y ra, nh\u01b0ng r\u1ea5t kh\u00f3 \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh \u0111\u00e2u l\u00e0 c\u01a1 ch\u1ebf ch\u00ednh li\u00ean quan \u0111\u1ebfn c\u00e1i ch\u1ebft c\u1ee7a t\u1ebf b\u00e0o vi khu\u1ea9n sau khi ti\u1ebfp x\u00fac v\u1edbi baz\u01a1 m\u1ea1nh.<\/p>\n<p>C\u00e1c ion hydroxyl t\u1eeb Ca(OH)2 ph\u00e1t huy c\u01a1 ch\u1ebf c\u1ee7a ch\u00fang ho\u1ea1t \u0111\u1ed9ng trong m\u00e0ng t\u1ebf b\u00e0o ch\u1ea5t v\u00ec \u0111\u00f3 l\u00e0 n\u01a1i \u0111\u1eb7t c\u00e1c v\u1ecb tr\u00ed enzym. C\u00e1c enzym ngo\u1ea1i b\u00e0o t\u00e1c \u0111\u1ed9ng l\u00ean c\u00e1c ch\u1ea5t dinh d\u01b0\u1ee1ng, carbohydrate, protein v\u00e0 lipid, th\u00f4ng qua qu\u00e1 tr\u00ecnh th\u1ee7y ph\u00e2n, c\u00f3 l\u1ee3i cho qu\u00e1 tr\u00ecnh ti\u00eau h\u00f3a. C\u00e1c enzym n\u1ed9i b\u00e0o n\u1eb1m trong t\u1ebf b\u00e0o c\u00f3 l\u1ee3i cho ho\u1ea1t \u0111\u1ed9ng h\u00f4 h\u1ea5p c\u1ee7a c\u1ea5u tr\u00fac th\u00e0nh t\u1ebf b\u00e0o. \u0110\u1ed9 pH c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o ch\u1ea5t b\u1ecb thay \u0111\u1ed5i do n\u1ed3ng \u0111\u1ed9 cao c\u1ee7a c\u00e1c ion hydroxyl t\u1eeb canxi hydroxit t\u00e1c \u0111\u1ed9ng l\u00ean c\u00e1c protein c\u1ee7a m\u00e0ng (s\u1ef1 bi\u1ebfn t\u00ednh protein). \u0110\u1ed9 pH cao c\u1ee7a Ca(OH)2 l\u00e0m thay \u0111\u1ed5i t\u00ednh to\u00e0n v\u1eb9n c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o ch\u1ea5t b\u1eb1ng c\u00e1ch g\u00e2y t\u1ed5n th\u01b0\u01a1ng h\u00f3a h\u1ecdc \u0111\u1ed1i v\u1edbi c\u00e1c th\u00e0nh ph\u1ea7n h\u1eefu c\u01a1 v\u00e0 v\u1eadn chuy\u1ec3n ch\u1ea5t dinh d\u01b0\u1ee1ng ho\u1eb7c b\u1eb1ng c\u00e1ch ph\u00e1 h\u1ee7y phospholipid ho\u1eb7c axit b\u00e9o kh\u00f4ng b\u00e3o h\u00f2a c\u1ee7a m\u00e0ng t\u1ebf b\u00e0o ch\u1ea5t trong qu\u00e1 tr\u00ecnh peroxy h\u00f3a, \u0111\u00f3 l\u00e0 ph\u1ea3n \u1ee9ng x\u00e0 ph\u00f2ng h\u00f3a.<\/p>\n<p>Vi\u1ec7c \u0111i\u1ec1u ch\u1ec9nh pH n\u1ed9i b\u00e0o b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi c\u00e1c qu\u00e1 tr\u00ecnh t\u1ebf b\u00e0o kh\u00e1c nhau, ch\u1eb3ng h\u1ea1n nh\u01b0 chuy\u1ec3n h\u00f3a t\u1ebf b\u00e0o, thay \u0111\u1ed5i h\u00ecnh d\u1ea1ng, t\u00ednh di \u0111\u1ed9ng, \u0111i\u1ec1u ch\u1ec9nh ch\u1ea5t v\u1eadn chuy\u1ec3n v\u00e0 tr\u00f9ng h\u1ee3p c\u00e1c th\u00e0nh ph\u1ea7n t\u1ebf b\u00e0o, k\u00edch ho\u1ea1t t\u0103ng sinh v\u00e0 ph\u00e1t tri\u1ec3n t\u1ebf b\u00e0o, d\u1eabn \u0111i\u1ec7n v\u00e0 v\u1eadn chuy\u1ec3n qua m\u00e0ng, v\u00e0 th\u1ec3 t\u00edch t\u1ebf b\u00e0o th\u1ea9m th\u1ea5u. Do \u0111\u00f3, nhi\u1ec1u ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi \u0111\u1ed9 pH, bao g\u1ed3m c\u1ea3 c\u00e1c enzym c\u1ea7n thi\u1ebft cho qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a t\u1ebf b\u00e0o. Estrela v\u00e0 c\u1ed9ng s\u1ef1 nh\u1eadn th\u1ea5y r\u1eb1ng s\u1ef1 b\u1ea5t ho\u1ea1t enzym c\u1ee7a vi khu\u1ea9n trong \u0111i\u1ec1u ki\u1ec7n pH kh\u1eafc nghi\u1ec7t trong m\u1ed9t th\u1eddi gian d\u00e0i l\u00e0 kh\u00f4ng th\u1ec3 \u0111\u1ea3o ng\u01b0\u1ee3c.<\/p>\n<p><img decoding=\"async\" class=\"size-medium wp-image-43248\" src=\"https:\/\/yhoccongdong.com\/du-an-khac\/wp-content\/uploads\/sites\/6\/2023\/06\/Tac-dong-diet-khuan-cua-caoh2-300x204-1.jpg\" alt=\"Tac-dong-diet-khuan-cua-caoh2\" width=\"300\" height=\"204\" \/><\/p>\n<p style=\"text-align: center\"><strong><em>S\u01a1 \u0111\u1ed3 <\/em><em>T\u00e1c \u0111\u1ed9ng di\u1ec7t khu\u1ea9n c\u1ee7a Ca(OH)2.<\/em><\/strong><\/p>\n<p style=\"text-align: center\"><em>Ngu\u1ed3n: <\/em><em>Mohammadi at al (2012) [14]<\/em><\/p>\n<h2><strong> K\u1ebft lu\u1eadn Calcium hydroxyde trong b\u1ec7nh l\u00fd tu\u1ef7<\/strong><\/h2>\n<p>T\u00f3m l\u1ea1i, v\u1edbi l\u1ecbch s\u1eed \u1ee9ng d\u1ee5ng h\u01a1n 100 n\u0103m trong nha khoa, Calcium hydroxyde \u0111\u00e3 th\u1ec3 hi\u1ec7n nh\u1eefng \u0111\u00f3ng g\u00f3p to l\u1edbn c\u1ee7a m\u00ecnh \u0111\u1eb7c bi\u1ec7t l\u00e0 trong n\u1ed9i nha.<\/p>\n<p>Ho\u1ea1t t\u00ednh kh\u00e1ng khu\u1ea9n c\u1ee7a Ca(OH)2 c\u00f3 li\u00ean quan \u0111\u1ebfn vi\u1ec7c gi\u1ea3i ph\u00f3ng c\u00e1c ion hydroxyl c\u00f3 ho\u1ea1t t\u00ednh cao trong m\u00f4i tr\u01b0\u1eddng n\u01b0\u1edbc, ch\u1ee7 y\u1ebfu \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn m\u00e0ng t\u1ebf b\u00e0o ch\u1ea5t, protein v\u00e0 DNA.<\/p>\n<p>Nhi\u1ec1u nghi\u00ean c\u1ee9u <em>in vitro<\/em> v\u00e0 l\u00e2m s\u00e0ng \u0111\u00e3 ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 c\u1ee7a Ca(OH)2 nh\u01b0 m\u1ed9t lo\u1ea1i thu\u1ed1c trong \u1ed1ng t\u1ee7y, v\u1edbi c\u01a1 ch\u1ebf : l\u00e0m t\u1ed5n th\u01b0\u01a1ng m\u00e0ng t\u1ebf b\u00e0o ch\u1ea5t c\u1ee7a vi khu\u1ea9n; bi\u1ebfn t\u00ednh protein; v\u00e0 g\u00e2y thi\u1ec7t h\u1ea1i cho DNA<\/p>\n<h2><strong>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/strong><\/h2>\n<ol>\n<li>Athanassiadis B, Abbott PV, Walsh LJ. (2007), &#8220;The use of calcium hydroxide, antibiotics and biocidesas antimicrobial medicaments in endodontics&#8221;, <em>Australian dental journal<\/em>, 52, S64-82<\/li>\n<li>Estrela C., Sydney G. B., Bammann L. L., Felippe O. (1994), &#8220;Estudo do efeito biol\u00f3gico do pH na atividade enzim\u00e1tica de bact\u00e9rias anaer\u00f3bias&#8221;, <em>Rev Fac Odontol Bauru<\/em>, 2, 29\u201336<\/li>\n<li>Estrela C., P\u00e9cora J. D., Silva R. S. (1998), &#8220;pH analysis of vehicles and calcium hydroxide pastes&#8221;, <em>Braz Endod J,<\/em> 3, 41\u201347<\/li>\n<li>Hermann BW (1920), <em>Calcium hydroxyd als mittel zurn behandel und f\u00fcllen vonxahnwurzelkan\u00e4len<\/em>, [Thesis] W\u00fcrzburg; 1920. 50p<\/li>\n<li>Nishanthi R., Vignesh R. (2020), &#8220;Role of Calcium Hydroxide in Dentistry: A Review&#8221;, <em>International Journal of Pharmaceutical Research<\/em>, 12(2), 2822-2827<\/li>\n<li>Paster BJ, Olsen I, Aas JA, Dewhirst FE (2006), &#8220;The breadth of bacterial diversity in the human periodontal pocket and other oral sites&#8221;, <em>Periodontol 2000<\/em>, 42, 80\u20137<\/li>\n<li>Safavi KE, Nichols FC. (1994), \u201cAlteration of biological properties of bacterial lipopolysaccharide by calcium hydroxide treatment\u201d, <em>J Endod.<\/em> 1994;20:127\u2013129<\/li>\n<li>Sahithi Reddy, Venkatachalam Prakash, Arunajatesan Subbiya, Suresh Mitthra (2020), \u201c100 Years of Calcium Hydroxide in Dentistry: A Review of Literature&#8221;, <em>Indian Journal of Forensic Medicine and Toxicology,<\/em> 14(4), 1203-1209<\/li>\n<li>Sang Hyuk Park et al (2015), \u201cInflammation of the Dental Pulp\u201d, <em>Mediators of Inflammation 2015<\/em>, Article ID 980196,1-2<\/li>\n<li>Siqueira JF. (2001), &#8220;Strategies to treat infected root canals&#8221;, <em>J Calif Dent Assoc<\/em>, 29, 825\u2013837<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Calcium hydroxyde \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t v\u1eadt li\u1ec7u che tu\u1ef7 t\u1eeb nh\u1eefng n\u0103m 1920 v\u00e0 sau \u0111\u00f3 d\u1ea7n tr\u1edf n\u00ean ph\u1ed5 bi\u1ebfn trong nha khoa nh\u01b0 m\u1ed9t c\u00f4ng th\u1ee9c kh\u00e1ng vi sinh v\u1eadt \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong \u0111i\u1ec1u tr\u1ecb trong n\u1ed9i nha, ch\u1eb3ng h\u1ea1n nh\u01b0 thu\u1ed1c \u0111\u1eb7t trong \u1ed1ng t\u1ee7y gi\u1eefa c\u00e1c cu\u1ed9c h\u1eb9n.<\/p>\n","protected":false},"author":1,"featured_media":9482,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5148,5241,3816],"tags":[5359,4147],"series":[1510],"coauthors":[3268],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - 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