{"id":5074,"date":"2021-09-05T12:36:26","date_gmt":"2021-09-05T05:36:26","guid":{"rendered":"https:\/\/yhoccongdong.org\/san-phu-khoa\/folate-va-axit-folic-trong-thai-ky\/"},"modified":"2024-04-28T23:44:06","modified_gmt":"2024-04-28T16:44:06","slug":"folate-va-axit-folic-trong-thai-ky","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/san-phu-khoa\/folate-va-axit-folic-trong-thai-ky\/","title":{"rendered":"Folate v\u00e0 Axit Folic trong thai k\u1ef3"},"content":{"rendered":"<p style=\"text-align: right;\"><em><strong>Bi\u00ean d\u1ecbch: Ma Th\u1ecb Hu\u1ec7<\/strong><\/em><\/p>\n<p style=\"text-align: right;\"><strong><em>Hi\u1ec7u \u0111\u00ednh: BS. L\u00ea H\u1eefu Th\u1eafng<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\">Folate v\u00e0\u00a0<a href=\"https:\/\/yhoccongdong.com\/thongtin\/acid-folic\/\" target=\"_blank\" rel=\"noopener\">Axit Folic<\/a> r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 ph\u00e1t tri\u1ec3n m\u1ed9t thai nhi kh\u1ecfe m\u1ea1nh v\u00ec n\u00f3 ng\u0103n ng\u1eeba khuy\u1ebft t\u1eadt \u1ed1ng th\u1ea7n kinh. \u1ed0ng th\u1ea7n kinh ph\u00e1t tri\u1ec3n trong v\u00f2ng 28 ng\u00e0y \u0111\u1ea7u c\u1ee7a thai k\u1ef3. Do \u0111\u00f3 t\u1ea5t c\u1ea3 ph\u1ee5 n\u1eef trong \u0111\u1ed9 tu\u1ed5i sinh s\u1ea3n \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o b\u1ed5 sung folate. Folate ng\u0103n ng\u1eeba m\u1ed9t s\u1ed1 b\u1ea5t th\u01b0\u1eddng v\u1ec1 tim, s\u1ee9t m\u00f4i v\u00e0 h\u1edf h\u00e0m \u1ebfch. \u0110\u1ed3ng th\u1eddi gi\u1ea3m nguy c\u01a1 thi\u1ebfu m\u00e1u, s\u1ea9y thai, sinh non v\u00e0 tr\u1ebb s\u01a1 sinh nh\u1eb9 c\u00e2n. N\u00f3 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong ng\u0169 c\u1ed1c \u0103n s\u00e1ng t\u0103ng c\u01b0\u1eddng, \u0111\u1eadu l\u0103ng, m\u00ec \u00dd, g\u1ea1o, c\u00e1c lo\u1ea1i \u0111\u1eadu, b\u00f4ng c\u1ea3i xanh, n\u01b0\u1edbc cam, rau ch\u00e2n v\u1ecbt v\u00e0 d\u00e2u t\u00e2y.<\/p>\n<h2 style=\"text-align: justify;\"><strong>Vai tr\u00f2 c\u1ee7a Folate v\u00e0 Axit Folic trong thai k\u1ef3 l\u00e0 g\u00ec?<\/strong><\/h2>\n<p style=\"text-align: justify;\">Folate (vitamin B9) r\u1ea5t quan tr\u1ecdng trong h\u00ecnh th\u00e0nh h\u1ed3ng c\u1ea7u, cho s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 ch\u1ee9c n\u0103ng c\u1ee7a t\u1ebf b\u00e0o kh\u1ecfe m\u1ea1nh, l\u00e0 ch\u1ea5t dinh d\u01b0\u1ee1ng quan tr\u1ecdng trong th\u1eddi k\u1ef3 \u0111\u1ea7u mang thai \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 d\u1ecb t\u1eadt b\u1ea9m sinh v\u1ec1 n\u00e3o v\u00e0 c\u1ed9t s\u1ed1ng. L\u01b0\u1ee3ng folate m\u1ed7i ng\u00e0y \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o cho ng\u01b0\u1eddi l\u1edbn l\u00e0 400 microgam (mcg). Ph\u1ee5 n\u1eef c\u00f3 k\u1ebf ho\u1ea1ch mang thai ho\u1eb7c \u0111ang mang thai n\u00ean b\u1ed5 sung 400 \u0111\u1ebfn 1.000 mcg axit folic m\u1ed7i ng\u00e0y.<\/p>\n<p style=\"text-align: justify;\">Folate \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong c\u00e1c lo\u1ea1i rau xanh l\u00e1 \u0111\u1eadm, \u0111\u1eadu H\u00e0 Lan v\u00e0 c\u00e1c lo\u1ea1i h\u1ea1t. Tr\u00e1i c\u00e2y gi\u00e0u folate bao g\u1ed3m cam, chanh, chu\u1ed1i, d\u01b0a v\u00e0 d\u00e2u t\u00e2y. D\u1ea1ng t\u1ed5ng h\u1ee3p c\u1ee7a folate l\u00e0 axit folic. N\u00f3 l\u00e0 m\u1ed9t th\u00e0nh ph\u1ea7n vitamin thi\u1ebft y\u1ebfu tr\u01b0\u1edbc khi sinh v\u00e0 c\u00f3 trong nhi\u1ec1u lo\u1ea1i th\u1ef1c ph\u1ea9m t\u0103ng c\u01b0\u1eddng nh\u01b0 ng\u0169 c\u1ed1c v\u00e0 m\u00ec \u1ed1ng.<\/p>\n<p style=\"text-align: justify;\">Ch\u1ebf \u0111\u1ed9 \u0103n ki\u00eang thi\u1ebfu th\u1ef1c ph\u1ea9m gi\u00e0u folate ho\u1eb7c axit folic c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn thi\u1ebfu folate. Thi\u1ebfu folate c\u0169ng c\u00f3 th\u1ec3 x\u1ea3y ra \u1edf nh\u1eefng ng\u01b0\u1eddi m\u1eafc c\u00e1c b\u1ec7nh, ch\u1eb3ng h\u1ea1n nh\u01b0 b\u1ec7nh celiac. B\u1ec7nh n\u00e0y ng\u0103n c\u1ea3n ru\u1ed9t non h\u1ea5p th\u1ee5 ch\u1ea5t dinh d\u01b0\u1ee1ng t\u1eeb th\u1ee9c \u0103n (h\u1ed9i ch\u1ee9ng k\u00e9m h\u1ea5p thu).<\/p>\n<h2 style=\"text-align: justify;\"><strong>S\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa Folate v\u00e0 Axit Folic l\u00e0 g\u00ec?<\/strong><\/h2>\n<p style=\"text-align: justify;\">M\u1ecdi ng\u01b0\u1eddi th\u01b0\u1eddng s\u1eed d\u1ee5ng c\u1ea3 2 lo\u1ea1i thay th\u1ebf cho nhau v\u00ec ch\u00fang \u0111\u1ec1u l\u00e0 c\u00e1c d\u1ea1ng vitamin B9. Nh\u01b0ng tr\u00ean th\u1ef1c t\u1ebf c\u00f3 m\u1ed9t s\u1ef1 kh\u00e1c bi\u1ec7t quan tr\u1ecdng. Axit folic l\u00e0 d\u1ea1ng t\u1ed5ng h\u1ee3p \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong th\u1ef1c ph\u1ea9m \u0111\u00e3 ch\u1ebf bi\u1ebfn v\u00e0 th\u1ef1c ph\u1ea9m b\u1ed5 sung. Folate \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong th\u1ef1c ph\u1ea9m t\u1ef1 nhi\u00ean nh\u01b0 rau xanh, tr\u1ee9ng v\u00e0 tr\u00e1i c\u00e2y h\u1ecd cam qu\u00fdt. Nghi\u00ean c\u1ee9u v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng folate v\u00e0 b\u1ed5 sung axit folic cho c\u00e1c tr\u01b0\u1eddng h\u1ee3p c\u1ee5 th\u1ec3 cho th\u1ea5y:<\/p>\n<ul>\n<li style=\"text-align: justify;\"><strong>D\u1ecb t\u1eadt b\u1ea9m sinh.<\/strong> B\u1ed5 sung axit folic c\u00f3 th\u1ec3 ng\u0103n ng\u1eeba d\u1ecb t\u1eadt b\u1ea9m sinh c\u1ee7a \u1ed1ng th\u1ea7n kinh. U\u1ed1ng vitamin h\u00e0ng ng\u00e0y tr\u01b0\u1edbc khi sinh &#8211; th\u1eddi \u0111i\u1ec3m l\u00fd t\u01b0\u1edfng l\u00e0 t\u1eeb ba th\u00e1ng tr\u01b0\u1edbc khi th\u1ee5 thai &#8211; c\u00f3 th\u1ec3 gi\u00fap \u0111\u1ea3m b\u1ea3o ph\u1ee5 n\u1eef nh\u1eadn \u0111\u1ee7 ch\u1ea5t dinh d\u01b0\u1ee1ng n\u00e0y.<\/li>\n<li style=\"text-align: justify;\"><strong>Thi\u1ebfu axit folic.<\/strong> S\u1ef1 thi\u1ebfu folate trong dinh d\u01b0\u1ee1ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1ch u\u1ed1ng b\u1ed5 sung axit folic. Lo\u1ea1i thi\u1ebfu h\u1ee5t n\u00e0y kh\u00f4ng c\u00f2n l\u00e0 v\u1ea5n \u0111\u1ec1 \u1edf nhi\u1ec1u qu\u1ed1c gia, n\u01a1i t\u0103ng c\u01b0\u1eddng axit folic trong th\u1ef1c ph\u1ea9m nh\u01b0 ng\u0169 c\u1ed1c v\u00e0 m\u00ec \u1ed1ng.<\/li>\n<li style=\"text-align: justify;\"><strong>C\u00e1c b\u1ec7nh l\u00fd tim v\u00e0 m\u1ea1ch m\u00e1u v\u00e0 \u0111\u1ed9t qu\u1ef5.<\/strong> Axit folic ho\u1ea1t \u0111\u1ed9ng c\u00f9ng v\u1edbi vitamin B6 v\u00e0 B12 \u0111\u1ec3 ki\u1ec3m so\u00e1t n\u1ed3ng \u0111\u1ed9 cao c\u1ee7a homocysteine trong m\u00e1u. N\u1ed3ng \u0111\u1ed9 homocysteine t\u0103ng cao c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 m\u1eafc c\u00e1c b\u1ec7nh v\u1ec1 tim m\u1ea1ch.<\/li>\n<li style=\"text-align: justify;\"><strong>Ung th\u01b0.<\/strong> M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u cho th\u1ea5y folate c\u00f3 th\u1ec3 l\u00e0m gi\u1ea3m nguy c\u01a1 m\u1eafc b\u1ec7nh ung th\u01b0.<\/li>\n<li style=\"text-align: justify;\"><strong>Tr\u1ea7m c\u1ea3m.<\/strong> M\u1ed9t s\u1ed1 b\u1eb1ng ch\u1ee9ng cho th\u1ea5y axit folic c\u00f3 th\u1ec3 h\u1eefu \u00edch trong \u0111i\u1ec1u tr\u1ecb tr\u1ea7m c\u1ea3m.<\/li>\n<li style=\"text-align: justify;\"><strong>Sa s\u00fat tr\u00ed tu\u1ec7.<\/strong> Kh\u00f4ng c\u00f3 \u0111\u1ee7 b\u1eb1ng ch\u1ee9ng \u1ee7ng h\u1ed9 vi\u1ec7c b\u1ed5 sung axit folic \u0111\u1ec3 ng\u0103n ng\u1eeba sa s\u00fat tr\u00ed tu\u1ec7.<\/li>\n<\/ul>\n<h2 style=\"text-align: justify;\"><strong>L\u00e0m th\u1ebf n\u00e0o m\u00e0 c\u00e1c y\u1ebfu t\u1ed1 di truy\u1ec1n c\u00f3 th\u1ec3 quy\u1ebft \u0111\u1ecbnh \u0111\u1ebfn qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a vitamin B9?<\/strong><\/h2>\n<p style=\"text-align: justify;\">Ti\u1ebfn s\u0129 Chris D. Meletis gi\u1ea3i th\u00edch r\u1eb1ng \u01b0\u1edbc t\u00ednh 25 &#8211; 60% d\u00e2n s\u1ed1 c\u00f3 \u0111\u1ed9t bi\u1ebfn \u1edf m\u1ed9t trong c\u00e1c gen MTHFR. \u0110i\u1ec1u n\u00e0y t\u00e1c \u0111\u1ed9ng b\u1ea5t l\u1ee3i \u0111\u1ebfn kh\u1ea3 n\u0103ng chuy\u1ec3n h\u00f3a axit folic (d\u1ea1ng t\u1ed5ng h\u1ee3p c\u1ee7a B9) v\u00e0 m\u1ed9t s\u1ed1 folate t\u1ef1 nhi\u00ean trong th\u1ef1c ph\u1ea9m th\u00e0nh d\u1ea1ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a folate. N\u1ebfu b\u1ea1n \u0111ang c\u1ed1 g\u1eafng mang thai, h\u00e3y c\u00e2n nh\u1eafc th\u1ef1c hi\u1ec7n x\u00e9t nghi\u1ec7m gen \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh xem b\u1ea1n c\u00f3 \u0111\u1ed9t bi\u1ebfn gene MTHFR hay kh\u00f4ng. K\u1ebft qu\u1ea3 s\u1ebd gi\u00fap b\u1ea1n \u0111\u01b0a ra l\u1ef1a ch\u1ecdn s\u00e1ng su\u1ed1t v\u1ec1 nhu c\u1ea7u dinh d\u01b0\u1ee1ng c\u1ee7a ri\u00eang b\u1ea1n, bao g\u1ed3m c\u1ea3 vi\u1ec7c b\u1ea1n c\u00f3 n\u00ean ch\u1ecdn c\u00e1c ch\u1ea5t b\u1ed5 sung tr\u01b0\u1edbc sinh v\u00e0 mang thai \u1edf d\u1ea1ng ho\u1ea1t \u0111\u1ed9ng, d\u1ea1ng methylfolate c\u1ee7a axit folic hay kh\u00f4ng.<\/p>\n<h2 style=\"text-align: justify;\"><strong>MTHFR chuy\u1ec3n \u0111\u1ed5i vitamin B9 t\u1eeb d\u1ea1ng t\u1ed5ng h\u1ee3p th\u00e0nh d\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc<\/strong><\/h2>\n<p style=\"text-align: justify;\">Vitamin B9 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf d\u1ea1ng t\u1ed5ng h\u1ee3p (axit folic) xu\u1ea5t hi\u1ec7n trong nhi\u1ec1u th\u1ef1c ph\u1ea9m b\u1ed5 sung vitamin v\u00e0 th\u1ef1c ph\u1ea9m t\u0103ng c\u01b0\u1eddng ho\u1eb7c d\u1ea1ng t\u1ef1 nhi\u00ean c\u00f3 trong th\u1ee9c \u0103n (folate). C\u1ea3 folate t\u1ed5ng h\u1ee3p v\u00e0 h\u1ea7u h\u1ebft folate c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb th\u1ee9c \u0103n m\u00e0 ch\u00fang ta ti\u00eau th\u1ee5 ph\u1ea3i \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a th\u00f4ng qua con \u0111\u01b0\u1eddng enzyme t\u1ef1 nhi\u00ean trong c\u01a1 th\u1ec3, th\u00e0nh d\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh sinh h\u1ecdc cu\u1ed1i c\u00f9ng \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 L-methylfolate (c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 5-MTHF). Khi MTHF \u0111\u01b0\u1ee3c t\u1ea1o ra, d\u1ea1ng B9 ho\u1ea1t \u0111\u1ed9ng n\u00e0y c\u00f3 th\u1ec3 x\u00e2m nh\u1eadp v\u00e0o c\u00e1c t\u1ebf b\u00e0o v\u00e0 v\u01b0\u1ee3t qua h\u00e0ng r\u00e0o m\u00e1u n\u00e3o \u0111\u1ec3 gi\u00fap nu\u00f4i d\u01b0\u1ee1ng c\u00e1c m\u00f4 v\u00e0 n\u00e3o c\u1ee7a ch\u00fang ta. Vi\u1ec7c chuy\u1ec3n h\u00f3a th\u00e0nh c\u00f4ng t\u1eeb axit folic ho\u1eb7c folate th\u00e0nh MTHF ph\u1ee5 thu\u1ed9c v\u00e0o m\u1ed9t lo\u1ea1i enzym chuy\u1ec3n \u0111\u1ed5i \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 MTHFR.<\/p>\n<h2 style=\"text-align: justify;\"><strong>MTHFR l\u00e0 nguy\u00ean nh\u00e2n l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 homocysteine li\u00ean quan \u0111\u1ebfn s\u1ea9y thai li\u00ean ti\u1ebfp<\/strong><\/h2>\n<p style=\"text-align: justify;\">Homocysteine l\u00e0 m\u1ed9t axit amin t\u1ef1 nhi\u00ean \u0111\u01b0\u1ee3c t\u1ea1o ra khi protein b\u1ecb ph\u00e2n (gi\u1ea3i) h\u1ee7y trong c\u01a1 th\u1ec3. N\u00f3 kh\u00f4ng c\u00f3 h\u1ea1i \u1edf n\u1ed3ng \u0111\u1ed9 th\u1ea5p, nh\u01b0ng khi \u1edf n\u1ed3ng \u0111\u1ed9 cao, n\u00f3 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u00ecnh tr\u1ea1ng t\u0103ng \u0111\u00f4ng m\u00e1u. Khi \u0111\u00f3 m\u00e1u c\u1ee7a b\u1ea1n c\u00f3 xu h\u01b0\u1edbng d\u1ec5 \u0111\u00f4ng l\u1ea1i h\u01a1n b\u00ecnh th\u01b0\u1eddng. Ph\u1ee5 n\u1eef c\u00f3 n\u1ed3ng \u0111\u1ed9 homocysteine cao c\u00f3 th\u1ec3 t\u0103ng nguy c\u01a1 s\u1ea9y thai, ti\u1ec1n s\u1ea3n gi\u1eadt v\u00e0 th\u1eadm ch\u00ed sinh non &#8211; r\u1ea5t c\u00f3 th\u1ec3 l\u00e0 do s\u1ef1 gia t\u0103ng \u0111\u00f4ng m\u00e1u g\u00e2y ra b\u1edfi n\u1ed3ng \u0111\u1ed9 homocysteine t\u0103ng cao.<\/p>\n<p style=\"text-align: justify;\">T\u1ea1i sao n\u1ed3ng \u0111\u1ed9 homocysteine t\u0103ng cao? Methylfolate, d\u1ea1ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a axit folic, \u0111\u00f3ng vai tr\u00f2 chuy\u1ec3n \u0111\u1ed5i homocysteine th\u00e0nh methionine (m\u1ed9t axit amin v\u00f4 h\u1ea1i). V\u00ec v\u1eady n\u1ebfu thi\u1ebfu methylfolate do \u0111\u1ed9t bi\u1ebfn MTHFR, homocysteine c\u00f3 th\u1ec3 t\u00edch t\u1ee5 \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 nguy hi\u1ec3m.<\/p>\n<p style=\"text-align: justify;\">C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 ph\u00e1t hi\u1ec7n ra m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa n\u1ed3ng \u0111\u1ed9 homocysteine cao v\u00e0 s\u1ea9y thai li\u00ean ti\u1ebfp. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y \u0111\u1ed9t bi\u1ebfn di truy\u1ec1n MTHFR c\u00f3 th\u1ec3 \u0111\u00f3ng m\u1ed9t vai tr\u00f2 trong vi\u1ec7c s\u1ea9y thai.<\/p>\n<h2 style=\"text-align: justify;\"><strong>M\u1ed1i li\u00ean h\u1ec7 gi\u1eefa MTHFR v\u00e0 PCOS<\/strong><\/h2>\n<p style=\"text-align: justify;\">T\u00ecnh tr\u1ea1ng ph\u1ed5 bi\u1ebfn nh\u1ea5t g\u00e2y v\u00f4 sinh \u1edf ph\u1ee5 n\u1eef l\u00e0 h\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang (PCOS). Ph\u1ee5 n\u1eef m\u1eafc h\u1ed9i ch\u1ee9ng bu\u1ed3ng tr\u1ee9ng \u0111a nang d\u1ec5 m\u1ea5t c\u00e2n b\u1eb1ng n\u1ed9i ti\u1ebft v\u00e0 chuy\u1ec3n h\u00f3a, bao g\u1ed3m r\u1ed1i lo\u1ea1n \u0111i\u1ec1u h\u00f2a \u0111\u01b0\u1eddng m\u00e1u, c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \u0111\u1ec1 kh\u00e1ng insulin. C\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 chuy\u1ec3n h\u00f3a c\u00f3 th\u1ec3 g\u00e2y ra hi\u1ec7n t\u01b0\u1ee3ng kh\u00f4ng r\u1ee5ng tr\u1ee9ng m\u1ea1n t\u00ednh (bu\u1ed3ng tr\u1ee9ng kh\u00f4ng ph\u00f3ng th\u00edch no\u00e3n trong chu k\u1ef3 kinh nguy\u1ec7t), kinh nguy\u1ec7t kh\u00f4ng \u0111\u1ec1u, c\u01b0\u1eddng androgen v\u00e0 \u0111\u1ec1 kh\u00e1ng insulin. V\u1edbi h\u00e0ng lo\u1ea1t tri\u1ec7u ch\u1ee9ng li\u00ean quan \u0111\u1ebfn kh\u1ea3 n\u0103ng sinh s\u1ea3n, kh\u00f4ng c\u00f3 g\u00ec \u0111\u00e1ng ng\u1ea1c nhi\u00ean khi PCOS l\u00e0 nguy\u00ean nh\u00e2n h\u00e0ng \u0111\u1ea7u g\u00e2y v\u00f4 sinh.<\/p>\n<p style=\"text-align: justify;\">Nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111ang \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 t\u00ecm hi\u1ec3u c\u00e1c nguy\u00ean nh\u00e2n c\u01a1 b\u1ea3n c\u1ee7a PCOS. M\u1ed9t nghi\u00ean c\u1ee9u n\u0103m 2014 \u0111\u00e3 t\u00ecm th\u1ea5y m\u1ed1i li\u00ean quan gi\u1eefa PCOS v\u00e0 \u0111\u1ed9t bi\u1ebfn gene MTHFR. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u k\u1ebft lu\u1eadn r\u1eb1ng m\u1ed9t \u0111\u1ed9t bi\u1ebfn MTHFR \u0111\u1eb7c th\u00f9 l\u00e0m t\u0103ng kh\u1ea3 n\u0103ng m\u1eafc PCOS. M\u1ed1i li\u00ean h\u1ec7 chung gi\u1eefa MTHFR v\u00e0 PCOS l\u1ea1i m\u1ed9t l\u1ea7n n\u1eefa li\u00ean quan \u0111\u1ebfn n\u1ed3ng \u0111\u1ed9 homocysteine. N\u00f3i chung, nguy\u00ean nh\u00e2n ph\u1ed5 bi\u1ebfn nh\u1ea5t l\u00e0m t\u0103ng n\u1ed3ng \u0111\u1ed9 homocysteine (hyperhomocysteinemia) l\u00e0 gi\u1ea3m ho\u1ea1t \u0111\u1ed9ng c\u1ee7a MTHFR d\u1eabn \u0111\u1ebfn gi\u1ea3m s\u1ea3n xu\u1ea5t methylfolate. Nh\u1eefng ph\u1ee5 n\u1eef m\u1eafc PCOS th\u01b0\u1eddng c\u00f3 n\u1ed3ng \u0111\u1ed9 homocysteine cao h\u01a1n nh\u1eefng ph\u1ee5 n\u1eef kh\u1ecfe m\u1ea1nh kh\u00e1c. Nhi\u1ec1u nghi\u00ean c\u1ee9u \u0111ang \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh quan h\u1ec7 ch\u00ednh x\u00e1c gi\u1eefa MTHFR v\u00e0 PCOS.<\/p>\n<h2 style=\"text-align: justify;\"><strong>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/strong><\/h2>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/americanpregnancy.org\/getting-pregnant\/infertility\/folate-vs-folic-acid\/?fbclid=IwAR1STKLPD3j0hkuFzpZeXDIw7uSr9iLqVLy7Ck29m4Gtyv2Z-flYWS9tA0Y\" target=\"_blank\" rel=\"noopener\">Folate and Folic Acid in Pregnancy &#8211; American Pregnancy Association<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Folate v\u00e0 axit folic r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 ph\u00e1t tri\u1ec3n m\u1ed9t thai nhi kh\u1ecfe m\u1ea1nh, \u0111\u1ed3ng th\u1eddi gi\u1ea3m nguy c\u01a1 thi\u1ebfu m\u00e1u, s\u1ea9y thai, sinh non.<\/p>\n","protected":false},"author":519,"featured_media":5075,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5180],"tags":[5320,5321,4226],"series":[1994],"coauthors":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Folate v\u00e0 Axit Folic trong thai k\u1ef3 - D\u1ef1 \u00e1n S\u1ea3n Ph\u1ee5 Khoa<\/title>\n<meta name=\"description\" content=\"Folate v\u00e0 Axit Folic trong thai k\u1ef3 - D\u1ef1 \u00e1n S\u1ea3n Ph\u1ee5 Khoa\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/yhoccongdong.com\/san-phu-khoa\/folate-va-axit-folic-trong-thai-ky\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Folate v\u00e0 Axit Folic trong thai k\u1ef3 - D\u1ef1 \u00e1n S\u1ea3n Ph\u1ee5 Khoa\" \/>\n<meta property=\"og:description\" content=\"Folate v\u00e0 Axit Folic trong thai k\u1ef3 - D\u1ef1 \u00e1n S\u1ea3n Ph\u1ee5 Khoa\" \/>\n<meta property=\"og:url\" content=\"https:\/\/yhoccongdong.com\/san-phu-khoa\/folate-va-axit-folic-trong-thai-ky\/\" \/>\n<meta property=\"og:site_name\" content=\"D\u1ef1 \u00e1n S\u1ea3n Ph\u1ee5 Khoa\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/le.thang.DHY\" \/>\n<meta property=\"article:published_time\" content=\"2021-09-05T05:36:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-28T16:44:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/yhoccongdong.com\/san-phu-khoa\/wp-content\/uploads\/sites\/4\/2021\/09\/folate-va-axit-folic-trong-thai-ky.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"660\" \/>\n\t<meta property=\"og:image:height\" content=\"330\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"ThS. 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