{"id":12046,"date":"2018-03-29T23:52:24","date_gmt":"2018-03-29T16:52:24","guid":{"rendered":"https:\/\/yhoccongdong.org\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/"},"modified":"2018-03-29T23:52:24","modified_gmt":"2018-03-29T16:52:24","slug":"ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/","title":{"rendered":"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi"},"content":{"rendered":"

Trong nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, nhi\u1ec1u b\u1ec7nh vi\u1ec7n v\u00e0 k\u00eanh truy\u1ec1n th\u00f4ng tr\u00ean th\u1ebf gi\u1edbi, trong \u0111\u00f3 c\u00f3 c\u1ea3 Vi\u1ec7t Nam hay nh\u1eafc t\u1edbi t\u1eeb \u201cc\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb\u201d hay \u201cPersonalized Medicine\u201d nh\u01b0 l\u00e0 m\u1ed9t b\u01b0\u1edbc ti\u1ebfn trong y h\u1ecdc. <\/span><\/p>\n

Th\u1eadt ra, vi\u1ec7c ti\u1ebfp c\u1eadn ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0 \u0111\u00e3 c\u00f3 xu h\u01b0\u1edbng c\u00e1 nh\u00e2n h\u00f3a t\u1eeb r\u1ea5t l\u00e2u, kh\u1edfi ngu\u1ed3n t\u1eeb n\u0103m 1847, khi b\u00e1c s\u0129 Rudolf Virchow s\u1eed d\u1ee5ng k\u00ednh hi\u1ec3n vi \u0111\u1ec3 m\u00f4 t\u1ea3 c\u00e1c t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u sinh s\u00f4i b\u1ea5t th\u01b0\u1eddng trong c\u01a1 th\u1ec3 b\u1ec7nh nh\u00e2n ung th\u01b0 m\u00e1u. Ph\u00e1t hi\u1ec7n n\u00e0y \u0111\u00e3 \u0111\u00e1nh d\u1ea5u s\u1ef1 h\u00ecnh th\u00e0nh ng\u00e0nh <\/span>Gi\u1ea3i ph\u1eabu b\u1ec7nh vi th\u1ec3<\/b> (Microscopic Pathology) nh\u1eefng n\u0103m 1870s. Nh\u1eefng n\u0103m 1890s \u0111\u00e1nh d\u1ea5u th\u1eddi \u0111i\u1ec3m m\u00e0 Ti\u1ebfn s\u0129 Roentgen s\u1eed d\u1ee5ng <\/span>tia X trong ch\u1ea9n \u0111o\u00e1n ung b\u01b0\u1edbu<\/b> v\u00e0 1910s l\u00e0 th\u1eddi gian m\u00e0 B\u00e1c s\u0129 William Osler gi\u1ea3ng gi\u1ea3i cho c\u00e1c \u0111\u1ed3 \u0111\u1ec7 trong y gi\u1edbi v\u1ec1 <\/span>Ch\u1ea9n \u0111o\u00e1n ph\u00e2n bi\u1ec7t<\/b> khi ti\u1ebfp c\u1eadn tri\u1ec7u ch\u1ee9ng. \u0110\u1ebfn nh\u1eefng n\u0103m 1950s, Bloom v\u00e0 Richardson \u0111\u1ec1 x\u01b0\u1edbng c\u00e1c <\/span>\u0111\u00e1nh gi\u00e1 m\u1ee9c \u0111\u1ed9 ung th\u01b0<\/b> (Tumor grade), k\u1ebf t\u1ee5c con \u0111\u01b0\u1eddng d\u00f9 c\u00f2n hoang s\u01a1 nh\u01b0ng r\u1ea5t quan tr\u1ecdng \u0111\u1ec3 ph\u00e2n lo\u1ea1i v\u00e0 m\u00f4 t\u1ea3 s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh t\u1eadt nh\u1eb1m ngh\u0129 ti\u1ebfp ph\u01b0\u01a1ng c\u00e1ch \u0111i\u1ec1u tr\u1ecb h\u1ee3p l\u00fd.<\/span><\/p>\n

Sau \u0111\u00f3, h\u01a1n 200 m\u1eb7t b\u1ec7nh ung th\u01b0 kh\u00e1c nhau \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u chuy\u00ean bi\u1ec7t h\u01a1n v\u00e0 nhi\u1ec1u d\u1ea1ng ung th\u01b0 \u0111\u00e3 c\u00f3 th\u00eam nhi\u1ec1u ti\u1ebfn b\u1ed9 v\u01b0\u1ee3t b\u1eadc trong \u0111i\u1ec1u tr\u1ecb. C\u1ee5 th\u1ec3 nh\u01b0 Ung th\u01b0 v\u00fa, c\u1ea3m th\u1ee5 th\u1ec3 Estrogen (Estrogen Receptor) v\u00e0 HER2 \u0111\u00e3 \u0111\u01b0\u1ee3c McGuire v\u00e0 Slamon l\u1ea7n l\u01b0\u1ee3t ph\u00e1t hi\u1ec7n n\u0103m 1970s v\u00e0 1980s, r\u1ed3i sau \u0111\u00f3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 li\u00ean quan t\u1edbi ti\u00ean l\u01b0\u1ee3ng b\u1ec7nh. Nh\u1eefng ph\u00e1t ki\u1ebfn n\u00e0y, c\u00f9ng v\u1edbi s\u1ef1 ra \u0111\u1eddi c\u00e1c li\u1ec7u ph\u00e1p hormone v\u00e0 thu\u1ed1c nh\u1eafm \u0111\u00edch t\u01b0\u01a1ng \u1ee9ng \u0111\u00e3 thay \u0111\u1ed5i g\u1ea7n nh\u01b0 ho\u00e0n to\u00e0n chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb tr\u01b0\u1edbc \u0111\u00f3, ch\u1ea5m d\u1ee9t th\u1eddi \u0111\u1ea1i m\u00e0 h\u1ea7u h\u1ebft b\u1ec7nh nh\u00e2n ung th\u01b0 v\u00fa ch\u1ec9 c\u00f3 v\u00e0i ph\u00e1c \u0111\u1ed3 h\u00f3a tr\u1ecb \u0111\u1ec3 l\u1ef1a ch\u1ecdn s\u1eed d\u1ee5ng. <\/span><\/p>\n

Ch\u01b0a d\u1eebng l\u1ea1i \u1edf \u0111\u00f3, n\u0103m 2010s c\u00e1c b\u00e1c s\u0129 l\u00e2m s\u00e0ng l\u1ea1i th\u00eam m\u1ed9t l\u1ea7n \u201cchao \u0111\u1ea3o\u201d v\u00ec c\u00e1c nghi\u00ean c\u1ee9u li\u00ean quan t\u1edbi gene BRCA v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a thu\u1ed1c \u1ee9c ch\u1ebf PARP \u0111\u01b0\u1ee3c ch\u1ee9ng minh b\u1edfi Ashworth v\u00e0 nhi\u1ec1u c\u1ed9ng s\u1ef1. \u201cChao \u0111\u1ea3o\u201d l\u00e0 v\u00ec c\u00e1c ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 v\u00fa gi\u1edd \u0111\u00e2y \u0111\u00e3 tr\u1edf n\u00ean r\u1ea5t \u0111a d\u1ea1ng, nh\u01b0ng \u0111\u00f4i khi l\u1ea1i kh\u00f4ng c\u00f3 \u0111\u00e1p \u00e1n r\u00f5 r\u00e0ng v\u00ec \u1edf m\u1ed9t s\u1ed1 t\u00ecnh hu\u1ed1ng ph\u00e1c \u0111\u1ed3 A t\u1ed1t h\u01a1n C, ph\u00e1c \u0111\u1ed3 B c\u0169ng t\u1ed1t h\u01a1n C nh\u01b0ng ch\u01b0a bi\u1ebft A v\u00e0 B, c\u00e1i n\u00e0o t\u1ed1t h\u01a1n?! <\/span><\/p>\n

V\u00ec t\u00ednh ph\u1ee9c t\u1ea1p v\u00e0 \u0111a d\u1ea1ng \u0111\u00f3, c\u00e1c b\u00e1c s\u0129 ph\u1ea3i tr\u0103n tr\u1edf nhi\u1ec1u h\u01a1n, c\u0103n c\u1ee9 v\u00e0o nhi\u1ec1u ti\u00eau ch\u00ed li\u00ean quan t\u1edbi \u0111\u1eb7c \u0111i\u1ec3m sinh h\u1ecdc c\u1ee7a kh\u1ed1i u, \u0111\u1eb7c t\u00ednh v\u00e0 nguy\u1ec7n v\u1ecdng c\u1ee7a b\u1ec7nh nh\u00e2n, danh s\u00e1ch t\u00e1c d\u1ee5ng ngo\u1ea1i \u00fd c\u1ee7a thu\u1ed1c,..\u0111\u1ec3 t\u01b0 v\u1ea5n h\u01b0\u1edbng \u0111i\u1ec1u tr\u1ecb h\u1ee3p l\u00fd nh\u1ea5t cho t\u1eebng ng\u01b0\u1eddi b\u1ec7nh. N\u00f3i c\u00e1ch kh\u00e1c, <\/span>kh\u00f4ng c\u00f3 \u0111i\u1ec1u tr\u1ecb n\u00e0o ph\u00f9 h\u1ee3p v\u1edbi t\u1ea5t c\u1ea3 m\u1ecdi ng\u01b0\u1eddi <\/span>m\u00e0 <\/span>\u0111i\u1ec1u tr\u1ecb s\u1ebd \u0111\u01b0\u1ee3c \u201cc\u00e1 nh\u00e2n h\u00f3a\u201d nh\u1eb1m gi\u1ea3m thi\u1ec3u kh\u1ea3 n\u0103ng b\u1ecb t\u00e1c d\u1ee5ng kh\u00f4ng mong mu\u1ed1n v\u00e0 mang l\u1ea1i k\u1ebft qu\u1ea3 t\u1ed1t nh\u1ea5t tr\u00ean t\u1eebng ng\u01b0\u1eddi b\u1ec7nh<\/b>.<\/span><\/p>\n

\u1ede m\u1ed9t s\u1ed1 t\u00e0i li\u1ec7u, \u201cc\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb\u201d th\u01b0\u1eddng \u0111\u01b0\u1ee3c hi\u1ec3u t\u01b0\u01a1ng \u0111\u01b0\u01a1ng l\u00e0 \u201c\u0111i\u1ec1u tr\u1ecb ch\u00ednh x\u00e1c\u201d hay \u201cPrecision Medicine\u201d, v\u00ec c\u00e1ch ti\u1ebfp c\u1eadn theo t\u1eebng c\u00e1 nh\u00e2n \u0111\u01b0\u1ee3c cho l\u00e0 s\u1ebd ph\u00f9 h\u1ee3p hay ch\u00ednh x\u00e1c h\u01a1n c\u00e1ch truy\u1ec1n th\u1ed1ng l\u00e0 t\u1ea5t c\u1ea3 \u0111\u1ec1u d\u00f9ng m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p. Tuy nhi\u00ean, y h\u1ecdc c\u00f2n c\u00f3 th\u1ec3 \u201cc\u00e1 nh\u00e2n h\u00f3a\u201d hay \u201cch\u00ednh x\u00e1c\u201d h\u01a1n n\u1eefa kh\u00f4ng?<\/span><\/p>\n

C\u00e2u tr\u1ea3 l\u1eddi l\u00e0 C\u00f3<\/b>, v\u00e0 xu h\u01b0\u1edbng n\u00e0y \u0111ang ng\u00e0y c\u00e0ng m\u1ea1nh m\u1ebd v\u1edbi c\u00e1c ti\u1ebfp c\u1eadn Omics, t\u1ee9c ph\u00e2n t\u00edch t\u1ed5ng th\u1ec3, c\u00f3 h\u1ec7 th\u1ed1ng c\u00e1c thay \u0111\u1ed5i li\u00ean quan t\u1edbi DNA, RNA, Protein v\u00e0 c\u00e1c h\u1ec7 sinh h\u1ecdc kh\u00e1c. Ph\u1ed5 bi\u1ebfn nh\u1ea5t hi\u1ec7n nay l\u00e0 c\u00e1c x\u00e9t nghi\u1ec7m li\u00ean quan t\u1edbi DNA (c\u00f2n g\u1ecdi l\u00e0 gi\u1ea3i tr\u00ecnh t\u1ef1 gene, genomic sequencing), \u0111\u01b0\u1ee3c tr\u00edch ly t\u1eeb kh\u1ed1i u qua sinh thi\u1ebft\/ph\u1eabu thu\u1eadt, ho\u1eb7c g\u1ea7n \u0111\u00e2y h\u01a1n l\u00e0 t\u1eeb x\u00e9t nghi\u1ec7m m\u00e1u (Liquid Biopsy).<\/span><\/p>\n

Th\u00e1ng 5 n\u0103m 2017, FDA Hoa K\u1ef3 \u0111\u00e3 cho ph\u00e9p s\u1eed d\u1ee5ng m\u1ed9t s\u1ed1 \u0111i\u1ec1u tr\u1ecb nh\u1eafm \u0111\u00edch (targeted therapy) d\u1ef1a v\u00e0o biomarker (ch\u1ec9 d\u1ea5u sinh h\u1ecdc) hay m\u1ed9t s\u1ed1 \u0111\u1eb7c \u0111i\u1ec3m gene c\u1ee5 th\u1ec3 (specific genetic feature) t\u00ecm th\u1ea5y \u1edf b\u1ec7nh nh\u00e2n. Nh\u1eefng ch\u1ec9 d\u1ea5u sinh h\u1ecdc n\u00e0y nhi\u1ec1u khi \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 actionable mutation, c\u00f3 ngh\u0129a l\u00e0 m\u1ed9t \u0111\u1ed9t bi\u1ebfn gene quan tr\u1ecdng trong qu\u00e1 tr\u00ecnh h\u00ecnh th\u00e0nh, ph\u00e1t tri\u1ec3n kh\u1ed1i u c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c nh\u1eafm \u0111\u00edch\/\u1ee9c ch\u1ebf b\u1eb1ng thu\u1ed1c. Ngo\u00e0i ra, nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f3 biomarker c\u1ee5 th\u1ec3 c\u00f3 th\u1ec3 tham gia v\u00e0o c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, \u0111ang \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh theo d\u1ea1ng umbrella trial ho\u1eb7c basket trial (xem th\u00eam ph\u1ea7n ch\u00fa th\u00edch) \u0111\u1ec3 ki\u1ec3m \u0111\u1ecbnh hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1ch ti\u1ebfp c\u1eadn m\u1edbi. V\u00ec c\u00e0ng \u201cc\u00e1 nh\u00e2n h\u00f3a\u201d th\u00ec c\u00e0ng kh\u00f3 t\u00ecm th\u1ea5y ng\u01b0\u1eddi c\u00f3 \u0111\u1eb7c \u0111i\u1ec3m sinh h\u1ecdc chung (m\u1ed9t s\u1ed1 biomarker c\u00f3 t\u1ea7n su\u1ea5t nh\u1ecf h\u01a1n 1-5% d\u00e2n s\u1ed1), m\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u \u0111ang \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n li\u00ean qu\u1ed1c gia \u0111\u1ec3 r\u00fat ng\u1eafn qu\u00e1 tr\u00ecnh thu th\u1eadp s\u1ed1 li\u1ec7u. Tuy nhi\u00ean, v\u1eabn \u0111ang c\u00f3 nhi\u1ec1u r\u00e0o c\u1ea3n v\u1ec1 ph\u00e1p l\u00fd, t\u00e0i ch\u00ednh, tr\u00ecnh \u0111\u1ed9 v\u00e0 h\u1ec7 th\u1ed1ng y t\u1ebf-ch\u0103m s\u00f3c,\u2026gi\u1eefa c\u00e1c n\u01a1i n\u00ean s\u1ed1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng xuy\u00ean l\u1ee5c \u0111\u1ecba nh\u01b0 v\u1eady ch\u01b0a nhi\u1ec1u. D\u00f9 v\u1eady, nhi\u1ec1u b\u1ec7nh nh\u00e2n v\u1eabn k\u1ef3 v\u1ecdng v\u00e0o c\u00e1c th\u1eed nghi\u1ec7m n\u00e0y v\u00ec n\u00f3 gi\u00fap h\u1ecd ti\u1ebfp c\u1eadn v\u1edbi thu\u1ed1c m\u1edbi s\u1edbm h\u01a1n v\u00e0 gi\u1ea3m b\u1edbt g\u00e1nh n\u1eb7ng kinh t\u1ebf khi \u0111i\u1ec1u tr\u1ecb. <\/span><\/p>\n

Nh\u01b0ng n\u00f3i \u0111i c\u0169ng ph\u1ea3i n\u00f3i l\u1ea1i; c\u1ea7n l\u01b0u \u00fd r\u1eb1ng nh\u1eefng ti\u1ebfp c\u1eadn n\u00f3i tr\u00ean h\u1ea7u h\u1ebft v\u1eabn \u0111ang trong giai \u0111o\u1ea1n nghi\u00ean c\u1ee9u, v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee5 th\u1ec3 c\u1ee7a n\u00f3 tr\u00ean b\u1ec7nh nh\u00e2n, so v\u1edbi gi\u00e1 ti\u1ec1n ph\u1ea3i tr\u1ea3 cho thu\u1ed1c nh\u1eafm \u0111\u00edch c\u1ef1c m\u1eafc l\u00e0 nh\u1eefng ch\u1ee7 \u0111\u1ec1 c\u00f2n b\u00e0n c\u00e3i. <\/span><\/p>\n

H\u01a1n n\u1eefa, nhi\u1ec1u x\u00e9t nghi\u1ec7m gi\u1ea3i tr\u00ecnh t\u1ef1 gene \u0111ang \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u00e0 qu\u1ea3ng c\u00e1o theo d\u1ea1ng \u201ctr\u0103m hoa \u0111ua n\u1edf\u201d v\u1edbi nhi\u1ec1u d\u1ecbch v\u1ee5 ch\u01b0a qua ki\u1ec3m \u0111\u1ecbnh hay chu\u1ea9n h\u00f3a m\u1ed9t c\u00e1ch nghi\u00eam ng\u1eb7t. V\u00ec s\u1ef1 \u201clo\u1ea1n c\u00e0o c\u00e0o\u201d \u0111\u00f3 m\u00e0 g\u1ea7n \u0111\u00e2y Hi\u1ec7p h\u1ed9i ung th\u01b0 l\u00e2m s\u00e0ng Hoa K\u1ef3 (ASCO) \u0111\u00e3 \u0111\u01b0a ra khuy\u1ebfn c\u00e1o r\u1eb1ng kh\u00f4ng ph\u1ea3i t\u1ea5t c\u1ea3 x\u00e9t nghi\u1ec7m gene \u0111\u1ec1u nh\u01b0 nhau (x\u00e9t nghi\u1ec7m kh\u00e1c nhau th\u00ec k\u1ebft qu\u1ea3 c\u00f3 th\u1ec3 kh\u00e1c nhau!) v\u00e0 ch\u1ec9 n\u00ean d\u00f9ng nh\u1eefng test \u0111\u00e3 ki\u1ec3m \u0111\u1ecbnh theo Clinical Laboratory Improvement Amendments (CLIA) c\u1ee7a ch\u00ednh ph\u1ee7 M\u1ef9.<\/span><\/p>\n

\u0110\u00f3 l\u00e0 v\u00ec <\/span>m\u1ed9t Biomarker sai c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i ch\u1eb3ng kh\u00e1c g\u00ec m\u1ed9t lo\u1ea1i thu\u1ed1c d\u00f9ng sai<\/b>. <\/span><\/p>\n

C\u0169ng nh\u01b0 vi\u1ec7c kh\u00f4ng ai mu\u1ed1n u\u1ed1ng m\u1ed9t lo\u1ea1i thu\u1ed1c kh\u00f4ng r\u00f5 c\u00e1ch pha ch\u1ebf v\u00e0 n\u1ed3ng \u0111\u1ed9, c\u00f3 l\u1ebd s\u1ebd kh\u00f4ng ai mu\u1ed1n d\u1ef1a v\u00e0o m\u1ed9t x\u00e9t nghi\u1ec7m m\u00e0 kh\u00f4ng r\u00f5 n\u00f3 \u0111o ch\u1ea5t g\u00ec, c\u00f3 ch\u00ednh x\u00e1c v\u00e0 c\u00f3 t\u00ednh l\u1eb7p l\u1ea1i (<\/span>Analytical validity<\/b>) kh\u00f4ng, c\u00f3 th\u1eadt s\u1ef1 t\u00ecm ra kh\u00e1c bi\u1ec7t sinh h\u1ecdc c\u00f3 \u00fd ngh\u0129a l\u00e2m s\u00e0ng (<\/span>Biologic validity<\/b>) v\u00e0 c\u00f3 gi\u00fap d\u1eabn t\u1edbi quy\u1ebft \u0111\u1ecbnh \u0111i\u1ec1u tr\u1ecb thay \u0111\u1ed5i k\u1ebft c\u1ee5c c\u1ee7a b\u1ec7nh nh\u00e2n (<\/span>Clinical utility<\/b>) hay kh\u00f4ng. M\u1ed9t x\u00e9t nghi\u1ec7m kh\u00f4ng th\u1ecfa m\u00e3n \u0111\u1ee7 3 ti\u00eau ch\u00ed n\u00f3i tr\u00ean th\u00ec s\u1ebd ch\u1ec9 l\u00e0m b\u1ec7nh nh\u00e2n v\u00e0 b\u00e1c s\u0129 l\u00fang t\u00fang v\u00e0 \u201cchao \u0111\u1ea3o\u201d h\u01a1n m\u00e0 th\u00f4i!<\/span><\/p>\n

C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb ung th\u01b0, v\u00ec th\u1ebf \u0111ang l\u00e0 m\u1ed9t b\u1ee9c tranh m\u00e0u n\u01b0\u1edbc c\u00f2n ch\u01b0a kh\u00f4 r\u00e1o. \u1ede \u0111\u00f3 ch\u00fang ta c\u00f3 th\u1ec3 th\u1ea5y k\u1ef3 v\u1ecdng cao c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 c\u1ed9ng \u0111\u1ed3ng v\u00e0 th\u1ec9nh tho\u1ea3ng l\u00e0 v\u00e0i b\u00e0i b\u00e1o ca ng\u1ee3i th\u00e0nh c\u00f4ng khi \u0111i\u1ec1u tr\u1ecb nh\u1eafm \u0111\u00edch \u0111\u1ea9y l\u00f9i c\u0103n b\u1ec7nh. C\u0169ng \u1edf \u0111\u00f3 l\u00e0 l\u1eddi c\u1ea3nh b\u00e1o t\u1eeb c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u v\u00e0 c\u1ea3 c\u00e1c b\u00e1c s\u0129 v\u1edbi nhi\u1ec1u c\u00e2u h\u1ecfi ho\u00e0i nghi v\u1ec1 t\u00ednh th\u1ef1c d\u1ee5ng v\u00e0 kh\u1ea3 thi c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p m\u1edbi. <\/span><\/p>\n

Ngay c\u1ea3 \u1edf B\u1ec7nh vi\u1ec7n \u0110\u1ea1i h\u1ecdc Kyoto v\u00e0 nhi\u1ec1u Trung t\u00e2m ung th\u01b0 l\u1edbn kh\u00e1c tr\u00ean th\u1ebf gi\u1edbi, ng\u01b0\u1eddi ta ph\u1ea3i t\u1ed5 ch\u1ee9c h\u1ed9i ch\u1ea9n v\u1edbi 15-20 th\u00e0nh vi\u00ean, bao g\u1ed3m c\u00e1c b\u00e1c s\u0129 \u0111i\u1ec1u tr\u1ecb, b\u00e1c s\u0129 gi\u1ea3i ph\u1eabu b\u1ec7nh, chuy\u00ean gia di truy\u1ec1n y h\u1ecdc, v\u00e0 c\u00e1c chuy\u00ean gia th\u1ed1ng k\u00ea y sinh,\u2026\u0111\u1ec3 b\u00e0n lu\u1eadn v\u1ec1 \u00fd ngh\u0129a l\u00e2m s\u00e0ng c\u1ee7a c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m gene t\u00ecm th\u1ea5y tr\u00ean t\u1eebng ng\u01b0\u1eddi b\u1ec7nh. \u0110\u1ed1i v\u1edbi m\u1ed7i \u0111\u1eb7c \u0111i\u1ec3m \u0111\u00f3, c\u1ea3 nh\u00f3m s\u1ebd c\u00f9ng xem x\u00e9t ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 s\u1ed1 l\u01b0\u1ee3ng c\u00e1c b\u1eb1ng ch\u1ee9ng c\u1ee7a thu\u1ed1c nh\u1eafm \u0111\u00edch t\u01b0\u01a1ng \u1ee9ng (v\u00ec nhi\u1ec1u thu\u1ed1c ch\u1ec9 \u0111ang nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng, tr\u00ean t\u1ebf b\u00e0o ho\u1eb7c \u0111\u1ed9ng v\u1eadt), t\u1eeb \u0111\u00f3 ch\u1ec9 c\u00e2n nh\u1eafc nh\u1eefng l\u1ef1a ch\u1ecdn c\u00f3 kh\u1ea3 n\u0103ng c\u00f3 l\u1ee3i nhi\u1ec1u nh\u1ea5t. Ngay c\u1ea3 khi b\u1ec7nh nh\u00e2n \u0111\u1ed3ng \u00fd \u0111i\u1ec1u tr\u1ecb th\u1eed nghi\u1ec7m, h\u1ecd ph\u1ea3i \u0111\u01b0\u1ee3c H\u1ed9i \u0111\u1ed3ng y \u0111\u1ee9c\/lu\u00e2n l\u00fd x\u00e9t duy\u1ec7t th\u00ec m\u1edbi \u0111\u01b0\u1ee3c d\u00f9ng thu\u1ed1c. <\/span><\/p>\n

Gi\u1ea3i tr\u00ecnh t\u1ef1 DNA, RNA hay protein \u0111ang l\u00e0 nh\u1eefng c\u00f4ng c\u1ee5 m\u1edbi gi\u00fap \u0111\u1ea9y nhanh m\u1ed9t xu h\u01b0\u1edbng c\u0169 l\u00e0 c\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0. Hi v\u1ecdng b\u00e0i vi\u1ebft n\u00e0y g\u00f3p ph\u1ea7n cung c\u1ea5p th\u00eam th\u00f4ng tin v\u00e0 m\u1ed9t s\u1ed1 khuy\u1ebfn c\u00e1o cho c\u1ed9ng \u0111\u1ed3ng, nh\u1ea5t l\u00e0 nh\u1eefng b\u1ec7nh nh\u00e2n v\u00e0 ng\u01b0\u1eddi th\u00e2n \u0111ang c\u00e2n nh\u1eafc t\u00ecm h\u01b0\u1edbng \u0111i\u1ec1u tr\u1ecb m\u1edbi.<\/span><\/p>\n

T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h2>\n
    \n
  1. Kumar-Sinha C, Chinnaiyan AM. Precision oncology in the age of integrative genomics. Nat Biotechnol. 2018;36(1):46-60.<\/span><\/li>\n
  2. https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm560167.htm<\/span><\/a><\/li>\n
  3. https:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm592347.htm<\/span><\/a><\/li>\n
  4. http:\/\/www.cancernetwork.com\/cancer-and-genetics\/caution-urged-when-using-liquid-biopsies-clinic<\/span><\/a><\/li>\n
  5. Torga G, Pienta KJ. Patient-Paired Sample Congruence Between 2 Commercial Liquid Biopsy Tests. JAMA Oncol. 2017.<\/span><\/li>\n<\/ol>\n

    Ch\u00fa th\u00edch: <\/span><\/p>\n

    Umbrella trial, t\u1ea1m d\u1ecbch \u201cTh\u1eed nghi\u1ec7m d\u1ea1ng d\u00f9\u201d, l\u00e0 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng trong \u0111\u00f3 c\u00e1c b\u1ec7nh nh\u00e2n c\u1ee7a c\u00f9ng m\u1ed9t lo\u1ea1i ung th\u01b0 (v\u00ed d\u1ee5: ung th\u01b0 Ph\u1ed5i kh\u00f4ng t\u1ebf b\u00e0o nh\u1ecf) s\u1ebd \u0111\u01b0\u1ee3c ph\u00e2n nh\u00f3m nh\u1ecf h\u01a1n theo biomarker, m\u1ed7i nh\u00f3m s\u1ebd \u0111\u01b0\u1ee3c ch\u1eefa b\u1eb1ng m\u1ed9t lo\u1ea1i thu\u1ed1c nh\u1eafm \u0111\u00edch ri\u00eang bi\u1ec7t t\u01b0\u01a1ng \u1ee9ng (v\u00ed d\u1ee5: Vemurafenib cho BRAF_V600, palbociclib cho CDK4\/6)<\/span><\/p>\n

    \"Umbrella\"<\/p>\n

    Basket trial, t\u1ea1m d\u1ecbch \u201cTh\u1eed nghi\u1ec7m d\u1ea1ng gi\u1ecf\u201d, l\u00e0 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng trong \u0111\u00f3 c\u00e1c b\u1ec7nh nh\u00e2n c\u1ee7a c\u00f3 c\u00f9ng m\u1ed9t lo\u1ea1i biomarker (v\u00ed d\u1ee5: BRAF_V600) s\u1ebd \u0111\u01b0\u1ee3c ph\u00e2n nh\u00f3m nh\u1ecf h\u01a1n theo lo\u1ea1i ung th\u01b0 (v\u00ed d\u1ee5: ung th\u01b0 ph\u1ed5i, ung th\u01b0 \u0111\u1ea1i tr\u00e0ng, ung th\u01b0 tuy\u1ebfn gi\u00e1p, ung th\u01b0 \u0111\u01b0\u1eddng m\u1eadt,\u2026) v\u00e0 ch\u1eefa b\u1eb1ng c\u00f9ng m\u1ed9t lo\u1ea1i thu\u1ed1c nh\u1eafm \u0111\u00edch (v\u00ed d\u1ee5: Vemurafenib).<\/span><\/p>\n

    \"Basket\"<\/p>\n","protected":false},"excerpt":{"rendered":"

    \u1ede m\u1ed9t s\u1ed1 t\u00e0i li\u1ec7u, \u201cc\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb\u201d th\u01b0\u1eddng \u0111\u01b0\u1ee3c hi\u1ec3u t\u01b0\u01a1ng \u0111\u01b0\u01a1ng l\u00e0 \u201c\u0111i\u1ec1u tr\u1ecb ch\u00ednh x\u00e1c\u201d hay \u201cPrecision Medicine\u201d. Tuy nhi\u00ean, y h\u1ecdc c\u00f2n c\u00f3 th\u1ec3 \u201cc\u00e1 nh\u00e2n h\u00f3a\u201d hay \u201cch\u00ednh x\u00e1c\u201d h\u01a1n n\u1eefa kh\u00f4ng?<\/p>\n","protected":false},"author":108,"featured_media":12047,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[3845,2471],"series":[3817],"coauthors":[],"acf":[],"yoast_head":"\nC\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi - D\u1ef1 \u00e1n Ung Th\u01b0<\/title>\n<meta name=\"description\" content=\"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi - D\u1ef1 \u00e1n Ung Th\u01b0\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi - D\u1ef1 \u00e1n Ung Th\u01b0\" \/>\n<meta property=\"og:description\" content=\"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi - D\u1ef1 \u00e1n Ung Th\u01b0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/\" \/>\n<meta property=\"og:site_name\" content=\"D\u1ef1 \u00e1n Ung Th\u01b0\" \/>\n<meta property=\"article:author\" content=\"http:\/\/facebook.com\/beequy\" \/>\n<meta property=\"article:published_time\" content=\"2018-03-29T16:52:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/03\/ca-nhan-hoa-trong-dieu-tri-ung-thu.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"660\" \/>\n\t<meta property=\"og:image:height\" content=\"330\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"BS.TS. Ph\u1ea1m Nguy\u00ean Qu\u00fd\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u0110\u01b0\u1ee3c vi\u1ebft b\u1edfi\" \/>\n\t<meta name=\"twitter:data1\" content=\"BS.TS. Ph\u1ea1m Nguy\u00ean Qu\u00fd\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u01af\u1edbc t\u00ednh th\u1eddi gian \u0111\u1ecdc\" \/>\n\t<meta name=\"twitter:data2\" content=\"13 ph\u00fat\" \/>\n\t<meta name=\"twitter:label3\" content=\"Vi\u1ebft b\u1edfi\" \/>\n\t<meta name=\"twitter:data3\" content=\"BS.TS. Ph\u1ea1m Nguy\u00ean Qu\u00fd\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/\",\"url\":\"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/\",\"name\":\"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi - D\u1ef1 \u00e1n Ung Th\u01b0\",\"isPartOf\":{\"@id\":\"https:\/\/yhoccongdong.com\/ung-thu\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/03\/ca-nhan-hoa-trong-dieu-tri-ung-thu.jpg\",\"datePublished\":\"2018-03-29T16:52:24+00:00\",\"dateModified\":\"2018-03-29T16:52:24+00:00\",\"author\":{\"@id\":\"https:\/\/yhoccongdong.com\/ung-thu\/#\/schema\/person\/a7fea78d1655edee66f7910d8102f8ca\"},\"description\":\"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi - D\u1ef1 \u00e1n Ung Th\u01b0\",\"breadcrumb\":{\"@id\":\"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/#breadcrumb\"},\"inLanguage\":\"vi\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"vi\",\"@id\":\"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/#primaryimage\",\"url\":\"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/03\/ca-nhan-hoa-trong-dieu-tri-ung-thu.jpg\",\"contentUrl\":\"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/03\/ca-nhan-hoa-trong-dieu-tri-ung-thu.jpg\",\"width\":660,\"height\":330},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Trang ch\u1ee7\",\"item\":\"https:\/\/yhoccongdong.com\/ung-thu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/yhoccongdong.com\/ung-thu\/#website\",\"url\":\"https:\/\/yhoccongdong.com\/ung-thu\/\",\"name\":\"D\u1ef1 \u00e1n Ung Th\u01b0\",\"description\":\"Hi\u1ec3u \u0111\u1ec3 chi\u1ebfn th\u1eafng Chia s\u1ebb \u0111\u1ec3 c\u1ea3m th\u00f4ng\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/yhoccongdong.com\/ung-thu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"vi\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/yhoccongdong.com\/ung-thu\/#\/schema\/person\/a7fea78d1655edee66f7910d8102f8ca\",\"name\":\"BS.TS. Ph\u1ea1m Nguy\u00ean Qu\u00fd\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"vi\",\"@id\":\"https:\/\/yhoccongdong.com\/ung-thu\/#\/schema\/person\/image\/02f559f44b45e5dfec28ceaacd2532cc\",\"url\":\"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/2022\/10\/bs-pham-nguyen-quy-96x96.jpg\",\"contentUrl\":\"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/2022\/10\/bs-pham-nguyen-quy-96x96.jpg\",\"caption\":\"BS.TS. Ph\u1ea1m Nguy\u00ean Qu\u00fd\"},\"description\":\"BS.TS. Ph\u1ea1m Nguy\u00ean Qu\u00fd C\u00f3 m\u1ed9t ph\u00e9p thu\u1eadt bi\u1ebfn m\u1ecdi \u01b0\u1edbc m\u01a1 th\u00e0nh hi\u1ec7n th\u1ef1c, \u0111\u00f3 l\u00e0 KI\u00caN TR\u00cc THEO \u0110U\u1ed4I! N\u01a1i l\u00e0m vi\u1ec7c:\u00a0B\u00e1c s\u0129 N\u1ed9i T\u1ed5ng Qu\u00e1t Kyoto Miniren Central Hospital\/B\u00e1c s\u0129 n\u1ed9i tr\u00fa Ung th\u01b0 n\u1ed9i khoa v\u00e0 visiting researcher Kyoto University Hospital Ng\u00e0nh: \u0110a khoa Chuy\u00ean ng\u00e0nh: Ung th\u01b0 Qu\u00e1 tr\u00ecnh \u0111\u00e0o t\u1ea1o: Ti\u1ebfn s\u0129, chuy\u00ean ng\u00e0nh Sinh l\u00fd v\u00e0 T\u1ebf b\u00e0o h\u1ecdc, \u0110\u1ea1i H\u1ecdc Y Nha Tokyo n\u0103m\u00a02013 B\u00e1c s\u0129 \u0111a khoa, \u0110\u1ea1i H\u1ecdc Y Nha Khoa Tokyo n\u0103m 2009\",\"sameAs\":[\"http:\/\/facebook.com\/beequy\"],\"url\":\"https:\/\/yhoccongdong.com\/ung-thu\/author\/pham-nguyen-quy\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi - D\u1ef1 \u00e1n Ung Th\u01b0","description":"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi - D\u1ef1 \u00e1n Ung Th\u01b0","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/","og_locale":"vi_VN","og_type":"article","og_title":"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi - D\u1ef1 \u00e1n Ung Th\u01b0","og_description":"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi - D\u1ef1 \u00e1n Ung Th\u01b0","og_url":"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/","og_site_name":"D\u1ef1 \u00e1n Ung Th\u01b0","article_author":"http:\/\/facebook.com\/beequy","article_published_time":"2018-03-29T16:52:24+00:00","og_image":[{"width":660,"height":330,"url":"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/03\/ca-nhan-hoa-trong-dieu-tri-ung-thu.jpg","type":"image\/jpeg"}],"author":"BS.TS. Ph\u1ea1m Nguy\u00ean Qu\u00fd","twitter_card":"summary_large_image","twitter_misc":{"\u0110\u01b0\u1ee3c vi\u1ebft b\u1edfi":"BS.TS. Ph\u1ea1m Nguy\u00ean Qu\u00fd","\u01af\u1edbc t\u00ednh th\u1eddi gian \u0111\u1ecdc":"13 ph\u00fat","Vi\u1ebft b\u1edfi":"BS.TS. Ph\u1ea1m Nguy\u00ean Qu\u00fd"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/","url":"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/","name":"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi - D\u1ef1 \u00e1n Ung Th\u01b0","isPartOf":{"@id":"https:\/\/yhoccongdong.com\/ung-thu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/#primaryimage"},"image":{"@id":"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/#primaryimage"},"thumbnailUrl":"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/03\/ca-nhan-hoa-trong-dieu-tri-ung-thu.jpg","datePublished":"2018-03-29T16:52:24+00:00","dateModified":"2018-03-29T16:52:24+00:00","author":{"@id":"https:\/\/yhoccongdong.com\/ung-thu\/#\/schema\/person\/a7fea78d1655edee66f7910d8102f8ca"},"description":"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi - D\u1ef1 \u00e1n Ung Th\u01b0","breadcrumb":{"@id":"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/#breadcrumb"},"inLanguage":"vi","potentialAction":[{"@type":"ReadAction","target":["https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/"]}]},{"@type":"ImageObject","inLanguage":"vi","@id":"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/#primaryimage","url":"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/03\/ca-nhan-hoa-trong-dieu-tri-ung-thu.jpg","contentUrl":"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/03\/ca-nhan-hoa-trong-dieu-tri-ung-thu.jpg","width":660,"height":330},{"@type":"BreadcrumbList","@id":"https:\/\/yhoccongdong.com\/ung-thu\/ca-nhan-hoa-dieu-tri-benh-ung-thu-xu-huong-cu-voi-cong-cu-moi\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Trang ch\u1ee7","item":"https:\/\/yhoccongdong.com\/ung-thu\/"},{"@type":"ListItem","position":2,"name":"C\u00e1 nh\u00e2n h\u00f3a \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ung th\u01b0: Xu h\u01b0\u1edbng c\u0169 v\u1edbi c\u00f4ng c\u1ee5 m\u1edbi"}]},{"@type":"WebSite","@id":"https:\/\/yhoccongdong.com\/ung-thu\/#website","url":"https:\/\/yhoccongdong.com\/ung-thu\/","name":"D\u1ef1 \u00e1n Ung Th\u01b0","description":"Hi\u1ec3u \u0111\u1ec3 chi\u1ebfn th\u1eafng Chia s\u1ebb \u0111\u1ec3 c\u1ea3m th\u00f4ng","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/yhoccongdong.com\/ung-thu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"vi"},{"@type":"Person","@id":"https:\/\/yhoccongdong.com\/ung-thu\/#\/schema\/person\/a7fea78d1655edee66f7910d8102f8ca","name":"BS.TS. Ph\u1ea1m Nguy\u00ean Qu\u00fd","image":{"@type":"ImageObject","inLanguage":"vi","@id":"https:\/\/yhoccongdong.com\/ung-thu\/#\/schema\/person\/image\/02f559f44b45e5dfec28ceaacd2532cc","url":"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/2022\/10\/bs-pham-nguyen-quy-96x96.jpg","contentUrl":"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/2022\/10\/bs-pham-nguyen-quy-96x96.jpg","caption":"BS.TS. Ph\u1ea1m Nguy\u00ean Qu\u00fd"},"description":"BS.TS. Ph\u1ea1m Nguy\u00ean Qu\u00fd C\u00f3 m\u1ed9t ph\u00e9p thu\u1eadt bi\u1ebfn m\u1ecdi \u01b0\u1edbc m\u01a1 th\u00e0nh hi\u1ec7n th\u1ef1c, \u0111\u00f3 l\u00e0 KI\u00caN TR\u00cc THEO \u0110U\u1ed4I! N\u01a1i l\u00e0m vi\u1ec7c:\u00a0B\u00e1c s\u0129 N\u1ed9i T\u1ed5ng Qu\u00e1t Kyoto Miniren Central Hospital\/B\u00e1c s\u0129 n\u1ed9i tr\u00fa Ung th\u01b0 n\u1ed9i khoa v\u00e0 visiting researcher Kyoto University Hospital Ng\u00e0nh: \u0110a khoa Chuy\u00ean ng\u00e0nh: Ung th\u01b0 Qu\u00e1 tr\u00ecnh \u0111\u00e0o t\u1ea1o: Ti\u1ebfn s\u0129, chuy\u00ean ng\u00e0nh Sinh l\u00fd v\u00e0 T\u1ebf b\u00e0o h\u1ecdc, \u0110\u1ea1i H\u1ecdc Y Nha Tokyo n\u0103m\u00a02013 B\u00e1c s\u0129 \u0111a khoa, \u0110\u1ea1i H\u1ecdc Y Nha Khoa Tokyo n\u0103m 2009","sameAs":["http:\/\/facebook.com\/beequy"],"url":"https:\/\/yhoccongdong.com\/ung-thu\/author\/pham-nguyen-quy\/"}]}},"_links":{"self":[{"href":"https:\/\/yhoccongdong.com\/ung-thu\/wp-json\/wp\/v2\/posts\/12046"}],"collection":[{"href":"https:\/\/yhoccongdong.com\/ung-thu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/yhoccongdong.com\/ung-thu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/yhoccongdong.com\/ung-thu\/wp-json\/wp\/v2\/users\/108"}],"replies":[{"embeddable":true,"href":"https:\/\/yhoccongdong.com\/ung-thu\/wp-json\/wp\/v2\/comments?post=12046"}],"version-history":[{"count":0,"href":"https:\/\/yhoccongdong.com\/ung-thu\/wp-json\/wp\/v2\/posts\/12046\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/yhoccongdong.com\/ung-thu\/wp-json\/wp\/v2\/media\/12047"}],"wp:attachment":[{"href":"https:\/\/yhoccongdong.com\/ung-thu\/wp-json\/wp\/v2\/media?parent=12046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/yhoccongdong.com\/ung-thu\/wp-json\/wp\/v2\/categories?post=12046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/yhoccongdong.com\/ung-thu\/wp-json\/wp\/v2\/tags?post=12046"},{"taxonomy":"series","embeddable":true,"href":"https:\/\/yhoccongdong.com\/ung-thu\/wp-json\/wp\/v2\/series?post=12046"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/yhoccongdong.com\/ung-thu\/wp-json\/wp\/v2\/coauthors?post=12046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}