{"id":12118,"date":"2018-07-10T00:33:57","date_gmt":"2018-07-09T17:33:57","guid":{"rendered":"https:\/\/yhoccongdong.org\/ung-thu\/giai-trinh-tu-gene-trong-dieu-tri-ung-thu-can-duoc-giai-trinh-chu-dao\/"},"modified":"2018-07-10T00:33:57","modified_gmt":"2018-07-09T17:33:57","slug":"giai-trinh-tu-gene-trong-dieu-tri-ung-thu-can-duoc-giai-trinh-chu-dao","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/ung-thu\/giai-trinh-tu-gene-trong-dieu-tri-ung-thu-can-duoc-giai-trinh-chu-dao\/","title":{"rendered":"Gi\u1ea3i tr\u00ecnh t\u1ef1 gene trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0: C\u1ea7n \u0111u\u1ee3c \u201cgi\u1ea3i tr\u00ecnh\u201d chu \u0111\u00e1o"},"content":{"rendered":"

Ung th\u01b0 th\u01b0\u1eddng x\u1ea3y ra do s\u1ef1 xu\u1ea5t hi\u1ec7n v\u00e0 t\u00edch t\u1ee5 c\u00e1c \u0111\u1ed9t bi\u1ebfn gene li\u00ean quan t\u1edbi ki\u1ec3m so\u00e1t sinh s\u1ea3n v\u00e0 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o. Gi\u1ea3i tr\u00ecnh t\u1ef1 gene l\u00e0 m\u1ed9t x\u00e9t nghi\u1ec7m t\u00e2n ti\u1ebfn \u0111\u1ec3 ph\u00e1t hi\u1ec7n c\u00e1c \u0111\u1ed9t bi\u1ebfn gene \u0111\u00f3, l\u00e0 c\u00f4ng c\u1ee5 h\u1ee9a h\u1eb9n c\u00f3 th\u1ec3 gi\u00fap b\u1ec7nh nh\u00e2n ung th\u01b0 t\u00ecm ra thu\u1ed1c nh\u1eafm \u0111\u00edch (targeted therapy) ph\u00f9 h\u1ee3p \u0111\u1ec3 c\u00f3 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb cao h\u01a1n.<\/p>\n

Tuy nhi\u00ean, gi\u1edbi khoa h\u1ecdc v\u00e0 b\u00e1c s\u0129 v\u1eabn \u0111ang r\u1ea5t th\u1eadn tr\u1ecdng v\u1edbi k\u1ef9 thu\u1eadt m\u1edbi n\u00e0y, v\u00ec k\u1ef3 v\u1ecdng thi\u1ebft th\u1ef1c (Hope) v\u00e0 l\u1eddi \u0111\u1ed3n th\u1ea7n tho\u1ea1i (Hype) th\u01b0\u1eddng kh\u00f3 ph\u00e2n \u0111\u1ecbnh.<\/p>\n

B\u00e0i vi\u1ebft n\u00e0y cung c\u1ea5p th\u00f4ng tin v\u1ec1 th\u1ef1c tr\u1ea1ng \u1ee9ng d\u1ee5ng x\u00e9t nghi\u1ec7m n\u00e0y t\u1ea1i Nh\u1eadt B\u1ea3n, hi v\u1ecdng gi\u00fap c\u00e1c b\u1ec7nh nh\u00e2n t\u1ea1i Vi\u1ec7t Nam c\u00e2n nh\u1eafc s\u00e1ng su\u1ed1t h\u01a1n.<\/p>\n

Nhi\u1ec1u ch\u1ea5t ch\u1ec9 th\u1ecb \u0111ang gi\u00fap \u0111\u1ea9y m\u1ea1nh c\u00e1 nh\u00e2n h\u00f3a trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0<\/h2>\n

Hi\u1ec7n nay, trong m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0, ng\u01b0\u1eddi ta \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c c\u00e1c \u0111\u1ed9t bi\u1ebfn gene quan tr\u1ecdng c\u00f3 vai tr\u00f2 c\u1ed1t l\u00f5i trong vi\u1ec7c ph\u00e1t tri\u1ec3n kh\u1ed1i u (driver mutations). C\u00e1c thu\u1ed1c nh\u1eafm \u0111\u00edch (targeted therapy) ng\u0103n ch\u1eadn t\u00edn hi\u1ec7u li\u00ean quan t\u1edbi \u0111\u1ed9t bi\u1ebfn \u0111\u00f3 c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u \u1ee9ng d\u1ee5ng v\u00e0 ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 r\u00f5 r\u1ec7t trong nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p. Nhi\u1ec1u v\u00ed d\u1ee5 n\u1ed5i ti\u1ebfng nh\u01b0 Erlotinib v\u1edbi \u0111\u1ed9t bi\u1ebfn EGFR trong ung th\u01b0 ph\u1ed5i hay Trastuzumab trong c\u00e1c ca c\u00f3 \u0111\u1ed9t bi\u1ebfn HER2 \u1edf ung th\u01b0 v\u00fa.<\/p>\n

V\u1edbi c\u00e1c c\u1eb7p \u0111\u00f4i \u201cch\u1ea5t ch\u1ec9 th\u1ecb-tr\u1ecb li\u1ec7u nh\u1eafm \u0111\u00edch\u201d (marker-targeted therapy) nh\u01b0 v\u1eady, nhi\u1ec1u lo\u1ea1i ung th\u01b0 \u0111\u00e3 v\u00e0 \u0111ang \u0111u\u1ee3c \u0111i\u1ec1u tr\u1ecb theo h\u01b0\u1edbng c\u00e1 nh\u00e2n ho\u00e1 v\u00e0 ch\u00ednh x\u00e1c h\u01a1n ng\u00e0y x\u01b0a d\u1ef1a tr\u00ean c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m sinh h\u1ecdc v\u00e0 di truy\u1ec1n c\u1ee7a t\u1eebng b\u1ec7nh nh\u00e2n.<\/p>\n

Gi\u1ea3i tr\u00ecnh t\u1ef1 gene c\u00f3 th\u1ec3 gi\u00fap \u00edch nh\u01b0 th\u1ebf n\u00e0o?<\/h2>\n

Ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u c\u1eb7p \u0111\u00f4i \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n (H\u00ecnh 1), v\u00e0 d\u00f9 v\u1edbi t\u1ea7n su\u1ea5t r\u1ea5t th\u1ea5p ho\u1eb7c kh\u00f4ng\u2026bi\u1ebft, ng\u01b0\u1eddi ta ng\u00e0y c\u00e0ng mu\u1ed1n kh\u1ea3o s\u00e1t xem kh\u1ed1i u c\u00f3 mang \u0111\u1ed9t bi\u1ebfn n\u00e0o m\u00e0 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c nh\u1eafm t\u1edbi b\u1eb1ng thu\u1ed1c \u0111\u00edch kh\u00f4ng (actionable mutation). V\u00ec vi\u1ec7c x\u00e9t nghi\u1ec7m c\u1ea3 tr\u0103m lo\u1ea1i marker b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p truy\u1ec1n th\u1ed1ng (H\u00f3a m\u00f4 mi\u1ec5n d\u1ecbch, PCR, FISH,\u2026) l\u00e0 b\u1ea5t kh\u1ea3 thi ho\u1eb7c r\u1ea5t t\u1ed1n k\u00e9m, gi\u1ea3i tr\u00ecnh t\u1ef1 gene \u0111\u01b0\u1ee3c cho l\u00e0 gi\u1ea3i ph\u00e1p kh\u1ea3 d\u0129 h\u01a1n (\u0111\u1ee1 t\u1ed1n h\u01a1n nh\u01b0ng v\u1eabn c\u00f2n m\u1eafc).<\/p>\n

\"M\u1ed9t<\/p>\n

H\u00ecnh 1. M\u1ed9t s\u1ed1 thu\u1ed1c nh\u1eafm \u0111\u00edch (c\u1ed9t \u0111\u1ea7u) t\u01b0\u01a1ng \u1ee9ng v\u1edbi lo\u1ea1i \u0111\u1ed9t bi\u1ebfn (c\u1ed9t gi\u1eefa).<\/em><\/p>\n

H\u01a1n n\u1eefa, nh\u01b0 trong ung th\u01b0 ph\u1ed5i, \u0111\u1ec3 kh\u1ea3o s\u00e1t 3-5 ch\u1ea5t ch\u1ec9 th\u1ecb\/markers th\u00ec nhi\u1ec1u khi m\u1eabu sinh thi\u1ebft kh\u00f4ng \u0111\u1ee7 v\u00ec qu\u00e1 nh\u1ecf! Vi\u1ec7c x\u00e9t nghi\u1ec7m khi kh\u00f4ng c\u00f3 \u0111\u1ee7 l\u01b0\u1ee3ng t\u1ebf b\u00e0o \u00e1c t\u00ednh trong m\u1eabu c\u00f3 th\u1ec3 d\u1eabn t\u1edbi ch\u1ea9n \u0111o\u00e1n sai. Gi\u1ea3i tr\u00ecnh t\u1ef1 gene c\u00f3 th\u1ec3 gi\u00fap gi\u1ea3i quy\u1ebft b\u00e0i to\u00e1n n\u00e0y b\u1eb1ng x\u00e9t nghi\u1ec7m m\u1ed9t l\u1ea7n \u0111\u1ec3 cho ra h\u1ebft c\u00e1c k\u1ebft qu\u1ea3 n\u00f3i tr\u00ean, qu\u1ea3 th\u1eadt r\u1ea5t ti\u1ec7n!<\/p>\n

G\u1ea7n \u0111\u00e2y, nhi\u1ec1u b\u00e1o c\u00e1o cho th\u1ea5y vi\u1ec7c d\u00f9ng thu\u1ed1c \u0111\u00edch ch\u1ecdn l\u1ecdc nh\u1edd vi\u1ec7c gi\u1ea3i tr\u00ecnh t\u1ef1 gene c\u00f3 th\u1ec3 mang l\u1ea1i k\u1ebft qu\u1ea3 \u0111i\u1ec1u tr\u1ecb t\u1ed1t h\u01a1n ti\u1ebfp c\u1eadn truy\u1ec1n th\u1ed1ng (m\u1eb7c d\u00f9 t\u1ed1t h\u01a1n m\u1ed9t ch\u00fat hay \u201cnhi\u1ec1u ch\u00fat\u201d so v\u1edbi s\u1ed1 ti\u1ec1n b\u1ecf ra v\u1eabn \u0111ang \u0111\u01b0\u1ee3c tranh c\u00e3i). Th\u00e1ng 11 n\u0103m ngo\u00e1i, FDA (Hoa K\u1ef3) \u0111\u00e3 cho ph\u00e9p c\u00e1c b\u00e1c s\u0129 l\u00e2m s\u00e0ng s\u1eed d\u1ee5ng m\u1ed9t x\u00e9t nghi\u1ec7m gi\u1ea3i tr\u00ecnh t\u1ef1 gene tr\u00ean m\u1ecdi b\u1ec7nh nh\u00e2n ung th\u01b0 \u0111\u1eb7c (solid tumor) giai \u0111o\u1ea1n III\/IV. \u0110i\u1ec1u n\u00e0y g\u1ee3i ra r\u1ea5t nhi\u1ec1u k\u1ef3 v\u1ecdng cho b\u1ec7nh nh\u00e2n ung th\u01b0, nh\u1ea5t l\u00e0 khi l\u00e2m v\u00e0o t\u00ecnh hu\u1ed1ng kh\u00f4ng c\u00f3 nhi\u1ec1u l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb.<\/p>\n

Tuy nhi\u00ean, c\u00e2u chuy\u1ec7n kh\u00f4ng \u0111\u01a1n gi\u1ea3n nh\u01b0 v\u1eady\u2026<\/p>\n

Gi\u1ea3i tr\u00ecnh t\u1ef1 gene l\u00e0 c\u00f3 th\u1ec3 ch\u1ec9 l\u00e0m b\u1ec7nh nh\u00e2n th\u00eam bu\u1ed3n n\u1ebfu kh\u00f4ng c\u00f3 h\u1ed7 tr\u1ee3 ti\u1ebfp c\u1eadn thu\u1ed1c \u0111\u00edch \u0111i k\u00e8m<\/h2>\n

\u1ede Nh\u1eadt B\u1ea3n, ngay c\u1ea3 khi gi\u1ea3i tr\u00ecnh t\u1ef1 gene \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n mi\u1ec5n ph\u00ed v\u1edbi ti\u1ec1n qu\u1ef9 c\u1ee7a v\u00e0i nghi\u00ean c\u1ee9u to\u00e0n qu\u1ed1c, t\u00ecm ra 58-67% ca b\u1ec7nh c\u00f3 th\u1ec3 c\u00f3 l\u1ee3i nh\u1edd thu\u1ed1c \u0111\u00edch th\u00ec ch\u1ec9 10-15% ng\u01b0\u1eddi b\u1ec7nh \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi thu\u1ed1c \u0111\u00edch. \u0110\u00f3 l\u00e0 v\u00ec s\u1ed1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1edbi thu\u1ed1c nh\u1eafm \u0111\u00edch \u1edf Nh\u1eadt B\u1ea3n \u00edt h\u01a1n nhi\u1ec1u so v\u1edbi Hoa K\u1ef3 (304 so v\u1edbi 5564) v\u00e0 h\u1ea7u nh\u01b0 kh\u00f4ng c\u00f3 ch\u1ebf \u0111\u1ed9 v\u00e0 h\u1ed7 tr\u1ee3 t\u00e0i ch\u00ednh cho vi\u1ec7c d\u00f9ng thu\u1ed1c ngo\u00e0i ch\u1ec9 \u0111\u1ecbnh b\u1ea3o hi\u1ec3m. Ngo\u00e0i ra, quy tr\u00ecnh x\u00e9t cho d\u00f9ng thu\u1ed1c theo y\u00eau c\u1ea7u b\u1ec7nh nh\u00e2n th\u01b0\u1eddng m\u1ea5t 3-6 th\u00e1ng v\u00e0 nhi\u1ec1u b\u1ec7nh nh\u00e2n kh\u00f4ng ch\u1edd \u0111\u01b0\u1ee3c t\u1edbi l\u00fac \u0111\u00f3. Ph\u1ea7n l\u1edbn b\u1ec7nh nh\u00e2n kh\u00f4ng ti\u1ebfp c\u1eadn \u0111\u01b0\u1ee3c v\u1edbi thu\u1ed1c v\u00ec gi\u00e1 qu\u00e1 m\u1eafc, \u1edf xa n\u01a1i th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, ho\u1eb7c v\u00ec ch\u1ee9c n\u0103ng gan, th\u1eadn v\u00e0 s\u1ee9c kho\u1ebb t\u1ed5ng tr\u1ea1ng kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 v\u00e0o th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.<\/p>\n

Trong m\u1ed9t kh\u1ea3o s\u00e1t t\u1ea7m qu\u1ed1c gia (TOP-GEAR study), 25 b\u1ec7nh nh\u00e2n ti\u1ebfp c\u1eadn \u0111\u01b0\u1ee3c v\u1edbi thu\u1ed1c \u0111\u00edch (13% trong t\u1ed5ng s\u1ed1 ca x\u00e9t nghi\u1ec7m) th\u00ec 15 ca th\u1ef1c hi\u1ec7n qua th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, 4 ca l\u00e0 t\u1ef1 t\u00fac ho\u00e0n to\u00e0n (thu\u1ed1c ngo\u00e0i b\u1ea3o hi\u1ec3m) v\u00e0 ch\u1ec9 c\u00f3 6 ca (3.1%) l\u00e0 t\u00ecm \u0111\u01b0\u1ee3c thu\u1ed1c n\u1eb1m trong ph\u1ea1m vi b\u1ea3o hi\u1ec3m. Nhi\u1ec1u b\u1ec7nh nh\u00e2n n\u00f3i r\u1eb1ng b\u1ecf s\u1ed1 ti\u1ec1n l\u1edbn \u0111\u1ec3 x\u00e9t nghi\u1ec7m v\u00e0 t\u00ecm ra thu\u1ed1c r\u1ed3i nh\u01b0ng r\u1ed1t cu\u1ed9c kh\u00f4ng c\u00f3 thu\u1ed1c x\u00e0i th\u00ec c\u00f2n tuy\u1ec7t v\u1ecdng h\u01a1n.<\/p>\n

Nh\u00ecn v\u1ec1 Vi\u1ec7t Nam, nhi\u1ec1u b\u00e1o c\u00e1o n\u00f3i r\u1eb1ng ti\u1ebfp c\u1eadn thu\u1ed1c \u0111\u00edch \u1edf n\u01b0\u1edbc ta c\u00f2n kh\u00f3 kh\u0103n h\u01a1n v\u00e0 th\u01b0\u1eddng ch\u1eadm h\u01a1n c\u00e1c n\u01b0\u1edbc ti\u00ean ti\u1ebfn t\u1eeb 3-7 n\u0103m. N\u1ebfu kh\u00f4ng c\u00f3 h\u1ec7 th\u1ed1ng h\u1ed7 tr\u1ee3 ti\u1ebfp c\u1eadn thu\u1ed1c k\u1ecbp th\u1eddi, ho\u1eb7c kh\u00f4ng \u0111\u1ee7 ti\u1ec1m l\u1ef1c t\u00e0i ch\u00ednh th\u00ec gi\u1ea3i tr\u00ecnh t\u1ef1 gene ch\u1eb3ng kh\u00e1c n\u00e0o l\u00e0m cho bi\u1ebft ho\u1eb7c l\u00e0m cho th\u00eam bu\u1ed3n.<\/p>\n

Gi\u1ea3i tr\u00ecnh t\u1ef1 gene c\u00f3 th\u1ec3 kh\u00f4ng t\u00ecm ra th\u00f4ng tin h\u1eefu \u00edch n\u00e0o<\/h2>\n

Th\u00eam v\u00e0o \u0111\u00f3, kh\u00f4ng ph\u1ea3i lo\u1ea1i ung th\u01b0 n\u00e0o c\u0169ng c\u00f3 \u0111\u1ed9t bi\u1ebfn \u201cc\u1ed1t l\u00f5i\u201d (driver mutation) nh\u01b0 EGFR trong ung th\u01b0 ph\u1ed5i. Kh\u00f4ng ph\u1ea3i ai c\u0169ng t\u00ecm ra \u0111\u1ed9t bi\u1ebfn gene c\u00f3 \u00fd ngh\u0129a trong \u0111i\u1ec1u tr\u1ecb. \u0110\u00f3 l\u00e0 v\u00ec trong c\u01a1 th\u1ec3 ch\u00fang ta c\u00f3 r\u1ea5t nhi\u1ec1u \u0111\u1ed9t bi\u1ebfn v\u00e0 d\u00f9 ch\u00fang c\u00f3 xu h\u01b0\u1edbng t\u00edch t\u1ee5 t\u0103ng d\u1ea7n theo n\u0103m th\u00e1ng, nhi\u1ec1u \u0111\u1ed9t bi\u1ebfn \u1edf d\u1ea1ng \u201ct\u00ecnh c\u1edd g\u1eb7p khi qua \u0111\u01b0\u1eddng\u201d (bystander), \u201ckh\u00f4ng r\u00f5 \u00fd ngh\u0129a\u201d ho\u1eb7c \u201ckh\u00f4ng c\u00f3 gi\u00e1 tr\u1ecb trong \u0111i\u1ec1u tr\u1ecb\u201d. Cho d\u00f9 c\u00f3 thu\u1ed1c \u0111\u00edch nh\u1eafm t\u1edbi c\u00e1c \u0111\u1ed9t bi\u1ebfn n\u00e0y, hi\u1ec7u qu\u1ea3 c\u1ee7a ch\u00fang l\u00e0 kh\u00f4ng ch\u1eafc ch\u1eafn, v\u00e0 c\u00e1c H\u1ed9i chuy\u00ean ng\u00e0nh khuy\u1ebfn c\u00e1o kh\u00f4ng n\u00ean s\u1eed d\u1ee5ng.<\/p>\n

Gi\u1ea3i tr\u00ecnh t\u1ef1 gene c\u00f2n c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i gi\u00e1n ti\u1ebfp<\/h2>\n

Vi\u1ec7c gi\u1ea3i tr\u00ecnh t\u1ef1 gene c\u00f3 th\u1ec3 l\u00e0m b\u00e1c s\u0129 v\u00e0 b\u1ec7nh nh\u00e2n t\u00ecnh c\u1edd ph\u00e1t hi\u1ec7n ra c\u00e1c lo\u1ea1i \u0111\u1ed9t bi\u1ebfn gene c\u00f3 t\u00ednh di truy\u1ec1n trong gia \u0111\u00ecnh. M\u1eb7c d\u00f9 m\u1ed9t s\u1ed1 gia \u0111\u00ecnh th\u1ea5y m\u1eebng v\u00ec bi\u1ebft \u0111\u01b0\u1ee3c nguy c\u01a1 c\u1ee7a m\u00ecnh, nh\u1eefng th\u00f4ng tin nh\u1ea1y c\u1ea3m n\u00e0y l\u1ea1i c\u00f3 th\u1ec3 l\u00e0m anh em, con c\u00e1i b\u1ec7nh nh\u00e2n lo l\u1eafng qu\u00e1 m\u1ee9c c\u1ea7n thi\u1ebft. Th\u1eed t\u01b0\u1edfng t\u01b0\u1ee3ng con c\u1ee7a b\u1ec7nh nh\u00e2n c\u00f2n tr\u1ebb tu\u1ed5i s\u1ebd s\u1ed1ng nh\u01b0 th\u1ebf n\u00e0o v\u1edbi s\u1ef1 hoang mang v\u1ec1 nguy c\u01a1 cao c\u0169ng kh\u00f4ng cao m\u00e0 th\u1ea5p c\u0169ng kh\u00f4ng th\u1ea5p? V\u1ea5n \u0111\u1ec1 ph\u00e2n bi\u1ec7t di truy\u1ec1n (v\u00ed d\u1ee5 kh\u00f4ng cho k\u1ebft h\u00f4n) c\u0169ng c\u00f3 th\u1ec3 r\u1ea5t nghi\u00eam tr\u1ecdng khi s\u1ef1 hi\u1ec3u bi\u1ebft c\u1ee7a c\u1ed9ng \u0111\u1ed3ng v\u1ec1 y h\u1ecdc, di truy\u1ec1n, \u201cgenome\u201d,\u2026c\u00f2n r\u1ea5t m\u00f9 m\u1edd. Hi\u1ec7p h\u1ed9i ung th\u01b0 Nh\u1eadt B\u1ea3n k\u00eau g\u1ecdi th\u1eadn tr\u1ecdng v\u1ec1 v\u1ea5n \u0111\u1ec1 n\u00e0y, v\u00e0 c\u00e1c b\u00e1c s\u0129 \u0111\u1ec1u ph\u1ea3i d\u00e0nh th\u1eddi gian gi\u1ea3i th\u00edch v\u00e0 h\u1ecfi \u00fd b\u1ec7nh nh\u00e2n xem h\u1ecd mu\u1ed1n bi\u1ebft hay c\u00f4ng b\u1ed1 th\u00f4ng tin \u0111\u1ebfn m\u1ee9c n\u00e0o. Nh\u1eadt B\u1ea3n v\u1eabn c\u00f2n thi\u1ebfu r\u1ea5t nhi\u1ec1u chuy\u00ean vi\u00ean\/\u0111\u01a1n v\u1ecb t\u01b0 v\u1ea5n di truy\u1ec1n, v\u00e0 c\u00f3 l\u1ebd Vi\u1ec7t Nam c\u0169ng c\u1ea7n ph\u1ea3i \u0111\u00e0o t\u1ea1o th\u00eam m\u1ea3ng n\u00e0y \u0111\u1ec3 h\u1ed7 tr\u1ee3 ph\u00f9 h\u1ee3p.<\/p>\n

M\u1ed9t \u0111i\u1ec3m c\u1ea7n l\u01b0u \u00fd n\u1eefa l\u00e0 kh\u00f4ng ph\u1ea3i x\u00e9t nghi\u1ec7m n\u00e0o c\u0169ng gi\u1ed1ng nhau. \u0110\u00e3 c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u ch\u1ec9 ra s\u1ef1 kh\u00e1c bi\u1ec7t khi d\u00f9ng 2 h\u1ec7 gi\u1ea3i tr\u00ecnh t\u1ef1 kh\u00e1c nhau tr\u00ean c\u00f9ng m\u1ed9t ca b\u1ec7nh. V\u00ec hi\u1ec7n tr\u1ea1ng \u201ctr\u0103m hoa \u0111ua n\u1edf\u201d d\u00f9ng k\u1ef9 thu\u1eadt cao \u201clo\u1ea1n c\u00e0o c\u00e0o\u201d n\u00e0y m\u00e0 Hi\u1ec7p h\u1ed9i l\u00e2m s\u00e0ng Hoa K\u1ef3 \u0111ang k\u00eau g\u1ecdi s\u1eed d\u1ee5ng c\u00e1c x\u00e9t nghi\u1ec7m \u0111\u01b0\u1ee3c ch\u1ee9ng nh\u1eadn qua Clinical Laboratory Improvement Amendments (CLIA). \u0110\u00f3 c\u0169ng l\u00e0 v\u00ec m\u1ed9t ch\u1ea5t ch\u1ec9 th\u1ecb\/marker sai c\u00f3 t\u00e1c h\u1ea1i ch\u1eb3ng kh\u00e1c n\u00e0o m\u1ed9t lo\u1ea1i thu\u1ed1c t\u1ed3i, v\u00e0 n\u00f3 s\u1ebd gi\u00e1n ti\u1ebfp t\u01b0\u1edbc \u0111i c\u01a1 h\u1ed9i \u0111i\u1ec1u tr\u1ecb c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh.<\/p>\n

V\u1ecb tr\u00ed c\u1ee7a gi\u1ea3i tr\u00ecnh t\u1ef1 gene trong ung th\u01b0 t\u1ea1i Nh\u1eadt B\u1ea3n<\/h2>\n

V\u00ec m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p ch\u1ec9 \u0111\u01b0\u1ee3c b\u1ea3o hi\u1ec3m chi tr\u1ea3 khi n\u00f3 ch\u1ee9ng minh \u0111\u01b0\u1ee3c s\u1ef1 c\u1ea7n thi\u1ebft v\u00e0 s\u1ef1 h\u1ee3p l\u00fd, x\u00e9t nghi\u1ec7m n\u00e0y ch\u01b0a \u0111\u01b0\u1ee3c b\u1ea3o hi\u1ec3m chi tr\u1ea3 \u1edf Nh\u1eadt B\u1ea3n. Hi\u1ec7n nay, ngo\u00e0i ph\u1ea1m vi th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, m\u1ed9t s\u1ed1 trung t\u00e2m ung th\u01b0 \u0111ang cung c\u1ea5p d\u1ecbch v\u1ee5 x\u00e9t nghi\u1ec7m n\u00e0y cho m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n kh\u00f4ng c\u00f3 ho\u1eb7c kh\u00f4ng c\u00f2n \u0111i\u1ec1u tr\u1ecb ti\u00eau chu\u1ea9n. \u0110\u00f3 l\u00e0 nh\u1eefng b\u1ec7nh nh\u00e2n ch\u1eb3ng may b\u1ecb ung th\u01b0 d\u1ea1ng hi\u1ebfm, ung th\u01b0 kh\u00f4ng r\u00f5 nguy\u00ean ph\u00e1t ho\u1eb7c c\u00e1c d\u1ea1ng ung th\u01b0 ph\u1ed5 bi\u1ebfn h\u01a1n nh\u01b0ng b\u1ecb l\u1eddn h\u1ebft thu\u1ed1c. V\u00ec m\u1ecdi th\u1ee9 l\u00e0 t\u1ef1 t\u00fac, v\u00e0 qu\u00e1 tr\u00ecnh xin thu\u1ed1c \u0111i\u1ec1u tr\u1ecb sau \u0111\u00f3 m\u1ea5t t\u1eeb 3-6 th\u00e1ng, ch\u1ec9 nh\u1eefng b\u1ec7nh nh\u00e2n c\u00f2n kh\u1ecfe m\u1ea1nh v\u00e0 c\u00f3 \u0111i\u1ec1u ki\u1ec7n t\u00e0i ch\u00ednh kh\u00e1 m\u1ea1nh m\u1edbi l\u00e0m gi\u1ea3i tr\u00ecnh t\u1ef1 \u0111\u1ec3 t\u00ecm v\u1eadn may.<\/p>\n

V\u00ec nhi\u1ec1u b\u1ec7nh nh\u00e2n \u0111\u00e3 kh\u00f4ng c\u00f2n \u0111\u1ee7 kh\u1ecfe khi ti\u1ebfn h\u00e0nh x\u00e9t nghi\u1ec7m, m\u1ed9t s\u1ed1 b\u00e1c s\u0129 \u0111ang v\u1eadn \u0111\u1ed9ng \u0111\u01b0a x\u00e9t nghi\u1ec7m n\u00e0y v\u00e0o d\u1ea1ng b\u1ea3o hi\u1ec3m \u0111\u1ec3 b\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 kh\u1ea3o s\u00e1t \u0111\u1ed9t bi\u1ebfn gene s\u1edbm h\u01a1n.<\/p>\n

Thay l\u1eddi k\u1ebft<\/h2>\n

L\u00e0 m\u1ed9t th\u00e0nh vi\u00ean c\u1ee7a nh\u00f3m H\u1ed9i ch\u1ea9n ph\u00e2n t\u1eed ung th\u01b0 (Tumor Molecular Board), B\u1ec7nh vi\u1ec7n \u0110\u1ea1i h\u1ecdc Kyoto, tr\u1ef1c ti\u1ebfp l\u00e0m vi\u1ec7c li\u00ean quan t\u1edbi gi\u1ea3i tr\u00ecnh t\u1ef1 gene tr\u00ean l\u00e2m s\u00e0ng, t\u00f4i vi\u1ebft b\u00e0i n\u00e0y hi v\u1ecdng gi\u00fap c\u00e1c b\u1ec7nh nh\u00e2n t\u1ea1i Vi\u1ec7t Nam hi\u1ec3u h\u01a1n v\u1ec1 k\u1ef9 thu\u1eadt n\u00e0y. B\u1ec7nh nh\u00e2n c\u00f3 \u0111i\u1ec1u ki\u1ec7n t\u00e0i ch\u00ednh d\u1ed3i d\u00e0o \u0111\u1ec3 theo \u0111u\u1ed5i \u0111i\u1ec1u tr\u1ecb tr\u1ef1c di\u1ec7n ung th\u01b0 th\u00ec c\u1ee9 n\u00ean c\u00e2n nh\u1eafc v\u00ec bi\u1ebft \u0111\u00e2u t\u00ecm ra thu\u1ed1c cho m\u00ecnh! Ho\u1eb7c ch\u00ed \u00edt c\u0169ng g\u00f3p ph\u1ea7n c\u1ed1ng hi\u1ebfn cho n\u1ec1n y h\u1ecdc t\u01b0\u01a1ng lai. B\u1ec7nh nh\u00e2n ngh\u00e8o th\u00ec c\u0169ng kh\u00f4ng n\u00ean bu\u1ed3n v\u00ec l\u1ee3i \u00edch th\u1ef1c t\u1ebf c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p n\u00e0y v\u1eabn c\u00f2n r\u1ea5t m\u00f9 m\u1edd v\u00e0 ch\u1eb3ng \u0111\u00e1ng \u0111\u1ec3 b\u00e1n nh\u00e0 theo n\u00f3.<\/p>\n

V\u00ec nh\u1eefng kh\u00eda c\u1ea1nh ph\u1ee9c t\u1ea1p c\u1ee7a x\u00e9t nghi\u1ec7m n\u00e0y, c\u00e1c b\u00e1c s\u0129 \u1edf \u0110\u1ea1i h\u1ecdc Kyoto th\u01b0\u1eddng y\u00eau c\u1ea7u g\u1eb7p tr\u1ef1c ti\u1ebfp b\u1ec7nh nh\u00e2n, v\u00e0 d\u00e0nh 25-30 ph\u00fat \u0111\u1ec3 t\u01b0 v\u1ea5n gi\u00fap b\u1ec7nh nh\u00e2n v\u00e0 ng\u01b0\u1eddi nh\u00e0 c\u00e2n nh\u1eafc k\u1ef9 lu\u1ee1ng tru\u1edbc khi th\u1ef1c hi\u1ec7n.<\/p>\n

V\u00e0 c\u0169ng\u00a0 ch\u00ednh v\u00ec nh\u1eefng l\u1ee3i \u00edch v\u00e0 nguy c\u01a1 n\u00eau tr\u00ean, n\u1ebfu kh\u00f4ng \u0111\u1ee7 c\u00f4ng t\u00e2m v\u00e0 kh\u00f4ng ngh\u0129 t\u1edbi l\u1ee3i \u00edch t\u1ed5ng th\u1ec3 c\u1ee7a ng\u01b0\u1eddi b\u1ec7nh, ng\u01b0\u1eddi b\u00e1c s\u0129 v\u00e0 nh\u00e0 nghi\u00ean c\u1ee9u r\u1ea5t d\u1ec5 \u0111i v\u00e0o con \u0111\u01b0\u1eddng qu\u1ea3ng c\u00e1o th\u1ed5i ph\u1ed3ng, n\u00e2ng cao k\u1ef3 v\u1ecdng \u0111\u1ec3 d\u1eabn d\u1eaft b\u1ec7nh nh\u00e2n l\u00e0m x\u00e9t nghi\u1ec7m, gi\u00e1n ti\u1ebfp l\u00e0m l\u1ee3i cho \u0111\u01a1n v\u1ecb kinh doanh, ho\u1eb7c \u0111\u01a1n gi\u1ea3n l\u00e0 \u0111\u1ec3 th\u1ecfa m\u00e3n s\u1ef1 t\u00f2 m\u00f2 c\u1ee7a ch\u00ednh m\u00ecnh.<\/p>\n","protected":false},"excerpt":{"rendered":"

Gi\u1ea3i tr\u00ecnh t\u1ef1 gene l\u00e0 m\u1ed9t x\u00e9t nghi\u1ec7m t\u00e2n ti\u1ebfn \u0111\u1ec3 ph\u00e1t hi\u1ec7n c\u00e1c \u0111\u1ed9t bi\u1ebfn gene \u0111\u00f3, h\u1ee9a h\u1eb9n gi\u00fap b\u1ec7nh nh\u00e2n ung th\u01b0 t\u00ecm ra thu\u1ed1c nh\u1eafm \u0111\u00edch ph\u00f9 h\u1ee3p \u0111\u1ec3 c\u00f3 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb cao h\u01a1n.<\/p>\n","protected":false},"author":108,"featured_media":12119,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[3851,3852,2476],"series":[3817],"coauthors":[],"acf":[],"yoast_head":"\nGi\u1ea3i tr\u00ecnh t\u1ef1 gene trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0: C\u1ea7n \u0111u\u1ee3c \u201cgi\u1ea3i tr\u00ecnh\u201d chu \u0111\u00e1o<\/title>\n<meta name=\"description\" content=\"Gi\u1ea3i tr\u00ecnh t\u1ef1 gene l\u00e0 m\u1ed9t x\u00e9t nghi\u1ec7m t\u00e2n ti\u1ebfn \u0111\u1ec3 ph\u00e1t hi\u1ec7n c\u00e1c \u0111\u1ed9t bi\u1ebfn gene \u0111\u00f3, h\u1ee9a h\u1eb9n gi\u00fap b\u1ec7nh nh\u00e2n ung th\u01b0 t\u00ecm ra thu\u1ed1c nh\u1eafm \u0111\u00edch ph\u00f9 h\u1ee3p \u0111\u1ec3 c\u00f3 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb cao h\u01a1n.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/yhoccongdong.com\/ung-thu\/giai-trinh-tu-gene-trong-dieu-tri-ung-thu-can-duoc-giai-trinh-chu-dao\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gi\u1ea3i tr\u00ecnh t\u1ef1 gene trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0: C\u1ea7n \u0111u\u1ee3c \u201cgi\u1ea3i tr\u00ecnh\u201d chu \u0111\u00e1o\" \/>\n<meta property=\"og:description\" content=\"Gi\u1ea3i tr\u00ecnh t\u1ef1 gene l\u00e0 m\u1ed9t x\u00e9t nghi\u1ec7m t\u00e2n ti\u1ebfn \u0111\u1ec3 ph\u00e1t hi\u1ec7n c\u00e1c \u0111\u1ed9t bi\u1ebfn gene \u0111\u00f3, h\u1ee9a h\u1eb9n gi\u00fap b\u1ec7nh nh\u00e2n ung th\u01b0 t\u00ecm ra thu\u1ed1c nh\u1eafm \u0111\u00edch ph\u00f9 h\u1ee3p \u0111\u1ec3 c\u00f3 hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb cao h\u01a1n.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/yhoccongdong.com\/ung-thu\/giai-trinh-tu-gene-trong-dieu-tri-ung-thu-can-duoc-giai-trinh-chu-dao\/\" \/>\n<meta property=\"og:site_name\" content=\"D\u1ef1 \u00e1n Ung Th\u01b0\" \/>\n<meta property=\"article:author\" content=\"http:\/\/facebook.com\/beequy\" \/>\n<meta property=\"article:published_time\" content=\"2018-07-09T17:33:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/07\/giai-trinh-tu-gene-trong-dieu-tri-ung-thu.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"660\" \/>\n\t<meta property=\"og:image:height\" content=\"330\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"BS.TS. 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