{"id":12132,"date":"2018-08-26T15:38:12","date_gmt":"2018-08-26T08:38:12","guid":{"rendered":"https:\/\/yhoccongdong.org\/ung-thu\/te-bao-goc-trung-mo-ung-dung-va-hieu-qua-tren-lam-sang\/"},"modified":"2018-08-26T15:38:12","modified_gmt":"2018-08-26T08:38:12","slug":"te-bao-goc-trung-mo-ung-dung-va-hieu-qua-tren-lam-sang","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/ung-thu\/te-bao-goc-trung-mo-ung-dung-va-hieu-qua-tren-lam-sang\/","title":{"rendered":"T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4: \u1ee8ng d\u1ee5ng v\u00e0 hi\u1ec7u qu\u1ea3 tr\u00ean l\u00e2m s\u00e0ng?"},"content":{"rendered":"<ul>\n<li style=\"text-align: justify\">L\u00e2u l\u00e2u b\u1ea1n nghe \u201cng\u01b0\u1eddi ta\u201d k\u1ec3 r\u1eb1ng \u201cai \u0111\u00f3\u201d s\u1eed d\u1ee5ng tr\u1ecb li\u1ec7u t\u1ebf b\u00e0o g\u1ed1c th\u00e0nh c\u00f4ng v\u00e0 h\u1ebft b\u1ec7nh.<\/li>\n<li style=\"text-align: justify\">Th\u1ec9nh tho\u1ea3ng b\u1ea1n \u0111\u1ecdc th\u1ea5y v\u00e0i m\u1eabu tin t\u1ee9c, th\u1eadm ch\u00ed tr\u00ean c\u00e1c b\u00e1o l\u1edbn nh\u01b0 CNN, BBC, &#8230; v\u00e0 v\u00f4 s\u1ed1 h\u00e3ng kh\u00e1c k\u1ec3 c\u00e2u chuy\u1ec7n b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c tr\u1ecb li\u1ec7u t\u1ebf b\u00e0o g\u1ed1c th\u00e0nh c\u00f4ng \u1edf Mexico, Brazil, &#8230;<\/li>\n<\/ul>\n<p style=\"text-align: justify\">Nh\u1eefng c\u00e2u chuy\u1ec7n n\u00e0y c\u00f3 l\u00e0m b\u1ea1n t\u1ef1 h\u1ecfi:<\/p>\n<ul style=\"text-align: justify\">\n<li>T\u1ea1i sao li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o g\u1ed1c th\u1ea7n k\u00ec nh\u01b0 v\u1eady m\u00e0 l\u1ea1i kh\u00f4ng \u0111em ra l\u00e0m \u0111\u1ea1i tr\u00e0 cho b\u1ec7nh nh\u00e2n kh\u00f4ng?<\/li>\n<li>C\u00f3 ph\u1ea3i nh\u1eefng t\u1ed5 ch\u1ee9c qu\u1ea3n l\u00fd nh\u01b0 FDA (C\u1ee5c qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m) c\u1ee7a M\u1ef9 v\u00e0 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng c\u1ee7a ch\u00e2u \u00c2u l\u00e0m qu\u00e1 v\u00e0 gi\u00e1m s\u00e1t qu\u00e1 nghi\u00eam ng\u1eb7t kh\u00f4ng? T\u1ea1i sao h\u1ecd ph\u1ea3i l\u00e0m v\u1eady? \u0110\u1ec3 \u00e9p c\u00e1c c\u01a1 s\u1edf y t\u1ebf d\u1ecbch v\u1ee5?<\/li>\n<li>Nh\u1eefng li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o g\u1ed1c th\u01b0\u1eddng \u0111\u01b0\u1ee3c n\u00f3i t\u1edbi \u0111\u00f3 thu\u1ed9c d\u1ea1ng n\u00e0o?<\/li>\n<\/ul>\n<p style=\"text-align: justify\">C\u00f3 th\u1ec3 n\u00f3i r\u1eb1ng ph\u1ea7n l\u1edbn c\u00e1c d\u1ea1ng d\u1ecbch v\u1ee5 t\u1ebf b\u00e0o g\u1ed1c tr\u00ean th\u1ecb tr\u01b0\u1eddng hi\u1ec7n nay s\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c (tbg) trung m\u00f4. B\u00ean c\u1ea1nh \u0111\u00f3, s\u1ed1 l\u01b0\u1ee3ng c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1edbi tbg trung m\u00f4 \u0111ang t\u0103ng m\u1ea1nh nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y (850 th\u1eed nghi\u1ec7m t\u1ea1i th\u1eddi \u0111i\u1ec3m hi\u1ec7n t\u1ea1i). Danh s\u00e1ch c\u00e1c c\u0103n b\u1ec7nh \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m v\u1edbi tbg trung m\u00f4 ng\u00e0y c\u00e0ng d\u00e0i ra, t\u1eeb ti\u1ec3u \u0111\u01b0\u1eddng, tim m\u1ea1ch, th\u1ea5p kh\u1edbp, COPD, t\u1ef1 k\u1ec9, &#8230; v\u00e0 c\u1ea3 trong l\u00e0m \u0111\u1eb9p.<\/p>\n<p style=\"text-align: justify\">M\u1eb7c d\u00f9 tbg trung m\u00f4 d\u1ec5 thu nh\u1eadn t\u1eeb ch\u00ednh b\u1ec7nh nh\u00e2n. Nh\u01b0ng <strong>hi\u1ec7u qu\u1ea3 v\u00e0 t\u00e1c \u0111\u1ed9ng c\u1ee7a ch\u00fang c\u00f2n r\u1ea5t r\u1ea5t nhi\u1ec1u \u0111i\u1ec1u ch\u01b0a r\u00f5 r\u00e0ng, v\u1eabn c\u00f2n \u0111ang b\u1ecb b\u00e0n c\u00e3i.<\/strong><\/p>\n<h2 style=\"text-align: justify\"><strong>T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 \u2013 c\u00e1i t\u00ean kh\u00f4ng c\u00f3 xu\u1ea5t x\u1ee9 v\u00e0 c\u0103n c\u1ee9 r\u00f5 r\u00e0ng<\/strong><\/h2>\n<p style=\"text-align: justify\">L\u1ea7n theo l\u1ecbch s\u1eed, TS Alexander Fridenstein l\u00e0 ng\u01b0\u1eddi \u0111\u1ea7u ti\u00ean t\u00ecm ra t\u1ebf b\u00e0o n\u1ec1n (stromal cells) c\u00f3 vai tr\u00f2 h\u1ed7 tr\u1ee3 tbg t\u1ea1o m\u00e1u trong tu\u1ef7 x\u01b0\u01a1ng. N\u00ean ch\u00fang \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 t\u1ebf b\u00e0o n\u1ec1n t\u1eeb tu\u1ef7 x\u01b0\u01a1ng. Sau \u0111\u00f3, m\u1eb7c d\u00f9 ch\u1ec9 v\u1edbi m\u1ed9t \u00edt d\u1eef li\u1ec7u th\u1ef1c nghi\u1ec7m, ng\u01b0\u1eddi ta l\u1ea1i cho r\u1eb1ng nh\u1eefng t\u1ebf b\u00e0o n\u1ec1n n\u00e0y c\u00f3 th\u1ec3 t\u1ea1o th\u00e0nh c\u01a1, s\u1ee5n, &#8230; n\u00ean \u0111\u1ed5i t\u00ean ch\u00fang th\u00e0nh \u201ctbg trung m\u00f4\u201d (mesenchymal stem cell).<\/p>\n<p style=\"text-align: justify\">Nh\u01b0ng m\u00e0 th\u1ef1c ra, ch\u1eef \u201ctrung m\u00f4\u201d \u2013 mesenchyme l\u1ea1i c\u0169ng kh\u00f4ng ch\u00ednh x\u00e1c. Mesenchyme l\u00e0 m\u1ed9t d\u1ea1ng m\u00f4 ch\u1ec9 t\u1ed3n t\u1ea1i trong qu\u00e1 tr\u00ecnh ph\u00e1t tri\u1ec3n ph\u00f4i, c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n th\u00e0nh m\u00f4 li\u00ean k\u1ebft (connective tissue \u2013 l\u00e0 d\u1ea1ng m\u00f4 \u0111\u1ec7m, n\u1eb1m gi\u1eefa k\u1ebft n\u1ed1i c\u00e1c lo\u1ea1i m\u00f4 kh\u00e1c l\u1ea1i v\u1edbi nhau) v\u00e0 h\u1ec7 m\u00e1u v\u00e0 m\u1ea1ch m\u00e1u. Trong khi \u0111\u00f3, nh\u1eefng \u201ctbg trung m\u00f4\u201d \u0111\u01b0\u1ee3c thu nh\u1eadn \u1edf ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh th\u00ec l\u1ea1i kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng \u0111\u00f3!<\/p>\n<p style=\"text-align: justify\">Th\u00f4ng th\u01b0\u1eddng, \u0111\u1ec3 ph\u00e2n l\u1eadp m\u1ed9t lo\u1ea1i tbg, ng\u01b0\u1eddi ta th\u01b0\u1eddng d\u1ef1a v\u00e0o m\u1ed9t \u2013 v\u00e0i protein \u0111\u1eb7c tr\u01b0ng (marker) cho lo\u1ea1i tbg \u0111\u00f3. \u0110\u00e1ng bu\u1ed3n l\u00e0 ng\u01b0\u1eddi ta l\u1ea1i kh\u00f4ng t\u00ecm \u0111\u01b0\u1ee3c m\u1ed9t lo\u1ea1i protein n\u00e0o \u0111\u1eb7c tr\u01b0ng cho tbg trung m\u00f4 c\u1ea3. V\u00ec v\u1eady, ch\u00fang th\u01b0\u1eddng \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 lo\u1ea1i cu\u1ed1i c\u00f9ng, c\u00f2n s\u00f3t l\u1ea1i, sau khi lo\u1ea1i b\u1ecf t\u1ea5t c\u1ea3 nh\u1eefng lo\u1ea1i t\u1ebf b\u00e0o kh\u00e1c.<strong> (Quy tr\u00ecnh ph\u00e2n l\u1eadp n\u00e0y \u0111\u01b0\u1ee3c tr\u00ecnh b\u00e0y chi ti\u1ebft trong Ch\u01b0\u01a1ng 11 c\u1ee7a cu\u1ed1n s\u00e1ch Tbg \u2013 Kh\u00e1m ph\u00e1 c\u00f9ng nh\u00e0 khoa h\u1ecdc).<\/strong><\/p>\n<p style=\"text-align: justify\">T\u1eeb t\u1eeb, b\u1ea5t k\u1ec3 t\u1eeb m\u00f4 hay c\u01a1 quan n\u00e0o, c\u1ee9 lo\u1ea1i b\u1ecf h\u1ebft nh\u1eefng t\u1ebf b\u00e0o kh\u00e1c \u0111i, c\u00f2n s\u00f3t l\u1ea1i th\u00ec \u0111\u01b0\u1ee3c cho l\u00e0 tbg trung m\u00f4. Th\u00f4ng th\u01b0\u1eddng, d\u1ea1ng t\u1ebf b\u00e0o s\u00f3t l\u1ea1i n\u00e0y th\u01b0\u1eddng l\u00e0 t\u1eeb m\u00f4 li\u00ean k\u1ebft. N\u00ean ng\u01b0\u1eddi ta l\u1ea1i \u0111\u1ed3ng ho\u00e1 \u201ctbg trung m\u00f4\u201d v\u1edbi m\u00f4 li\u00ean k\u1ebft. V\u00e0 c\u1ee9 nh\u01b0 v\u1eady th\u00ec tbg trung m\u00f4 c\u00f3 \u1edf m\u1ecdi c\u01a1 quan trong c\u01a1 th\u1ec3. M\u00e0 n\u1ebfu \u0111i\u1ec1u n\u00e0y l\u00e0 \u0111\u00fang \u0111i n\u1eefa, th\u00ec m\u00f4 li\u00ean k\u1ebft \u1edf m\u1ed7i c\u01a1 quan l\u1ea1i r\u1ea5t kh\u00e1c nhau. N\u00ean tbg trung m\u00f4 c\u00f3 xu\u1ea5t x\u1ee9 kh\u00e1c nhau c\u0169ng kh\u00e1c bi\u1ec7t v\u00e0 kh\u00f4ng th\u1ec3 \u0111\u00e1nh \u0111\u1ed3ng. Ch\u1ee9c n\u0103ng v\u00e0 ph\u1ea3n \u1ee9ng c\u1ee7a ch\u00fang \u1edf m\u1ed7i m\u00f4i tr\u01b0\u1eddng c\u0169ng kh\u00e1c nhau v\u00e0 kh\u00f3 d\u1ef1 \u0111o\u00e1n \u0111\u01b0\u1ee3c. \u0110i\u1ec1u n\u00e0y s\u1ebd \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn hi\u1ec7u qu\u1ea3 tr\u1ecb li\u1ec7u s\u1ebd \u0111\u01b0\u1ee3c \u0111\u1ec1 c\u1eadp \u0111\u1ebfn \u1edf ph\u1ea7n sau.<\/p>\n<p style=\"text-align: justify\">C\u00e1i t\u00ean n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng kh\u00f4ng ch\u00ednh x\u00e1c, \u0111\u00e3 \u0111i qu\u00e1 xa so v\u1edbi ngu\u1ed3n g\u1ed1c v\u00e0 \u00fd ngh\u0129a ban \u0111\u1ea7u c\u1ee7a n\u00f3. Nhi\u1ec1u chuy\u00ean gia \u0111\u1ec1 xu\u1ea5t lo\u1ea1i b\u1ecf c\u00e1i t\u00ean \u201ctbg trung m\u00f4\u201d ra kh\u1ecfi h\u1ec7 th\u1ed1ng thu\u1eadt ng\u1eef c\u1ee7a tbg. N\u1ebfu trong nghi\u00ean c\u1ee9u, c\u00e1c nh\u00e0 khoa h\u1ecdc s\u1eed d\u1ee5ng thu\u1eadt ng\u1eef n\u00e0y th\u1eadn tr\u1ecdng bao nhi\u00eau, th\u00ec tr\u00ean th\u1ecb tr\u01b0\u1eddng d\u1ecbch v\u1ee5 tbg, n\u00f3 l\u1ea1i \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u201cv\u00f4 t\u1ed9i v\u1ea1\u201d b\u1ea5y nhi\u00eau.<\/p>\n<p style=\"text-align: justify\">C\u00e1i t\u00ean th\u1ec3 hi\u1ec7n b\u1ea3n ch\u1ea5t c\u1ee7a s\u1ef1 vi\u1ec7c. M\u1ed9t c\u00e1i t\u00ean kh\u00f4ng \u0111\u00fang v\u00e0 ch\u00ednh x\u00e1c, nh\u1ea5t l\u00e0 trong khoa h\u1ecdc, th\u01b0\u1eddng d\u1eabn \u0111\u1ebfn nhi\u1ec1u ng\u1ed9 nh\u1eadn v\u00e0 hi\u1ec3u l\u1ea7m. C\u00e1i t\u00ean \u201ctbg trung m\u00f4\u201d l\u00e0 m\u1ed9t tr\u01b0\u1eddng h\u1ee3p nh\u01b0 v\u1eady.<\/p>\n<h2 style=\"text-align: justify\"><strong>T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 hi\u1ec7n nay \u0111\u01b0\u1ee3c l\u1ea5y t\u1eeb \u0111\u00e2u?<\/strong><\/h2>\n<p style=\"text-align: justify\">Nh\u01b0 \u0111\u00e3 n\u00f3i \u1edf tr\u00ean, c\u1ee9 l\u00e0 th\u00e0nh ph\u1ea7n t\u1ebf b\u00e0o c\u00f2n s\u00f3t l\u1ea1i, sau khi lo\u1ea1i b\u1ecf nh\u1eefng t\u1ebf b\u00e0o kh\u00e1c, th\u00ec \u0111\u01b0\u1ee3c cho l\u00e0 tbg trung m\u00f4. N\u00ean ng\u01b0\u1eddi ta c\u00f3 th\u1ec3 t\u00ecm th\u1ea5y n\u00f3 \u1edf m\u1ecdi n\u01a1i trong c\u01a1 th\u1ec3. Trong tr\u1ecb li\u1ec7u, m\u00f4 m\u1ee1, cu\u1ed1ng r\u1ed1n, tu\u1ef7 x\u01b0\u01a1ng l\u00e0 nh\u1eefng \u0111\u1ecba \u0111i\u1ec3m \u0111\u01b0\u1ee3c \u01b0a chu\u1ed9ng \u0111\u1ec3 ph\u00e2n l\u1eadp c\u00e1c t\u1ebf b\u00e0o \u2013 \u0111\u01b0\u1ee3c cho l\u00e0 tbg trung m\u00f4. \u0110\u1eb7c bi\u1ec7t, m\u00f4 m\u1ee1 &#8211; lo\u1ea1i m\u00f4 b\u1ecb gh\u00e9t b\u1ecf nh\u1ea5t \u2013 l\u1ea1i l\u00e0 n\u01a1i \u0111\u01b0\u1ee3c cho l\u00e0 c\u00f3 nhi\u1ec1u tbg trung m\u00f4 nh\u1ea5t. C\u1ee9 l\u1ea5y m\u1ee1 ra l\u00e0 c\u00f3 tbg!<\/p>\n<p style=\"text-align: justify\">G\u1ea7n \u0111\u00e2y, tbg trung m\u00f4 c\u00f2n \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb tbg v\u1ea1n n\u0103ng nh\u00e2n t\u1ea1o iPSC n\u1eefa. Hi\u1ec7n c\u00f3 v\u00f4 s\u1ed1 quy tr\u00ecnh \u201cs\u1ea3n xu\u1ea5t\u201d tbg trung m\u00f4 d\u1ea1ng n\u00e0y, m\u1ed7i quy tr\u00ecnh t\u1ea1o ra m\u1ed9t s\u1ea3n ph\u1ea9m kh\u00e1c nhau.<\/p>\n<h2 style=\"text-align: justify\"><strong>T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 c\u00f3 kh\u1ea3 n\u0103ng t\u1ea1o th\u00e0nh t\u1ebf b\u00e0o ch\u1ee9c n\u0103ng g\u00ec?<\/strong><\/h2>\n<p style=\"text-align: justify\">M\u1ed9t \u0111\u1eb7c t\u00ednh s\u1ed1ng c\u00f2n c\u1ee7a tbg l\u00e0 kh\u1ea3 n\u0103ng bi\u1ec7t ho\u00e1 \u2013 t\u1ee9c l\u00e0 kh\u1ea3 n\u0103ng t\u1ea1o ra nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o ch\u1ee9c n\u0103ng kh\u00e1c nhau. \u201cTbg trung m\u00f4\u201d t\u1eeb tu\u1ef7 x\u01b0\u01a1ng n\u00f3i ri\u00eang v\u00e0 c\u00e1c c\u01a1 quan kh\u00e1c n\u00f3i chung, c\u00f3 kh\u1ea3 n\u0103ng bi\u1ec7t ho\u00e1 <strong>r\u1ea5t h\u1ea1n ch\u1ebf<\/strong>, t\u1ea1o th\u00e0nh x\u01b0\u01a1ng, s\u1ee5n v\u00e0 m\u00f4 m\u1ee1 m\u00e0 th\u00f4i. Kh\u1ea3 n\u0103ng bi\u1ec7t ho\u00e1 h\u1ea1n ch\u1ebf n\u00e0y kh\u00f4ng c\u00f3 gi\u00e1 tr\u1ecb nhi\u1ec1u trong tr\u1ecb li\u1ec7u. Nh\u01b0ng c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n.<\/p>\n<h2 style=\"text-align: justify\"><strong>T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 v\u1edbi kh\u1ea3 n\u0103ng \u0111i\u1ec1u ho\u00e0 mi\u1ec5n d\u1ecbch<\/strong><\/h2>\n<p style=\"text-align: justify\">Theo k\u1ef3 v\u1ecdng v\u00e0 ti\u00ean \u0111o\u00e1n c\u1ee7a nhi\u1ec1u ng\u01b0\u1eddi, kh\u1ea3 n\u0103ng \u0111i\u1ec1u ho\u00e0 mi\u1ec5n d\u1ecbch c\u1ee7a tbg trung m\u00f4 l\u00e0 t\u1ef1 nhi\u00ean v\u00e0 v\u00f4 song. \u1ede hi\u1ec7n t\u1ea1i,<strong> kh\u00f4ng<\/strong> c\u00f3 \u0111\u1ee7 d\u1eef li\u1ec7u th\u1ef1c nghi\u1ec7m v\u00e0 l\u00e2m s\u00e0ng ch\u1ee9ng t\u1ecf cho k\u1ef3 v\u1ecdng \u0111\u00f3!<\/p>\n<p style=\"text-align: justify\">\u0110i\u1ec1u ho\u00e0 mi\u1ec5n d\u1ecbch (immunomodulation) l\u00e0 kh\u1ea3 n\u0103ng ti\u1ebft ra c\u00e1c h\u1ee3p ch\u1ea5t sinh h\u1ecdc \u0111\u1ec3 \u0111i\u1ec1u ho\u00e0 h\u1ec7 mi\u1ec5n d\u1ecbch, duy tr\u00ec s\u1ef1 c\u00e2n b\u1eb1ng cho c\u01a1 th\u1ec3. B\u1edfi v\u00ec n\u1ebfu h\u1ec7 mi\u1ec5n d\u1ecbch ho\u1ea1t \u0111\u1ed9ng qu\u00e1 m\u1ea1nh hay qu\u00e1 y\u1ebfu \u0111\u1ec1u d\u1eabn \u0111\u1ebfn nhi\u1ec1u b\u1ec7nh t\u1eadt. Tbg trung m\u00f4 c\u00f3 kh\u1ea3 n\u0103ng n\u00e0y kh\u00f4ng? C\u00f3. nh\u01b0ng \u0111i\u1ec1u ho\u00e0 nh\u01b0 th\u1ebf n\u00e0o, \u1edf \u0111\u00e2u, b\u1eb1ng ph\u01b0\u01a1ng th\u1ee9c g\u00ec, t\u00e1c \u0111\u1ed9ng ra sao,&#8230; th\u00ec v\u00f4 c\u00f9ng kh\u00e1c nhau tu\u1ef3 v\u00e0o ngu\u1ed3n g\u1ed1c c\u1ee7a tbg trung m\u00f4, n\u01a1i n\u00f3 t\u1edbi, m\u00f4i tr\u01b0\u1eddng xung quanh, t\u00ecnh tr\u1ea1ng c\u01a1 th\u1ec3,&#8230; S\u1ed1 li\u1ec7u v\u00e0 b\u1eb1ng ch\u1ee9ng t\u1eeb th\u1ef1c nghi\u1ec7m v\u00e0 l\u00e2m s\u00e0ng cho nh\u1eefng c\u00e2u h\u1ecfi n\u00e0y v\u1eabn c\u00f2n r\u1ea5t \u00edt \u1ecfi.<\/p>\n<p style=\"text-align: justify\">Ch\u1eb3ng h\u1ea1n, tbg trung m\u00f4 t\u1eeb tu\u1ef7 x\u01b0\u01a1ng \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 th\u1ec3 \u1ee9c ch\u1ebf\/k\u00edch ho\u1ea1t\/\u0111i\u1ec1u ho\u00e0 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a m\u1ed9t lo\u1ea1t t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch nh\u01b0 t\u1ebf b\u00e0o T, B, NK,&#8230; Nh\u01b0ng, tbg trung m\u00f4 t\u1eeb c\u00e1c c\u01a1 quan kh\u00e1c th\u00ec kh\u1ea3 n\u0103ng n\u00e0y r\u1ea5t kh\u00e1c nhau v\u00e0 h\u1ea1n ch\u1ebf. M\u1ed9t nghi\u00ean c\u1ee9u xem x\u00e9t kh\u1ea3 n\u0103ng \u1ee9c ch\u1ebf t\u1ebf b\u00e0o T, B, NK \u1edf m\u00e1u ngo\u1ea1i vi v\u00e0 th\u1ea5y r\u1eb1ng tbg trung m\u00f4 t\u1eeb cu\u1ed1ng r\u1ed1n kh\u00f4ng c\u00f3 t\u00e1c d\u1ee5ng nhi\u1ec1u v\u1edbi t\u1ebf b\u00e0o B v\u00e0 NK.<\/p>\n<h2 style=\"text-align: justify\"><strong>C\u00e1c v\u1ea5n \u0111\u1ec1 khi s\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 v\u00e0o tr\u1ecb li\u1ec7u<\/strong><\/h2>\n<p style=\"text-align: justify\">V\u00ec b\u1ea3n ch\u1ea5t, ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 s\u1ed1 l\u01b0\u1ee3ng c\u1ee7a tbg trung m\u00f4 ph\u1ee5 thu\u1ed9c v\u00e0o qu\u00e1 nhi\u1ec1u y\u1ebfu t\u1ed1 nh\u01b0 b\u1ec7nh nh\u00e2n, lo\u1ea1i m\u00f4 \u0111\u01b0\u1ee3c thu nh\u1eadn, quy tr\u00ecnh thu nh\u1eadn\/nu\u00f4i c\u1ea5y. C\u00f2n t\u00e1c d\u1ee5ng c\u1ee7a tbg trung m\u00f4 sau khi c\u1ea5y gh\u00e9p th\u00ec c\u0169ng b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi d\u1ea1ng b\u1ec7nh, c\u01a1 quan b\u1ecb b\u1ec7nh, lo\u1ea1i t\u1ebf b\u00e0o b\u1ecb b\u1ec7nh,&#8230; Ngo\u00e0i ra, ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a tbg trung m\u00f4 c\u00f2n ph\u1ee5 thu\u1ed9c r\u1ea5t nhi\u1ec1u v\u00e0o thao t\u00e1c trong quy tr\u00ecnh thu nh\u1eadn, nu\u00f4i c\u1ea5y v\u00e0 b\u1ea3o qu\u1ea3n. V\u00ed d\u1ee5 tbg trung m\u00f4 t\u1eeb m\u00f4 m\u1ee1 \u0111\u01b0\u1ee3c c\u1ea5y v\u00e0o kh\u1edbp th\u00ec s\u1ebd c\u00f3 t\u00e1c d\u1ee5ng kh\u00e1c v\u1edbi c\u1ea5y l\u00ean m\u1eb7t trong th\u1ea9m m\u1ef9. \u1ede m\u1ed7i n\u01a1i, l\u00e0m sao bi\u1ebft \u0111\u01b0\u1ee3c ch\u00fang s\u1ebd c\u00f3 t\u00e1c d\u1ee5ng nh\u01b0 th\u1ebf n\u00e0o?<\/p>\n<p style=\"text-align: justify\"><strong><em>\u0110\u00e2y l\u00e0 l\u00ed do m\u00e0 FDA v\u00e0 c\u00e1c t\u1ed5 ch\u1ee9c t\u01b0\u01a1ng \u0111\u01b0\u01a1ng qu\u1ea3n l\u00ed v\u00e0 gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd \u0111\u1ed1i v\u1edbi c\u00e1c quy tr\u00ecnh tr\u1ecb li\u1ec7u tbg trung m\u00f4.\u00a0<\/em><\/strong>\u0110\u1ed1i v\u1edbi m\u1ed7i ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb m\u1edbi, nh\u01b0 \u00e1p d\u1ee5ng lo\u1ea1i tbg trung m\u00f4 n\u00e0o \u0111\u1ec3 ch\u1eefa b\u1ec7nh g\u00ec, nh\u1eefng ng\u01b0\u1eddi th\u1ef1c hi\u1ec7n ph\u1ea3i \u0111\u01b0a ra k\u1ebft qu\u1ea3 v\u00e0 d\u1eef li\u1ec7u c\u1ee7a <em>nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng <\/em>tr\u00ean \u0111\u1ed9ng v\u1eadt v\u00e0 th\u1ef1c hi\u1ec7n <em>th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng <\/em>theo quy tr\u00ecnh ch\u1eb7t ch\u1ebd, trong t\u1eebng giai \u0111o\u1ea1n t\u1eeb I \u2013 IV. (\u0110\u1ecdc th\u00eam v\u1ec1 c\u00e1c quy \u0111\u1ecbnh m\u1edbi c\u1ee7a FDA: <a href=\"https:\/\/www.facebook.com\/notes\/s%C3%A1ch-t%E1%BA%BF-b%C3%A0o-g%E1%BB%91c-kh%C3%A1m-ph%C3%A1-c%C3%B9ng-nh%C3%A0-khoa-h%E1%BB%8Dc\/%C4%91%E1%BB%8Dc-b%C3%A1o-gi%C3%B9m-b%E1%BA%A1n-c%C3%A2n-b%E1%BA%B1ng-gi%E1%BB%AFa-an-to%C3%A0n-v%C3%A0-ph%C3%A1t-minh-cho-ng%C3%A0nh-y-h%E1%BB%8Dc-t%C3%A1i-t%E1%BA%A1o\/263055587568334\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.facebook.com\/notes\/s\u00e1ch-tbg-kh\u00e1m-ph\u00e1-c\u00f9ng-nh\u00e0-khoa-h\u1ecdc\/\u0111\u1ecdc-b\u00e1o-gi\u00f9m-b\u1ea1n-c\u00e2n-b\u1eb1ng-gi\u1eefa-an-to\u00e0n-v\u00e0-ph\u00e1t-minh-cho-ng\u00e0nh-y-h\u1ecdc-t\u00e1i-t\u1ea1o\/263055587568334\/<\/a>).<\/p>\n<p style=\"text-align: justify\">Hi\u1ec7n t\u1ea1i, m\u1eb7c d\u00f9 c\u00f3 r\u1ea5t nhi\u1ec1u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng v\u1edbi tbg trung m\u00f4. Nh\u01b0ng nh\u1eefng th\u1eed nghi\u1ec7m n\u00e0y th\u01b0\u1eddng kh\u00f4ng cho hi\u1ec7u qu\u1ea3 r\u00f5 r\u00e0ng v\u00ec nh\u1eefng l\u00fd do sau:<\/p>\n<ul style=\"text-align: justify\">\n<li>Nhi\u1ec1u th\u1eed nghi\u1ec7m cho th\u1ea5y hi\u1ec7u qu\u1ea3 do \u0111i\u1ec1u tr\u1ecb tbg trung m\u00f4 so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c (placebo) l\u00e0 kh\u00f4ng kh\u00e1c bi\u1ec7t \u0111\u00e1ng k\u1ec3.<\/li>\n<li>Nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p th\u1eed nghi\u1ec7m (\u0111\u1eb7c bi\u1ec7t do trung t\u00e2m y t\u1ebf d\u1ecbch v\u1ee5) kh\u00f4ng c\u00f4ng b\u1ed1 nh\u1eefng tr\u01b0\u1eddng h\u1ee3p c\u00f3 k\u1ebft qu\u1ea3 x\u1ea5u ho\u1eb7c kh\u00f4ng \u0111\u00e1ng k\u1ec3.<\/li>\n<li>V\u1edbi nhi\u1ec1u y\u1ebfu t\u1ed1 bi\u1ebfn \u0111\u1ed9ng nh\u01b0 v\u1eady, \u0111\u1ec3 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f3 k\u1ebft qu\u1ea3 \u0111\u00e1ng tin c\u1eady th\u00ec c\u1ea7n s\u1ed1 l\u01b0\u1ee3ng m\u1eabu l\u1edbn. Tuy nhi\u00ean, h\u1ea7u h\u1ebft c\u00e1c th\u1eed nghi\u1ec7m ch\u1ec9 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n v\u1edbi s\u1ed1 \u00edt b\u1ec7nh nh\u00e2n. H\u01a1n n\u1eefa, c\u00e1c th\u1eed nghi\u1ec7m c\u0169ng d\u00e0n tr\u1ea3i tr\u00ean r\u1ea5t nhi\u1ec1u lo\u1ea1i b\u1ec7nh, n\u00ean r\u1ea5t kh\u00f3 \u0111\u1ec3 so s\u00e1nh hi\u1ec7u qu\u1ea3 v\u00e0 c\u00e1ch th\u1ee9c t\u00e1c \u0111\u1ed9ng.<\/li>\n<li>S\u1ef1 thay \u0111\u1ed5i v\u1ec1 ngu\u1ed3n tbg trung m\u00f4 v\u00e0 tu\u1ed5i c\u1ee7a b\u1ec7nh nh\u00e2n c\u0169ng \u1ea3nh h\u01b0\u1edfng nhi\u1ec1u \u0111\u1ebfn k\u1ebft qu\u1ea3.<\/li>\n<li>C\u00e1c quy tr\u00ecnh thao t\u00e1c kh\u00f4ng nh\u1ea5t qu\u00e1n c\u00f3 th\u1ec3 l\u00e0m thay \u0111\u1ed5i ch\u1ea5t l\u01b0\u1ee3ng tbg trung m\u00f4 trong th\u1eed nghi\u1ec7m.<\/li>\n<\/ul>\n<h2 style=\"text-align: justify\"><strong>T\u00f3m t\u1eaft<\/strong><\/h2>\n<p style=\"text-align: justify\">T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 r\u1ea5t \u0111a d\u1ea1ng v\u1ec1 ngu\u1ed3n g\u1ed1c v\u00e0 xu\u1ea5t x\u1ee9. V\u00ec v\u1eady t\u00e1c \u0111\u1ed9ng v\u00e0 hi\u1ec7u qu\u1ea3 cho t\u1eebng b\u1ec7nh c\u0169ng r\u1ea5t kh\u00e1c nhau. Tr\u01b0\u1edbc khi \u00e1p d\u1ee5ng v\u00e0o \u0111i\u1ec1u tr\u1ecb m\u1ed9t lo\u1ea1i b\u1ec7nh m\u1edbi. C\u1ea7n ph\u1ea3i th\u1ef1c hi\u1ec7n quy tr\u00ecnh nghi\u00ean c\u1ee9u v\u00e0 th\u1eed nghi\u1ec7m \u0111\u1ea7y \u0111\u1ee7 \u0111\u1ec3 hi\u1ec3u r\u00f5 t\u00e1c d\u1ee5ng v\u00e0 \u0111\u1ed9 an to\u00e0n. B\u00ean c\u1ea1nh \u0111\u00f3, c\u1ea7n chu\u1ea9n ho\u00e1 quy tr\u00ecnh ph\u00e2n l\u1eadp, thao t\u00e1c, nu\u00f4i c\u1ea5y, b\u1ea3o qu\u1ea3n tbg trung m\u00f4. C\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng c\u1ee7a tbg trung m\u00f4 \u0111\u1ed1i v\u1edbi t\u1eebng lo\u1ea1i b\u1ec7nh c\u0169ng c\u1ea7n \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u l\u00e0m r\u00f5. C\u00e1c b\u1ec7nh nh\u00e2n n\u00ean t\u00ecm hi\u1ec3u r\u00f5 quy tr\u00ecnh v\u00e0 ph\u00e1c \u0111\u1ed3 \u0111i\u1ec1u tr\u1ecb, th\u00f4ng tin v\u1ec1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, t\u00ednh an to\u00e0n c\u1ee7a m\u1ed7i quy tr\u00ecnh tr\u01b0\u1edbc khi tham gia.<\/p>\n<h2 style=\"text-align: justify\"><strong>T\u00e0i li\u1ec7u tham kh\u1ea3o <\/strong><\/h2>\n<ol style=\"text-align: justify\">\n<li><a href=\"https:\/\/l.facebook.com\/l.php?u=https%3A%2F%2Fwww.nature.com%2Farticles%2Fcddis2015327%2523ref1&amp;h=AT2s-ze6OiuJuagoGelu5NlhtXgp61ukQn890rVrYUPE2196AaxHIxOJk4gGpudCNuqh8AvkXgq642djJL1wkZRqoIVK0gdWGnDhzpSiIB8X498ZGWiHzFYNXO2bTkGoinA\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/cddis2015327#ref1<\/a><\/li>\n<li><a href=\"https:\/\/l.facebook.com\/l.php?u=https%3A%2F%2Fwww.nature.com%2Farticles%2Fnrm.2016.10&amp;h=AT22o3bV4dU1OL6upXVoCARHtgWgHRsBhu7wtGCE00rF0xd6MWCDLAlbapR-lrtfFMz6VRGNtcwtIldPUfntrDmE1yM4Vq-FciHsQdzRL5X0l3II864UlT6xPKZSZ-RPQ5s\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/nrm.2016.10<\/a><\/li>\n<li><a href=\"https:\/\/l.facebook.com\/l.php?u=https%3A%2F%2Fwww.nature.com%2Farticles%2Fnm.3028&amp;h=AT0AqVSqdBFN41SCbszHa93jxwJBlUTpKe9_vWE2PUVWBnreeiZAAyBaxCu8gduqI9GSndXzyrLzOfhW6VI7fJLQTZh1gilABqSC4D_lHafBpeO3QBKjNeYstgUTQcccVqk\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/nm.3028<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/nbt.2816\" target=\"_blank\" rel=\"noopener\">https:\/\/www.nature.com\/articles\/nbt.2816<\/a><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5399967\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5399967\/<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 r\u1ea5t \u0111a d\u1ea1ng v\u1ec1 ngu\u1ed3n g\u1ed1c v\u00e0 xu\u1ea5t x\u1ee9, v\u00ec v\u1eady t\u00e1c \u0111\u1ed9ng v\u00e0 hi\u1ec7u qu\u1ea3 cho t\u1eebng b\u1ec7nh c\u0169ng r\u1ea5t kh\u00e1c nhau.<\/p>\n","protected":false},"author":380,"featured_media":12133,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[3854,3842,3855],"series":[3817],"coauthors":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4: \u1ee8ng d\u1ee5ng v\u00e0 hi\u1ec7u qu\u1ea3 tr\u00ean l\u00e2m s\u00e0ng?<\/title>\n<meta name=\"description\" content=\"T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 r\u1ea5t \u0111a d\u1ea1ng v\u1ec1 ngu\u1ed3n g\u1ed1c v\u00e0 xu\u1ea5t x\u1ee9, v\u00ec v\u1eady t\u00e1c \u0111\u1ed9ng v\u00e0 hi\u1ec7u qu\u1ea3 cho t\u1eebng b\u1ec7nh c\u0169ng r\u1ea5t kh\u00e1c nhau.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/yhoccongdong.com\/ung-thu\/te-bao-goc-trung-mo-ung-dung-va-hieu-qua-tren-lam-sang\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4: \u1ee8ng d\u1ee5ng v\u00e0 hi\u1ec7u qu\u1ea3 tr\u00ean l\u00e2m s\u00e0ng?\" \/>\n<meta property=\"og:description\" content=\"T\u1ebf b\u00e0o g\u1ed1c trung m\u00f4 r\u1ea5t \u0111a d\u1ea1ng v\u1ec1 ngu\u1ed3n g\u1ed1c v\u00e0 xu\u1ea5t x\u1ee9, v\u00ec v\u1eady t\u00e1c \u0111\u1ed9ng v\u00e0 hi\u1ec7u qu\u1ea3 cho t\u1eebng b\u1ec7nh c\u0169ng r\u1ea5t kh\u00e1c nhau.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/yhoccongdong.com\/ung-thu\/te-bao-goc-trung-mo-ung-dung-va-hieu-qua-tren-lam-sang\/\" \/>\n<meta property=\"og:site_name\" content=\"D\u1ef1 \u00e1n Ung Th\u01b0\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/kimvybear\" \/>\n<meta property=\"article:published_time\" content=\"2018-08-26T08:38:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/08\/Te-bao-goc-trung-mo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"660\" \/>\n\t<meta property=\"og:image:height\" content=\"330\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"TS. 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