{"id":12194,"date":"2018-12-04T08:30:04","date_gmt":"2018-12-04T01:30:04","guid":{"rendered":"https:\/\/yhoccongdong.org\/ung-thu\/giac-ngu-don-dep-chat-thai-ba-trong-nao-benh-alzheimer\/"},"modified":"2018-12-04T08:30:04","modified_gmt":"2018-12-04T01:30:04","slug":"giac-ngu-don-dep-chat-thai-ba-trong-nao-benh-alzheimer","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/ung-thu\/giac-ngu-don-dep-chat-thai-ba-trong-nao-benh-alzheimer\/","title":{"rendered":"Gi\u1ea5c ng\u1ee7 – d\u1ecdn d\u1eb9p ch\u1ea5t th\u1ea3i b\u00e3 trong n\u00e3o – b\u1ec7nh Alzheimer"},"content":{"rendered":"

Gi\u1ea5c ng\u1ee7 v\u1edbi s\u1ee9c kh\u1ecfe con ng\u01b0\u1eddi<\/strong><\/h2>\n

Ch\u00fang ta \u0111\u1ec1u bi\u1ebft gi\u1ea5c ng\u1ee7 l\u00e0 v\u00f4 c\u00f9ng quan tr\u1ecdng v\u1edbi s\u1ee9c kho\u1ebb th\u1ec3 ch\u1ea5t v\u00e0 tinh th\u1ea7n. Gi\u1ea5c ng\u1ee7 kh\u00f4ng ch\u1ec9 l\u00e0 th\u1eddi gian cho c\u01a1 th\u1ec3 ngh\u1ec9 ng\u01a1i<\/strong>, m\u00e0 c\u00f2n gi\u00fap t\u0103ng c\u01b0\u1eddng tr\u00ed nh\u1edb<\/strong>, s\u1ef1 t\u1eadp trung<\/strong>, s\u1ef1 s\u00e1ng t\u1ea1o<\/strong> c\u1ee7a c\u00e1c ho\u1ea1t \u0111\u1ed9ng th\u1ea7n kinh. Thi\u1ebfu ng\u1ee7 v\u00e0 m\u1ea5t ng\u1ee7<\/a> l\u00e2u d\u00e0i c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn nh\u1eefng r\u1ed1i lo\u1ea1n, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng v\u00e0 ho\u1ea1t \u0111\u1ed9ng tr\u00ed n\u00e3o c\u1ee7a con ng\u01b0\u1eddi. Tuy v\u1eady, ch\u1ec9 g\u1ea7n \u0111\u00e2y c\u00e1c nh\u00e0 khoa h\u1ecdc m\u1edbi b\u1eaft \u0111\u1ea7u hi\u1ec3u \u0111\u01b0\u1ee3c nguy\u00ean nh\u00e2n v\u00ec sao gi\u1ea5c ng\u1ee7 l\u1ea1i quan tr\u1ecdng nh\u01b0 v\u1eady v\u1edbi b\u1ed9 n\u00e3o. \u0110\u00f3 l\u00e0 b\u1edfi v\u00ec khi ch\u00fang ta ng\u1ee7, ch\u00ednh l\u00e0 l\u00fac b\u1ed9 n\u00e3o \u201cd\u1ecdn d\u1eb9p\u201d c\u0103n nh\u00e0 c\u1ee7a m\u00ecnh<\/strong>.<\/p>\n

V\u00ec sao gi\u1ea5c ng\u1ee7 l\u1ea1i quan tr\u1ecdng nh\u01b0 v\u1eady v\u1edbi b\u1ed9 n\u00e3o?<\/strong><\/h2>\n

Ngo\u00e0i b\u1ed9 n\u00e3o, ph\u1ea7n c\u00f2n l\u1ea1i c\u1ee7a c\u01a1 th\u1ec3 \u0111\u1ec1u ti\u1ebfp x\u00fac v\u1edbi m\u1ea1ch m\u00e1u c\u1ee7a h\u1ec7 tu\u1ea7n ho\u00e0n v\u00e0 m\u1ea1ch b\u1ea1ch huy\u1ebft<\/a> c\u1ee7a h\u1ec7 b\u1ea1ch huy\u1ebft (lymphatic system). N\u1ebfu nh\u01b0 m\u1ea1ch m\u00e1u \u0111em ch\u1ea5t dinh d\u01b0\u1ee1ng v\u00e0 oxy \u0111\u1ebfn nu\u00f4i c\u00e1c c\u01a1 quan v\u00e0 t\u1ebf b\u00e0o, th\u00ec m\u1ea1ch b\u1ea1ch huy\u1ebft \u0111\u00f3ng vai tr\u00f2 thu gom<\/strong>, d\u1ecdn s\u1ea1ch nh\u1eefng ch\u1ea5t th\u1ea3<\/strong>i do t\u1ebf b\u00e0o t\u1ea1o ra nh\u01b0 acid lactic, amoniac,… r\u1ed3i nh\u1eadp chung v\u1edbi h\u1ec7 tu\u1ea7n ho\u00e0n v\u00e0 \u0111\u01b0\u1ee3c x\u1eed l\u00fd t\u1ea1i th\u1eadn.<\/p>\n

Ng\u01b0\u1ee3c l\u1ea1i, b\u1ed9 n\u00e3o c\u00f3 m\u1ed9t lo\u1ea1i m\u00e0ng \u0111\u1eb7c bi\u1ec7t, c\u00f3 t\u00ean l\u00e0 h\u00e0ng r\u00e0o m\u00e1u n\u00e3o<\/strong> (blood brain barrier). H\u00e0ng r\u00e0o n\u00e0y t\u00e1ch bi\u1ec7t d\u00f2ng m\u00e1u \u0111\u1ebfn n\u00e3o v\u1edbi d\u1ecbch n\u00e3o tu\u1ef7 (cerebrospinal fluid) – m\u1ed9t dung d\u1ecbch n\u1eb1m \u1edf m\u00e0ng n\u00e3o v\u00e0 n\u00e3o th\u1ea5t, c\u00f3 vai tr\u00f2 \u0111\u1ec7m, \u0111i\u1ec1u ho\u00e0, b\u1ea3o v\u1ec7 v\u00e0 l\u00e0m s\u1ea1ch n\u00e3o. H\u00e0ng r\u00e0o m\u00e1u n\u00e3o c\u00f3 c\u1ea5u t\u1ea1o r\u1ea5t \u0111\u1eb7c bi\u1ec7t, ch\u1ec9 cho ph\u00e9p m\u1ed9t s\u1ed1 ph\u00e2n t\u1eed nh\u1ecf nh\u01b0 n\u01b0\u1edbc, kh\u00ed, glucose, amino acid, ch\u1ea5t b\u00e9o \u0111i qua. B\u1ed9 n\u00e3o ho\u00e0n to\u00e0n kh\u00f4ng c\u00f3 h\u1ec7 b\u1ea1ch huy\u1ebft. Ch\u1ea5t th\u1ea3i t\u1eeb c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh \u0111\u01b0\u1ee3c ti\u1ebft ra d\u1ecbch m\u00f4 k\u1ebd (interstitial fluid) v\u00e0 \u0111\u01b0\u1ee3c thu gom l\u1ea1i \u1edf d\u1ecbch n\u00e3o tu\u1ef7.<\/p>\n

H\u1ec7 b\u1ea1ch huy\u1ebft G<\/strong><\/h2>\n

T\u1eeb nghi\u00ean c\u1ee9u \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed Science n\u0103m 2013 v\u00e0 nhi\u1ec1u nghi\u00ean c\u1ee9u ti\u1ebfp theo sau \u0111\u00f3, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 t\u00ecm th\u1ea5y v\u00e0 x\u00e1c \u0111\u1ecbnh \u0111\u1eb7c t\u00ednh, c\u00e1ch th\u1ee9c ho\u1ea1t \u0111\u1ed9ng c\u1ee7a m\u1ed9t h\u1ec7 th\u1ed1ng k\u00eanh nh\u1ecf, \u0111\u01b0\u1ee3c \u0111\u1eb7t t\u00ean l\u00e0 h\u1ec7 b\u1ea1ch huy\u1ebft g<\/strong> (glymphatic system). Ch\u1eef \u201cg\u201d l\u00e0 v\u00ec nh\u1eefng k\u00eanh nh\u1ecf n\u00e0y thu\u1ed9c v\u1ec1 c\u00e1c t\u1ebf b\u00e0o glial<\/strong>, m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o n\u1eb1m trong n\u00e3o nh\u01b0ng kh\u00f4ng ph\u1ea3i l\u00e0 t\u1ebf b\u00e0o th\u1ea7n kinh<\/strong>. H\u1ec7 th\u1ed1ng n\u00e0y c\u00f3 vai tr\u00f2 nh\u01b0 h\u1ec7 b\u1ea1ch huy\u1ebft c\u1ee7a b\u1ed9 n\u00e3o, v\u1eadn chuy\u1ec3n v\u00e0 lo\u1ea1i b\u1ecf nh\u1eefng ch\u1ea5t th\u1ea3i b\u00e3 v\u00e0 ch\u1ea5t \u0111\u1ed9c<\/strong> t\u1eeb c\u00e1c ho\u1ea1t \u0111\u1ed9ng th\u1ea7n kinh.<\/p>\n

Ho\u1ea1t \u0111\u1ed9ng c\u1ee7a h\u1ec7 th\u1ed1ng k\u00eanh n\u00e0y c\u1ea7n r\u1ea5t nhi\u1ec1u n\u0103ng l\u01b0\u1ee3ng n\u00ean h\u1ec7 th\u1ea7n kinh<\/a> kh\u00f4ng th\u1ec3 l\u00e0m vi\u1ec7c n\u00e0y c\u00f9ng l\u00fac v\u1edbi c\u00e1c ho\u1ea1t \u0111\u1ed9ng th\u1ea7n kinh \u0111\u01b0\u1ee3c. Thay v\u00e0o \u0111\u00f3, c\u00e1c k\u00eanh n\u00e0y l\u00e0m vi\u1ec7c t\u00edch c\u1ef1c h\u01a1n khi h\u1ec7 th\u1ea7n kinh d\u1eebng ho\u1ea1t \u0111\u1ed9ng \u2013 ch\u00ednh l\u00e0 l\u00fac ng\u1ee7<\/strong>. Nh\u00f3m nghi\u00ean c\u1ee9u th\u1ea5y r\u1eb1ng khi nh\u1eefng ch\u00fa chu\u1ed9t ngh\u1ec9 ng\u01a1i v\u00e0 ng\u1ee7, th\u00ec d\u00f2ng ch\u1ea3y c\u1ee7a d\u1ecbch n\u00e3o tu\u1ef7 t\u0103ng l\u00ean g\u1ea7n 20 l\u1ea7n. Khi c\u00e1c ch\u00fa chu\u1ed9t c\u00f2n th\u1ee9c, d\u00f2ng ch\u1ea3y d\u1ecbch n\u00e3o tu\u1ef7 ch\u1ee7 y\u1ebfu \u1edf v\u00f5 n\u00e3o, nh\u01b0ng khi ng\u1ee7 th\u00ec d\u00f2ng ch\u1ea3y n\u00e0y \u0111i s\u00e2u v\u00e0o b\u00ean trong n\u00e3o.<\/p>\n

Xem th\u00eam b\u00e0i vi\u1ebft S\u1eed d\u1ee5ng c\u00f4ng ngh\u1ec7 CRISPR \u0111\u1ec3 ch\u1eefa \u0111\u01b0\u1ee3c t\u1eadn g\u1ed1c c\u00e1c b\u1ec7nh di truy\u1ec1n c\u1ee7a con ng\u01b0\u1eddi - \u1ea3o v\u1ecdng hay th\u1ef1c t\u1ebf?<\/a> c\u1ee7a TS. Nguy\u1ec5n Ng\u1ecdc Kim Vy<\/a><\/pre>\n
Hi\u1ec7u qu\u1ea3 c\u1ee7a t\u0103ng d\u00f2ng ch\u1ea3y d\u1ecbch n\u00e3o t\u1ee7y<\/strong><\/h2>\n
Vi\u1ec7c t\u0103ng d\u00f2ng ch\u1ea3y c\u1ee7a d\u1ecbch n\u00e3o tu\u1ef7 gi\u00fap n\u00e3o lo\u1ea1i b\u1ecf m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3 c\u00e1c ch\u1ea5t th\u1ea3i b\u00e3 do h\u1ec7 th\u1ea7n kinh t\u1ea1o ra trong qu\u00e1 tr\u00ecnh ho\u1ea1t \u0111\u1ed9ng, v\u00ed d\u1ee5 nh\u01b0 \u03b2-amyloid. Ng\u01b0\u1eddi b\u00ecnh th\u01b0\u1eddng c\u00f3 \u03b2-amyloid d\u1ea1ng ho\u00e0 tan, kh\u00f4ng \u0111\u1ed9c v\u00e0 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c th\u1ea3i lo\u1ea1i. Nh\u01b0ng khi l\u01b0\u1ee3ng \u03b2-amyloid n\u00e0y t\u00edch t\u1ee5 qu\u00e1 nhi\u1ec1u th\u00ec b\u1eaft \u0111\u1ea7u t\u1ea1o ra d\u1ea1ng k\u1ebft t\u1ee7a<\/strong> (amyloid plague) th\u01b0\u1eddng th\u1ea5y \u1edf ng\u01b0\u1eddi b\u1ec7nh Alzheimer<\/a>. Nh\u1eefng quan s\u00e1t tr\u00ean c\u1ea3 m\u00f4 h\u00ecnh chu\u1ed9t v\u00e0 ng\u01b0\u1eddi cho th\u1ea5y l\u01b0\u1ee3ng \u03b2-amyloid l\u00ean xu\u1ed1ng tu\u1ea7n t\u1ef1 theo chu k\u1ef3 th\u1ee9c v\u00e0 ng\u1ee7. Vi\u1ec7c m\u1ea5t ng\u1ee7 m\u00e3n t\u00ednh l\u00e0m t\u0103ng s\u1ef1 k\u1ebft t\u1ee7a c\u1ee7a d\u1ea1ng \u03b2-amyloid. Nh\u1eefng thay \u0111\u1ed5i v\u1ec1 s\u1ed1 l\u01b0\u1ee3ng gi\u1edd ng\u1ee7 v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng gi\u1ea5c ng\u1ee7 th\u01b0\u1eddng l\u00e0 nh\u1eefng d\u1ea5u hi\u1ec7u s\u1edbm c\u1ee7a b\u1ec7nh Alzheimer v\u00e0 th\u01b0\u1eddng song h\u00e0nh v\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ec7nh.<\/p>\n
N\u1ebfu ch\u00fang ta c\u00f3 cu\u1ed1i tu\u1ea7n \u0111\u1ec3 ngh\u1ec9 ng\u01a1i, th\u01b0 gi\u00e3n, th\u00ec b\u1ed9 n\u00e3o c\u0169ng c\u1ea7n th\u1eddi gian t\u01b0\u01a1ng t\u1ef1, \u0111\u00f3 l\u00e0 gi\u1ea5c ng\u1ee7. N\u1ebfu ch\u00fang ta \u0103n \u1edf s\u1ea1ch s\u1ebd, d\u1ecdn nh\u00e0 \u0111\u1ec1u \u0111\u1eb7n th\u00ec b\u1ed9 n\u00e3o c\u0169ng l\u00e0m vi\u1ec7c \u0111\u00f3 h\u00e0ng ng\u00e0y khi ch\u00fang ta ng\u1ee7. H\u00e3y th\u1eed t\u01b0\u1edfng t\u01b0\u1ee3ng, b\u1ea1n kh\u00f4ng d\u1ecdn nh\u00e0 trong 1-2 th\u00e1ng, th\u00ec c\u00e1c th\u1ec3 lo\u1ea1i r\u00e1c s\u1ebd t\u1ed3n \u0111\u1ecdng t\u1edbi m\u1ee9c n\u00e0o? B\u1ed9 n\u00e3o c\u0169ng th\u1ebf. V\u1eady n\u00ean h\u00e3y ch\u0103m s\u00f3c gi\u1ea5c ng\u1ee7 c\u1ee7a m\u00ecnh b\u1eb1ng c\u00e1ch ng\u1ee7 \u0111\u1ee7, ng\u1ee7 s\u00e2u.<\/p>\n
Vy Nguy\u1ec5n<\/strong> t\u1ed5ng h\u1ee3p<\/p>\n
T\u00e0i li\u1ec7u tham kh\u1ea3o<\/strong><\/h2>\n
    \n
  1. https:\/\/www.facebook.com\/SinhhocSucKhoe\/giac-ngu-don-dep-chat-thai-ba-trong-nao-benh-Alzheimer<\/a><\/li>\n
  2. https:\/\/www.youtube.com\/one-more-reason-to-get-a-good-night’s-sleep<\/a><\/li>\n
  3. https:\/\/www.youtube.com\/dan-gartenberg-th-brain-benefits-of-deep-sleep-and-how-to-get-more-of-it<\/a><\/li>\n
  4. https:\/\/www.nature.com\/articles\/Sleep and Alzheimer disease pathology\u2014a bidirectional relationship<\/a><\/li>\n
  5. http:\/\/science.sciencemag.org\/Sleep It Out<\/a><\/li>\n
  6. http:\/\/science.sciencemag.org\/Sleep: The Brain’s Housekeeper?<\/a><\/li>\n
  7. http:\/\/science.sciencemag.org\/Sleep Drives Metabolite Clearance from the Adult Brain<\/a><\/li>\n
  8. https:\/\/jamanetwork.com\/journals\/Effects of Age and Amyloid Deposition on A\u03b2 Dynamics in the Human Central Nervous System<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
    H\u00e3y th\u1eed t\u01b0\u1edfng t\u01b0\u1ee3ng, b\u1ea1n kh\u00f4ng d\u1ecdn nh\u00e0 trong 1-2 th\u00e1ng, th\u00ec c\u00e1c th\u1ec3 lo\u1ea1i r\u00e1c s\u1ebd t\u1ed3n \u0111\u1ecdng t\u1edbi m\u1ee9c n\u00e0o? B\u1ed9 n\u00e3o c\u0169ng th\u1ebf. V\u1eady n\u00ean h\u00e3y ch\u0103m s\u00f3c gi\u1ea5c ng\u1ee7 c\u1ee7a m\u00ecnh b\u1eb1ng c\u00e1ch ng\u1ee7 \u0111\u1ee7, ng\u1ee7 s\u00e2u.<\/p>\n","protected":false},"author":14,"featured_media":12195,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[3875,3876,3877],"series":[3817],"coauthors":[],"acf":[],"yoast_head":"\nGi\u1ea5c ng\u1ee7 - d\u1ecdn d\u1eb9p ch\u1ea5t th\u1ea3i b\u00e3 trong n\u00e3o - b\u1ec7nh Alzheimer - Y H\u1ecdc C\u1ed9ng \u0110\u1ed3ng<\/title>\n<meta name=\"description\" content=\"Thay \u0111\u1ed5i s\u1ed1 l\u01b0\u1ee3ng gi\u1edd ng\u1ee7 v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng gi\u1ea5c ng\u1ee7 th\u01b0\u1eddng l\u00e0 nh\u1eefng d\u1ea5u hi\u1ec7u s\u1edbm c\u1ee7a b\u1ec7nh Alzheimer v\u00e0 th\u01b0\u1eddng song h\u00e0nh v\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n b\u1ec7nh.\" \/>\n<meta name=\"robots\" content=\"index, follow, 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