{"id":12489,"date":"2018-10-07T16:30:24","date_gmt":"2018-10-07T09:30:24","guid":{"rendered":"https:\/\/yhoccongdong.org\/ung-thu\/nhung-dieu-co-ban-ve-thu-nghiem-lam-sang-biet-de-tu-bao-ve\/"},"modified":"2018-10-07T16:30:24","modified_gmt":"2018-10-07T09:30:24","slug":"nhung-dieu-co-ban-ve-thu-nghiem-lam-sang-biet-de-tu-bao-ve","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/ung-thu\/nhung-dieu-co-ban-ve-thu-nghiem-lam-sang-biet-de-tu-bao-ve\/","title":{"rendered":"Nh\u1eefng \u0111i\u1ec1u c\u01a1 b\u1ea3n v\u1ec1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng: bi\u1ebft \u0111\u1ec3 t\u1ef1 b\u1ea3o v\u1ec7"},"content":{"rendered":"<div class=\"_39k2\">\n<div>Hi\u1ec7u \u0111\u00ednh: Ch\u00e2u Ti\u1ec3u Lan.<\/div>\n<div id=\"js_kj\" class=\"_4lmk _2vxa autofocus _5s6c _5f0v\">\u1ede c\u00e1c n\u01b0\u1edbc ph\u00e1t tri\u1ec3n, vi\u1ec7c quan t\u00e2m, tham gia, hi\u1ec3u bi\u1ebft, n\u1eafm r\u00f5 th\u00f4ng tin v\u1ec1 c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u0111i\u1ec1u tr\u1ecb v\u00e0 s\u1ee9c kho\u1ebb kh\u00f4ng c\u00f2n l\u00e0 \u0111i\u1ec1u m\u1edbi m\u1ebb v\u1edbi ph\u1ea7n \u0111\u00f4ng c\u00f4ng ch\u00fang. \u0110\u00e2y l\u00e0 m\u1ed9t v\u00f2ng tr\u00f2n h\u1ed7 t\u01b0\u01a1ng gi\u1eefa c\u1ed9ng \u0111\u1ed3ng (nh\u1eefng ng\u01b0\u1eddi tham gia) v\u1edbi c\u00e1c nh\u00e0 khoa h\u1ecdc v\u00e0 b\u00e1c s\u0129\/d\u01b0\u1ee3c s\u0129 (nh\u1eefng ng\u01b0\u1eddi th\u1ef1c hi\u1ec7n) v\u1edbi c\u00e1c nh\u00e0 ch\u1ee9c tr\u00e1ch (FDA, b\u1ed9 Y t\u1ebf, c\u00e1c h\u1ed9i \u0111\u1ed3ng th\u1ea9m \u0111\u1ecbnh, \u2026).<\/div>\n<\/div>\n<div class=\"_39k5 _5s6c\">\n<div class=\"_2cuy _3dgx _2vxa\">\u1ede Vi\u1ec7t Nam, v\u00ec s\u1ed1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u00f2n kh\u00e1 h\u1ea1n ch\u1ebf v\u00e0 vi\u1ec7c th\u1ef1c hi\u1ec7n ch\u01b0a ph\u1ed5 bi\u1ebfn, n\u00ean ph\u1ea7n l\u1edbn ng\u01b0\u1eddi d\u00e2n ch\u01b0a c\u00f3 \u0111i\u1ec1u ki\u1ec7n n\u1eafm r\u00f5 \u0111\u01b0\u1ee3c nh\u1eefng th\u00f4ng tin v\u00e0 c\u00e1c nguy\u00ean t\u1eafc c\u01a1 b\u1ea3n c\u1ee7a h\u00ecnh th\u1ee9c nghi\u00ean c\u1ee9u n\u00e0y. G\u1ea7n \u0111\u00e2y, c\u00f3 nhi\u1ec1u c\u00e1 nh\u00e2n v\u00e0 t\u1ed5 ch\u1ee9c \u0111\u00e3 l\u1ee3i d\u1ee5ng s\u1ef1 thi\u1ebfu hi\u1ec3u bi\u1ebft n\u00e0y \u0111\u1ec3 chi\u00eau m\u1ed9, d\u1ee5 d\u1ed7 b\u1ec7nh nh\u00e2n, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng ng\u01b0\u1eddi b\u1ecb b\u1ec7nh n\u1eb7ng nh\u01b0 ung th\u01b0&#8230; tham gia v\u00e0o c\u00e1c d\u1ea1ng th\u1eed nghi\u1ec7m c\u1ee7a h\u1ecd. <span class=\"_4yxo\">Nh\u01b0ng<\/span> nh\u1eefng th\u1eed nghi\u1ec7m n\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p, qu\u1ea3n l\u00fd hay gi\u00e1m s\u00e1t, c\u00e0ng <span class=\"_4yxo\">kh\u00f4ng<\/span> c\u00f3 bi\u1ec7n ph\u00e1p b\u1ea3o v\u1ec7 ng\u01b0\u1eddi b\u1ec7nh. (Xem link b\u00ean d\u01b0\u1edbi)<\/div>\n<div class=\"_2cuy _3dgx _2vxa\">Tr\u01b0\u1edbc t\u00ecnh h\u00ecnh \u0111\u00f3, ch\u00fang t\u00f4i vi\u1ebft b\u00e0i n\u00e0y nh\u1eb1m cung c\u1ea5p nh\u1eefng ki\u1ebfn th\u1ee9c ph\u1ed5 th\u00f4ng nh\u1ea5t v\u1ec1 th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c ti\u00eau chu\u1ea9n ho\u00e1 v\u00e0 th\u1ef1c hi\u1ec7n tr\u00ean th\u1ebf gi\u1edbi. Ch\u00fang t\u00f4i hi v\u1ecdng r\u1eb1ng khi \u00fd th\u1ee9c \u0111\u01b0\u1ee3c n\u00e2ng cao v\u00e0 nhu c\u1ea7u tham gia th\u1eed nghi\u1ec7m \u1edf VN c\u0169ng t\u0103ng l\u00ean, s\u1ebd ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng t\u1ed1t \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n nh\u1eb1m \u0111em l\u1ea1i nhi\u1ec1u l\u1ee3i \u00edch cho b\u1ec7nh nh\u00e2n v\u00e0 g\u00f3p ph\u1ea7n v\u00e0o hi\u1ec3u bi\u1ebft chung c\u1ee7a nh\u00e2n lo\u1ea1i.<\/div>\n<h2 class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxo\">Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng l\u00e0 g\u00ec?<\/span><\/h2>\n<div class=\"_2cuy _3dgx _2vxa\">Khi b\u1ea1n \u0111i mua m\u1ed9t chi\u1ebfc xe m\u1edbi, b\u1ea1n h\u1eb3n mu\u1ed1n bi\u1ebft n\u00f3 c\u00f3 ho\u1ea1t \u0111\u1ed9ng hay kh\u00f4ng, ch\u1ea1y c\u00f3 nhanh kh\u00f4ng, c\u00f3 an to\u00e0n kh\u00f4ng? Nh\u1eefng th\u00f4ng tin n\u00e0y th\u01b0\u1eddng \u0111\u01b0\u1ee3c nh\u00e0 s\u1ea3n xu\u1ea5t, nh\u00e0 ph\u00e2n ph\u1ed1i cung c\u1ea5p. Trong nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p, b\u1ea1n c\u00f3 th\u1ec3 ch\u1ea1y th\u1eed n\u1eefa. N\u1ebfu kh\u00f4ng ch\u1eafc xe c\u00f3 th\u1ec3 ch\u1ea1y \u0111\u01b0\u1ee3c, b\u1ea1n c\u00f3 mu\u1ed1n mua kh\u00f4ng?<\/div>\n<div class=\"_2cuy _3dgx _2vxa\">T\u01b0\u01a1ng t\u1ef1, khi ti\u1ebfp nh\u1eadn m\u1ed9t ph\u01b0\u01a1ng th\u1ee9c \u0111i\u1ec1u tr\u1ecb, b\u1ea1n c\u1ea7n \u0111\u1eb7t ra nh\u1eefng c\u00e2u h\u1ecfi nh\u01b0: Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y c\u00f3 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 kh\u00f4ng, \u0111\u1ebfn m\u1ee9c n\u00e0o? C\u00f3 \u0111\u01b0\u1ee3c ki\u1ec3m ch\u1ee9ng v\u00e0 th\u1ef1c hi\u1ec7n ch\u01b0a? Ai ki\u1ec3m ch\u1ee9ng?<\/div>\n<div class=\"_2cuy _3dgx _2vxa\">N\u1ebfu c\u00e2u tr\u1ea3 l\u1eddi l\u00e0 <span class=\"_4yxo\">ch\u01b0a<\/span>, th\u00ec c\u00f3 ngh\u0129a l\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u00f3 c\u00f2n <span class=\"_4yxo\">m\u1edbi<\/span>. N\u1ebfu b\u1ea1n v\u1eabn mu\u1ed1n ti\u1ebfp nh\u1eadn \u0111i\u1ec1u tr\u1ecb, t\u1ee9c l\u00e0 b\u1ea1n \u0111ang tham gia v\u00e0o m\u1ed9t d\u1ea1ng nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 <span class=\"_4yxo\">Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng <\/span>(TNLS \u2013 clinical trials). TNLS l\u00e0 quy tr\u00ecnh ki\u1ec3m tra xem c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb m\u1edbi, d\u01b0\u1ee3c ph\u1ea9m m\u1edbi,&#8230; c\u00f3 <span class=\"_4yxo\">an to\u00e0n<\/span> v\u00e0 <span class=\"_4yxo\">hi\u1ec7u qu\u1ea3<\/span> cho <span class=\"_4yxo\">con ng\u01b0\u1eddi<\/span> kh\u00f4ng tr\u01b0\u1edbc khi \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ea1i tr\u00e0.<\/div>\n<div class=\"_2cuy _3dgx _2vxa\">Trong l\u0129nh v\u1ef1c Y Sinh h\u1ecdc, TNLS th\u01b0\u1eddng \u0111\u01b0\u1ee3c tri\u1ec3n khai d\u1ef1a v\u00e0o k\u1ebft qu\u1ea3 c\u1ee7a nh\u1eefng nghi\u00ean c\u1ee9u <span class=\"_4yxp\">ti\u1ec1n l\u00e2m s\u00e0ng <\/span>(preclinical trials) tr\u00ean t\u1ebf b\u00e0o v\u00e0 \u0111\u1ed9ng v\u1eadt (nh\u01b0 chu\u1ed9t, kh\u1ec9, &#8230;) v\u1ed1n \u0111\u00e3 c\u00f3 k\u1ebft qu\u1ea3 kh\u1ea3 quan. Th\u00f4ng qua nh\u1eefng k\u1ebft qu\u1ea3 n\u00e0y, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 bi\u1ebft \u0111\u01b0\u1ee3c nguy\u00ean t\u1eafc v\u00e0 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb li\u1ec7u m\u1edbi.<\/div>\n<h2 class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxo\">M\u1ee5c \u0111\u00edch c\u1ee7a th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng<\/span> <span class=\"_4yxo\">l\u00e0 g\u00ec?<\/span><\/h2>\n<div class=\"_2cuy _3dgx _2vxa\">TNLS l\u00e0 \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 t\u00ednh <span class=\"_4yxo\">an to\u00e0n<\/span> v\u00e0 <span class=\"_4yxo\">hi\u1ec7u qu\u1ea3<\/span> c\u1ee7a m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi <span class=\"_4yxo\">tr\u00ean m\u1ed9t s\u1ed1 l\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n t\u0103ng d\u1ea7n tr\u01b0\u1edbc khi tri\u1ec3n khai \u0111i\u1ec1u tr\u1ecb r\u1ed9ng r\u00e3i v\u00e0 ch\u00ednh th\u1ee9c.<\/span><\/div>\n<h2 class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxo\">Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng g\u1ed3m nh\u1eefng b\u01b0\u1edbc n\u00e0o?<\/span><\/h2>\n<div class=\"_2cuy _3dgx _2vxa\">V\u1edbi m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi, ng\u01b0\u1eddi ta th\u01b0\u1eddng ch\u01b0a bi\u1ebft \u0111\u01b0\u1ee3c m\u1ee9c \u0111\u1ed9 an to\u00e0n c\u1ee7a n\u00f3, n\u00ean TNLS \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1eebng b\u01b0\u1edbc m\u1ed9t, v\u1edbi s\u1ed1 l\u01b0\u1ee3ng ng\u01b0\u1eddi tham gia t\u0103ng l\u00ean d\u1ea7n. M\u1ed9t TNLS th\u00f4ng th\u01b0\u1eddng c\u00f3 4 giai \u0111o\u1ea1n. V\u00ec th\u1eed thu\u1ed1c (d\u01b0\u1ee3c ph\u1ea9m) chi\u1ebfm ph\u1ea7n l\u1edbn c\u00e1c TNLS, n\u00ean tr\u00ecnh t\u1ef1 v\u00e0 n\u1ed9i dung c\u1ee7a TNLS ch\u1ee7 y\u1ebfu \u0111\u01b0\u1ee3c x\u00e2y d\u1ef1ng d\u1ef1a v\u00e0o quy tr\u00ecnh n\u00e0y. Tuy nhi\u00ean, quy tr\u00ecnh TNLS t\u01b0\u01a1ng t\u1ef1 c\u0169ng \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng v\u1edbi c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng kh\u00e1c nh\u01b0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi, thi\u1ebft b\u1ecb y t\u1ebf m\u1edbi, li\u1ec7u ph\u00e1p m\u1edbi (nh\u01b0 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o g\u1ed1c)&#8230;<\/div>\n<div><img decoding=\"async\" class=\"size-medium wp-image-24579 aligncenter\" src=\"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/10\/nhung-dieu-can-biet-ve-thu-nghiem-lam-sang-300x150-1.jpg\" alt=\"nhung-dieu-can-biet-ve-thu-nghiem-lam-sang\" width=\"300\" height=\"150\" \/><\/div>\n<figure class=\"_2cuy _4nuy _2vxa\">\n<div class=\"_h2x _h2y\">\n<div class=\"_h2w _50f8 _50f4\" style=\"text-align: center\">H\u00ecnh tr\u00edch t\u1eeb ch\u01b0\u01a1ng 7 c\u1ee7a cu\u1ed1n s\u00e1ch T\u1ebf b\u00e0o g\u1ed1c &#8211; kh\u00e1m ph\u00e1 c\u00f9ng nh\u00e0 khoa h\u1ecdc<\/div>\n<\/div>\n<\/figure>\n<ul>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxr\">Giai \u0111o\u1ea1n 0<\/span>: th\u01b0\u1eddng kh\u00f4ng b\u1eaft bu\u1ed9c, v\u1edbi ch\u1ec9 kho\u1ea3ng 10-15 ng\u01b0\u1eddi tham gia. N\u1ebfu l\u00e0 th\u1eed nghi\u1ec7m thu\u1ed1c m\u1edbi th\u00ec li\u1ec1u s\u1eed d\u1ee5ng th\u1ea5p, d\u01b0\u1edbi ng\u01b0\u1ee1ng \u0111i\u1ec1u tr\u1ecb, ch\u1ee7 y\u1ebfu \u0111\u1ec3 ng\u01b0\u1eddi th\u1ef1c hi\u1ec7n quan s\u00e1t v\u1ec1 s\u1ef1 h\u1ea5p thu, ph\u00e2n ph\u1ed1i, th\u1ea3i lo\u1ea1i, &#8230; thu\u1ed1c.<\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxr\">Giai \u0111o\u1ea1n 1<\/span>: TNLS ch\u00ednh th\u1ee9c b\u1eaft \u0111\u1ea7u, th\u01b0\u1eddng v\u1edbi 1 nh\u00f3m nh\u1ecf 20 \u2013 80 ng\u01b0\u1eddi. M\u1ee5c ti\u00eau quan tr\u1ecdng l\u00e0 \u0111\u00e1nh gi\u00e1 t\u00ednh <span class=\"_4yxo _4yxr\">an to\u00e0n<\/span><span class=\"_4yxr\">, <\/span>x\u00e1c \u0111\u1ecbnh li\u1ec1u l\u01b0\u1ee3ng an to\u00e0n v\u00e0 ph\u1ea3n \u1ee9ng ph\u1ee5. Tuy nhi\u00ean, v\u00ec li\u1ec1u s\u1eed d\u1ee5ng v\u1eabn c\u00f2n th\u1ea5p, n\u00ean \u1edf giai \u0111o\u1ea1n n\u00e0y ng\u01b0\u1eddi ta th\u01b0\u1eddngv\u1eabn ch\u01b0a c\u00f3 \u0111\u1ea7y \u0111\u1ee7 th\u00f4ng s\u1ed1 v\u1ec1 ph\u1ea3n \u1ee9ng ph\u1ee5.<\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxr\">Giai \u0111o\u1ea1n 2<\/span>: N\u1ebfu k\u1ebft qu\u1ea3 giai \u0111o\u1ea1n 1 cho th\u1ea5y ph\u01b0\u01a1ng ph\u00e1p m\u1edbi an to\u00e0n, th\u00ec ng\u01b0\u1eddi ta s\u1ebd t\u0103ng s\u1ed1 l\u01b0\u1ee3ng ng\u01b0\u1eddi tham gia l\u00ean 100 \u2013 300 \u0111\u1ec3 ti\u1ebfp t\u1ee5c \u0111\u00e1nh gi\u00e1 <span class=\"_4yxo _4yxr\">hi\u1ec7u qu\u1ea3 <\/span>v\u00e0 thu th\u1eadp nhi\u1ec1u h\u01a1n c\u00e1c s\u1ed1 li\u1ec7u v\u1ec1 t\u00ednh an to\u00e0n.<\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxr\">Giai \u0111o\u1ea1n 3<\/span>: N\u1ebfu k\u1ebft qu\u1ea3 c\u1ee7a giai \u0111o\u1ea1n 2 l\u00e0 c\u00f3 hi\u1ec7u qu\u1ea3 v\u00e0 an to\u00e0n, th\u00ec ng\u01b0\u1eddi ta s\u1ebd m\u1edf r\u1ed9ng th\u1eed nghi\u1ec7m ra v\u1edbi nh\u00f3m l\u1edbn h\u01a1n, 1000 \u2013 3000 ng\u01b0\u1eddi. \u0110\u00e2y l\u00e0 l\u00fac \u0111\u1ec3 <span class=\"_4yxo _4yxr\">kh\u1eb3ng \u0111\u1ecbnh <\/span>l\u1ea1i s\u1ef1 hi\u1ec7u qu\u1ea3, theo d\u00f5i c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5, so s\u00e1nh v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c v\u00e0 thu th\u1eadp nhi\u1ec1u s\u1ed1 li\u1ec7u h\u01a1n v\u1ec1 t\u00ednh an to\u00e0n.<\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxr\">Giai \u0111o\u1ea1n 4<\/span>: N\u1ebfu k\u1ebft qu\u1ea3 t\u1eeb giai \u0111o\u1ea1n 3 l\u00e0 kh\u1ea3 quan, l\u00fac n\u00e0y thu\u1ed1c c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111\u01b0a ra th\u1ecb tr\u01b0\u1eddng. Tuy nhi\u00ean, c\u00e1c nh\u00e0 s\u1ea3n xu\u1ea5t v\u00e0 th\u1ef1c hi\u1ec7n TNLS v\u1eabn <span class=\"_4yxo _4yxr\">ti\u1ebfp t\u1ee5c theo d\u00f5i, thu th\u1eadp s\u1ed1 li\u1ec7u <\/span>v\u1edbi s\u1ed1 l\u01b0\u1ee3ng ng\u01b0\u1eddi d\u00f9ng l\u1edbn h\u01a1n, v\u1ec1 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf m\u1ee9c \u0111\u1ed9 d\u00e0i h\u1ea1n.<\/li>\n<\/ul>\n<h2 class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxo\">Ai tr\u1ef1c ti\u1ebfp ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng?<\/span><\/h2>\n<div class=\"_2cuy _3dgx _2vxa\">Th\u01b0\u1eddng m\u1ed9t TNLS \u0111\u00f2i h\u1ecfi chuy\u00ean m\u00f4n c\u1ee7a c\u1ea3 nh\u00e0 nghi\u00ean c\u1ee9u v\u00e0 b\u00e1c s\u0129 l\u00e2m s\u00e0ng.<\/div>\n<h2 class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxo\">V\u00ec sao b\u1ea1n n\u00ean tham gia v\u00e0o th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng?<\/span><\/h2>\n<ol>\n<li class=\"_2cuy _3dgx _2vxa\">C\u00f3 c\u01a1 h\u1ed9i \u0111\u01b0\u1ee3c ti\u1ebfp nh\u1eadn tr\u01b0\u1edbc ti\u00ean c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi v\u00e0 ti\u00ean ti\u1ebfn nh\u1ea5t.<\/li>\n<li class=\"_2cuy _3dgx _2vxa\">G\u00f3p ph\u1ea7n quan tr\u1ecdng v\u00e0o nghi\u00ean c\u1ee9u Y sinh h\u1ecdc, gi\u00fap c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi \u0111ang ti\u1ebfn h\u00e0nh.<\/li>\n<li class=\"_2cuy _3dgx _2vxa\">N\u1ebfu TNLS \u0111\u01b0\u1ee3c qu\u1ea3n l\u00fd v\u00e0 gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd v\u00e0 minh b\u1ea1ch, s\u1ee9c kho\u1ebb v\u00e0 s\u1ef1 an to\u00e0n c\u1ee7a ng\u01b0\u1eddi tham gia s\u1ebd \u0111\u01b0\u1ee3c b\u1ea3o v\u1ec7.<\/li>\n<\/ol>\n<h2 class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxo\">Ai c\u00f3 th\u1ec3 tham gia th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng?<\/span><\/h2>\n<div class=\"_2cuy _3dgx _2vxa\">M\u1ed7i th\u1eed nghi\u1ec7m c\u00f3 m\u1ed9t ti\u00eau ch\u00ed ch\u1ecdn \u0111\u1ed1i t\u01b0\u1ee3ng tham gia v\u1edbi nh\u1eefng ch\u1ec9 s\u1ed1 v\u1ec1 s\u1ee9c kho\u1ebb kh\u00e1c nhau, n\u00ean tr\u01b0\u1edbc khi tham gia h\u1ecd th\u01b0\u1eddng \u0111\u01b0\u1ee3c ki\u1ec3m tra v\u1ec1 c\u00e1c ch\u1ec9 s\u1ed1 nh\u01b0 huy\u1ebft \u00e1p, nh\u1ecbp tim, nhi\u1ec7t \u0111\u1ed9 c\u01a1 th\u1ec3, \u0111i\u1ec7n t\u00e2m \u0111\u1ed3, ki\u1ec3m tra m\u00e1u, n\u01b0\u1edbc ti\u1ec3u, c\u00e2n n\u1eb7ng, chi\u1ec1u cao, &#8230; Nh\u1eefng ng\u01b0\u1eddi t\u00ecnh nguy\u1ec7n th\u01b0\u1eddng ph\u1ea3i \u0111\u00e1p \u1ee9ng \u0111\u1ea7y \u0111\u1ee7 c\u00e1c ch\u1ec9 ti\u00eau th\u00ec m\u1edbi \u0111\u01b0\u1ee3c tham gia.<\/div>\n<div class=\"_2cuy _3dgx _2vxa\">Ngo\u00e0i ra, t\u00f9y v\u00e0o quy \u0111\u1ecbnh qu\u1ea3n l\u00fd c\u1ee7a m\u1ed7i n\u01b0\u1edbc, c\u00f3 khi ng\u01b0\u1eddi tham gia bu\u1ed9c ph\u1ea3i l\u00e0 ng\u01b0\u1eddi th\u01b0\u1eddng tr\u00fa v\u00e0 c\u00f3 b\u1ea3o hi\u1ec3m s\u1ee9c kh\u1ecfe t\u1ea1i n\u01b0\u1edbc s\u1edf t\u1ea1i; tuy c\u0169ng c\u00f3 khi n\u1ebfu l\u00e0 b\u1ec7nh hi\u1ebfm th\u00ec ng\u01b0\u1eddi n\u01b0\u1edbc ngo\u00e0i s\u1ebd c\u00f3 kh\u1ea3 n\u0103ng \u0111\u01b0\u1ee3c ch\u1ea5p nh\u1eadn.<\/div>\n<h2 class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxo\">Ai c\u1ea5p ph\u00e9p v\u00e0 gi\u00e1m s\u00e1t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng?<\/span><\/h2>\n<div class=\"_2cuy _3dgx _2vxa\">Tr\u01b0\u1edbc khi \u0111i v\u00e0o th\u1ef1c hi\u1ec7n, TNLS ph\u1ea3i \u0111\u01b0\u1ee3c \u0111\u1ec7 tr\u00ecnh l\u00ean H\u1ed9i \u0111\u1ed3ng Y \u0111\u1ee9c \u0111\u1ec3 x\u00e9t duy\u1ec7t v\u00e0 ch\u1ea5p nh\u1eadn. \u1ede M\u1ef9, h\u1ed9i \u0111\u1ed3ng n\u00e0y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 Institutional Review Board (IRB), c\u00f2n \u1edf ch\u00e2u \u00c2u g\u1ecdi l\u00e0 Ethics Committees.<\/div>\n<div class=\"_2cuy _3dgx _2vxa\">\u1ede M\u1ef9 trong qu\u00e1 tr\u00ecnh ti\u1ebfn h\u00e0nh, k\u1ebft qu\u1ea3 c\u1ee7a t\u1eebng giai \u0111o\u1ea1n ph\u1ea3i \u0111\u01b0\u1ee3c n\u1ed9p l\u00ean cho FDA th\u1ea9m \u0111\u1ecbnh v\u00e0 ki\u1ec3m tra tr\u01b0\u1edbc khi thu\u1ed1c m\u1edbi \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn v\u00e0 cho ph\u00e9p l\u01b0u h\u00e0nh.<\/div>\n<div class=\"_2cuy _3dgx _2vxa\">\u1ede Vi\u1ec7t Nam, vi\u1ec7c c\u1ea5p ph\u00e9p v\u00e0 gi\u00e1m s\u00e1t n\u00e0y ch\u1ee7 y\u1ebfu th\u00f4ng qua C\u1ee5c Khoa h\u1ecdc c\u00f4ng ngh\u1ec7 v\u00e0 \u0110\u00e0o t\u1ea1o c\u1ee7a B\u1ed9 Y t\u1ebf.<\/div>\n<h2 class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxo\">Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng th\u01b0\u1eddng \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf nh\u01b0 th\u1ebf n\u00e0o?<\/span><\/h2>\n<div class=\"_2cuy _3dgx _2vxa\">V\u00ec m\u1ee5c ti\u00eau c\u1ee7a TNLS l\u00e0 kh\u1ea3o s\u00e1t v\u00e0 ch\u1ee9ng minh s\u1ef1 hi\u1ec7u qu\u1ea3 c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb li\u1ec7u m\u1edbi, n\u00ean thi\u1ebft k\u1ebf TNLS l\u00e0 v\u00f4 c\u00f9ng quan tr\u1ecdng, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong Giai \u0111o\u1ea1n 2 v\u00e0 3 <span class=\"_4yxo\">\u0111\u1ec3 \u0111\u00e1nh gi\u00e1 v\u00e0 so s\u00e1nh <\/span>hi\u1ec7u qu\u1ea3. \u0110\u1ec3 c\u00e1c \u0111\u00e1nh gi\u00e1 \u0111\u01b0\u1ee3c kh\u00e1ch quan, m\u1ed9t TNLS th\u01b0\u1eddng c\u00f3 2 nh\u00f3m: <span class=\"_4yxo\">nh\u00f3m nh\u1eadn tr\u1ecb li\u1ec7u v\u00e0 nh\u00f3m \u0111\u1ed1i ch\u1ee9ng<\/span>. Vi\u1ec7c ph\u00e2n ph\u1ed1i ng\u01b0\u1eddi tham gia v\u00e0o 2 nh\u00f3m n\u00e0y c\u00f3 th\u1ec3 theo c\u00e1c ph\u01b0\u01a1ng ph\u00e1p nh\u01b0 sau:<\/div>\n<ol>\n<li class=\"_2cuy _3dgx _2vxa\">\u00a0Ph\u01b0\u01a1ng ph\u00e1p ng\u1eabu nhi\u00ean (randomized test): ng\u01b0\u1eddi tham gia \u0111\u01b0\u1ee3c ph\u00e2n ph\u1ed1i m\u1ed9t c\u00e1ch ng\u1eabu nhi\u00ean v\u00e0o m\u1ed7i nh\u00f3m.<\/li>\n<li class=\"_2cuy _3dgx _2vxa\">Ph\u01b0\u01a1ng ph\u00e1p \u1ea9n nh\u00f3m (blind test): ng\u01b0\u1eddi tham gia kh\u00f4ng bi\u1ebft h\u1ecd thu\u1ed9c nh\u00f3m n\u00e0o. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u c\u00f2n \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf ki\u1ec3u <span class=\"_4yxo\">\u1ea9n<\/span> <span class=\"_4yxo\">nh\u00f3m<\/span> <span class=\"_4yxo\">2<\/span> <span class=\"_4yxo\">chi\u1ec1u <\/span>(double blind), t\u1ee9c l\u00e0 c\u1ea3 ng\u01b0\u1eddi tham gia l\u1eabn ng\u01b0\u1eddi th\u1ef1c hi\u1ec7n th\u1eed nghi\u1ec7m \u0111\u1ec1u kh\u00f4ng bi\u1ebft ai thu\u1ed9c nh\u00f3m n\u00e0o. \u0110i\u1ec1u n\u00e0y l\u00e0 \u0111\u1ec3 ng\u0103n kh\u00f4ng cho ng\u01b0\u1eddi th\u1ef1c hi\u1ec7n c\u00f3 s\u1ef1 ph\u00e2n bi\u1ec7t n\u00e0o trong tr\u1ecb li\u1ec7u gi\u1eefa 2 nh\u00f3m.<\/li>\n<li class=\"_2cuy _3dgx _2vxa\">\u0110\u1ed1i ch\u1ee9ng v\u1edbi gi\u1ea3 d\u01b0\u1ee3c (placebo): gi\u1ea3 d\u01b0\u1ee3c l\u00e0 d\u1ea1ng s\u1ea3n ph\u1ea9m gi\u1ed1ng thu\u1ed1c th\u1eadt nh\u01b0ng l\u1ea1i kh\u00f4ng c\u00f3 d\u01b0\u1ee3c ch\u1ea5t. Nh\u00f3m n\u00e0y \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 gi\u00fap ng\u01b0\u1eddi th\u1ef1c hi\u1ec7n \u0111\u00e1nh gi\u00e1 hi\u1ec7u qu\u1ea3 th\u1ef1c s\u1ef1 c\u1ee7a d\u01b0\u1ee3c ch\u1ea5t.<\/li>\n<\/ol>\n<div class=\"_2cuy _3dgx _2vxa\">K\u1ebft qu\u1ea3 c\u1ee7a t\u1eebng nh\u00f3m n\u00e0y s\u1ebd \u0111\u01b0\u1ee3c ph\u00e2n t\u00edch v\u00e0 so s\u00e1nh v\u1edbi nhau. S\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa nh\u00f3m nh\u1eadn tr\u1ecb li\u1ec7u v\u1edbi nh\u00f3m \u0111\u1ed1i ch\u1ee9ng v\u00e0 nh\u00f3m gi\u1ea3 d\u01b0\u1ee3c c\u00e0ng l\u1edbn th\u00ec ch\u1ee9ng t\u1ecf hi\u1ec7u qu\u1ea3 c\u00e0ng cao. V\u00ec s\u1ed1 li\u1ec7u \u0111\u01b0\u1ee3c thu th\u1eadp tr\u00ean nhi\u1ec1u nh\u00f3m ng\u01b0\u1eddi, n\u00ean c\u00e1c ph\u01b0\u01a1ng ph\u00e1p t\u00ednh to\u00e1n th\u1ed1ng k\u00ea th\u01b0\u1eddng \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng v\u00e0 s\u1ef1 kh\u00e1c bi\u1ec7t th\u01b0\u1eddng ph\u1ea3i c\u00f3 \u00fd ngh\u0129a th\u1ed1ng k\u00ea.<\/div>\n<h2 class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxo\">Khi tham gia th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, c\u1ea7n c\u00e2n nh\u1eafc \u0111i\u1ec1u g\u00ec?<\/span><\/h2>\n<div class=\"_2cuy _3dgx _2vxa\">Ng\u01b0\u1eddi tham gia c\u1ea7n n\u1eafm r\u00f5 c\u00e0ng nhi\u1ec1u th\u00f4ng tin v\u1ec1 TNLS c\u00e0ng t\u1ed1t. H\u1ecd c\u1ea7n t\u00ecm hi\u1ec3m v\u00e0 trao \u0111\u1ed5i v\u1edbi b\u00e1c s\u0129 v\u00e0 nh\u1eefng ng\u01b0\u1eddi c\u00f3 chuy\u00ean m\u00f4n trong l\u0129nh v\u1ef1c \u0111\u00f3. Tr\u01b0\u1edbc khi tham gia, h\u1ecd n\u00ean c\u00f3 \u0111\u1ee7 th\u00f4ng tin cho nh\u1eefng c\u00e2u h\u1ecfi quan tr\u1ecdng sau:<\/div>\n<ol>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxp\">M\u1ee5c \u0111\u00edch c\u1ee7a th\u1eed nghi\u1ec7m l\u00e0 g\u00ec?<\/span><\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxp\">Ai l\u00e0 ng\u01b0\u1eddi ch\u1ee7 tr\u00ec v\u00e0 nh\u1eefng ai s\u1ebd th\u1ef1c hi\u1ec7n th\u1eed nghi\u1ec7m?<\/span><\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxp\">L\u00e0m sao h\u1ecd bi\u1ebft \u0111\u01b0\u1ee3c \u0111i\u1ec1u h\u1ecd \u0111ang th\u1eed nghi\u1ec7m kh\u1ea3 quan kh\u00f4ng? H\u1ecd \u0111\u00e3 c\u00f3 s\u1ed1 li\u1ec7u s\u01a1 kh\u1edfi c\u1ee7a c\u00e1c nghi\u00ean c\u1ee9u ti\u1ec1n l\u00e2m s\u00e0ng ch\u01b0a?<\/span><\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxp\">C\u00f3 nh\u1eefng x\u00e9t nghi\u1ec7m hay th\u1eed nghi\u1ec7m n\u00e0o s\u1ebd \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh?<\/span><\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxp\">C\u00f3 nh\u1eefng nguy c\u01a1, t\u00e1c d\u1ee5ng ph\u1ee5 v\u00e0 l\u1ee3i \u00edch g\u00ec? So v\u1edbi ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb li\u1ec7u c\u0169 th\u00ec sao?<\/span><\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxp\">Th\u1eed nghi\u1ec7m k\u00e9o d\u00e0i bao l\u00e2u?<\/span><\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxp\">Th\u1eed nghi\u1ec7m c\u00f3 \u0111\u00f2i h\u1ecfi ph\u1ea3i nh\u1eadp vi\u1ec7n kh\u00f4ng?<\/span><\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxp\">\u00a0Ai s\u1ebd tr\u1ea3 ti\u1ec1n cho nh\u1eefng tr\u1ecb li\u1ec7u trong th\u1eed nghi\u1ec7m?<\/span><\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxp\">Ng\u01b0\u1eddi tham gia c\u00f3 \u0111\u01b0\u1ee3c theo d\u00f5i quan s\u00e1t v\u1ec1 s\u1ee9c kho\u1ebb trong v\u00e0 sau th\u1eed nghi\u1ec7m kh\u00f4ng?<\/span><\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxp\">Ai s\u1ebd ch\u1ecbu tr\u00e1ch nhi\u1ec7m ch\u0103m s\u00f3c s\u1ee9c kho\u1ebb cho ng\u01b0\u1eddi tham gia?<\/span><\/li>\n<li class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxp\">L\u00e0m sao bi\u1ebft \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m th\u00e0nh c\u00f4ng hay th\u1ea5t b\u1ea1i? H\u1ecd c\u00f3 cung c\u1ea5p k\u1ebft qu\u1ea3 cho ng\u01b0\u1eddi tham gia kh\u00f4ng?<\/span><\/li>\n<\/ol>\n<h2 class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxo\">Ng\u01b0\u1eddi tham gia c\u00f3 nh\u1eefng quy\u1ec1n l\u1ee3i g\u00ec?<\/span><\/h2>\n<div class=\"_2cuy _3dgx _2vxa\">Ng\u01b0\u1eddi tham gia c\u1ea7n c\u00f3 \u0111\u01b0\u1ee3c nh\u1eefng quy\u1ec1n l\u1ee3i nh\u01b0:<\/div>\n<ol>\n<li class=\"_2cuy _3dgx _2vxa\">\u0110\u01b0\u1ee3c t\u01b0 v\u1ea5n \u0111\u1ea7y \u0111\u1ee7 tr\u01b0\u1edbc khi k\u00fd cam k\u1ebft tham gia th\u1eed nghi\u1ec7m.<\/li>\n<li class=\"_2cuy _3dgx _2vxa\">Quy\u1ec1n \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ea7y \u0111\u1ee7 th\u00f4ng tin c\u1ea7n thi\u1ebft v\u1ec1 th\u1eed nghi\u1ec7m.<\/li>\n<li class=\"_2cuy _3dgx _2vxa\">Quy\u1ec1n \u0111\u01b0\u1ee3c ch\u0103m s\u00f3c v\u00e0 theo d\u00f5i trong v\u00e0 ngay c\u1ea3 sau th\u1eed nghi\u1ec7m.<\/li>\n<\/ol>\n<h2 class=\"_2cuy _3dgx _2vxa\"><span class=\"_4yxo\">Th\u00f4ng tin v\u00e0 k\u1ebft qu\u1ea3 th\u1eed nghi\u1ec7m \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 \u1edf \u0111\u00e2u?<\/span><\/h2>\n<div class=\"_2cuy _3dgx _2vxa\">Hi\u1ec7n nay trang clinicaltrials.gov l\u00e0 n\u01a1i ch\u1ee9a th\u00f4ng tin v\u1ec1 c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u00e3 v\u00e0 \u0111ang di\u1ec5n ra. Tuy nhi\u00ean \u0111\u00f3 ch\u1ec9 l\u00e0 n\u01a1i \u0111\u1ec3 nh\u1eefng ng\u01b0\u1eddi th\u1ef1c hi\u1ec7n cung c\u1ea5p th\u00f4ng tin \u0111\u0103ng k\u00fd ch\u1ee9 kh\u00f4ng c\u00f3 ngh\u0129a r\u1eb1ng c\u00e1c th\u1eed nghi\u1ec7m n\u00e0y \u0111\u00e3 th\u00e0nh c\u00f4ng.<\/div>\n<div class=\"_2cuy _3dgx _2vxa\">K\u1ebft qu\u1ea3 c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u0169ng th\u01b0\u1eddng \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean nh\u1eefng t\u1ea1p ch\u00ed khoa h\u1ecdc v\u00e0 y h\u1ecdc.<\/div>\n<div class=\"_2cuy _3dgx _2vxa\"><\/div>\n<h2 class=\"_2cuy _3dgx _2vxa\">T\u00e0i li\u1ec7u tham kh\u1ea3o:<\/h2>\n<div class=\"_2cuy _3dgx _2vxa\">Ch\u01b0\u01a1ng 7-9, Cu\u1ed1n s\u00e1ch T\u1ebf b\u00e0o g\u1ed1c \u2013 Kh\u00e1m ph\u00e1 c\u00f9ng nh\u00e0 khoa h\u1ecdc.<\/div>\n<ol>\n<li><a href=\"https:\/\/l.facebook.com\/l.php?u=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FClinical_trial%23Participant_recruitment_and_participation&amp;h=AT1jlE6dXjNhLjRCxiQjvnFiLSFl_f2tvTSsp_OnOD0Ug9KqlWfiuZttAAkiqwXs5LMFVncxQ3QCtxXs1lNWsVf2mk4HJanX_shKOcQjcE655dxCBFrVIKG8CHf57h09yTwI\" target=\"_blank\" rel=\"noopener nofollow\"><span class=\"_4yxr\">https:\/\/en.wikipedia.org\/wiki\/Clinical_trial#Participant_recruitment_and_participation<\/span><\/a><\/li>\n<li><a href=\"https:\/\/l.facebook.com\/l.php?u=https%3A%2F%2Fwww.cancer.org%2Ftreatment%2Ftreatments-and-side-effects%2Fclinical-trials%2Fwhat-you-need-to-know.html&amp;h=AT3_gWTQAKZNtqE0l59Q9QviVST8ujhjklJ7ZlcIHNeD5Mb7l06UhkERPFTpQtRc2LNQAkoAHmCRbW3vtl63HEHlw9JJTH88WhLfPr_AKo4SDAjHIfWu2krBDWcnDyqyTyrU4S9Mp5tbrpdLqA\" target=\"_blank\" rel=\"noopener nofollow\"><span class=\"_4yxr\">https:\/\/www.cancer.org\/treatment\/treatments-and-side-effects\/clinical-trials\/what-you-need-to-know.html<\/span><\/a><\/li>\n<li><a href=\"https:\/\/l.facebook.com\/l.php?u=https%3A%2F%2Fthuvienphapluat.vn%2Fvan-ban%2FThe-thao-Y-te%2FThong-tu-quy-dinh-thu-thuoc-tren-lam-sang-2016-329759.aspx&amp;h=AT18aqU1aF4ka1xspBWkDNOw-KAR95uKaRJarHhvLLrvwdWMyK3PIZwiphIS-HqhThHijF5elVxvgd5NAjujQEzR3bczwRA3uWJzEPAsiAnsLLmkJD4GxXcnBkGPTdUvxRKs\" target=\"_blank\" rel=\"noopener nofollow\"><span class=\"_4yxr\">https:\/\/thuvienphapluat.vn\/van-ban\/The-thao-Y-te\/Thong-tu-quy-dinh-thu-thuoc-tren-lam-sang-2016-329759.aspx<\/span><\/a><\/li>\n<\/ol>\n<div class=\"_2cuy _3dgx _2vxa\">Tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh nh\u00e2n b\u1ecb l\u1ee3i d\u1ee5ng \u1edf VN:<\/div>\n<ol>\n<li><a href=\"https:\/\/www.facebook.com\/notes\/vu-hong-nguyen\/nh%E1%BB%AFng-c%C3%A1i-b%E1%BA%ABy-cho-ng%C6%B0%E1%BB%9Di-b%E1%BB%87nh-ngh%C3%A8o\/10157769239290299\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.facebook.com\/notes\/vu-hong-nguyen\/nh\u1eefng-c\u00e1i-b\u1eaby-cho-ng\u01b0\u1eddi-b\u1ec7nh-ngh\u00e8o\/10157769239290299\/<\/a><\/li>\n<li><a href=\"https:\/\/www.facebook.com\/notes\/vu-hong-nguyen\/nh%E1%BB%AFng-con-k%E1%BB%81n-k%E1%BB%81n-r%E1%BB%89a-x%C3%A1c-s%E1%BB%91ng\/10157775096970299\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.facebook.com\/notes\/vu-hong-nguyen\/nh\u1eefng-con-k\u1ec1n-k\u1ec1n-r\u1ec9a-x\u00e1c-s\u1ed1ng\/10157775096970299\/<\/a><\/li>\n<\/ol>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u1ede c\u00e1c n\u01b0\u1edbc ph\u00e1t tri\u1ec3n, vi\u1ec7c quan t\u00e2m, tham gia, hi\u1ec3u bi\u1ebft v\u00e0 n\u1eafm r\u00f5 th\u00f4ng tin v\u1ec1 c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng li\u00ean quan \u0111\u1ebfn vi\u1ec7c \u0111i\u1ec1u tr\u1ecb v\u00e0 s\u1ee9c kho\u1ebb kh\u00f4ng c\u00f2n l\u00e0 \u0111i\u1ec1u m\u1edbi m\u1ebb v\u1edbi ph\u1ea7n \u0111\u00f4ng c\u00f4ng ch\u00fang.<\/p>\n","protected":false},"author":380,"featured_media":12490,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[3203],"series":[3976],"coauthors":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - 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