{"id":12506,"date":"2018-11-30T08:28:11","date_gmt":"2018-11-30T01:28:11","guid":{"rendered":"https:\/\/yhoccongdong.org\/ung-thu\/lieu-phap-mien-dich-car-t-trong-dieu-tri-ung-thu\/"},"modified":"2018-11-30T08:28:11","modified_gmt":"2018-11-30T01:28:11","slug":"lieu-phap-mien-dich-car-t-trong-dieu-tri-ung-thu","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/ung-thu\/lieu-phap-mien-dich-car-t-trong-dieu-tri-ung-thu\/","title":{"rendered":"Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch CAR-T trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0"},"content":{"rendered":"<p>Theo \u201ctr\u00e0o l\u01b0u \u0111ang l\u00ean\u201d c\u1ee7a <a href=\"https:\/\/yhoccongdong.com\/thongtin\/hieu-ve-lieu-phap-mien-dich\/\" target=\"_blank\" rel=\"noopener\">li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch<\/a>, Y h\u1ecdc c\u1ed9ng \u0111\u1ed3ng xin gi\u1edbi thi\u1ec7u b\u00e0i vi\u1ebft v\u1ec1 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o CAR-T, m\u1ed9t \u201cng\u01b0\u1eddi anh em\u201d v\u1edbi gi\u1ea3i Nobel Y h\u1ecdc n\u0103m nay. CAR-T c\u00f3 th\u1ec3 c\u0169ng l\u00e0 m\u1ed9t \u1ee9ng c\u1eed vi\u00ean n\u1eb7ng k\u00ed cho gi\u1ea3i Nobel Y h\u1ecdc trong nh\u1eefng n\u0103m t\u1edbi.<\/p>\n<p>Ng\u00e0y 30 th\u00e1ng 8 n\u0103m 2017, C\u1ee5c qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m c\u1ee7a M\u1ef9 (FDA) \u0111\u00e3 ch\u00ednh th\u1ee9c ch\u1ea5p thu\u1eadn li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch c\u00f3 t\u00ean g\u1ecdi CTL019 (hay c\u00f2n g\u1ecdi l\u00e0 \u2013 CAR-T), d\u00e0nh cho tr\u1ebb em v\u00e0 ng\u01b0\u1eddi l\u1edbn b\u1ecb m\u1eafc b\u1ec7nh ung th\u01b0 m\u00e1u t\u1ebf b\u00e0o B (m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u) c\u1ea5p t\u00ednh v\u00e0 \u0111\u00e3 b\u1ecb t\u00e1i l\u1ea1i t\u1eeb 2 l\u1ea7n tr\u1edf l\u00ean. Ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb li\u1ec7u m\u1edbi n\u00e0y kh\u1edfi ph\u00e1t t\u1eeb nghi\u00ean c\u1ee9u c\u1ee7a TS Carl June, hi\u1ec7n l\u00e0 gi\u00e1o s\u01b0 v\u1ec1 Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ea1i tr\u01b0\u1eddng Y Perelman, \u0110\u1ea1i h\u1ecdc Pennsylvania.<\/p>\n<h3><strong>Ph\u00e2n t\u00edch t\u1eebng th\u00e0nh ph\u1ea7n trong CAR-T<\/strong><\/h3>\n<p>\u0110\u1ec3 hi\u1ec3u \u0111\u01b0\u1ee3c b\u1ea3n ch\u1ea5t v\u00e0 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a t\u1ebf b\u00e0o CAR-T, h\u00e3y l\u1ea7n l\u01b0\u1ee3t ph\u00e2n t\u00edch t\u1eebng th\u00e0nh ph\u1ea7n trong c\u00e1i t\u00ean <strong>Chimeric \u2013 Antigen \u2013 Receptor \u2013 T cell<\/strong> theo th\u1ee9 t\u1ef1 \u0111\u1ea3o ng\u01b0\u1ee3c.<\/p>\n<p><strong>T cell<\/strong>: Trong h\u1ec7 mi\u1ec5n d\u1ecbch, t\u1ebf b\u00e0o T l\u00e0 t\u1ebf b\u00e0o d\u00f2ng b\u1ea1ch c\u1ea7u c\u00f3 kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o l\u1ea1 b\u1eb1ng 3 c\u00e1ch: ti\u00eau di\u1ec7t tr\u1ef1c ti\u1ebfp, k\u00edch ho\u1ea1t nh\u1eefng lo\u1ea1i t\u1ebf b\u00e0o kh\u00e1c (v\u00ed d\u1ee5 nh\u01b0 \u0111\u1ea1i th\u1ef1c b\u00e0o v\u00e0 t\u1ebf b\u00e0o NK &#8211; t\u1ebf b\u00e0o di\u1ec7t t\u1ef1 nhi\u00ean) tham gia, ho\u1eb7c ti\u1ebft ra c\u00e1c k\u00edch ho\u1ea1t t\u1ed1 (cytokine) \u0111\u1ec3 huy \u0111\u1ed9ng c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o kh\u00e1c trong h\u1ec7 mi\u1ec5n d\u1ecbch \u0111\u1ebfn c\u00f9ng tham gia.<\/p>\n<p><strong>T cell receptor<\/strong>: \u0110i\u1ec1u quan tr\u1ecdng tr\u01b0\u1edbc khi t\u1ebf b\u00e0o T ra tay ti\u00eau di\u1ec7t t\u1ebf b\u00e0o l\u1ea1 l\u00e0 ch\u00fang ph\u1ea3i c\u00f3 kh\u1ea3 n\u0103ng ph\u00e2n bi\u1ec7t \u0111\u01b0\u1ee3c t\u1ebf b\u00e0o l\u1ea1 v\u1edbi t\u1ebf b\u00e0o quen. \u0110i\u1ec1u n\u00e0y \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n th\u00f4ng qua th\u1ee5 th\u1ec3 tr\u00ean b\u1ec1 m\u1eb7t \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 T cell receptor &#8211; TCR. N\u1ebfu t\u01b0\u1edfng t\u01b0\u1ee3ng m\u1ed7i t\u1ebf b\u00e0o T l\u00e0 m\u1ed9t ng\u00f4i nh\u00e0, th\u00ec th\u1ee5 th\u1ec3 c\u1ee7a t\u1ebf b\u00e0o T gi\u1ed1ng nh\u01b0 c\u00e2y \u0103ng-ten v\u01b0\u01a1n l\u00ean t\u1eeb m\u00e1i ng\u00f4i nh\u00e0 \u0111\u00f3. C\u00e2y \u0103ng-ten th\u01b0\u1eddng c\u00f3 3 ph\u1ea7n, ph\u1ea7n ng\u1ecdn v\u01b0\u01a1n ra ngo\u00e0i \u0111\u1ec3 nh\u1eadn t\u00edn hi\u1ec7u, ph\u1ea7n g\u1ed1c \u0111\u1ec3 b\u00e1m v\u00e0o m\u00e1i nh\u00e0, ph\u1ea7n d\u00e2y b\u00ean trong \u0111\u1ec3 truy\u1ec1n t\u00edn hi\u1ec7u v\u00e0o trong nh\u00e0 (ti vi).<\/p>\n<p>Gi\u1ed1ng nh\u01b0 c\u00e2y \u0103ng-ten, th\u1ee5 th\u1ec3 c\u1ee7a t\u1ebf b\u00e0o T c\u0169ng c\u00f3 3 ph\u1ea7n, ph\u1ea7n ng\u1ecdn b\u00ean ngo\u00e0i t\u1ebf b\u00e0o th\u01b0\u1eddng c\u00f3 \u0111\u1ed9 \u0111a d\u1ea1ng v\u00e0 linh \u0111\u1ed9ng nhi\u1ec1u \u0111\u1ec3 nh\u1eadn di\u1ec7n nhi\u1ec1u lo\u1ea1i kh\u00e1ng nguy\u00ean, ph\u1ea7n g\u1ed1c \u0111\u1ec3 \u0111\u1ecbnh v\u1ecb tr\u00ean m\u00e0ng t\u1ebf b\u00e0o v\u00e0 ph\u1ea7n \u0111u\u00f4i l\u00e0m nhi\u1ec7m v\u1ee5 truy\u1ec1n t\u00edn hi\u1ec7u v\u00e0o b\u00ean trong t\u1ebf b\u00e0o.<\/p>\n<p><strong>Antigen &#8211; kh\u00e1ng nguy\u00ean<\/strong> l\u00e0 nh\u1eefng ph\u00e2n t\u1eed \u0111\u1eb7c bi\u1ec7t, c\u00f3 kh\u1ea3 n\u0103ng k\u00edch th\u00edch \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch. V\u00ec mang nhi\u1ec1u \u0111\u1ed9t bi\u1ebfn, n\u00ean t\u1ebf b\u00e0o ung th\u01b0 th\u01b0\u1eddng mang nh\u1eefng ph\u00e2n t\u1eed l\u1ea1, kh\u00e1c v\u1edbi nh\u1eefng t\u1ebf b\u00e0o xung quanh. \u0110\u00e2y l\u00e0 \u0111\u1ea7u m\u1ed1i \u0111\u1ec3 h\u1ec7 mi\u1ec5n d\u1ecbch n\u00f3i chung v\u00e0 t\u1ebf b\u00e0o T n\u00f3i ri\u00eang ph\u00e1t hi\u1ec7n ra v\u00e0 ti\u00eau di\u1ec7t ch\u00fang. Tuy nhi\u00ean \u0111\u1ec3 \u0111\u1ea3m b\u1ea3o ch\u1ec9 c\u00f3 t\u1ebf b\u00e0o ung th\u01b0 b\u1ecb ti\u00eau di\u1ec7t, c\u00e1c nh\u00e0 khoa h\u1ecdc ph\u1ea3i ch\u1ecdn ra \u0111\u01b0\u1ee3c 1 lo\u1ea1i kh\u00e1ng nguy\u00ean CH\u1ec8 \u0111\u1eb7c tr\u01b0ng cho t\u1ebf b\u00e0o ung th\u01b0 m\u00e0 th\u00f4i.<\/p>\n<p><strong>Chimeric (t\u1ed5ng h\u1ee3p):<\/strong> K\u1ebft n\u1ed1i nh\u1eefng nh\u00e2n t\u1ed1 quan tr\u1ecdng n\u00e0y l\u1ea1i v\u1edbi nhau: Th\u1ee5 th\u1ec3 &#8211; Kh\u00e1ng nguy\u00ean &#8211; Nh\u1eadn di\u1ec7n &#8211; \u0110\u1eb7c hi\u1ec7u, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 \u0111\u01b0a th\u00eam v\u00e0o m\u1ed9t tr\u00ecnh t\u1ef1 \u0111\u1eb7c bi\u1ec7t tr\u00ean th\u1ee5 th\u1ec3 nh\u1eb1m \u0111\u1ea3m b\u1ea3o r\u1eb1ng t\u1ebf b\u00e0o CAR-T s\u1ebd lu\u00f4n nh\u1eadn di\u1ec7n \u0111\u01b0\u1ee3c v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0. Th\u00eam v\u00e0o \u0111\u00f3, kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t c\u1ee7a t\u1ebf b\u00e0o T c\u0169ng \u0111\u01b0\u1ee3c t\u0103ng c\u01b0\u1eddng nh\u1edd v\u00e0o m\u1ed9t s\u1ed1 thay \u0111\u1ed5i \u1edf ph\u1ea7n \u0111u\u00f4i c\u1ee7a th\u1ee5 th\u1ec3 nh\u1eb1m khu\u1ebfch \u0111\u1ea1i t\u00edn hi\u1ec7u. V\u00ec t\u1ebf b\u00e0o CAR-T mang th\u1ee5 th\u1ec3 \u0111\u1eb7c bi\u1ec7t v\u1edbi c\u00e1c ph\u1ea7n m\u1edbi v\u1edbi ngu\u1ed3n g\u1ed1c kh\u00e1c nhau n\u00ean c\u00f3 t\u00ean l\u00e0 Chimeric (t\u1ed5ng h\u1ee3p).<\/p>\n<p>Hi\u1ec7n nay c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111ang ti\u1ebfp t\u1ee5c c\u1ea3i ti\u1ebfn t\u1ebf b\u00e0o CAR-T c\u0169ng nh\u01b0 t\u00ecm ra lo\u1ea1i kh\u00e1ng nguy\u00ean \u0111\u1eb7c tr\u01b0ng cho c\u00e1c lo\u1ea1i ung th\u01b0 kh\u00e1c \u0111\u1ec3 \u1ee9ng d\u1ee5ng v\u00e0o \u0111i\u1ec1u tr\u1ecb.<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-25541 size-full\" src=\"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/11\/43650818_459695634522138_2217518097693147136_o.jpg\" alt=\"\" width=\"1200\" height=\"665\" \/><\/p>\n<h3><strong>T\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a CAR-T<\/strong><\/h3>\n<p>Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o CAR-T c\u0169ng \u0111i k\u00e8m v\u1edbi m\u1ed9t s\u1ed1 t\u00e1c d\u1ee5ng ph\u1ee5 nguy hi\u1ec3m nh\u01b0 h\u1ed9i ch\u1ee9ng gi\u1ea3i ph\u00f3ng k\u00edch ho\u1ea1t t\u1ed1 (cytokine-release syndrome), r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng n\u00e3o (encephalopathy), h\u1ed9i ch\u1ee9ng ph\u00e2n gi\u1ea3i kh\u1ed1i u (tumor lysis syndrome).<\/p>\n<ul>\n<li><strong>H\u1ed9i ch\u1ee9ng gi\u1ea3i ph\u00f3ng k\u00edch ho\u1ea1t t\u1ed1<\/strong>: Do t\u1ebf b\u00e0o CAR-T \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i \u0111\u1ec3 th\u00fac \u0111\u1ea9y hi\u1ec7n t\u01b0\u1ee3ng gi\u1ea3i ph\u00f3ng k\u00edch ho\u1ea1t t\u1ed1 nh\u1eb1m huy \u0111\u1ed9ng c\u00e1c lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch kh\u00e1c tham gia lo\u1ea1i b\u1ecf t\u1ebf b\u00e0o ung th\u01b0. Khi t\u1ebf b\u00e0o T \u0111\u01b0\u1ee3c t\u0103ng ho\u1ea1t, l\u01b0\u1ee3ng k\u00edch ho\u1ea1t t\u1ed1 \u0111\u01b0\u1ee3c ti\u1ebft ra c\u0169ng nhi\u1ec1u l\u00ean v\u00e0 k\u1ebft qu\u1ea3 l\u00e0 ph\u1ea3n \u1ee9ng vi\u00eam x\u1ea3y ra tr\u00ean di\u1ec7n r\u1ed9ng v\u00e0 m\u1ea1nh h\u01a1n.<\/li>\n<\/ul>\n<p>B\u1ec7nh nh\u00e2n c\u00f3 th\u1ec3 b\u1ecb c\u00e1c tri\u1ec7u ch\u1ee9ng nh\u1eb9 nh\u01b0 s\u1ed1t cao v\u00e0 \u0111au c\u01a1, v\u00e0 c\u0169ng c\u00f3 nh\u1eefng tri\u1ec7u ch\u1ee9ng n\u1eb7ng nh\u01b0 v\u1ee1 m\u1ea1ch m\u00e1u, huy\u1ebft \u00e1p th\u1ea5p, suy h\u00f4 h\u1ea5p,&#8230; H\u01a1n 70% s\u1ed1 b\u1ec7nh nh\u00e2n th\u1eed nghi\u1ec7m b\u1ecb h\u1ed9i ch\u1ee9ng n\u00e0y v\u00e0 ph\u1ea3i nh\u1eadp vi\u1ec7n \u0111\u1ec3 theo d\u00f5i s\u00e1t sao v\u00e0 \u0111i\u1ec1u tr\u1ecb k\u1ecbp th\u1eddi. Th\u1eadm ch\u00ed m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p b\u1ecb n\u1eb7ng th\u00ec c\u1ea7n ph\u1ea3i \u0111\u01b0\u1ee3c h\u1ed7 tr\u1ee3 h\u00f4 h\u1ea5p.<\/p>\n<ul>\n<li><strong>R\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng n\u00e3o:<\/strong> Hi\u1ec7n nay c\u00f3 kho\u1ea3ng 4 tr\u01b0\u1eddng h\u1ee3p t\u1eed vong li\u00ean quan \u0111\u1ebfn c\u00e1c th\u1eed nghi\u1ec7m t\u1ebf b\u00e0o CAR-T, m\u00e0 h\u1ea7u h\u1ebft l\u00e0 do c\u00e1c bi\u1ebfn ch\u1ee9ng li\u00ean quan \u0111\u1ebfn n\u00e3o. Nguy\u00ean nh\u00e2n d\u1eabn \u0111\u1ebfn c\u00e1c bi\u1ebfn ch\u1ee9ng n\u00e0y v\u1eabn c\u00f2n \u0111ang b\u1ecb tranh c\u00e3i v\u00e0 \u0111\u01b0\u1ee3c l\u00e0m r\u00f5. Ngo\u00e0i ra b\u1ec7nh nh\u00e2n b\u1ecb m\u1ed9t s\u1ed1 r\u1ed1i lo\u1ea1n t\u1ea1m th\u1eddi do s\u1ed1t cao nh\u01b0 m\u00ea s\u1ea3ng, \u0111\u1ebfn r\u1ed1i lo\u1ea1n to\u00e0n b\u1ed9 nh\u01b0 m\u1ea5t kh\u1ea3 n\u0103ng ng\u00f4n ng\u1eef, m\u00ea s\u1ea3ng, \u1ea3o gi\u00e1c.<\/li>\n<li><strong>H\u1ed9i ch\u1ee9ng ph\u00e2n gi\u1ea3i kh\u1ed1i u:<\/strong>\u00a0S\u1ed1 l\u01b0\u1ee3ng t\u1ebf b\u00e0o ung th\u01b0 ch\u1ebft h\u00e0ng lo\u1ea1t l\u00e0m r\u1ed1i lo\u1ea1n c\u00e1c chuy\u1ec3n ho\u00e1 trong c\u01a1 th\u1ec3. H\u1ed9i ch\u1ee9ng n\u00e0y c\u0169ng l\u00e0m ch\u1ebft 1 b\u1ec7nh nh\u00e2n trong qu\u00e1 tr\u00ecnh th\u1eed nghi\u1ec7m.<\/li>\n<li><strong>V\u1ea5n \u0111\u1ec1 tr\u00fang \u0111\u00edch v\u00e0 l\u1ea1c \u0111\u00edch:<\/strong> Trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p, lo\u1ea1i kh\u00e1ng nguy\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m m\u1ee5c ti\u00eau t\u1ea5n c\u00f4ng c\u1ee7a t\u1ebf b\u00e0o CAR-T c\u0169ng c\u00f3 bi\u1ec3u hi\u1ec7n trong m\u1ed9t v\u00e0i lo\u1ea1i t\u1ebf b\u00e0o b\u00ecnh th\u01b0\u1eddng. V\u00ec v\u1eady ch\u00fang tr\u1edf th\u00e0nh l\u00e0 \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ecb ti\u00eau di\u1ec7t.<\/li>\n<\/ul>\n<p>Trong m\u1ed9t th\u1eed nghi\u1ec7m khi ErbB2 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m kh\u00e1ng nguy\u00ean \u0111\u1ec3 t\u1ea5n c\u00f4ng c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 ph\u1ed5i, m\u1ed9t b\u1ec7nh nh\u00e2n b\u1ecb ch\u1ebft do suy h\u00f4 h\u1ea5p, v\u00ec t\u1ebf b\u00e0o b\u00ecnh th\u01b0\u1eddng c\u1ee7a ng\u01b0\u1eddi n\u00e0y c\u0169ng c\u00f3 ErbB2. Ngo\u00e0i ra trong tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh ALL, v\u00ec kh\u00e1ng nguy\u00ean CD19 \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n \u1edf c\u1ea3 t\u1ebf b\u00e0o B \u00e1c t\u00ednh v\u00e0 t\u1ebf b\u00e0o B b\u00ecnh th\u01b0\u1eddng, n\u00ean trong v\u00f2ng 1 n\u0103m sau tr\u1ecb li\u1ec7u, b\u1ec7nh nh\u00e2n ho\u00e0n to\u00e0n kh\u00f4ng c\u00f3 t\u1ebf b\u00e0o B, cho \u0111\u1ebfn khi l\u01b0\u1ee3ng t\u1ebf b\u00e0o CAR-T b\u1ecb th\u1ea3i lo\u1ea1i ho\u00e0n to\u00e0n. V\u00ec t\u1ebf b\u00e0o B l\u00e0 ngu\u1ed3n s\u1ea3n xu\u1ea5t kh\u00e1ng th\u1ec3, n\u00ean b\u1ec7nh nh\u00e2n c\u1ea7n ph\u1ea3i ti\u1ebfp nh\u1eadn ngu\u1ed3n kh\u00e1ng th\u1ec3 ngo\u1ea1i sinh t\u1eeb b\u00ean ngo\u00e0i.<\/p>\n<h3><strong>Nghi\u00ean c\u1ee9u c\u00e1ch gi\u1ea3i quy\u1ebft\u00a0<\/strong><\/h3>\n<p>V\u00ec v\u1eady \u0111\u1ec3 hi\u1ec7n th\u1ef1c ho\u00e1 v\u00e0 t\u1ed1i \u01b0u ho\u00e1 li\u1ec7u ph\u00e1p n\u00e0y, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111ang t\u00ecm c\u00e1ch gi\u1ea3i quy\u1ebft m\u1ed9t s\u1ed1 v\u1ea5n \u0111\u1ec1:<\/p>\n<ul>\n<li><strong>Ch\u1ecdn kh\u00e1ng nguy\u00ean \u0111\u1eb7c tr\u01b0ng cho t\u1ebf b\u00e0o ung th\u01b0 d\u1ef1a v\u00e0o m\u1ed9t v\u00e0i th\u00f4ng s\u1ed1 nh\u01b0:<\/strong> m\u1ee9c \u0111\u1ed9 ph\u00e2n b\u1ed1 c\u1ee7a lo\u1ea1i kh\u00e1ng nguy\u00ean trong kh\u1ed1i u (t\u1ebf b\u00e0o ung th\u01b0 n\u00e0o c\u0169ng c\u00f3, hay c\u00e1i c\u00f3 c\u00e1i kh\u00f4ng), \u0111\u1ed9 \u1ed5n \u0111\u1ecbnh c\u1ee7a kh\u00e1ng nguy\u00ean trong c\u00e1c giai \u0111o\u1ea1n kh\u00e1c nhau c\u1ee7a ung th\u01b0 v\u00ec l\u00fac c\u00f3 l\u00fac kh\u00f4ng th\u00ec hi\u1ec7u qu\u1ea3 s\u1ebd kh\u00f4ng cao v\u00e0 c\u00f3 nguy c\u01a1 t\u00e1i ph\u00e1t.<\/li>\n<li><strong>Vi\u1ec7c nh\u00e2n r\u1ed9ng t\u1ebf b\u00e0o CAR-T b\u00ean ngo\u00e0i c\u01a1 th\u1ec3 ng\u01b0\u1eddi b\u1ec7nh.<\/strong> Hi\u1ec7n nay ch\u1ee7 y\u1ebfu v\u1eabn l\u00e0 quy tr\u00ecnh t\u1ef1 gh\u00e9p, t\u1ee9c l\u00e0 l\u1ea5y t\u1ebf b\u00e0o c\u1ee7a b\u1ec7nh nh\u00e2n, x\u1eed l\u00fd r\u1ed3i ti\u00eam truy\u1ec1n l\u1ea1i v\u00e0o cho b\u1ec7nh nh\u00e2n. Vi\u1ec7c th\u00e0nh l\u1eadp c\u00e1c ng\u00e2n h\u00e0ng v\u00e0 d\u1eef li\u1ec7u v\u1ec1 t\u1ebf b\u00e0o CAR-T l\u00e0 m\u1ed9t \u0111i\u1ec1u c\u1ea7n thi\u1ebft \u0111\u1ec3 ti\u1ebft ki\u1ec7m th\u1eddi gian v\u00e0 chi ph\u00ed ch\u1eefa b\u1ec7nh.<\/li>\n<li><strong>X\u00e1c \u0111\u1ecbnh li\u1ec1u l\u01b0\u1ee3ng v\u00e0 th\u1eddi gian ti\u00eam truy\u1ec1n t\u1ebf b\u00e0o CAR-T<\/strong> \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c hi\u1ec7u qu\u1ea3 cao nh\u1ea5t v\u00e0 gi\u1ea3m c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n.<\/li>\n<li><strong>C\u1ea3i ti\u1ebfn c\u00e1c k\u1ef9 thu\u1eadt di truy\u1ec1n \u0111\u1ec3 thi\u1ebft k\u1ebf t\u1ebf b\u00e0o CAR-T th\u00f4ng minh h\u01a1n<\/strong> nh\u01b0 s\u1eed d\u1ee5ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u1ec9nh s\u1eeda b\u1ed9 gene thay v\u00ec d\u00f9ng virus \u0111\u1ec3 chuy\u1ec3n gene.<\/li>\n<li><strong>\u0110\u1ed1i v\u1edbi nh\u1eefng lo\u1ea1i kh\u1ed1i u c\u1ee9ng,<\/strong> t\u1ebf b\u00e0o CAR-T c\u1ea7n ph\u1ea3i c\u00f3 kh\u1ea3 n\u0103ng th\u00e2m nh\u1eadp cao h\u01a1n \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng hi\u1ec7u qu\u1ea3.<\/li>\n<li><strong>Kh\u1ed1i u \u0111\u01b0\u1ee3c bi\u1ebft t\u1edbi v\u1edbi kh\u1ea3 n\u0103ng ti\u1ebfn ho\u00e1 v\u00e0 th\u00edch nghi r\u1ea5t cao,<\/strong> n\u00ean c\u00f3 kh\u1ea3 n\u0103ng l\u00e0 t\u1ef1 ph\u00e1t tri\u1ec3n nhi\u1ec1u h\u00e0ng r\u00e0o b\u1ea3o v\u1ec7, ch\u1ed1ng l\u1ea1i t\u1ebf b\u00e0o CAR-T. V\u00ec v\u1eady nhi\u1ec1u ph\u01b0\u01a1ng \u00e1n c\u00f2n \u0111ang \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m \u0111\u1ec3 tr\u00e1nh hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y.<br \/>\n***<br \/>\nCu\u1ed1i c\u00f9ng, c\u1ea7n ph\u1ea3i nh\u1ea5n m\u1ea1nh l\u1ea1i r\u1eb1ng, li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o CAR-T v\u1eabn c\u00f2n m\u1edbi v\u00e0 \u0111ang \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m, vi\u1ec7c ch\u1eefa tr\u1ecb c\u0169ng \u0111i k\u00e8m v\u1edbi nhi\u1ec1u nguy c\u01a1 cho b\u1ec7nh nh\u00e2n. V\u00ec v\u1eady vi\u1ec7c th\u1eed nghi\u1ec7m v\u00e0 ch\u1eefa tr\u1ecb c\u1ea7n ph\u1ea3i \u0111i k\u00e8m v\u1edbi qu\u00e1 tr\u00ecnh theo d\u00f5i s\u00e1t sao \u0111\u1ec3 c\u00f3 nh\u1eefng can thi\u1ec7p y t\u1ebf k\u1ecbp th\u1eddi v\u00e0 hi\u1ec7u qu\u1ea3.<\/li>\n<\/ul>\n<h3>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/h3>\n<ol>\n<li><a href=\"http:\/\/embomolmed.embopress.org\/content\/9\/9\/1183.long?fbclid=IwAR1ApYODAqLeuy3E3aNx6co7gBcfBG2qXeapcSox4NnrvAkSpXCCFBzXXqs\" target=\"_blank\" rel=\"noopener nofollow\">http:\/\/embomolmed.embopress.org\/content\/9\/9\/1183.long<\/a><\/li>\n<li><a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/nejmoa1407222?fbclid=IwAR0dLbsZo7emPSqCxHePfxEiGcZDsCQ6ZBr2I0VQhEgqEs6SBQPB55JCofg#t=article\" target=\"_blank\" rel=\"noopener nofollow\">http:\/\/www.nejm.org\/doi\/full\/10.1056\/nejmoa1407222#t=article<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/nrc.2016.97?fbclid=IwAR1AXi1cfQxmYpkTZJ1kh-VyDHsh9NkWlFCwHRm7GM9UuyqVgxgshfdt5T8\" target=\"_blank\" rel=\"noopener nofollow\">https:\/\/www.nature.com\/articles\/nrc.2016.97<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o CAR-T v\u1eabn c\u00f2n m\u1edbi v\u00e0 \u0111ang \u0111\u01b0\u1ee3c th\u1eed nghi\u1ec7m, vi\u1ec7c ch\u1eefa tr\u1ecb c\u0169ng \u0111i k\u00e8m v\u1edbi nhi\u1ec1u nguy c\u01a1 cho b\u1ec7nh nh\u00e2n. V\u00ec v\u1eady vi\u1ec7c th\u1eed nghi\u1ec7m v\u00e0 ch\u1eefa tr\u1ecb c\u1ea7n ph\u1ea3i \u0111i k\u00e8m v\u1edbi qu\u00e1 tr\u00ecnh theo d\u00f5i s\u00e1t sao \u0111\u1ec3 c\u00f3 nh\u1eefng can thi\u1ec7p y t\u1ebf k\u1ecbp th\u1eddi v\u00e0 hi\u1ec7u qu\u1ea3.<\/p>\n","protected":false},"author":380,"featured_media":12214,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[2624,2471],"series":[3976],"coauthors":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch CAR-T trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 - Y H\u1ecdc C\u1ed9ng \u0110\u1ed3ng<\/title>\n<meta name=\"description\" content=\"Theo \u201ctr\u00e0o l\u01b0u \u0111ang l\u00ean\u201d c\u1ee7a li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch, Y h\u1ecdc c\u1ed9ng \u0111\u1ed3ng xin gi\u1edbi thi\u1ec7u b\u00e0i vi\u1ebft v\u1ec1 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o CAR-T, m\u1ed9t \u201cng\u01b0\u1eddi anh em\u201d v\u1edbi gi\u1ea3i Nobel Y h\u1ecdc n\u0103m nay. CAR-T c\u00f3 th\u1ec3 c\u0169ng l\u00e0 m\u1ed9t \u1ee9ng c\u1eed vi\u00ean n\u1eb7ng k\u00ed cho gi\u1ea3i Nobel Y h\u1ecdc trong nh\u1eefng n\u0103m t\u1edbi.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/yhoccongdong.com\/ung-thu\/lieu-phap-mien-dich-car-t-trong-dieu-tri-ung-thu\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch CAR-T trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 - Y H\u1ecdc C\u1ed9ng \u0110\u1ed3ng\" \/>\n<meta property=\"og:description\" content=\"Theo \u201ctr\u00e0o l\u01b0u \u0111ang l\u00ean\u201d c\u1ee7a li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch, Y h\u1ecdc c\u1ed9ng \u0111\u1ed3ng xin gi\u1edbi thi\u1ec7u b\u00e0i vi\u1ebft v\u1ec1 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o CAR-T, m\u1ed9t \u201cng\u01b0\u1eddi anh em\u201d v\u1edbi gi\u1ea3i Nobel Y h\u1ecdc n\u0103m nay. CAR-T c\u00f3 th\u1ec3 c\u0169ng l\u00e0 m\u1ed9t \u1ee9ng c\u1eed vi\u00ean n\u1eb7ng k\u00ed cho gi\u1ea3i Nobel Y h\u1ecdc trong nh\u1eefng n\u0103m t\u1edbi.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/yhoccongdong.com\/ung-thu\/lieu-phap-mien-dich-car-t-trong-dieu-tri-ung-thu\/\" \/>\n<meta property=\"og:site_name\" content=\"D\u1ef1 \u00e1n Ung Th\u01b0\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/kimvybear\" \/>\n<meta property=\"article:published_time\" content=\"2018-11-30T01:28:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/11\/lieu-phap-mien-dich-car-t-trong-dieu-tri-ung-thu-4.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"660\" \/>\n\t<meta property=\"og:image:height\" content=\"330\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"TS. 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