{"id":7944,"date":"2018-09-01T03:53:12","date_gmt":"2018-08-31T20:53:12","guid":{"rendered":"https:\/\/yhoccongdong.org\/ung-thu\/hieu-ve-lieu-phap-nham-dich\/"},"modified":"2018-09-01T03:53:12","modified_gmt":"2018-08-31T20:53:12","slug":"hieu-ve-lieu-phap-nham-dich","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/ung-thu\/hieu-ve-lieu-phap-nham-dich\/","title":{"rendered":"Hi\u1ec3u v\u1ec1 li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch"},"content":{"rendered":"<p style=\"text-align: justify\"><span style=\"font-weight: 400\">Li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch (Targeted Therapy) l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb ung th\u01b0 b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng thu\u1ed1c. N\u00f3 kh\u00e1c v\u1edbi li\u1ec7u ph\u00e1p h\u00f3a tr\u1ecb truy\u1ec1n th\u1ed1ng. Thu\u1ed1c \u1edf \u0111\u00e2y l\u00e0 m\u1ed9t li\u1ec7u ph\u00e1p c\u00f3 m\u1ee5c ti\u00eau c\u1ee5 th\u1ec3 gi\u00fap ng\u0103n ch\u1eb7n s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 lan r\u1ed9ng c\u1ee7a kh\u1ed1i u. Ch\u00fang ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch t\u1ea5n c\u00f4ng v\u00e0o c\u00e1c gene hay protein chuy\u00ean bi\u1ec7t. Nh\u1eefng gene v\u00e0 protein n\u00e0y \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf t\u1ebf b\u00e0o ung th\u01b0 ho\u1eb7c nh\u1eefng t\u1ebf b\u00e0o c\u00f3 li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a kh\u1ed1i u, v\u00ed d\u1ee5 nh\u01b0 t\u1ebf b\u00e0o m\u1ea1ch m\u00e1u.<\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">B\u00e1c s\u0129 th\u01b0\u1eddng s\u1eed d\u1ee5ng k\u1ebft h\u1ee3p li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch v\u1edbi h\u00f3a tr\u1ecb v\u00e0 nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c. C\u1ee5c qu\u1ea3n l\u00ed Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m c\u1ee7a M\u1ef9 (FDA) \u0111\u00e3 th\u00f4ng qua li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch cho nhi\u1ec1u lo\u1ea1i ung th\u01b0. C\u00e1c nh\u00e0 khoa h\u1ecdc c\u0169ng \u0111ang th\u1eed nghi\u1ec7m thu\u1ed9c tr\u00ean nh\u1eefng lo\u1ea1i ung th\u01b0 m\u1edbi. <\/span><\/p>\n<p style=\"text-align: justify\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-medium wp-image-21903 aligncenter\" src=\"https:\/\/yhoccongdong.com\/ung-thu\/wp-content\/uploads\/sites\/2\/2018\/08\/shutterstock_83721097-300x223-1.jpg\" alt=\"\" width=\"300\" height=\"223\" \/><\/p>\n<p style=\"text-align: center\"><span style=\"font-weight: 400\">H\u00ecnh 1. Li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch c\u1ed1 g\u1eafng ti\u00eau di\u1ec7t \u0111\u1eb7c hi\u1ec7u kh\u1ed1i u.<\/span><\/p>\n<h2 style=\"text-align: justify\"><b>\u201c\u0110\u1ed1i t\u01b0\u1ee3ng\u201d c\u1ee7a li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch <\/b><\/h2>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">Bi\u1ebft ph\u01b0\u01a1ng th\u1ee9c ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 s\u1ebd gi\u00fap hi\u1ec3u \u0111\u01b0\u1ee3c li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch ho\u1ea1t \u0111\u1ed9ng nh\u01b0 th\u1ebf n\u00e0o. T\u1ebf b\u00e0o t\u1ea1o n\u00ean m\u1ecdi lo\u1ea1i m\u00f4 trong c\u01a1 th\u1ec3. C\u00f3 r\u1ea5t nhi\u1ec1u lo\u1ea1i t\u1ebf b\u00e0o nh\u01b0 t\u1ebf b\u00e0o m\u00e1u, t\u1ebf b\u00e0o n\u00e3o v\u00e0 t\u1ebf b\u00e0o da. M\u1ed7i lo\u1ea1i c\u00f3 m\u1ed9t ch\u1ee9c n\u0103ng chuy\u00ean bi\u1ec7t. Ung th\u01b0 b\u1eaft \u0111\u1ea7u khi nh\u1eefng gene chuy\u00ean bi\u1ec7t n\u00e0o \u0111\u00f3 trong t\u1ebf b\u00e0o kho\u1ebb m\u1ea1nh thay \u0111\u1ed5i. C\u00e1c nh\u00e0 khoa h\u1ecdc g\u1ecdi nh\u1eefng thay \u0111\u1ed5i n\u00e0y l\u00e0 \u0111\u1ed9t bi\u1ebfn. <\/span><span style=\"font-weight: 400\">T\u1ebf b\u00e0o t\u1ea1o ra protein t\u1eeb c\u00e1c gene \u0111\u1ec3 th\u1ef1c hi\u1ec7n c\u00e1c ch\u1ee9c n\u0103ng c\u1ee7a n\u00f3. N\u1ebfu gene thay \u0111\u1ed5i, nh\u1eefng protein n\u00e0y c\u0169ng thay \u0111\u1ed5i lu\u00f4n. Ch\u00ednh nh\u1eefng thay \u0111\u1ed5i n\u00e0y l\u00e0m t\u1ebf b\u00e0o ph\u00e2n chia b\u1ea5t b\u00ecnh th\u01b0\u1eddng ho\u1eb7c s\u1ed1ng qu\u00e1 l\u00e2u. Khi vi\u1ec7c n\u00e0y x\u1ea3y ra, t\u1ebf b\u00e0o s\u1ebd ph\u00e1t tri\u1ec3n m\u00e0 ngo\u00e0i t\u1ea7m ki\u1ec3m so\u00e1t. Ch\u00ednh nh\u1eefng t\u1ebf b\u00e0o ph\u00e1t tri\u1ec3n ngo\u00e0i t\u1ea7m ki\u1ec3m so\u00e1t n\u00e0y t\u1ea1o th\u00e0nh kh\u1ed1i u. <\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang t\u00ecm hi\u1ec3u v\u1ec1 s\u1ef1 thay \u0111\u1ed5i c\u1ee7a m\u1ed9t s\u1ed1 gene nh\u1ea5t \u0111\u1ecbnh t\u1ea1i m\u1ed9t s\u1ed1 lo\u1ea1i ung th\u01b0 nh\u1ea5t \u0111\u1ecbnh. T\u1eeb \u0111\u00f3 h\u1ecd m\u1edbi ph\u00e1t tri\u1ec3n c\u00e1c lo\u1ea1i thu\u1ed1c nh\u1eb1m v\u00e0o c\u00e1c thay \u0111\u1ed5i n\u00e0y. Nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3:<\/span><\/p>\n<ul style=\"text-align: justify\">\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Ng\u0103n ch\u1eb7n ho\u1eb7c d\u1eadp t\u1eaft c\u00e1c t\u00edn hi\u1ec7u \u201c\u0111\u00e8n xanh\u201d gi\u00fap t\u1ebf b\u00e0o ung th\u01b0 ph\u00e1t tri\u1ec3n hay ph\u00e2n chia.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">B\u1ea3o v\u1ec7 t\u1ebf b\u00e0o kh\u1ecfi hi\u1ec7n t\u01b0\u1ee3ng s\u1ed1ng l\u00e2u h\u01a1n b\u00ecnh th\u01b0\u1eddng.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Gi\u1ebft c\u00e1c t\u1ebf b\u00e0o ung th\u01b0.<\/span><\/li>\n<\/ul>\n<h2 style=\"text-align: justify\"><b>C\u00e1c lo\u1ea1i li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch<\/b><\/h2>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">C\u00f3 2 lo\u1ea1i li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch:<\/span><\/p>\n<ul style=\"text-align: justify\">\n<li style=\"font-weight: 400\"><b>Kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng<\/b><span style=\"font-weight: 400\">: Nh\u1eefng lo\u1ea1i thu\u1ed1c \u201ckh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng\u201d ng\u0103n ch\u1eb7n m\u1ed9t m\u1ee5c ti\u00eau c\u1ee5 th\u1ec3 t\u1eeb ph\u00eda b\u00ean ngo\u00e0i c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0 hay trong khu v\u1ef1c xung quanh kh\u1ed1i u. Nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y ho\u1ea1t \u0111\u1ed9ng nh\u01b0 nh\u1eefng c\u00e1i ph\u00edch \u0111i\u1ec7n c\u1eafm v\u00e0o nh\u1eefng \u1ed5 \u0111i\u1ec7n v\u1eady. Ph\u00edch \u0111i\u1ec7n ng\u0103n ng\u1eeba d\u00f2ng \u0111i\u1ec7n kh\u00f4ng ch\u1ea1y ra kh\u1ecfi nh\u1eefng \u1ed5 \u0111i\u1ec7n.\u00a0<\/span>Kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0a nh\u1eefng ch\u1ea5t \u0111\u1ed9c tr\u1ef1c ti\u1ebfp \u0111\u1ebfn cho t\u1ebf b\u00e0o ung th\u01b0. V\u00ed d\u1ee5 ch\u00fang c\u00f3 th\u1ec3 h\u1ed7 tr\u1ee3 \u0111\u1ec3 h\u00f3a tr\u1ecb v\u00e0 x\u1ea1 tr\u1ecb \u0111\u1ebfn \u0111\u01b0\u1ee3c t\u1edbi t\u1ebf b\u00e0o ung th\u01b0 hi\u1ec7u qu\u1ea3 h\u01a1n. D\u1ea1ng thu\u1ed1c n\u00e0y th\u01b0\u1eddng \u0111\u01b0\u1ee3c ti\u00eam d\u01b0\u1edbi da.<\/li>\n<li style=\"font-weight: 400\"><b>Thu\u1ed1c l\u00e0 nh\u1eefng ph\u00e2n t\u1eed nh\u1ecf<\/b><span style=\"font-weight: 400\">: D\u1ea1ng thu\u1ed1c \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \u201cph\u00e2n t\u1eed nh\u1ecf\u201d c\u00f3 th\u1ec3 ng\u0103n ch\u1eb7n c\u00e1c qu\u00e1 tr\u00ecnh gi\u00fap t\u1ebf b\u00e0o ung th\u01b0 nh\u00e2n l\u00ean v\u00e0 lan r\u1ed9ng. Nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y th\u01b0\u1eddng \u0111\u01b0\u1ee3c u\u1ed1ng d\u01b0\u1edbi d\u1ea1ng vi\u00ean. Ch\u1ea5t \u1ee9c ch\u1ebf qu\u00e1 tr\u00ecnh t\u1ea1o m\u1ea1ch m\u00e1u l\u00e0 m\u1ed9t v\u00ed d\u1ee5 v\u1ec1 d\u1ea1ng n\u00e0y trong li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch. Nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y ng\u0103n c\u1ea3n s\u1ef1 h\u00ecnh th\u00e0nh c\u00e1c m\u1ea1ch m\u00e1u m\u1edbi trong c\u00e1c m\u00f4 xung quanh kh\u1ed1i u. M\u1ed9t kh\u1ed1i u c\u1ea7n nhi\u1ec1u m\u1ea1ch m\u00e1u \u0111\u1ec3 mang \u0111\u1ebfn ch\u1ea5t dinh d\u01b0\u1ee1ng v\u00e0 gi\u00fap ch\u00fang ph\u00e1t tri\u1ec3n v\u00e0 lan r\u1ed9ng. D\u1ea1ng li\u1ec7u ph\u00e1p n\u00e0y b\u1ecf \u0111\u00f3i kh\u1ed1i u b\u1eb1ng c\u00e1ch ng\u0103n ch\u1eb7n, kh\u00f4ng cho c\u00e1c m\u1ea1ch m\u00e1u m\u1edbi ph\u00e1t tri\u1ec3n.<\/span><\/li>\n<\/ul>\n<h2 style=\"text-align: justify\"><b>T\u00ecm ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb h\u1ee3p v\u1edbi b\u1ec7nh nh\u00e2n<\/b><\/h2>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">C\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y r\u1eb1ng kh\u00f4ng ph\u1ea3i t\u1ea5t c\u1ea3 c\u00e1c kh\u1ed1i u \u0111\u1ec1u c\u00f3 c\u00f9ng m\u1ee5c ti\u00eau. V\u00ec v\u1eady c\u00e1ch ch\u1eefa tr\u1ecb h\u01b0\u1edbng v\u00e0o m\u1ed9t m\u1ee5c ti\u00eau gi\u1ed1ng nhau l\u1ea1i kh\u00f4ng hi\u1ec7u qu\u1ea3 cho t\u1ea5t c\u1ea3 m\u1ecdi ng\u01b0\u1eddi. V\u00ed d\u1ee5, m\u1ed9t gene g\u1ecdi l\u00e0 <\/span><i><span style=\"font-weight: 400\">KRAS<\/span><\/i><span style=\"font-weight: 400\"> ki\u1ec3m so\u00e1t s\u1ef1 ph\u00e1t tri\u1ec3n v\u00e0 lan r\u1ed9ng c\u1ee7a kh\u1ed1i u. Kho\u1ea3ng 40% trong s\u1ed1 c\u00e1c ca ung th\u01b0 \u0111\u1ea1i tr\u00e0ng c\u00f3 \u0111\u1ed9t bi\u1ebfn tr\u00ean gene n\u00e0y. Khi \u0111i\u1ec1u n\u00e0y x\u1ea3y ra, li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch cetuximab (Erbitux) v\u00e0 panitumumab (Vectibix) l\u1ea1i kh\u00f4ng hi\u1ec7u qu\u1ea3. N\u1ebfu b\u1ea1n b\u1ecb ung th\u01b0 \u0111\u1ea1i tr\u00e0ng, ki\u1ec3m tra t\u00ecnh tr\u1ea1ng c\u1ee7a <\/span><i><span style=\"font-weight: 400\">KRAS<\/span><\/i><span style=\"font-weight: 400\"> s\u1ebd gi\u00fap b\u00e1c s\u0129 x\u00e1c \u0111\u1ecbnh li\u1ec7u ph\u00e1p n\u00e0o l\u00e0 hi\u1ec7u qu\u1ea3 cho b\u1ea1n. N\u00f3 c\u0169ng b\u1ea3o v\u1ec7 b\u1ea1n kh\u1ecfi nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng c\u1ea7n thi\u1ebft. B\u1ea1n c\u0169ng kh\u00f4ng ph\u1ea3i tr\u1ea3 ti\u1ec1n cho nh\u1eefng lo\u1ea1i thu\u1ed1c c\u00f3 th\u1ec3 kh\u00f4ng gi\u00fap \u00edch \u0111\u01b0\u1ee3c g\u00ec.<\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">B\u00e1c s\u0129 c\u1ee7a c\u00f3 th\u1ec3 y\u00eau c\u1ea7u l\u00e0m m\u1ed9t s\u1ed1 ki\u1ec3m tra v\u1ec1 gene, protein v\u00e0 nh\u1eefng nh\u00e2n t\u1ed1 kh\u00e1c trong kh\u1ed1i u. \u0110i\u1ec1u n\u00e0y gi\u00fap h\u1ecd t\u00ecm ra \u0111\u01b0\u1ee3c li\u1ec7u ph\u00e1p hi\u1ec7u qu\u1ea3 nh\u1ea5t. Nhi\u1ec1u li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch c\u0169ng g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5. V\u00e0 ch\u00fang c\u0169ng \u0111\u1eaft \u0111\u1ecf n\u1eefa. V\u00ec v\u1eady, c\u00e1c b\u00e1c s\u0129 ph\u1ea3i c\u1ed1 g\u1eafng t\u00ecm ra c\u00e1c ch\u1eefa tr\u1ecb hi\u1ec7u qu\u1ea3 nh\u1ea5t d\u00e0nh cho m\u1ed7i kh\u1ed1i u. <\/span><\/p>\n<h2 style=\"text-align: justify\"><b>C\u00e1c v\u00ed d\u1ee5 v\u1ec1 li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch<\/b><\/h2>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">B\u00ean d\u01b0\u1edbi l\u00e0 m\u1ed9t v\u00e0i v\u00ed d\u1ee5 v\u1ec1 li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch. <\/span><\/p>\n<ul style=\"text-align: justify\">\n<li style=\"font-weight: 400\"><b>Ung th\u01b0 v\u00fa<\/b><span style=\"font-weight: 400\">: Kho\u1ea3ng 20-25% c\u00e1c lo\u1ea1i ung th\u01b0 v\u00fa c\u00f3 qu\u00e1 nhi\u1ec1u m\u1ed9t lo\u1ea1i protein g\u1ecdi l\u00e0 th\u1ee5 th\u1ec3 nh\u00e2n t\u1ed1 ph\u00e1t tri\u1ec3n bi\u1ec3u m\u00f4 s\u1ed1 2 (epidermal growth factor receptor 2 \u2013 HER2). Protein n\u00e0y l\u00e0m cho t\u1ebf b\u00e0o ung th\u01b0 ph\u00e1t tri\u1ec3n. N\u1ebfu kh\u1ed1i u l\u00e0 d\u01b0\u01a1ng t\u00ednh v\u1edbi HER2, m\u1ed9t v\u00e0i lo\u1ea1i li\u1ec7u ph\u00e1p h\u01b0\u1edbng v\u00e0o HER2 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng. <\/span><\/li>\n<li style=\"font-weight: 400\"><b>Ung th\u01b0 \u0111\u1ea1i tr\u00e0ng<\/b><span style=\"font-weight: 400\">: ung th\u01b0 \u0111\u1ea1i tr\u00e0ng th\u01b0\u1eddng c\u00f3 qu\u00e1 nhi\u1ec1u m\u1ed9t lo\u1ea1i protein g\u1ecdi l\u00e0 th\u1ee5 th\u1ec3 nh\u00e2n t\u1ed1 ph\u00e1t tri\u1ec3n bi\u1ec3u m\u00f4 (epidermal growth factor receptor \u2013 EGFR). C\u00e1c thu\u1ed1c ng\u0103n ch\u1eb7n EGFR c\u00f3 th\u1ec3 ch\u1eb7n \u0111\u1ee9ng ho\u1eb7c l\u00e0m ch\u1eadm l\u1ea1i s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ung th\u01b0. D\u1ea1ng ung th\u01b0 n\u00e0y ph\u1ea3i kh\u00f4ng mang theo \u0111\u1ed9t bi\u1ebfn <\/span><i><span style=\"font-weight: 400\">KRAS<\/span><\/i><span style=\"font-weight: 400\"> (nh\u01b0 \u0111\u00e3 n\u00f3i \u1edf tr\u00ean). M\u1ed9t l\u1ef1a ch\u1ecdn kh\u00e1c l\u00e0 thu\u1ed1c ng\u0103n ch\u1eb7n nh\u00e2n t\u1ed1 ph\u00e1t tri\u1ec3n th\u00e0nh m\u1ea1ch (vascular endothelial growth factor \u2013 VEGF). Protein n\u00e0y gi\u00fap t\u1ea1o ra c\u00e1c m\u1ea1ch m\u00e1u m\u1edbi. <\/span><\/li>\n<li style=\"font-weight: 400\"><b>Ung th\u01b0 ph\u1ed5i<\/b><span style=\"font-weight: 400\">: C\u00e1c thu\u1ed1c ng\u0103n ch\u1eb7n EGFR c\u0169ng c\u00f3 th\u1ec3 ch\u1eb7n \u0111\u1ee9ng ho\u1eb7c l\u00e0m ch\u1eadm s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a ung th\u01b0 ph\u1ed5i. \u0110i\u1ec1u n\u00e0y l\u00e0 c\u00f3 th\u1ec3 v\u1edbi m\u1ed9t s\u1ed1 \u0111\u1ed9t bi\u1ebfn nh\u1ea5t \u0111\u1ecbnh tr\u00ean EGFR. Li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch c\u0169ng c\u00f3 m\u1eb7t cho d\u1ea1ng ung th\u01b0 ph\u1ed5i mang \u0111\u1ed9t bi\u1ebfn \u1edf gene ALK v\u00e0 ROS. B\u00e1c s\u0129 c\u0169ng s\u1eed d\u1ee5ng c\u00e1c ch\u1ea5t \u1ee9c ch\u1ebf s\u1ef1 ph\u00e1t tri\u1ec3n m\u1ea1ch m\u00e1u cho m\u1ed9t s\u1ed1 d\u1ea1ng ung th\u01b0 ph\u1ed5i nh\u1ea5t \u0111\u1ecbnh.<\/span><\/li>\n<li style=\"font-weight: 400\"><b>Ung th\u01b0 s\u1eafc t\u1ed1 da<\/b><span style=\"font-weight: 400\">: Kho\u1ea3ng m\u1ed9t n\u1eefa ung th\u01b0 s\u1eafc t\u1ed1 da c\u00f3 \u0111\u1ed9t bi\u1ebfn tr\u00ean gene <\/span><i><span style=\"font-weight: 400\">BRAF<\/span><\/i><span style=\"font-weight: 400\">. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u bi\u1ebft \u0111\u01b0\u1ee3c c\u00e1c \u0111\u1ed9t bi\u1ebfn c\u1ee5 th\u1ec3 <\/span><i><span style=\"font-weight: 400\">BRAF<\/span><\/i><span style=\"font-weight: 400\"> \u0111\u1ec3 t\u1ea1o ra c\u00e1c lo\u1ea1i thu\u1ed1c t\u1ed1t. V\u00ec v\u1eady, FDA \u0111\u00e3 ch\u1ea5p thu\u1eadn m\u1ed9t v\u00e0i lo\u1ea1i ch\u1ea5t \u1ee9c ch\u1ebf <\/span><i><span style=\"font-weight: 400\">BRAF<\/span><\/i><span style=\"font-weight: 400\">. Nh\u1eefng lo\u1ea1i thu\u1ed1c n\u00e0y c\u00f3 th\u1ec3 nguy hi\u1ec3m n\u1ebfu b\u1ec7nh nh\u00e2n kh\u00f4ng mang \u0111\u1ed9t bi\u1ebfn <\/span><i><span style=\"font-weight: 400\">BRAF<\/span><\/i><span style=\"font-weight: 400\">. <\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">Danh s\u00e1ch tr\u00ean \u0111\u00e2y kh\u00f4ng bao g\u1ed3m to\u00e0n b\u1ed9 c\u00e1c li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u00f2n \u0111ang t\u00ecm t\u00f2i ra nhi\u1ec1u lo\u1ea1i m\u1ee5c ti\u00eau m\u1edbi v\u00e0 thu\u1ed1c m\u1edbi. <\/span><\/p>\n<h2 style=\"text-align: justify\"><b>C\u00e1c th\u00e1ch th\u1ee9c c\u1ee7a li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch<\/b><\/h2>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">S\u1eed d\u1ee5ng m\u1ed9t lo\u1ea1i thu\u1ed1c h\u1eefu hi\u1ec7u cho m\u1ed9t lo\u1ea1i ung th\u01b0 c\u1ee5 th\u1ec3 nghe c\u00f3 v\u1ebb \u0111\u01a1n gi\u1ea3n. Nh\u01b0ng li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch th\u00ec ph\u1ee9c t\u1ea1p h\u01a1n nhi\u1ec1u v\u00e0 kh\u00f4ng ph\u1ea3i l\u00fac n\u00e0o c\u0169ng hi\u1ec7u qu\u1ea3. \u0110i\u1ec1u quan tr\u1ecdng l\u00e0 h\u00e3y nh\u1edb r\u1eb1ng:<\/span><\/p>\n<ul style=\"text-align: justify\">\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">M\u1ed9t li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch s\u1ebd kh\u00f4ng hi\u1ec7u qu\u1ea3 n\u1ebfu kh\u1ed1i u kh\u00f4ng c\u00f3 m\u1ee5c ti\u00eau \u0111\u00f3.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">C\u00f3 m\u1ee5c ti\u00eau kh\u00f4ng c\u00f3 ngh\u0129a l\u00e0 kh\u1ed1i u s\u1ebd \u0111\u00e1p \u1ee9ng l\u1ea1i v\u1edbi thu\u1ed1c.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">\u0110\u00e1p \u1ee9ng v\u1edbi li\u1ec7u ph\u00e1p c\u00f3 th\u1ec3 ch\u1ec9 l\u00e0 t\u1ea1m th\u1eddi. <\/span><\/li>\n<\/ul>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">V\u00ed d\u1ee5, m\u1ee5c ti\u00eau c\u00f3 th\u1ec3 kh\u00f4ng quan tr\u1ecdng v\u1edbi kh\u1ed1i u nh\u01b0 l\u00e0 b\u00e1c s\u0129 t\u1eebng ngh\u0129. V\u00ec v\u1eady thu\u1ed1c c\u0169ng kh\u00f4ng gi\u00fap \u0111\u01b0\u1ee3c g\u00ec. Ho\u1eb7c thu\u1ed1c c\u00f3 th\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng ban \u0111\u1ea7u nh\u01b0ng sau \u0111\u00f3 th\u00ec kh\u00f4ng. Cu\u1ed1i c\u00f9ng c\u00e1c lo\u1ea1i thu\u1ed1c trong li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. Nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 n\u00e0y th\u01b0\u1eddng kh\u00e1c v\u1edbi t\u00e1c d\u1ee5ng ph\u1ee5 do h\u00f3a tr\u1ecb truy\u1ec1n th\u1ed1ng. V\u00ed d\u1ee5, b\u1ec7nh nh\u00e2n ti\u1ebfp nh\u1eadn li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch th\u01b0\u1eddng b\u1ecb c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 da, t\u00f3c, m\u00f3ng tay v\u00e0 m\u1eaft. <\/span><\/p>\n<p style=\"text-align: justify\"><span style=\"font-weight: 400\">Li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb li\u1ec7u ung th\u01b0 quan tr\u1ecdng. Nh\u01b0ng cho \u0111\u1ebfn nay, c\u00e1c b\u00e1c s\u0129 ch\u1ec9 c\u00f3 th\u1ec3 lo\u1ea1i b\u1ecf \u0111\u01b0\u1ee3c m\u1ed9t s\u1ed1 \u00edt c\u00e1c lo\u1ea1i ung th\u01b0 b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p n\u00e0y. H\u1ea7u h\u1ebft b\u1ec7nh nh\u00e2n v\u1eabn c\u1ea7n ph\u1eabu thu\u1eadt, h\u00f3a tr\u1ecb, x\u1ea1 tr\u1ecb v\u00e0 li\u1ec7u ph\u00e1p hormone. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u v\u1eabn \u0111ang ti\u1ebfp t\u1ee5c ph\u00e1t tri\u1ec3n th\u00eam nhi\u1ec1u lo\u1ea1i thu\u1ed1c nh\u1eafm \u0111\u00edch kh\u00e1c khi h\u1ecd bi\u1ebft \u0111\u01b0\u1ee3c nhi\u1ec1u h\u01a1n nh\u1eefng thay \u0111\u1ed5i \u0111\u1eb7c tr\u01b0ng x\u1ea3y ra trong t\u1ebf b\u00e0o ung th\u01b0. <\/span><\/p>\n<h2 style=\"text-align: justify\"><b>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/b><\/h2>\n<ol>\n<li style=\"text-align: justify\"><a href=\"https:\/\/www.nccn.org\/patients\/resources\/life_with_cancer\/treatment\/targeted_therapy.aspx\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">https:\/\/www.nccn.org\/patients\/resources\/life_with_cancer\/treatment\/targeted_therapy.aspx <\/span><\/a><\/li>\n<li style=\"text-align: justify\"><a href=\"https:\/\/www.cancer.net\/navigating-cancer-care\/how-cancer-treated\/personalized-and-targeted-therapies\/understanding-targeted-therapy\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">https:\/\/www.cancer.net\/navigating-cancer-care\/how-cancer-treated\/personalized-and-targeted-therapies\/understanding-targeted-therapy<\/span><\/a><\/li>\n<li style=\"text-align: justify\"><a href=\"https:\/\/tcc.sg\/services\/therapies\/targeted-therapy\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">https:\/\/tcc.sg\/services\/therapies\/targeted-therapy\/<\/span><\/a><\/li>\n<li style=\"text-align: justify\"><a href=\"https:\/\/www.cancer.gov\/about-cancer\/treatment\/types\/targeted-therapies\/targeted-therapies-fact-sheet\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">https:\/\/www.cancer.gov\/about-cancer\/treatment\/types\/targeted-therapies\/targeted-therapies-fact-sheet<\/span><\/a><\/li>\n<li style=\"text-align: justify\"><a href=\"https:\/\/www.cancer.gov\/about-cancer\/treatment\/types\/targeted-therapies\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400\">https:\/\/www.cancer.gov\/about-cancer\/treatment\/types\/targeted-therapies<\/span><\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch (Targeted Therapy) l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb ung th\u01b0 b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng thu\u1ed1c. N\u00f3 kh\u00e1c v\u1edbi li\u1ec7u ph\u00e1p h\u00f3a tr\u1ecb truy\u1ec1n th\u1ed1ng.<\/p>\n","protected":false},"author":380,"featured_media":4888,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2808,2611],"tags":[2906,2907,2908],"series":[1654],"coauthors":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Hi\u1ec3u v\u1ec1 li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch - Y H\u1ecdc C\u1ed9ng \u0110\u1ed3ng<\/title>\n<meta name=\"description\" content=\"Li\u1ec7u ph\u00e1p nh\u1eafm \u0111\u00edch (Targeted Therapy) l\u00e0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p tr\u1ecb ung th\u01b0 b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng thu\u1ed1c. 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