{"id":8464,"date":"2020-04-26T20:31:13","date_gmt":"2020-04-26T13:31:13","guid":{"rendered":"https:\/\/yhoccongdong.org\/ung-thu\/ung-thu-da-day-xam-nhiem-di-truyen\/"},"modified":"2024-03-12T14:03:43","modified_gmt":"2024-03-12T07:03:43","slug":"ung-thu-da-day-xam-nhiem-di-truyen","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/ung-thu\/ung-thu-da-day-xam-nhiem-di-truyen\/","title":{"rendered":"Ung th\u01b0 d\u1ea1 d\u00e0y x\u00e2m nhi\u1ec5m di truy\u1ec1n"},"content":{"rendered":"<p style=\"text-align: right\"><strong><em>Bi\u00ean d\u1ecbch: Nguy\u1ec5n T\u1ea5n Khanh<\/em><\/strong><\/p>\n<p style=\"text-align: right\"><strong><em>Hi\u1ec7u \u0111\u00ednh: TS.BS\u00a0<a href=\"https:\/\/yhoccongdong.com\/profile\/nguyen-thi-quynh-tho\/\" target=\"_blank\" rel=\"noopener\">Nguy\u1ec5n Th\u1ecb Qu\u1ef3nh Th\u01a1<\/a><\/em><\/strong><\/p>\n<h2><strong>Ung th\u01b0 d\u1ea1 d\u00e0y x\u00e2m<\/strong><strong> nhi\u1ec5m <\/strong><strong>di truy\u1ec1n l\u00e0 g\u00ec?<\/strong><\/h2>\n<p>Ung th\u01b0 d\u1ea1 d\u00e0y x\u00e2m nhi\u1ec5m di truy\u1ec1n (HDGC) l\u00e0 m\u1ed9t b\u1ec7nh l\u00fd di truy\u1ec1n hi\u1ebfm g\u1eb7p li\u00ean quan \u0111\u1ebfn t\u0103ng nguy c\u01a1 m\u1eafc ung th\u01b0 d\u1ea1 d\u00e0y. D\u1ea1 d\u00e0y n\u1eb1m \u1edf v\u00f9ng th\u01b0\u1ee3ng v\u1ecb v\u00e0 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c ti\u00eau h\u00f3a th\u1ee9c \u0103n. Th\u1ee9c \u0103n \u0111\u01b0\u1ee3c nu\u1ed1t, \u0111\u1ea9y xu\u1ed1ng d\u1ea1 d\u00e0y th\u00f4ng qua th\u1ef1c qu\u1ea3n. D\u1ea1 d\u00e0y co b\u00f3p \u0111\u1ec3 tr\u1ed9n th\u1ee9c \u0103n v\u00e0 ti\u1ebft ra d\u1ecbch gi\u00fap ti\u00eau h\u00f3a th\u1ee9c \u0103n. Th\u1ee9c \u0103n sau \u0111\u00f3 \u0111\u01b0\u1ee3c \u0111\u01b0a xu\u1ed1ng ru\u1ed9t non \u0111\u1ec3 ti\u1ebfp t\u1ee5c qu\u00e1 tr\u00ecnh ti\u00eau h\u00f3a. M\u1ed9t v\u00e0i ng\u01b0\u1eddi th\u01b0\u1eddng hi\u1ec3u d\u1ea1 d\u00e0y l\u00e0 to\u00e0n b\u1ed9 ph\u1ea7n b\u1ee5ng c\u1ee7a c\u01a1 th\u1ec3. Tuy nhi\u00ean, c\u00e1c b\u00e1c s\u0129 ph\u00e2n bi\u1ec7t r\u00f5 gi\u1eefa d\u1ea1 d\u00e0y v\u00e0 ph\u1ea7n b\u1ee5ng. D\u1ea1 d\u00e0y ch\u1ec9 l\u00e0 m\u1ed9t c\u01a1 quan, trong khi \u0111\u00f3 ph\u1ea7n b\u1ee5ng l\u00e0 m\u1ed9t v\u00f9ng c\u1ee7a c\u01a1 th\u1ec3 n\u1eb1m gi\u1eefa ng\u1ef1c v\u00e0 x\u01b0\u01a1ng ch\u1eadu ch\u1ee9a nhi\u1ec1u c\u01a1 quan kh\u00e1c.<\/p>\n<p>Ung th\u01b0 d\u1ea1 d\u00e0y x\u00e2m nhi\u1ec5m l\u00e0 m\u1ed9t lo\u1ea1i \u0111\u1eb7c bi\u1ec7t c\u1ee7a ung th\u01b0 d\u1ea1 d\u00e0y, c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \u201cung th\u01b0 d\u1ea1 d\u00e0y t\u1ebf b\u00e0o h\u00ecnh nh\u1eabn\u201d hay \u201cung th\u01b0 x\u01a1 c\u1ee9ng d\u1ea1 d\u00e0y\u201d. B\u1ec7nh c\u00f3 khuynh h\u01b0\u1edbng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn nhi\u1ec1u v\u1ecb tr\u00ed tr\u00ean d\u1ea1 d\u00e0y h\u01a1n l\u00e0 khu tr\u00fa m\u1ed9t v\u1ecb tr\u00ed. Kho\u1ea3ng 20% c\u00e1c b\u1ec7nh ung th\u01b0 li\u00ean quan \u0111\u1ebfn d\u1ea1 d\u00e0y l\u00e0 ung th\u01b0 \u01b0ng d\u1ea1 d\u00e0y th\u1ec3 x\u00e2m nhi\u1ec5m, m\u1ed9t s\u1ed1 \u00edt trong \u0111\u00f3 l\u00e0 do di truy\u1ec1n. \u0110\u1ed9 tu\u1ed5i trung b\u00ecnh c\u1ee7a nh\u1eefng ng\u01b0\u1eddi HDGC \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n ung th\u01b0 d\u1ea1 d\u00e0y l\u00e0 38 tu\u1ed5i. Trong khi \u0111\u00f3, ung th\u01b0 d\u1ea1 d\u00e0y kh\u00f4ng li\u00ean quan \u0111\u1ebfn HDGC th\u01b0\u1eddng x\u1ea3y ra v\u1edbi ng\u01b0\u1eddi c\u00f3 \u0111\u1ed9 tu\u1ed5i tr\u00ean 60. \u0110\u1ed1i v\u1edbi ph\u1ee5 n\u1eef m\u1eafc HDGC, gia t\u0103ng nguy c\u01a1 m\u1eafc <a href=\"https:\/\/www.cancer.net\/node\/31322\" target=\"_blank\" rel=\"noopener\">ung th\u01b0 v\u00fa<\/a> ti\u1ec3u th\u00f9y. M\u1ed9t v\u00e0i ng\u01b0\u1eddi li\u00ean quan \u0111\u1ebfn HDGC c\u00f3 th\u1ec3 b\u1ecb s\u1ee9t m\u00f4i ho\u1eb7c h\u1edf h\u00e0m \u1ebfch, m\u1eb7c d\u00f9 \u0111\u1ea1i \u0111a s\u1ed1 kh\u00f4ng li\u00ean quan \u0111\u1ebfn HDGC.<\/p>\n<h2><strong>\u0110i\u1ec1u g\u00ec g\u00e2y ra HDGC?<\/strong><\/h2>\n<p>HDGC l\u00e0 b\u1ec7nh l\u00fd di truy\u1ec1n hi\u1ebfm g\u1eb7p. Nguy c\u01a1 v\u00e0 d\u1ea5u hi\u1ec7u b\u1ec7nh c\u00f3 th\u1ec3 truy\u1ec1n t\u1eeb th\u1ebf h\u1ec7 n\u00e0y sang th\u1ebf h\u1ec7 kh\u00e1c trong gia \u0111\u00ecnh. Gen ph\u1ed5 bi\u1ebfn nh\u1ea5t li\u00ean quan \u0111\u1ebfn HDGC l\u00e0 CDH1. M\u1ed9t \u0111\u1ed9t bi\u1ebfn \u1edf CDH1 t\u0103ng nguy c\u01a1 ph\u00e1t tri\u1ec3n ung th\u01b0 d\u1ea1 d\u00e0y v\u00e0 c\u00e1c ung th\u01b0 kh\u00e1c li\u00ean quan \u0111\u1ebfn HDGC. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u tin r\u1eb1ng c\u00e1c gen kh\u00e1c bao g\u1ed3m CTNNA1 c\u00f3 th\u1ec3 li\u00ean quan \u0111\u1ebfn HDGC. C\u00e1c nghi\u00ean c\u1ee9u \u0111ang ti\u1ebfp t\u1ee5c t\u00ecm hi\u1ec3u th\u00eam v\u1ec1 t\u1ea5t c\u1ea3 c\u00e1c gen n\u00e0y. Tuy nhi\u00ean, vi\u1ec7c x\u00e9t nghi\u1ec7m t\u00ecm t\u1ea5t c\u1ea3 c\u00e1c \u0111\u1ed9t bi\u1ebfn di truy\u1ec1n \u1edf nh\u1eefng gen m\u1edbi n\u00e0y kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o, ngo\u1ea1i tr\u1eeb c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng.<\/p>\n<h2><strong>HDGC \u0111\u01b0\u1ee3c di truy\u1ec1n nh\u01b0 th\u1ebf n\u00e0o? <\/strong><\/h2>\n<p>Th\u00f4ng th\u01b0\u1eddng, m\u1ed7i t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c k\u1ebf th\u1eeba 2 b\u1ea3n sao c\u1ee7a m\u1ed7i gen: 1 b\u1ea3n sao t\u1eeb m\u1eb9, 1 b\u1ea3n sao t\u1eeb cha. HDGC tu\u00e2n theo m\u00f4 h\u00ecnh di truy\u1ec1n tr\u1ed9i t\u1ef1 ph\u00e1t, trong \u0111\u00f3 ng\u01b0\u1eddi mang \u0111\u1ed9t bi\u1ebfn ch\u1ec9 c\u1ea7n x\u1ea3y ra \u1edf m\u1ed9t b\u1ea3n sao c\u1ee7a gen \u0111\u00e3 c\u00f3 nguy c\u01a1 m\u1eafc b\u1ec7nh. \u0110i\u1ec1u n\u00e0y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \u0111\u1ed9t bi\u1ebfn d\u00f2ng m\u1ea7m. Cha m\u1eb9 mang m\u1ed9t gen \u0111\u1ed9t bi\u1ebfn c\u00f3 th\u1ec3 di truy\u1ec1n cho con b\u1ea3n sao c\u1ee7a gen b\u00ecnh th\u01b0\u1eddng ho\u1eb7c b\u1ea3n sao c\u1ee7a gen \u0111\u1ed9t bi\u1ebfn. Do \u0111\u00f3, m\u1ed9t tr\u1ebb c\u00f3 cha m\u1eb9 b\u1ecb \u0111\u1ed9t bi\u1ebfn, c\u00f3 50% kh\u1ea3 n\u0103ng nh\u1eadn \u0111\u1ed9t bi\u1ebfn \u0111\u00f3. Anh, ch\u1ecb, em ho\u1eb7c cha m\u1eb9 c\u1ee7a ng\u01b0\u1eddi b\u1ecb \u0111\u1ed9t bi\u1ebfn c\u0169ng c\u00f3 50% kh\u1ea3 n\u0103ng mang \u0111\u1ed9t bi\u1ebfn t\u01b0\u01a1ng t\u1ef1.<\/p>\n<p>C\u00f3 nh\u1eefng l\u1ef1a ch\u1ecdn cho ng\u01b0\u1eddi mu\u1ed1n c\u00f3 con kho\u1ebb m\u1ea1nh khi \u0111ang mang gen \u0111\u1ed9t bi\u1ebfn l\u00e0m t\u0103ng nguy c\u01a1 m\u1eafc h\u1ed9i ch\u1ee9ng ung th\u01b0 di truy\u1ec1n. Ch\u1ea9n \u0111o\u00e1n di truy\u1ec1n ti\u1ec1n l\u00e0m t\u1ed5 (PGD) l\u00e0 m\u1ed9t th\u1ee7 thu\u1eadt y khoa \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n k\u1ebft h\u1ee3p v\u1edbi th\u1ee5 tinh trong trong \u1ed1ng nghi\u1ec7m (IVF). Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y cho ph\u00e9p nh\u1eefng ng\u01b0\u1eddi mang gen \u0111\u1ed9t bi\u1ebfn gi\u1ea3m thi\u1ec3u kh\u1ea3 n\u0103ng truy\u1ec1n b\u1ec7nh l\u00fd n\u00e0y cho con. Tr\u1ee9ng c\u1ee7a ng\u01b0\u1eddi m\u1eb9 \u0111\u01b0\u1ee3c l\u1ea5y ra v\u00e0 th\u1ee5 tinh trong ph\u00f2ng th\u00ed nghi\u1ec7m. Khi ph\u00f4i \u0111\u1ea1t k\u00edch th\u01b0\u1edbc nh\u1ea5t \u0111\u1ecbnh, 1 t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c t\u00e1ch ra v\u00e0 ki\u1ec3m tra \u0111\u1eb7c t\u00ednh di truy\u1ec1n. T\u1eeb \u0111\u00f3, b\u1ed1 m\u1eb9 c\u00f3 th\u1ec3 l\u1ef1a ch\u1ecdn chuy\u1ec3n c\u00e1c ph\u00f4i kh\u00f4ng mang \u0111\u1ed9t bi\u1ebfn. K\u1ef9 thu\u1eadt PGD \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong h\u01a1n 2 th\u1eadp k\u1ef7 v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng cho m\u1ed9t s\u1ed1 h\u1ed9i ch\u1ee9ng ung th\u01b0 di truy\u1ec1n. Tuy nhi\u00ean, \u0111\u00e2y l\u00e0 m\u1ed9t th\u1ee7 thu\u1eadt ph\u1ee9c t\u1ea1p, v\u1edbi nhi\u1ec1u y\u1ebfu t\u1ed1 c\u1ea7n ph\u1ea3i xem x\u00e9t tr\u01b0\u1edbc khi b\u1eaft \u0111\u1ea7u nh\u01b0 v\u1ea5n \u0111\u1ec1 v\u1ec1 t\u00e0i ch\u00ednh, th\u1ec3 ch\u1ea5t, c\u1ea3m x\u00fac. \u0110\u1ec3 bi\u1ebft th\u00eam th\u00f4ng tin, b\u1ea1n n\u00ean tham v\u1ea5n v\u1edbi chuy\u00ean gia h\u1ed7 tr\u1ee3 sinh s\u1ea3n.<\/p>\n<h2><strong>HDGC ph\u1ed5 bi\u1ebfn nh\u01b0 th\u1ebf n\u00e0o?<\/strong><\/h2>\n<p>Hi\u1ec7n nay v\u1eabn ch\u01b0a r\u00f5 s\u1ed1 l\u01b0\u1ee3ng c\u1ee5 th\u1ec3 gia \u0111\u00ecnh c\u00f3 HDGC. T\u1ef7 l\u1ec7 m\u1eafc ung th\u01b0 d\u1ea1 d\u00e0y kh\u00e1c nhau \u1edf m\u1ed7i v\u00f9ng tr\u00ean th\u1ebf gi\u1edbi. T\u1ea1i Hoa K\u1ef3, ng\u01b0\u1eddi ta \u01b0\u1edbc t\u00ednh r\u1eb1ng d\u01b0\u1edbi 1% d\u00e2n s\u1ed1 b\u1ecb ung th\u01b0 d\u1ea1 d\u00e0y c\u00e1c th\u1ec3, m\u1ed9t ph\u1ea7n nh\u1ecf trong s\u1ed1 n\u00e0y l\u00e0 HDGC. T\u1ef7 l\u1ec7 ung th\u01b0 d\u1ea1 d\u00e0y cao nh\u1ea5t th\u1ebf gi\u1edbi n\u1eb1m \u1edf Trung Qu\u1ed1c, Nh\u1eadt B\u1ea3n, c\u00e1c n\u01b0\u1edbc \u0110\u00f4ng Nam \u00c1 v\u00e0 Trung v\u00e0 Nam M\u1ef9.<\/p>\n<h2><strong>HDGC \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n nh\u01b0 th\u1ebf n\u00e0o?<\/strong><\/h2>\n<p>H\u01b0\u1edbng d\u1eabn cho vi\u1ec7c ch\u1ea9n \u0111o\u00e1n h\u1ed9i ch\u1ee9ng HDGC \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t, nh\u01b0ng c\u00f3 th\u1ec3 thay \u0111\u1ed5i theo th\u1eddi gian khi c\u00f3 th\u00eam nhi\u1ec1u th\u00f4ng tin h\u01a1n v\u1ec1 h\u1ed9i ch\u1ee9ng n\u00e0y. Hi\u1ec7n t\u1ea1i, c\u1ea7n ngh\u0129 \u0111\u1ebfn ch\u1ea9n \u0111o\u00e1n HDGC v\u00e0 c\u00e2n nh\u1eafc x\u00e9t nghi\u1ec7m di truy\u1ec1n CHD1 n\u1ebfu m\u1ed9t ng\u01b0\u1eddi ho\u1eb7c m\u1ed9t gia \u0111\u00ecnh \u0111\u00e1p \u1ee9ng b\u1ea5t k\u00ec m\u1ed9t trong c\u00e1c ti\u00eau ch\u00ed \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea d\u01b0\u1edbi \u0111\u00e2y:<\/p>\n<ul>\n<li>C\u00f3 t\u1eeb 2 th\u00e0nh vi\u00ean trong gia \u0111\u00ecnh m\u1eafc ung th\u01b0 d\u1ea1 d\u00e0y, t\u1ed1i thi\u1ec3u m\u1ed9t ng\u01b0\u1eddi l\u00e0 ung th\u01b0 d\u1ea1 d\u00e0y th\u1ec3 x\u00e2m nhi\u1ec5m.<\/li>\n<li>M\u1ed9t th\u00e0nh vi\u00ean \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n ung th\u01b0 d\u1ea1 d\u00e0y th\u1ec3 x\u00e2m nhi\u1ec5m tr\u01b0\u1edbc 40 tu\u1ed5i.<\/li>\n<li>Ti\u1ec1n s\u1eed gia \u0111\u00ecnh c\u00f3 m\u1eafc ung th\u01b0 d\u1ea1 d\u00e0y th\u1ec3 x\u00e2m nhi\u1ec5m v\u00e0 ung th\u01b0 v\u00fa ti\u1ec3u th\u00f9y, t\u1ed1i thi\u1ec3u m\u1ed9t ng\u01b0\u1eddi \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n tr\u01b0\u1edbc 50 tu\u1ed5i.<\/li>\n<li>M\u1ed9t th\u00e0nh vi\u00ean b\u1ecb ung th\u01b0 d\u1ea1 d\u00e0y th\u1ec3 x\u00e2m nhi\u1ec5m v\u1edbi ti\u1ec1n s\u1eed c\u00e1 nh\u00e2n ho\u1eb7c gia \u0111\u00ecnh b\u1ecb s\u1ee9t m\u00f4i ho\u1eb7c h\u1edf h\u00e0m \u1ebfch.<\/li>\n<\/ul>\n<p>X\u00e9t nghi\u1ec7m di truy\u1ec1n t\u00ecm c\u00e1c \u0111\u1ed9t bi\u1ebfn gen CDH1 l\u00e0 ph\u00f9 h\u1ee3p. Tuy nhi\u00ean, ch\u1ec9 c\u00f3 kho\u1ea3ng 20% \u200b\u200b\u0111\u1ebfn 30% gia \u0111\u00ecnh m\u1eafc HDGC t\u00ecm th\u1ea5y \u0111\u1ed9t bi\u1ebfn gen CDH1. Do \u0111\u00f3, c\u1ea3 hai kh\u00eda c\u1ea1nh l\u00e2m s\u00e0ng v\u00e0 di truy\u1ec1n ph\u1ea3i \u0111\u01b0\u1ee3c xem x\u00e9t trong vi\u1ec7c t\u01b0 v\u1ea5n cho ng\u01b0\u1eddi b\u1ec7nh v\u1ec1 kh\u1ea3 n\u0103ng m\u1eafc HDGC c\u1ee7a gia \u0111\u00ecnh h\u1ecd. C\u00e1c th\u00e0nh vi\u00ean trong gia \u0111\u00ecnh \u0111\u01b0\u1ee3c khuy\u1ebfn kh\u00edch tham v\u1ea5n chuy\u00ean gia \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u00e0o t\u1ea1o v\u1ec1 c\u00e1c b\u1ec7nh di truy\u1ec1n, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 nh\u00e0 t\u01b0 v\u1ea5n di truy\u1ec1n.<\/p>\n<h2><strong>C\u00e1c nguy<\/strong><strong> c\u01a1 <\/strong><strong>ung th\u01b0 li\u00ean quan \u0111\u1ebfn HDGC l\u00e0 g\u00ec?<\/strong><\/h2>\n<p>Kh\u00f4ng ph\u1ea3i ai th\u1eeba h\u01b0\u1edfng \u0111\u1ed9t bi\u1ebfn gen li\u00ean quan \u0111\u1ebfn HDGC c\u0169ng b\u1ecb ung th\u01b0. \u1ede nh\u1eefng ng\u01b0\u1eddi b\u1ecb \u0111\u1ed9t bi\u1ebfn gen CDH1, nguy c\u01a1 m\u1eafc ung th\u01b0 d\u1ea1 d\u00e0y th\u1ec3 x\u00e2m nhi\u1ec5m \u01b0\u1edbc t\u00ednh t\u1eeb 67-70% \u0111\u1ed1i v\u1edbi nam v\u00e0 56-83% \u0111\u1ed1i v\u1edbi n\u1eef \u1edf tu\u1ed5i 80. Ph\u1ee5 n\u1eef b\u1ecb \u0111\u1ed9t bi\u1ebfn gen CDH1 c\u00f3 39%-52% nguy c\u01a1 ph\u00e1t tri\u1ec3n ung th\u01b0 v\u00fa ti\u1ec3u th\u00f9y \u1edf tu\u1ed5i 80. M\u1ed9t s\u1ed1 nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y th\u1ea5y m\u1ed1i li\u00ean h\u1ec7 HDGC v\u1edbi nguy c\u01a1 ung th\u01b0 ru\u1ed9t ho\u1eb7c tr\u1ef1c tr\u00e0ng, tuy nhi\u00ean, ph\u00e1t hi\u1ec7n hi\u1ec7n t\u1ea1i cho th\u1ea5y kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng t\u0103ng nguy c\u01a1 m\u1eafc c\u00e1c ung th\u01b0 n\u00e0y \u1edf nh\u1eefng ng\u01b0\u1eddi c\u00f3 \u0111\u1ed9t bi\u1ebfn CDH1.<\/p>\n<h2><strong>C\u00e1c l\u1ef1a ch\u1ecdn \u0111\u1ec3 gi\u1ea3m<\/strong><strong> thi\u1ec3u<\/strong> <strong>nguy<\/strong><strong> c\u01a1 <\/strong><strong>ung th\u01b0 li\u00ean quan \u0111\u1ebfn HDGC?<\/strong><\/h2>\n<p>Do nguy c\u01a1 m\u1eafc ung th\u01b0 li\u00ean quan \u0111\u1ebfn \u0111\u1ed9t bi\u1ebfn gen CDH1 d\u00f2ng m\u1ea7m, nh\u1eefng ng\u01b0\u1eddi mang gen \u0111\u1ed9t bi\u1ebfn \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o th\u1ea3o lu\u1eadn v\u1edbi chuy\u00ean gia y t\u1ebf \u0111\u1ec3 c\u00f3 k\u1ebf ho\u1ea1ch gi\u1ea3m thi\u1ec3u r\u1ee7i ro m\u1eafc ung th\u01b0.<\/p>\n<ul>\n<li><strong>Ung th\u01b0 d\u1ea1 d\u00e0y:<\/strong> N\u1ed9i soi l\u00e0 \u0111\u01b0a m\u1ed9t \u1ed1ng m\u1ecfng, \u0111\u01b0\u1ee3c chi\u1ebfu s\u00e1ng v\u00e0o h\u1ec7 th\u1ed1ng ti\u00eau h\u00f3a \u0111\u1ec3 ph\u00e1t hi\u1ec7n ung th\u01b0. Ki\u1ec3m tra n\u1ed9i soi \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb cho ng\u01b0\u1eddi mang gen \u0111\u1ed9t bi\u1ebfn. Tuy nhi\u00ean, c\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng s\u00e0ng l\u1ecdc b\u1eb1ng ki\u1ec3m tra n\u1ed9i soi th\u01b0\u1eddng kh\u00f4ng ph\u00e1t hi\u1ec7n \u0111\u01b0\u1ee3c ung th\u01b0 d\u1ea1 d\u00e0y th\u1ec3 x\u00e2m nhi\u1ec5m giai \u0111o\u1ea1n \u0111\u1ea7u.Do \u0111\u00f3, th\u1eed nghi\u1ec7m n\u1ed9i soi c\u00f3 th\u1ec3 kh\u00f4ng hi\u1ec7u qu\u1ea3 trong vi\u1ec7c ng\u0103n ng\u1eeba ho\u1eb7c ph\u00e1t hi\u1ec7n ung th\u01b0 d\u1ea1 d\u00e0y th\u1ec3 x\u00e2m nhi\u1ec5m giai \u0111o\u1ea1n s\u1edbm, nh\u1eefng ng\u01b0\u1eddi b\u1ecb \u0111\u1ed9t bi\u1ebfn gen CDH1 n\u00ean c\u00e2n nh\u1eafc ph\u1eabu thu\u1eadt c\u1eaft b\u1ecf d\u1ea1 d\u00e0y, c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 c\u1eaft d\u1ea1 d\u00e0y to\u00e0n b\u1ed9 d\u1ef1 ph\u00f2ng, ngay c\u1ea3 khi vi\u1ec7c n\u1ed9i soi c\u00f3 k\u1ebft qu\u1ea3 b\u00ecnh th\u01b0\u1eddng. Lo\u1ea1i ph\u1eabu thu\u1eadt n\u00e0y l\u00e0 c\u00e1ch hi\u1ec7u qu\u1ea3 duy nh\u1ea5t \u0111\u01b0\u1ee3c ch\u1ee9ng minh \u0111\u1ec3 ng\u0103n ng\u1eeba ung th\u01b0 d\u1ea1 d\u00e0y th\u1ec3 x\u00e2m nhi\u1ec5m \u1edf nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh HDGC. Tuy nhi\u00ean, \u0111i\u1ec1u quan tr\u1ecdng c\u1ea7n bi\u1ebft l\u00e0 ph\u1eabu thu\u1eadt c\u1eaft b\u1ecf d\u1ea1 d\u00e0y d\u1eabn \u0111\u1ebfn nh\u1eefng thay \u0111\u1ed5i v\u0129nh vi\u1ec5n cho \u0111\u01b0\u1eddng ti\u00eau h\u00f3a v\u00e0 c\u00f3 th\u1ec3 k\u00e8m theo c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 l\u00e2u d\u00e0i. Vi\u1ec7c quan tr\u1ecdng \u0111\u1ed1i v\u1edbi m\u1ed7i b\u1ec7nh nh\u00e2n l\u00e0 n\u00f3i chuy\u1ec7n v\u1edbi b\u00e1c s\u0129 v\u1ec1 nh\u1eefng x\u00e9t nghi\u1ec7m v\u00e0 quy tr\u00ecnh n\u00e0o th\u00edch h\u1ee3p v\u1edbi b\u1ea3n th\u00e2n.Nh\u1eefng ng\u01b0\u1eddi quy\u1ebft \u0111\u1ecbnh kh\u00f4ng ph\u1eabu thu\u1eadt c\u1eaft b\u1ecf d\u1ea1 d\u00e0y c\u00f3 th\u1ec3 xem x\u00e9t m\u1ed9t l\u1ecbch tr\u00ecnh gi\u00e1m s\u00e1t chuy\u00ean s\u00e2u c\u00f9ng b\u00e1c s\u0129, v\u1edbi EGD sinh thi\u1ebft ni\u00eam m\u1ea1c h\u00e0ng n\u0103m (l\u1edbn h\u01a1n 30). Vi\u1ec7c ph\u1eabu thu\u1eadt v\u00e0 n\u1ed9i soi cho nh\u1eefng ng\u01b0\u1eddi \u0111\u00e3 bi\u1ebft ho\u1eb7c nghi ng\u1edd c\u00f3 HDGC \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1ed1t nh\u1ea5t t\u1ea1i c\u00e1c trung t\u00e2m c\u00f3 chuy\u00ean m\u00f4n v\u1ec1 ch\u0103m s\u00f3c nh\u1eefng ng\u01b0\u1eddi m\u1eafc h\u1ed9i ch\u1ee9ng n\u00e0y.<\/li>\n<li><strong>S\u00e0ng l\u1ecdc b\u1ed5 sung cho ph\u1ee5 n\u1eef:<\/strong> Ph\u1ee5 n\u1eef b\u1ecb HDGC c\u00f3 nguy c\u01a1 cao m\u1eafc ung th\u01b0 v\u00fa ti\u1ec3u th\u00f9y, nh\u1eefng ng\u01b0\u1eddi n\u00e0y c\u1ea7n tham v\u1ea5n b\u00e1c s\u0129 v\u1ec1 vi\u1ec7c l\u1ef1a ch\u1ecdn ph\u01b0\u01a1ng ph\u00e1p s\u00e0ng l\u1ecdc ung th\u01b0 v\u00fa \u1edf tu\u1ed5i 30, ho\u1eb7c 10 n\u0103m tr\u01b0\u1edbc tu\u1ed5i ch\u1ea9n \u0111o\u00e1n ung th\u01b0 v\u00fa c\u1ee7a ng\u01b0\u1eddi m\u1eafc b\u1ec7nh tr\u1ebb nh\u1ea5t trong gia \u0111\u00ecnh. V\u1eabn ch\u01b0a c\u00f3 chi\u1ebfn l\u01b0\u1ee3c s\u00e0ng l\u1ecdc ung th\u01b0 v\u00fa t\u1ed1t nh\u1ea5t \u0111\u1ed1i v\u1edbi ph\u1ee5 n\u1eef c\u00f3 \u0111\u1ed9t bi\u1ebfn CDH1. C\u00e1c l\u1ef1a ch\u1ecdn s\u00e0ng l\u1ecdc bao g\u1ed3m:\n<ul>\n<li>T\u1ef1 th\u0103m kh\u00e1m v\u00fa h\u00e0ng th\u00e1ng<\/li>\n<li>Th\u0103m kh\u00e1m l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi b\u00e1c s\u0129 ho\u1eb7c y t\u00e1 c\u1ee9 sau 6 th\u00e1ng<\/li>\n<li>Th\u01b0\u1eddng xuy\u00ean ki\u1ec3m tra b\u1eb1ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p <a href=\"https:\/\/yhoccongdong.com\/thongtin\/x-quang-vu-con-goi-la-nhu-anh\/\" target=\"_blank\" rel=\"noopener\">ch\u1ee5p nh\u0169 \u1ea3nh<\/a>, <a href=\"https:\/\/www.cancer.net\/node\/24714\" target=\"_blank\" rel=\"noopener\">si\u00eau \u00e2m<\/a> v\u00e0\/ho\u1eb7c ch\u1ee5p <a href=\"https:\/\/yhoccongdong.com\/thongtin\/chup-cong-huong-tu-mri-scan\/\" target=\"_blank\" rel=\"noopener\">c\u1ed9ng h\u01b0\u1edfng t\u1eeb<\/a> (MRI)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>Ung th\u01b0 v\u00fa ti\u1ec3u th\u00f9y kh\u00f3 ph\u00e1t hi\u1ec7n khi ch\u1ee5p nh\u0169 \u1ea3nh, ch\u1ee5p MRI v\u00f9ng v\u00fa \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o trong s\u00e0ng l\u1ecdc ung th\u01b0 v\u00fa cho ph\u1ee5 n\u1eef c\u00f3 \u0111\u1ed9t bi\u1ebfn CDH1. \u0110\u00f4i khi, ph\u1eabu thu\u1eadt c\u1eaft b\u1ecf v\u00fa d\u1ef1 ph\u00f2ng \u0111\u01b0\u1ee3c khuy\u1ebfn ngh\u1ecb \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 ung th\u01b0 v\u00fa. N\u00ean th\u1ea3o lu\u1eadn v\u1edbi b\u00e1c s\u0129 v\u1ec1 c\u00e1c l\u1ef1a ch\u1ecdn \u0111\u1ec3 gi\u1ea3m thi\u1ec3u <a href=\"https:\/\/www.cancer.net\/node\/18621\" target=\"_blank\" rel=\"noopener\">nguy c\u01a1 ung th\u01b0 v\u00fa<\/a>.<\/p>\n<p><em>T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 <a href=\"https:\/\/www.cancer.net\/node\/24959\" target=\"_blank\" rel=\"noopener\">nh\u1eefng mong \u0111\u1ee3i \u1edf c\u00e1c x\u00e9t nghi\u1ec7m, th\u1ee7 thu\u1eadt v\u00e0 ch\u1ea9n \u0111o\u00e1n h\u00ecnh \u1ea3nh th\u00f4ng th\u01b0\u1eddng<\/a>.<\/em><\/p>\n<h2><strong>C\u00e2u h\u1ecfi \u0111\u1eb7t ra cho nh\u00f3m ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe<\/strong><\/h2>\n<p>N\u1ebfu b\u1ea1n lo l\u1eafng v\u1ec1 nguy c\u01a1 m\u1eafc b\u1ec7nh ung th\u01b0, h\u00e3y n\u00f3i chuy\u1ec7n v\u1edbi nh\u00f3m ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe. M\u1ed9t v\u00e0i c\u00e2u h\u1ecfi g\u1ee3i \u00fd:<\/p>\n<ul>\n<li>Nguy c\u01a1 ph\u00e1t tri\u1ec3n ung th\u01b0 d\u1ea1 d\u00e0y c\u1ee7a t\u00f4i l\u00e0 g\u00ec?<\/li>\n<li>Nguy c\u01a1 ph\u00e1t tri\u1ec3n c\u00e1c lo\u1ea1i ung th\u01b0 kh\u00e1c c\u1ee7a t\u00f4i l\u00e0 g\u00ec?<\/li>\n<li>T\u00f4i c\u00f3 th\u1ec3 l\u00e0m g\u00ec \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 ung th\u01b0?<\/li>\n<li>T\u00f4i n\u00ean s\u1eed d\u1ee5ng ph\u01b0\u01a1ng ph\u00e1p s\u00e0ng l\u1ecdc v\u00e0 ph\u00f2ng ch\u1ed1ng ung th\u01b0 n\u00e0o?<\/li>\n<\/ul>\n<p>N\u1ebfu b\u1ea1n lo l\u1eafng v\u1ec1 l\u1ecbch s\u1eed gia \u0111\u00ecnh c\u1ee7a b\u1ea1n v\u00e0 ngh\u0129 r\u1eb1ng b\u1ea1n ho\u1eb7c c\u00e1c th\u00e0nh vi\u00ean kh\u00e1c trong gia \u0111\u00ecnh c\u00f3 th\u1ec3 c\u00f3 HDGC. M\u1ed9t v\u00e0i c\u00e2u h\u1ecfi g\u1ee3i \u00fd:<\/p>\n<ul>\n<li>Ti\u1ec1n s\u1eed gia \u0111\u00ecnh t\u00f4i c\u00f3 l\u00e0m t\u00f4i t\u0103ng nguy c\u01a1 ung th\u01b0 d\u1ea1 d\u00e0y?<\/li>\n<li>Ti\u1ec1n s\u1eed gia \u0111\u00ecnh c\u00f3 c\u1ea7n thi\u1ebft \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 r\u1ee7i ro ung th\u01b0?<\/li>\n<li>T\u00f4i c\u00f3 c\u1ea7n tham v\u1ea5n chuy\u00ean gia di truy\u1ec1n kh\u00f4ng?<\/li>\n<li>T\u00f4i c\u00f3 n\u00ean th\u1ef1c hi\u1ec7n c\u00e1c <a href=\"https:\/\/www.cancer.net\/node\/24895\" target=\"_blank\" rel=\"noopener\">x\u00e9t nghi\u1ec7m di truy\u1ec1n<\/a>?<\/li>\n<\/ul>\n<h2><strong>Ngu\u1ed3n t\u00e0i li\u1ec7u li\u00ean quan<\/strong><\/h2>\n<p><a href=\"https:\/\/www.cancer.net\/node\/24897\" target=\"_blank\" rel=\"noopener\"><strong><u>Di truy\u1ec1n c\u1ee7a ung th\u01b0<\/u><\/strong><\/a><\/p>\n<p><a href=\"https:\/\/www.cancer.net\/node\/24895\" target=\"_blank\" rel=\"noopener\"><strong><u>X\u00e9t nghi\u1ec7m di truy\u1ec1n<\/u><\/strong><\/a><\/p>\n<p><a href=\"https:\/\/www.cancer.net\/node\/24907\" target=\"_blank\" rel=\"noopener\"><strong><u>Nh\u1eefng g\u00ec mong \u0111\u1ee3i khi g\u1eb7p m\u1ed9t c\u1ed1 v\u1ea5n di truy\u1ec1n<\/u><\/strong><\/a><\/p>\n<p><a href=\"https:\/\/www.cancer.net\/node\/30761\" target=\"_blank\" rel=\"noopener\"><strong><u>Thu th\u1eadp ti\u1ec1n s\u1eed ung th\u01b0 gia \u0111\u00ecnh b\u1ea1n<\/u><\/strong><\/a><\/p>\n<p><a href=\"https:\/\/www.cancer.net\/node\/36141\" target=\"_blank\" rel=\"noopener\"><strong><u>Chia s\u1ebb k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m di truy\u1ec1n v\u1edbi gia \u0111\u00ecnh b\u1ea1n<\/u><\/strong><\/a><\/p>\n<h2><strong>T\u00ecm hi\u1ec3u th\u00eam th\u00f4ng tin t\u1ea1i<\/strong><\/h2>\n<p><a href=\"http:\/\/www.nostomachforcancer.org\/\" target=\"_blank\" rel=\"noopener\"><strong>Kh\u00f4ng c\u00f3 d\u1ea1 d\u00e0y cho b\u1ec7nh ung th\u01b0, Inc.<\/strong><\/a><\/p>\n<p><a href=\"https:\/\/www.facingourrisk.org\/index.php\" target=\"_blank\" rel=\"noopener\"><strong>\u0110\u1ed1i m\u1eb7t v\u1edbi s\u1ee9c \u00e9p nguy c\u01a1 ung th\u01b0 (FORCE)<\/strong><\/a><\/p>\n<p><a href=\"http:\/\/www.cancer.gov\" target=\"_blank\" rel=\"noopener\"><strong>Vi\u1ec7n ung th\u01b0 qu\u1ed1c gia<\/strong><\/a><\/p>\n<p><a href=\"http:\/\/www.cancer.org\" target=\"_blank\" rel=\"noopener\"><strong>Hi\u1ec7p h\u1ed9i Ung th\u01b0 Hoa K\u1ef3<\/strong><\/a><\/p>\n<p><a href=\"http:\/\/www.cancercare.org\" target=\"_blank\" rel=\"noopener\"><strong>Ung th\u01b0<\/strong><\/a><\/p>\n<p><strong>\u0110\u1ec3 t\u00ecm m\u1ed9t c\u1ed1 v\u1ea5n di truy\u1ec1n h\u1ecdc trong khu v\u1ef1c c\u1ee7a b\u1ea1n, h\u00e3y h\u1ecfi b\u00e1c s\u0129 c\u1ee7a b\u1ea1n ho\u1eb7c truy c\u1eadp c\u00e1c trang web sau:<\/strong><\/p>\n<p><a href=\"http:\/\/www.nsgc.org\" target=\"_blank\" rel=\"noopener\"><strong>Hi\u1ec7p h\u1ed9i c\u1ed1 v\u1ea5n di truy\u1ec1n qu\u1ed1c gia<\/strong><\/a><\/p>\n<p><a href=\"http:\/\/www.cancer.gov\/cancertopics\/genetic\/directory\" target=\"_blank\" rel=\"noopener\"><strong>Vi\u1ec7n ung th\u01b0 qu\u1ed1c gia<\/strong><\/a><\/p>\n<h2><strong>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/strong><\/h2>\n<p><a href=\"https:\/\/www.cancer.net\/cancer-types\/hereditary-diffuse-gastric-cancer\" target=\"_blank\" rel=\"noopener\">https:\/\/www.cancer.net\/cancer-types\/hereditary-diffuse-gastric-cancer<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ung th\u01b0 d\u1ea1 d\u00e0y x\u00e2m nhi\u1ec5m di truy\u1ec1n (HDGC) l\u00e0 m\u1ed9t b\u1ec7nh l\u00fd di truy\u1ec1n hi\u1ebfm g\u1eb7p li\u00ean quan \u0111\u1ebfn t\u0103ng nguy c\u01a1 m\u1eafc ung th\u01b0 d\u1ea1 d\u00e0y.<\/p>\n","protected":false},"author":476,"featured_media":8465,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3708,3104,2460],"tags":[2920,3231],"series":[1953],"coauthors":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - 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