{"id":8470,"date":"2020-04-26T21:15:41","date_gmt":"2020-04-26T14:15:41","guid":{"rendered":"https:\/\/yhoccongdong.org\/ung-thu\/hoi-chung-peutz-jeghers\/"},"modified":"2020-04-26T21:15:41","modified_gmt":"2020-04-26T14:15:41","slug":"hoi-chung-peutz-jeghers","status":"publish","type":"post","link":"https:\/\/yhoccongdong.com\/ung-thu\/hoi-chung-peutz-jeghers\/","title":{"rendered":"H\u1ed9i ch\u1ee9ng Peutz-Jeghers"},"content":{"rendered":"<h2><strong>H\u1ed9i ch\u1ee9ng Peutz-Jeghers l\u00e0 g\u00ec?<\/strong><\/h2>\n<p>H\u1ed9i ch\u1ee9ng Peutz-Jeghers (PJS) l\u00e0 m\u1ed9t b\u1ec7nh l\u00fd di truy\u1ec1n l\u00e0m t\u0103ng nguy c\u01a1 xu\u1ea5t hi\u1ec7n c\u00e1c u m\u00f4 th\u1eeba d\u1ea1ng polyp trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a c\u0169ng nh\u01b0 ung th\u01b0 v\u00fa, \u0111\u1ea1i &#8211; tr\u1ef1c tr\u00e0ng, tuy\u1ebfn t\u1ee5y, d\u1ea1 d\u00e0y, tinh ho\u00e0n, bu\u1ed3ng tr\u1ee9ng, ph\u1ed5i, c\u1ed5 t\u1eed cung, v\u00e0 c\u00e1c lo\u1ea1i kh\u00e1c \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea d\u01b0\u1edbi \u0111\u00e2y. N\u1ebfu kh\u00f4ng c\u00f3 s\u1ef1 theo d\u00f5i ph\u00f9 h\u1ee3p, nguy c\u01a1 m\u1eafc ung th\u01b0 su\u1ed1t \u0111\u1eddi \u1edf nh\u1eefng ng\u01b0\u1eddi PJS c\u00f3 th\u1ec3 l\u00ean t\u1edbi 93%. U m\u00f4 th\u1eeba l\u00e0 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c m\u00f4 b\u00ecnh th\u01b0\u1eddng, t\u0103ng sinh th\u00e0nh m\u1ed9t kh\u1ed1i u l\u00e0nh t\u00ednh (kh\u00f4ng ung th\u01b0). Trong PJS, u m\u00f4 th\u1eeba d\u1ea1ng polyp th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n \u1edf ru\u1ed9t non v\u00e0 ru\u1ed9t gi\u00e0, ch\u00fang c\u00f3 th\u1ec3 g\u00e2y ch\u1ea3y m\u00e1u ho\u1eb7c c\u00e1c v\u1ea5n \u0111\u1ec1 kh\u00e1c nh\u01b0 t\u1eafc ru\u1ed9t.<\/p>\n<p>M\u1ed9t s\u1ed1 d\u1ea5u hi\u1ec7u c\u1ee7a PJS c\u00f3 th\u1ec3 xu\u1ea5t hi\u1ec7n \u1edf tr\u1ebb em v\u1edbi nh\u1eefng v\u00f9ng s\u1eafc t\u1ed1 tr\u00ean da v\u00e0 trong mi\u1ec7ng, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 t\u0103ng s\u1eafc t\u1ed1 ni\u00eam m\u1ea1c\/ da m\u00e0ng nh\u1ea7y (mucocutanneous). T\u00e0n nhang xanh \u0111\u1eadm ho\u1eb7c n\u00e2u s\u1eabm hay g\u1eb7p \u1edf nh\u1eefng ng\u01b0\u1eddi b\u1ecb PJS, \u0111\u1eb7c bi\u1ec7t l\u00e0 xung quanh mi\u1ec7ng, m\u00f4i, ng\u00f3n tay v\u00e0 ng\u00f3n ch\u00e2n. T\u00e0n nhang th\u01b0\u1eddng xu\u1ea5t hi\u1ec7n t\u1eeb th\u1eddi th\u01a1 \u1ea5u v\u00e0 m\u1edd d\u1ea7n theo tu\u1ed5i t\u00e1c, do \u0111\u00f3 ch\u00fang th\u01b0\u1eddng kh\u00f4ng th\u1ec3 nh\u00ecn th\u1ea5y \u1edf ng\u01b0\u1eddi l\u1edbn m\u1eafc PJS \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n ung th\u01b0. M\u1ed9t d\u1ea5u hi\u1ec7u kh\u00e1c c\u1ee7a PJS l\u00e0 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a polyp \u1edf \u0111\u01b0\u1eddng ti\u00eau h\u00f3a c\u00f3 th\u1ec3 g\u00e2y xu\u1ea5t huy\u1ebft v\u00e0 t\u1eafc ngh\u1ebdn. \u0110\u1ed9 tu\u1ed5i trung b\u00ecnh khi c\u00e1c tri\u1ec7u ch\u1ee9ng ti\u00eau h\u00f3a xu\u1ea5t hi\u1ec7n l\u00e0 10 tu\u1ed5i.<\/p>\n<p>Khi c\u00f3 \u00edt nh\u1ea5t 2 trong s\u1ed1 c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m sau \u0111\u00e2y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c coi l\u00e0 c\u00f3 PJS:<\/p>\n<ul>\n<li>\u00cdt nh\u1ea5t 2 u m\u00f4 th\u1eeba d\u1ea1ng polyp lo\u1ea1i Peutz-Jeghers trong ru\u1ed9t non<\/li>\n<li>T\u00e0n nhang \u0111\u1eb7c tr\u01b0ng c\u1ee7a mi\u1ec7ng, m\u00f4i, ng\u00f3n tay ho\u1eb7c ng\u00f3n ch\u00e2n<\/li>\n<li>\u00cdt nh\u1ea5t 1 ng\u01b0\u1eddi th\u00e2n \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n m\u1eafc PJS<\/li>\n<\/ul>\n<p>X\u00e9t nghi\u1ec7m di truy\u1ec1n \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o cho nh\u1eefng ng\u01b0\u1eddi th\u1ecfa m\u00e3n c\u00e1c ti\u00eau chu\u1ea9n tr\u00ean \u0111\u1ec3 t\u00ecm ki\u1ebfm \u0111\u1ed9t bi\u1ebfn di truy\u1ec1n c\u1ee7a gen STK11. Xem th\u00eam th\u00f4ng tin d\u01b0\u1edbi \u0111\u00e2y.<\/p>\n<h2><strong>Nguy\u00ean nh\u00e2n c\u1ee7a PJS?<\/strong><\/h2>\n<p>PJS l\u00e0 m\u1ed9t h\u1ed9i ch\u1ee9ng di truy\u1ec1n l\u00e0m t\u0103ng nguy c\u01a1 ph\u00e1t tri\u1ec3n ung th\u01b0 v\u00e0 polyp. \u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 h\u1ed9i ch\u1ee9ng n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c di truy\u1ec1n t\u1eeb th\u1ebf h\u1ec7 n\u00e0y sang th\u1ebf h\u1ec7 kh\u00e1c trong m\u1ed9t gia \u0111\u00ecnh. \u0110\u1ed9t bi\u1ebfn gen STK11, c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 gen LKB1 l\u00e0 nguy\u00ean nh\u00e2n g\u00e2y ra PJS. Ngo\u00e0i ra, c\u00f3 th\u1ec3 c\u00f3 nh\u1eefng gen kh\u00e1c g\u00e2y ra PJS nh\u01b0ng ch\u01b0a \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n.<\/p>\n<h2><strong>PJS \u0111\u01b0\u1ee3c di truy\u1ec1n nh\u01b0 th\u1ebf n\u00e0o?<\/strong><\/h2>\n<p>Th\u00f4ng th\u01b0\u1eddng, trong t\u1ebf b\u00e0o c\u00f3 2 b\u1ea3n sao c\u1ee7a m\u1ed7i gen: 1 \u0111\u01b0\u1ee3c th\u1eeba h\u01b0\u1edfng t\u1eeb m\u1eb9 v\u00e0 1 \u0111\u01b0\u1ee3c th\u1eeba h\u01b0\u1edfng t\u1eeb cha. PJS \u0111\u01b0\u1ee3c di truy\u1ec1n theo <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/books\/n\/gene\/glossary\/def-item\/autosomal-dominant\/\" target=\"_blank\" rel=\"noopener\">quy lu\u1eadt tr\u1ed9i \u1edf nhi\u1ec5m s\u1eafc th\u1ec3 th\u01b0\u1eddng<\/a> t\u1eeb b\u1ed1 ho\u1eb7c m\u1eb9 mang \u0111\u1ed9t bi\u1ebfn STK11. M\u1ed7i ng\u01b0\u1eddi th\u00e2n th\u1ebf h\u1ec7 th\u1ee9 nh\u1ea5t (cha ho\u1eb7c m\u1eb9, con c\u00e1i v\u00e0\/ho\u1eb7c anh ch\u1ecb em ru\u1ed9t) c\u1ee7a m\u1ed9t ng\u01b0\u1eddi m\u1eafc PJS c\u00f3 50% kh\u1ea3 n\u0103ng h\u1ecd b\u1ecb di truy\u1ec1n c\u00f9ng m\u1ed9t \u0111\u1ed9t bi\u1ebfn g\u00e2y ra b\u1ec7nh n\u00e0y.<\/p>\n<p>M\u1ed9t s\u1ed1 c\u00e1 nh\u00e2n m\u1eafc PJS kh\u00f4ng c\u00f3 ti\u1ec1n c\u0103n gia \u0111\u00ecnh v\u1ec1 c\u00e1c tri\u1ec7u ch\u1ee9ng ho\u1eb7c b\u1ec7nh l\u00fd ung th\u01b0 nh\u01b0 nh\u1eefng ng\u01b0\u1eddi m\u1eafc PJS kh\u00e1c. Ng\u01b0\u1eddi ta \u01b0\u1edbc t\u00ednh kho\u1ea3ng 25% tr\u01b0\u1eddng h\u1ee3p b\u1ec7nh PJS c\u00f3 \u0111\u1ed9t bi\u1ebfn gen STK11 m\u1edbi xu\u1ea5t hi\u1ec7n, kh\u00f4ng ph\u1ea3i di truy\u1ec1n t\u1eeb cha m\u1eb9. C\u00e1c th\u00e0nh vi\u00ean gia \u0111\u00ecnh c\u1ee7a m\u1ed9t ng\u01b0\u1eddi \u0111\u01b0\u1ee3c nghi ng\u1edd l\u00e0 \u0111\u1ed9t bi\u1ebfn STK11 m\u1edbi v\u1eabn n\u00ean x\u00e9t nghi\u1ec7m di truy\u1ec1n \u0111\u1ec3 x\u00e1c nh\u1eadn r\u1eb1ng \u0111\u00e2y th\u1ef1c s\u1ef1 l\u00e0 m\u1ed9t \u0111\u1ed9t bi\u1ebfn m\u1edbi. M\u1ed9t ng\u01b0\u1eddi c\u00f3 \u0111\u1ed9t bi\u1ebfn STK11 m\u1edbi kh\u1ea3 n\u0103ng truy\u1ec1n l\u1ea1i \u0111\u1ed9t bi\u1ebfn n\u00e0y cho con ru\u1ed9t c\u1ee7a h\u1ecd l\u00e0 50%.<\/p>\n<p>Nh\u1eefng ng\u01b0\u1eddi mang \u0111\u1ed9t bi\u1ebfn gen l\u00e0m t\u0103ng nguy c\u01a1 m\u1eafc ung th\u01b0 di truy\u1ec1n \u1edf con c\u00e1i nh\u01b0ng c\u00f3 nh\u1eefng l\u1ef1a ch\u1ecdn \u0111\u1ec3 c\u00f3 con ho\u00e0n to\u00e0n kh\u1ecfe m\u1ea1nh. Ch\u1ea9n \u0111o\u00e1n di truy\u1ec1n ti\u1ec1n l\u00e0m t\u1ed5 (PGD) l\u00e0 m\u1ed9t th\u1ee7 thu\u1eadt y khoa \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n k\u1ebft h\u1ee3p v\u1edbi th\u1ee5 tinh trong \u1ed1ng nghi\u1ec7m (IVF). N\u00f3 cho ph\u00e9p gi\u1ea3m kh\u1ea3 n\u0103ng di truy\u1ec1n b\u1ec7nh l\u00fd n\u00e0y sang con c\u00e1i \u1edf nh\u1eefng ng\u01b0\u1eddi mang gen \u0111\u1ed9t bi\u1ebfn. Tr\u1ee9ng c\u1ee7a m\u1ed9t ng\u01b0\u1eddi ph\u1ee5 n\u1eef \u0111\u01b0\u1ee3c l\u1ea5y ra v\u00e0 th\u1ee5 tinh trong ph\u00f2ng th\u00ed nghi\u1ec7m. Khi ph\u00f4i \u0111\u1ea1t \u0111\u1ebfn m\u1ed9t k\u00edch th\u01b0\u1edbc nh\u1ea5t \u0111\u1ecbnh, 1 t\u1ebf b\u00e0o s\u1ebd \u0111\u01b0\u1ee3c t\u00e1ch ra ki\u1ec3m tra t\u00ecnh tr\u1ea1ng di truy\u1ec1n v\u1ec1 gen \u0111\u1ed9t bi\u1ebfn. Sau \u0111\u00f3, cha m\u1eb9 c\u00f3 th\u1ec3 ch\u1ecdn chuy\u1ec3n ph\u00f4i kh\u00f4ng mang \u0111\u1ed9t bi\u1ebfn. PGD \u200b\u200b\u0111\u00e3 \u0111\u01b0\u1ee3c \u00e1p d\u1ee5ng trong h\u01a1n 2 th\u1eadp k\u1ef7, \u0111\u1eb7c bi\u1ec7t cho m\u1ed9t s\u1ed1 h\u1ed9i ch\u1ee9ng c\u00f3 th\u1ec3 g\u00e2y ung th\u01b0 di truy\u1ec1n. Tuy nhi\u00ean, \u0111\u00e2y l\u00e0 m\u1ed9t th\u1ee7 thu\u1eadt ph\u1ee9c t\u1ea1p v\u1edbi nhi\u1ec1u y\u1ebfu t\u1ed1 c\u1ea7n ph\u1ea3i xem x\u00e9t nh\u01b0 t\u00e0i ch\u00ednh v\u00e0 s\u1ee9c kh\u1ecfe v\u1ec1 c\u1ea3 th\u1ec3 ch\u1ea5t l\u1eabn tinh th\u1ea7n. \u0110\u1ec3 bi\u1ebft th\u00eam th\u00f4ng tin, h\u00e3y tham v\u1ea5n v\u1edbi b\u00e1c s\u1ef9 chuy\u00ean khoa h\u1ed7 tr\u1ee3 sinh s\u1ea3n.<\/p>\n<h2><strong>PJS c\u00f3 ph\u1ed5 bi\u1ebfn kh\u00f4ng?<\/strong><\/h2>\n<p>PJS l\u00e0 m\u1ed9t h\u1ed9i ch\u1ee9ng hi\u1ebfm g\u1eb7p. Ng\u01b0\u1eddi ta \u01b0\u1edbc t\u00ednh r\u1eb1ng t\u1eeb 1\/ 50.000 \u0111\u1ebfn 1\/200.000 ng\u01b0\u1eddi c\u00f3 PJS. H\u1ed9i ch\u1ee9ng n\u00e0y c\u00f3 th\u1ec3 b\u1ecb b\u1ecf s\u00f3t v\u00ec c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m da nh\u01b0 t\u00e0n nhang ho\u1eb7c \u0111\u1ed1m s\u1eafc t\u1ed1 th\u01b0\u1eddng kh\u00f4ng nh\u00ecn th\u1ea5y \u1edf tu\u1ed5i tr\u01b0\u1edfng th\u00e0nh.<\/p>\n<h2><strong>PJS \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n nh\u01b0 th\u1ebf n\u00e0o?<\/strong><\/h2>\n<p>Ch\u1ea9n \u0111o\u00e1n PJS \u0111\u01b0\u1ee3c ngh\u0129 \u0111\u1ebfn n\u1ebfu \u0111\u00e1p \u1ee9ng c\u00e1c ti\u00eau chu\u1ea9n ch\u1ea9n \u0111o\u00e1n \u0111\u01b0\u1ee3c li\u1ec7t k\u00ea \u1edf tr\u00ean. Nh\u1eefng ng\u01b0\u1eddi n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u01b0 v\u1ea5n di truy\u1ec1n v\u00e0 sau \u0111\u00f3 l\u00e0 x\u00e9t nghi\u1ec7m m\u00e1u \u0111\u1ec3 t\u00ecm ki\u1ebfm \u0111\u1ed9t bi\u1ebfn gen STK11. Khi t\u00ecm th\u1ea5y \u0111\u1ed9t bi\u1ebfn gen STK11, c\u00e1c th\u00e0nh vi\u00ean kh\u00e1c trong gia \u0111\u00ecnh c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n m\u1eafc PJS n\u1ebfu h\u1ecd \u0111\u01b0\u1ee3c x\u00e9t nghi\u1ec7m v\u00e0 c\u00f3 c\u00f9ng \u0111\u1ed9t bi\u1ebfn gen. Tuy nhi\u00ean, m\u1ed9t s\u1ed1 ng\u01b0\u1eddi \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n l\u00e2m s\u00e0ng PJS nh\u01b0ng l\u1ea1i kh\u00f4ng ph\u00e1t hi\u1ec7n \u0111\u1ed9t bi\u1ebfn tr\u00ean gen STK11. Nh\u1eefng ng\u01b0\u1eddi \u0111\u00e3 bi\u1ebft ho\u1eb7c nghi ng\u1edd m\u1eafc PJS \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o \u0111i kh\u00e1m b\u00e1c s\u0129 chuy\u00ean khoa \u0111\u1ec3 x\u00e1c nh\u1eadn ch\u1ea9n \u0111o\u00e1n v\u00e0 c\u00f3 chi\u1ebfn l\u01b0\u1ee3c theo d\u00f5i ph\u00f9 h\u1ee3p.<\/p>\n<h2><strong>Nguy c\u01a1 ung th\u01b0 li\u00ean quan \u0111\u1ebfn PJS l\u00e0 bao nhi\u00eau?<\/strong><\/h2>\n<ul>\n<li><a href=\"https:\/\/yhoccongdong.com\/thongtin\/ebook\/ung-thu-vu\/\" target=\"_blank\" rel=\"noopener\">Ung th\u01b0 v\u00fa\u00a0<\/a> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 30% \u0111\u1ebfn 50%<\/li>\n<li><a href=\"https:\/\/yhoccongdong.com\/thongtin\/ung-thu-dai-truc-trang\/\" target=\"_blank\" rel=\"noopener\">Ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng\u00a0<\/a> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 40%<\/li>\n<li><a href=\"https:\/\/yhoccongdong.com\/thongtin\/ung-thu-tuy\/\" target=\"_blank\" rel=\"noopener\">B\u1ec7nh ung th\u01b0 tuy\u1ebfn t\u1ee5y\u00a0<\/a> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 10% \u0111\u1ebfn 35%<\/li>\n<li><a href=\"https:\/\/yhoccongdong.com\/thongtin\/ung-thu-da-day\/\" target=\"_blank\" rel=\"noopener\">Ung th\u01b0 d\u1ea1 d\u00e0y\u00a0<\/a> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a030%<\/li>\n<li><a href=\"https:\/\/yhoccongdong.com\/thongtin\/ebook\/ung-thu-buong-trung\/\" target=\"_blank\" rel=\"noopener\">Ung th\u01b0 bu\u1ed3ng tr\u1ee9ng\u00a0<\/a> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 20%<\/li>\n<li><a href=\"https:\/\/yhoccongdong.com\/thongtin\/ung-thu-phoi\/\" target=\"_blank\" rel=\"noopener\">Ung th\u01b0 ph\u1ed5i\u00a0 \u00a0<\/a> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a015%<\/li>\n<li>Ung th\u01b0 ru\u1ed9t non\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a013%<\/li>\n<li><a href=\"https:\/\/yhoccongdong.com\/thongtin\/ung-thu-co-tu-cung\/\" target=\"_blank\" rel=\"noopener\">Ung th\u01b0 bi\u1ec3u m\u00f4 tuy\u1ebfn c\u1ed5 t\u1eed cung<\/a>\u00a0 10%<\/li>\n<li><a href=\"https:\/\/yhoccongdong.com\/thongtin\/ung-thu-tu-cung\/\" target=\"_blank\" rel=\"noopener\">Ung th\u01b0 t\u1eed cung\u00a0<\/a> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u00edt h\u01a1n 10%<\/li>\n<li><a href=\"https:\/\/yhoccongdong.com\/thongtin\/ung-thu-tinh-hoan\/\" target=\"_blank\" rel=\"noopener\">Ung th\u01b0 tinh ho\u00e0n\u00a0<\/a> \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00edt h\u01a1n 10%<\/li>\n<li><a href=\"https:\/\/yhoccongdong.com\/thongtin\/ung-thu-thuc-quan-lu%cc%a3a-chon-phuong-phap-dieu-tri\/\" target=\"_blank\" rel=\"noopener\">Ung th\u01b0 th\u1ef1c qu\u1ea3n<\/a>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a02%<\/li>\n<\/ul>\n<h2><strong>Ph\u01b0\u01a1ng ti\u1ec7n t\u1ea7m so\u00e1t cho ng\u01b0\u1eddi m\u1eafc PJS hay ng\u01b0\u1eddi nghi ng\u1edd m\u1eafc PJS?<\/strong><\/h2>\n<p>B\u1ea1n c\u1ea7n trao \u0111\u1ed5i v\u1edbi b\u00e1c s\u1ef9 \u0111\u1ec3 l\u1ef1a ch\u1ecdn ph\u01b0\u01a1ng ti\u1ec7n t\u1ea7m so\u00e1t ph\u00f9 h\u1ee3p, v\u00ec m\u1ed7i c\u00e1 nh\u00e2n l\u00e0 kh\u00e1c nhau:<\/p>\n<h3>T\u1ea7m so\u00e1t ung th\u01b0 n\u00f3i chung cho b\u1ea5t c\u1ee9 ai b\u1ecb PJS<\/h3>\n<ul>\n<li><a href=\"https:\/\/yhoccongdong.com\/thongtin\/noi-soi-da-day-gastroscopy\/\" target=\"_blank\" rel=\"noopener\">N\u1ed9i soi \u0111\u01b0\u1eddng ti\u00eau h\u00f3a tr\u00ean<\/a> v\u00e0 n\u1ed9i soi vi\u00ean nang quay video, b\u1eaft \u0111\u1ea7u l\u00fac 8 tu\u1ed5i. N\u1ebfu ph\u00e1t hi\u1ec7n polyp, c\u1ea7n l\u1eb7p l\u1ea1i x\u00e9t nghi\u1ec7m sau m\u1ed7i 2 \u0111\u1ebfn 3 n\u0103m. N\u1ebfu kh\u00f4ng c\u00f3 polyp n\u00e0o \u0111\u01b0\u1ee3c nh\u00ecn th\u1ea5y th\u1eddi \u0111i\u1ec3m 8 tu\u1ed5i, l\u1eb7p l\u1ea1i x\u00e9t nghi\u1ec7m \u1edf l\u00fac 18 tu\u1ed5i, v\u00e0 sau \u0111\u00f3 m\u1ed7i 2 \u0111\u1ebfn 3 n\u0103m. N\u1ed9i soi s\u1eed d\u1ee5ng m\u1ed9t \u1ed1ng m\u1ecfng, nh\u1eb9 v\u1edbi m\u1ed9t m\u00e1y quay video nh\u1ecf \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o mi\u1ec7ng, xu\u1ed1ng th\u1ef1c qu\u1ea3n \u0111\u1ec3 t\u00ecm kh\u1ed1i u ho\u1eb7c c\u00e1c b\u1ea5t th\u01b0\u1eddng kh\u00e1c.<\/li>\n<li><a href=\"https:\/\/yhoccongdong.com\/thongtin\/noi-soi-dai-trang-colonoscopy\/\" target=\"_blank\" rel=\"noopener\">N\u1ed9i soi \u0111\u1ea1i tr\u00e0ng<\/a>, b\u1eaft \u0111\u1ea7u l\u00fac 8 tu\u1ed5i. N\u1ebfu nh\u00ecn th\u1ea5y polyp, c\u1ea7n l\u1eb7p l\u1ea1i n\u1ed9i soi sau m\u1ed7i 2 \u0111\u1ebfn 3 n\u0103m. N\u1ebfu kh\u00f4ng nh\u00ecn th\u1ea5y polyp \u1edf th\u1eddi \u0111i\u1ec3m n\u00e0y, l\u1eb7p l\u1ea1i x\u00e9t nghi\u1ec7m \u1edf l\u00fac 18 tu\u1ed5i, v\u00e0 sau \u0111\u00f3 m\u1ed7i 2 \u0111\u1ebfn 3 n\u0103m. Khi n\u1ed9i soi, b\u00e1c s\u0129 s\u1ebd \u0111\u01b0a m\u1ed9t \u1ed1ng m\u1ec1m v\u1edbi m\u1ed9t m\u00e1y quay video nh\u1ecf v\u00e0o h\u1eadu m\u00f4n \u0111\u1ec3 ki\u1ec3m tra c\u00e1c v\u1ea5n \u0111\u1ec1 trong \u0111\u1ea1i tr\u00e0ng v\u00e0 tr\u1ef1c tr\u00e0ng.<\/li>\n<li>Si\u00eau \u00e2m qua n\u1ed9i soi h\u00e0ng n\u0103m v\u00e0\/ho\u1eb7c MRI t\u1ee5y \u0111\u1ec3 t\u1ea7m so\u00e1t ung th\u01b0 t\u1ee5y, b\u1eaft \u0111\u1ea7u \u1edf tu\u1ed5i 30 \u0111\u1ebfn 35, ho\u1eb7c n\u1ebfu trong gia \u0111\u00ecnh c\u00f3 ng\u01b0\u1eddi m\u1eafc ung th\u01b0 t\u1ee5y, t\u1ea7m so\u00e1t n\u00ean \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh tr\u01b0\u1edbc 10 n\u0103m t\u00ednh t\u1eeb tu\u1ed5i c\u1ee7a ng\u01b0\u1eddi tr\u1ebb nh\u1ea5t m\u1eafc ung th\u01b0.<\/li>\n<li>T\u1ea7m so\u00e1t ung th\u01b0 ph\u1ed5i chuy\u00ean bi\u1ec7t hi\u1ec7n kh\u00f4ng \u0111\u01b0\u1ee3c khuy\u1ebfn c\u00e1o, nh\u01b0ng nh\u1eefng ng\u01b0\u1eddi m\u1eafc PJS n\u00ean tr\u00e1nh h\u00fat thu\u1ed1c, do c\u00f3 m\u1ed1i li\u00ean h\u1ec7 gi\u1eefa h\u00fat thu\u1ed1c l\u00e1 v\u1edbi ung th\u01b0 ph\u1ed5i v\u00e0 ung th\u01b0 t\u1ee5y.<\/li>\n<\/ul>\n<h3>T\u1ea7m so\u00e1t ung th\u01b0 cho ph\u1ee5 n\u1eef m\u1eafc PJS<\/h3>\n<ul>\n<li>T\u1ef1 ki\u1ec3m tra v\u00fa h\u00e0ng th\u00e1ng v\u00e0 th\u0103m kh\u00e1m v\u00fa h\u00e0ng n\u0103m \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi b\u00e1c s\u0129 ho\u1eb7c \u0111i\u1ec1u d\u01b0\u1ee1ng, b\u1eaft \u0111\u1ea7u l\u00fac 20 tu\u1ed5i.<\/li>\n<li>Ch\u1ee5p <a href=\"https:\/\/yhoccongdong.com\/thongtin\/x-quang-vu-con-goi-la-nhu-anh\/\" target=\"_blank\" rel=\"noopener\">nh\u0169 \u1ea3nh<\/a> m\u1ed7i 2 \u0111\u1ebfn 3 n\u0103m, b\u1eaft \u0111\u1ea7u l\u00fac 20 tu\u1ed5i, sau \u0111\u00f3 ch\u1ee5p nh\u0169 \u1ea3nh h\u00e0ng n\u0103m t\u1eeb 40 tu\u1ed5i<\/li>\n<li>Ki\u1ec3m tra ph\u1ee5 khoa h\u00e0ng n\u0103m bao g\u1ed3m <a href=\"https:\/\/yhoccongdong.com\/thongtin\/giai-thich-nhung-ket-qua-bat-thuong-cua-xet-nghiem-pap\/\" target=\"_blank\" rel=\"noopener\">x\u00e9t nghi\u1ec7m Pap<\/a>, <a href=\"https:\/\/yhoccongdong.com\/thongtin\/sieu-am-nga-am-dao\/\">si\u00eau \u00e2m \u0111\u01b0\u1eddng \u00e2m \u0111\u1ea1o<\/a> v\u00e0 c\u00e2n nh\u1eafc v\u1ec1 vi\u1ec7c sinh thi\u1ebft t\u1eed cung, b\u1eaft \u0111\u1ea7u l\u00fac 25 tu\u1ed5i.<\/li>\n<li>N\u1eef gi\u1edbi m\u1eafc PJS c\u00f3 nguy c\u01a1 b\u1ecb u d\u00e2y sinh d\u1ee5c nguy\u00ean thu\u1ef7 v\u1edbi \u1ed1ng h\u00ecnh khuy\u00ean (Sex Cord Tumors with Annular Tubules &#8211; SCTAT), m\u1ed9t kh\u1ed1i u l\u00e0nh t\u00ednh c\u1ee7a bu\u1ed3ng tr\u1ee9ng v\u00e0 u tuy\u1ebfn \u00e1c t\u00ednh c\u1ee7a c\u1ed5 t\u1eed cung, m\u1ed9t lo\u1ea1i ung th\u01b0 x\u00e2m l\u1ea5n hi\u1ebfm g\u1eb7p th\u01b0\u1eddng \u0111\u01b0\u1ee3c \u0111\u1eb7c tr\u01b0ng b\u1edfi ti\u1ebft d\u1ecbch \u00e2m \u0111\u1ea1o nh\u1ea7y d\u00ednh.<\/li>\n<\/ul>\n<h3>T\u1ea7m so\u00e1t ung th\u01b0 cho nam gi\u1edbi m\u1eafc PJS<\/h3>\n<ul>\n<li>Kh\u00e1m tinh ho\u00e0n h\u00e0ng n\u0103m b\u1eaft \u0111\u1ea7u t\u1eeb th\u1eddi th\u01a1 \u1ea5u. <a href=\"https:\/\/www.cancer.net\/node\/24714\" target=\"_blank\" rel=\"noopener\">Si\u00eau \u00e2m<\/a> tinh ho\u00e0n n\u00ean \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 t\u00ecm ki\u1ebfm b\u1ea5t th\u01b0\u1eddng, si\u00eau \u00e2m c\u00f3 th\u1ec3 gi\u00fap ki\u1ec3m tra d\u1ea5u hi\u1ec7u c\u1ee7a c\u00e1c r\u1ed1i lo\u1ea1n<\/li>\n<li>Nam gi\u1edbi c\u00f3 th\u1ec3 ph\u00e1t tri\u1ec3n kh\u1ed1i u t\u1ebf b\u00e0o Sertoli ch\u1ee9a l\u01b0\u1ee3ng l\u1edbn canxi (LCST) \u1edf tinh ho\u00e0n, ti\u1ebft ra estrogen v\u00e0 c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn ng\u1ef1c to (gynecomastia), c\u1ed1t h\u00f3a x\u01b0\u01a1ng s\u1edbm v\u00e0 cu\u1ed1i c\u00f9ng l\u00e0 g\u00e2y ra t\u00ecnh tr\u1ea1ng l\u00f9n n\u1ebfu kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb.<\/li>\n<\/ul>\n<p>C\u00e1c ph\u01b0\u01a1ng ti\u1ec7n t\u1ea7m so\u00e1t c\u00f3 th\u1ec3 thay \u0111\u1ed5i theo th\u1eddi gian khi c\u00e1c c\u00f4ng ngh\u1ec7 m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u00e0 nhi\u1ec1u ki\u1ebfn th\u1ee9c m\u1edbi v\u1ec1 PJS \u0111\u01b0\u1ee3c c\u1eadp nh\u1eadt. \u0110i\u1ec1u quan tr\u1ecdng l\u00e0 tham v\u1ea5n \u00fd ki\u1ebfn b\u00e1c s\u1ef9 v\u1ec1 c\u00e1c x\u00e9t nghi\u1ec7m t\u1ea7m so\u00e1t ph\u00f9 h\u1ee3p.<\/p>\n<p><em>T\u00ecm hi\u1ec3u th\u00eam v\u1ec1 <a href=\"https:\/\/www.cancer.net\/node\/24959\" target=\"_blank\" rel=\"noopener\">Nh\u1eefng k\u1ebft qu\u1ea3 mong \u0111\u1ee3i khi th\u1ef1c hi\u1ec7n x\u00e9t nghi\u1ec7m, th\u1ee7 thu\u1eadt v\u00e0 h\u00ecnh \u1ea3nh h\u1ecdc th\u00f4ng th\u01b0\u1eddng<\/a>.<\/em><\/p>\n<h2><strong>B\u1ea1n c\u1ea7n h\u1ecfi b\u00e1c s\u0129 nh\u1eefng g\u00ec?<\/strong><\/h2>\n<p>N\u1ebfu b\u1ea1n lo l\u1eafng v\u1ec1 PJS v\u00e0 nguy c\u01a1 m\u1eafc b\u1ec7nh ung th\u01b0, h\u00e3y n\u00f3i chuy\u1ec7n v\u1edbi nh\u00f3m ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe. B\u1ea1n c\u00f3 th\u1ec3 h\u1ecfi nh\u1eefng c\u00e2u h\u1ecfi sau\u00a0:<\/p>\n<ul>\n<li>Nguy c\u01a1 xu\u1ea5t hi\u1ec7n ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng, ung th\u01b0 v\u00fa ho\u1eb7c c\u00e1c lo\u1ea1i ung th\u01b0 kh\u00e1c c\u1ee7a t\u00f4i nh\u01b0 th\u1ebf n\u00e0o?<\/li>\n<li>T\u00f4i c\u00f3 t\u1ed5ng c\u1ed9ng c\u00f3 bao nhi\u00eau polyp \u0111\u1ea1i tr\u00e0ng?<\/li>\n<li>T\u00f4i \u0111\u00e3 c\u00f3 lo\u1ea1i polyp \u0111\u1ea1i tr\u00e0ng n\u00e0o? Hai lo\u1ea1i ph\u1ed5 bi\u1ebfn nh\u1ea5t l\u00e0 t\u0103ng s\u1ea3n v\u00e0 u tuy\u1ebfn.<\/li>\n<li>T\u00f4i c\u00f3 th\u1ec3 l\u00e0m g\u00ec \u0111\u1ec3 gi\u1ea3m nguy c\u01a1 ung th\u01b0?<\/li>\n<li>T\u00f4i c\u00f3 th\u1ec3 l\u1ef1a ch\u1ecdn nh\u1eefng ph\u01b0\u01a1ng ti\u1ec7n n\u00e0o \u0111\u1ec3 \u0111\u00e1nh gi\u00e1 nguy c\u01a1 ung th\u01b0, t\u01b0 v\u1ea5n di truy\u1ec1n v\u00e0 x\u00e9t nghi\u1ec7m di truy\u1ec1n?<\/li>\n<li>T\u00f4i c\u00f3 th\u1ec3 l\u1ef1a ch\u1ecdn nh\u1eefng ph\u01b0\u01a1ng ti\u1ec7n n\u00e0o \u0111\u1ec3 t\u1ea7m so\u00e1t v\u00e0 ng\u0103n ng\u1eeba ung th\u01b0?<\/li>\n<\/ul>\n<p>N\u1ebfu b\u1ea1n lo l\u1eafng v\u1ec1 ti\u1ec1n s\u1eed gia \u0111\u00ecnh v\u00e0 ngh\u0129 r\u1eb1ng gia \u0111\u00ecnh m\u00ecnh c\u00f3 th\u1ec3 c\u00f3 PJS, b\u1ea1n c\u00f3 th\u1ec3 h\u1ecfi nh\u1eefng c\u00e2u h\u1ecfi sau\u00a0:<\/p>\n<ul>\n<li>Ti\u1ec1n c\u0103n gia \u0111\u00ecnh t\u00f4i l\u00e0m t\u0103ng nguy c\u01a1 ung th\u01b0 \u0111\u1ea1i tr\u1ef1c tr\u00e0ng, ung th\u01b0 v\u00fa ho\u1eb7c c\u00e1c lo\u1ea1i ung th\u01b0 kh\u00e1c kh\u00f4ng?<\/li>\n<li>T\u00f4i c\u00f3 c\u1ea7n ph\u1ea3i \u0111\u00e1nh gi\u00e1 nguy c\u01a1 ung th\u01b0 kh\u00f4ng?<\/li>\n<li>T\u00f4i c\u00f3 c\u1ea7n tham v\u1ea5n chuy\u00ean gia di truy\u1ec1n hay kh\u00f4ng?<\/li>\n<li>T\u00f4i c\u00f3 c\u1ea7n th\u1ef1c hi\u1ec7n c\u00e1c <a href=\"https:\/\/yhoccongdong.com\/thongtin\/xet-nghiem-di-truyen-nhung-dieu-can-biet\/\" target=\"_blank\" rel=\"noopener\">x\u00e9t nghi\u1ec7m di truy\u1ec1n<\/a>?<\/li>\n<\/ul>\n<h2><strong>C\u00e1c t\u00e0i nguy\u00ean li\u00ean quan<\/strong><\/h2>\n<p><a href=\"https:\/\/www.cancer.net\/node\/24897\" target=\"_blank\" rel=\"noopener\"><u>Di truy\u1ec1n h\u1ecdc c\u1ee7a ung th\u01b0<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.cancer.net\/node\/24864\" target=\"_blank\" rel=\"noopener\"><u>X\u00e9t nghi\u1ec7m di truy\u1ec1n<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.cancer.net\/node\/24907\" target=\"_blank\" rel=\"noopener\"><u>Nh\u1eefng g\u00ec mong \u0111\u1ee3i khi b\u1ea1n g\u1eb7p m\u1ed9t c\u1ed1 v\u1ea5n di truy\u1ec1n<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.cancer.net\/node\/24864\" target=\"_blank\" rel=\"noopener\"><u>Thu th\u1eadp ti\u1ec1n s\u1eed ung th\u01b0 gia \u0111\u00ecnh b\u1ea1n<\/u><\/a><\/p>\n<p><a href=\"https:\/\/www.cancer.net\/node\/36141\" target=\"_blank\" rel=\"noopener\"><u>Chia s\u1ebb k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m di truy\u1ec1n v\u1edbi gia \u0111\u00ecnh b\u1ea1n<\/u><\/a><\/p>\n<h2><strong>T\u00ecm hi\u1ec3u th\u00eam th\u00f4ng tin<\/strong><\/h2>\n<p><a href=\"https:\/\/www.ccalliance.org\/\" target=\"_blank\" rel=\"noopener\">Kh\u1ed1i li\u00ean minh ung th\u01b0 \u0111\u1ea1i tr\u00e0ng<\/a><\/p>\n<p><a href=\"http:\/\/www.facesourrisk.org\/\" target=\"_blank\" rel=\"noopener\">\u0110\u1ed1i m\u1eb7t v\u1edbi nguy c\u01a1 ung th\u01b0 c\u1ee7a ch\u00fang ta \u0111\u01b0\u1ee3c trao quy\u1ec1n (FORCE)<\/a><\/p>\n<p><a href=\"https:\/\/www.pancan.org\/\" target=\"_blank\" rel=\"noopener\">M\u1ea1ng l\u01b0\u1edbi h\u00e0nh \u0111\u1ed9ng v\u00ec ung th\u01b0 t\u1ee5y<\/a><\/p>\n<p><a href=\"https:\/\/www.cancer.gov\/\" target=\"_blank\" rel=\"noopener\">Vi\u1ec7n ung th\u01b0 qu\u1ed1c gia<\/a><\/p>\n<p><a href=\"https:\/\/www.cancer.org\/\" target=\"_blank\" rel=\"noopener\">Hi\u1ec7p h\u1ed9i Ung th\u01b0 Hoa K\u1ef3<\/a><\/p>\n<p><a href=\"https:\/\/www.cancercare.org\/\" target=\"_blank\" rel=\"noopener\">Ung th\u01b0<\/a><\/p>\n<p><em>\u0110\u1ec3 t\u00ecm m\u1ed9t c\u1ed1 v\u1ea5n di truy\u1ec1n trong khu v\u1ef1c c\u1ee7a b\u1ea1n, h\u00e3y tham v\u1ea5n b\u00e1c s\u0129 c\u1ee7a b\u1ea1n ho\u1eb7c truy c\u1eadp c\u00e1c trang web sau<\/em>:<\/p>\n<p><a href=\"https:\/\/www.nsgc.org\/\" target=\"_blank\" rel=\"noopener\">Hi\u1ec7p h\u1ed9i c\u1ed1 v\u1ea5n di truy\u1ec1n qu\u1ed1c gia<\/a><\/p>\n<p><a href=\"https:\/\/www.cancer.gov\/cancertopics\/genetic\/directory\" target=\"_blank\" rel=\"noopener\">Vi\u1ec7n Ung th\u01b0 Qu\u1ed1c gia: Th\u01b0 m\u1ee5c D\u1ecbch v\u1ee5 Di truy\u1ec1n Ung th\u01b0<\/a><\/p>\n<h2><strong>T\u00e0i li\u1ec7u tham kh\u1ea3o<\/strong><\/h2>\n<p><a href=\"https:\/\/www.cancer.net\/cancer-types\/peutz-jeghers-syndrome\" target=\"_blank\" rel=\"noopener\">https:\/\/www.cancer.net\/cancer-types\/peutz-jeghers-syndrome<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>H\u1ed9i ch\u1ee9ng Peutz-Jeghers (PJS) l\u00e0 b\u1ec7nh l\u00fd di truy\u1ec1n t\u0103ng nguy c\u01a1 xu\u1ea5t hi\u1ec7n u m\u00f4 th\u1eeba d\u1ea1ng polyp trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a c\u0169ng nh\u01b0 ung th\u01b0 v\u00fa, tinh ho\u00e0n, bu\u1ed3ng tr\u1ee9ng, ph\u1ed5i, c\u1ed5 t\u1eed cung, v\u00e0 c\u00e1c lo\u1ea1i kh\u00e1c&#8230;<\/p>\n","protected":false},"author":424,"featured_media":8471,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3104,2460],"tags":[3234,3106],"series":[1953],"coauthors":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>H\u1ed9i ch\u1ee9ng Peutz-Jeghers - D\u1ef1 \u00e1n Ung Th\u01b0<\/title>\n<meta name=\"description\" content=\"H\u1ed9i ch\u1ee9ng Peutz-Jeghers (PJS) l\u00e0 b\u1ec7nh l\u00fd di truy\u1ec1n t\u0103ng nguy c\u01a1 xu\u1ea5t hi\u1ec7n u m\u00f4 th\u1eeba d\u1ea1ng polyp trong \u0111\u01b0\u1eddng ti\u00eau h\u00f3a c\u0169ng nh\u01b0 ung th\u01b0 v\u00fa, tinh ho\u00e0n, bu\u1ed3ng tr\u1ee9ng, ph\u1ed5i, c\u1ed5 t\u1eed cung, v\u00e0 c\u00e1c lo\u1ea1i kh\u00e1c...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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